ALEXIS Biochemicals: TGX-221

ALX-270-464

Revised 13-Jun-07

TGX-221
SYNONYMS	7-Methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido-[1,2-a]pyrimidin-4-one
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phosphoinositide 3-kinase [PI(3)K] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-464-C100		100 µg	75.00 USD
ALX-270-464-M001		1 mg	580.00 USD

Product Specification

FORMULA:	C₂₁H₂₄N₄O₂
MW:	364.4
CAS NUMBER:	663619-89-4
PURITY:	≥98% (NMR)
APPEARANCE:	Pale yellow solid.
SOLUBILITY:	Soluble in DMSO, 100% ethanol or dimethyl formamide; sparingly soluble in aqueous buffers.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C

Product Description

Potent, selective and cell permeable inhibitor of phosphoinositide 3-kinase (PI(3)K) p110β.

Product Specific Literature References

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils: A.M. Condliffe, et al.; Blood 106, 1432 (2005) Abstract; Full Text
PI 3-kinase p110beta: a new target for antithrombotic therapy: S.P. Jackson, et al.; Nat. Med. 11, 507 (2005) Abstract; Full Text

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