ALEXIS Biochemicals: AS-604850

ALX-270-461

Revised 25-May-07

AS-604850
SYNONYMS	5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phosphoinositide 3-kinase [PI(3)K]/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-461-M001		1 mg	35.00 USD
ALX-270-461-M005		5 mg	130.00 USD
ALX-270-461-M025		25 mg	520.00 USD

Product Specification

FORMULA:	C₁₁H₅F₂NO₄S
MW:	285.2
PURITY:	≥98% (HPLC)
APPEARANCE:	Off-white to yellow solid.
SOLUBILITY:	Soluble in acetonitrile (6mg/ml), DMSO (50mg/ml), methanol (9mg/ml) or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	IRRITANT.
MELTINGPOINT:	200-202°C

Product Description

Potent, cell permeable and ATP-competitive inhibitor of phosphoinositide 3-kinase γ (PI(3)Kγ). Exhibits selectivity over other PI(3)K isoforms.

Product Specific Literature References

Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis: M. Camps, et al.; Nat. Med. 11, 936 (2005) Abstract
Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells: A. Bilancio, et al.; Blood 107, 642 (2006) Abstract; Full Text

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.