© 2008 Alexis Corporation
ALX-420-043
Revised 22-May-08
FTY720
SYNONYMS
2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol . HCl
Fingolimod . HCl
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Immunomodulators Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-420-043-M001
1 mg
40.00 USD
ALX-420-043-M005
5 mg
190.00 USD
Product Specification
FORMULA:
C
19
H
33
NO
2
. HCl
MW:
307.5 . 36.5
CAS NUMBER:
162359-56-0
PURITY:
≥98%
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
20mg/ml soluble in 100% ethanol, DMSO or dimethyl formamide; sparingly soluble in aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
We do not recommend storing aqueous solutions for more than one day.
Product Description
Analog of myriocin (Prod. No.
ALX-350-274
). Novel immune modulator that alters migration and homing of lymphocytes. Acts as a potent agonist of sphingosine 1-phosphate receptors (S1P) after phosphorylation by sphingosine kinase. Also inhibits cytosolic phospholipase A
2
independently of sphingosine 1-phosphate receptors.
Product Specific Literature References
The immune modulator FTY720 targets sphingosine 1-phosphate receptors:
V. Brinkmann, et al.; J. Biol. Chem.
277
, 21453 (2002)
Abstract
;
Full Text
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors:
S.G. Payne, et al.; Blood
109
, 1077 (2007)
Abstract
FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia:
P. Neviani, et al.; J. Clin. Invest.
117
, 2408 (2007)
Abstract
;
Full Text
Related Products
ALX-350-274
Myriocin
Further Categories Containing This Product:
PLA2 Inhibitors
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