ALEXIS Biochemicals: Diazoxide

ALX-550-260

Revised 29-Apr-08

Diazoxide
SYNONYMS	7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	K+ Channel Activators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-260-M500		500 mg	47.00 USD
ALX-550-260-G001		1 g	75.00 USD

Product Specification

FORMULA:	C₈H₇ClN₂O₂S
MW:	230.7
CAS NUMBER:	364-98-7
MERCK INDEX:	14: 3004
PURITY:	≥98%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO (25mg/ml); insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	HARMFUL.

Product Description

ATP-sensitive K⁺channel activator. Blocks desensitization of AMPA receptors. Acts in pancreatic β-cells, where it is more potent than pinacidil (Prod. No. ALX-550-285). Antihypertensive and vasodilatory agent.

Product Specific Literature References

Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells: G. Trube, et al.; Pflugers Arch. Eur. J. Physiol. 407, 493 (1986) Abstract
Protein phosphorylation is required for diazoxide to open ATP-sensitive potassium channels in insulin (RINm5F) secreting cells: M.J. Dunne; FEBS Lett. 250, 262 (1989) Abstract
In vitro and in vivo comparison of two K+ channel openers, diazoxide and cromakalim, and their inhibition by glibenclamide: U. Quast & N.S. Cook; J. Pharmacol. Exp. Ther. 250, 261 (1989) Abstract
The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim: D.T. Newgreen, et al.; Br. J. Pharmacol. 100, 605 (1990) Abstract
Comparative study of the effects of cromakalim (BRL 34915) and diazoxide on membrane potential, [Ca2+]i and ATP-sensitive potassium currents in insulin-secreting cells: M.J. Dunne, et al.; J. Membr. Biol. 114, 53 (1990) Abstract
Diazoxide-sensitivity of the adenosine 5'-triphosphate-dependent K+ channel in mouse pancreatic beta-cells: C. Schwanstecher, et al.; Br. J. Pharmacol. 107, 87 (1992) Abstract

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