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ALX-300-147 Revised 11-Jul-08
Dihomo-γ-linolenylethanolamide
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SYNONYMS N-(2-Hydroxyethyl)-8Z,11Z,14Z-eicosatrienamide
HEA
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Endocannabinoids
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-300-147-M005   5 mg 63.00 USD Add To Cart
Product Specification
FORMULA: C22H39NO2
MW: 349.6
CAS NUMBER: 150314-34-4
PURITY: ≥98%
FORMULATION: Liquid. Solution in ethanol.
SOLUBILITY: Soluble in  DMSO (30mg/ml) or dimethyl formamide (10mg/ml); 8mg/ml soluble in a 1:2 solution of ethanol:PBS (pH 7.2) (dilute the ethanol solution with PBS).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING: Protect from light.

Product Description
Endocannabinoid. Binds to recombinant human CB1 (Ki=857nM) and CB2 receptor (Ki=598nM). Also inhibits adenylyl cyclase (IC50=109nM).
Product Specific Literature References
Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor: L. Hanus, et al.; J. Med. Chem. 36, 3032 (1993) Abstract
Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction: C.C. Felder, et al.; PNAS 90, 7656 (1993) Abstract
Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides: J. Barg, et al.; Eur. J. Pharmacol. 287, 145 (1995) Abstract
Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors: C.C. Felder, et al.; Mol. Pharmacol. 48, 443 (1995) Abstract
Astrocytes in culture produce anandamide and other acylethanolamides: L. Walter, et al.; Biol. Chem. 277, 20869 (2002) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Adenylyl Cyclase Inhibitors
 
 
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