ALEXIS Biochemicals: Dimethylenastron

ALX-270-438

Revised 06-Dec-06

Dimethylenastron
SYNONYMS	7,7-Dimethyl-4-(3-hydroxyphenyl)-5-oxo-3,4,5,6,7,8-hexahydroquinazolin-2(1H)-thione
PRODUCT LINE	Cell Cycle
PRODUCT CATEGORY	Cell Cycle Blockers & Inhibitors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-438-M001		1 mg	75.00 USD

Product Specification

FORMULA:	C₁₆H₁₈N₂O₂S
MW:	302.4
CAS NUMBER:	863774-58-7
PURITY:	≥95%
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in DMSO (10mg/ml) or methanol (5mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months when stored at -20°C in the dark.
HANDLING:	Protect from light.
HAZARD:	HARMFUL.
IDENTITY:	Identity determined by ¹H-NMR, ¹³C-NMR and MS.

Product Description

Potent, cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC₅₀=200nM) by binding to the mitotic kinesin Eg5.

Product Specific Literature References

Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5: M. Gartner, et al.; ChemBioChem. 6, 1173 (2005) Abstract
Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5: N. Sunder-Plassmann, et al.; Bioorg. Med. Chem. 13, 6094 (2005) Abstract
Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells: C. Muller, et al.; Cancer Chemother. Pharmacol. 59, 157 (2007) Abstract

Further Categories Containing This Product:

Kinesin & Kinesin-like Proteins / Related Products

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