ALEXIS Biochemicals: Dinactin

ALX-380-226

Revised 03-Apr-08

Dinactin
SYNONYMS	Antibiotic AKD 1C Antibiotic S 3466A
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Ionophores

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-226-M001		1 mg	370.00 USD

Product Specification

FORMULA:	C₄₂H₆₈O₁₂
MW:	765.0
CAS NUMBER:	20261-85-2
SOURCE/HOST:	Isolated from Streptomyces sp. MST-AS5448.
PURITY:	≥95% (HPLC)
APPEARANCE:	Colorless film.
SOLUBILITY:	Soluble in ethyl acetate or DMSO; moderately soluble in 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Antibioit. Cation ionophore with high selectivity for ammonium and potassium. Inhibits T cell proliferation induced by IL-2 and cytokine production at nanomolar levels. Dimeric dinactin shows potent antineoplastic and antibacterial activities.

Product Specific Literature References

The in Vitro Activity of Nonactin and Its Homologs: Monactin, Dinactin and Trinactin: E. Meyers, et al.; J. Antibiot. (Tokyo) 18, 128 (1965) Abstract
Antibiotics as tools for metabolic studies. V. Effect of nonactin, monactin, dinactin, and trinactin on oxidative phosphorylation and adenosine triphosphatase induction: S.N. Graven, et al.; Biochemistry 5, 1729 (1966) Abstract
Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin: S.N. Graven, et al.; Biochemistry 5, 1735 (1966) Abstract
Immunosuppressive effects of polynactins (tetranactin, trinactin and dinactin) on experimental autoimmune uveoretinitis in rats: Y. Tanouchi and H. Shichi; Jpn. J. Ophthalmol. 31, 218 (1987) Abstract
Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation: S.P. Umland, et al.; Am. J. Respir. Cell. Mol. Biol. 20, 481 (1999) Abstract; Full Text
Antibacterial and antitumor macrolides from Streptomyces sp. Is9131: P.J. Zhao, et al.; Arch. Pharm. Res. 28, 1228 (2005) Abstract