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ALX-550-152 Revised 20-Sep-07
Domoic acid
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SYNONYMS [2S-[2α,3β,4β(1Z,3E,5R)]]-2-Carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-3-pyrrolidineacetic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-152-M001   1 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C15H21NO6
MW: 311.3
CAS NUMBER: 14277-97-5
MERCK INDEX: 14: 3417
SOURCE/HOST: Isolated from Nitzschia pungens f. multiseries.
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: 8mg/ml soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 3 months when stored at -20°C.
HAZARD: HARMFUL. POTENT NEUROTOXIN.

Product Description
Glutamate/kainate excitatory amino acid agonist with highest affinity for the kainate receptor of all known kainic acid analogs.
Product Specific Literature References
Structure-activity relations of excitatory amino acids on frog and rat spinal neurones: T.J. Biscoe, et al.; Br. J. Pharmacol. 58, 373 (1976) Abstract
A kainic acid receptor from frog brain purified using domoic acid affinity chromatography: D.R. Hampson & R.J. Wenthold; J. Biol. Chem. 263, 2500 (1988) Abstract; Full Text
Domoic acid, the alleged "mussel toxin," might produce its neurotoxic effect through kainate receptor activation: an electrophysiological study in the dorsal hippocampus: G. Debonnel, et al.; Can. J. Physiol. Pharmacol. 67, 29 (1989) Abstract
Identification of domoic acid, a neuroexcitatory amino acid, in toxic mussels from eastern Prince Edward Island: P. Wright, et al.; Can. J. Chem. 67, 481 (1989)
Domoic acid: a dementia-inducing excitotoxic food poison with kainic acid receptor specificity: G.R. Stewart, et al.; Exp. Neurol. 110, 127 (1990) Abstract
Pharmacology of systemically administered domoic acid in mice: R.A. Tasker, et al.; Can. J. Physiol. Pharmacol. 69, 378 (1991) Abstract
Transfer constants for blood-brain barrier permeation of the neuroexcitatory shellfish toxin, domoic acid: E. Preston & I. Hynie; Can. J. Neurol. Sci. 18, 39 (1991) Abstract
Interaction of domoic acid and several derivatives with kainic acid and AMPA binding sites in rat brain: D.R. Hampson, et al.; Eur. J. Pharmacol. 218, 1 (1992) Abstract
Parenteral domoic acid impairs spatial learning in mice: B.F. Petrie, et al.; Pharmacol. Biochem. Behav. 41, 211 (1992) Abstract
Evidence for hybrid NMDA/kainate receptors from protein reconstitution studies and expression of vertebrate CNS RNAs in Xenopus oocytes: P.N. Usherwood & E.A. Barnard; Comp. Biochem. Physiol. [C] 103, 19 (1992) Abstract
Domoic acid induced release of [3H]GABA in cultured chick retina cells: M. Alfonso, et al.; Neurochem. Int. 24, 267 (1994) Abstract
Domoic acid inhibits adenylate cyclase activity in rat brain membranes: M.S. Nijjar & B. Grimmelt; Mol. Cell. Biochem. 136, 105 (1994) Abstract
The activation of glutamate receptors by kainic acid and domoic acid: D.R. Hampson & J.L. Manalo; Nat. Toxins 6, 153 (1998), Review Abstract
Neurohistochemical biomarkers of the marine neurotoxicant, domoic acid: A.C. Scallet, et al.; Neurotoxicol. Teratol. 27, 745 (2005) Abstract
Further Categories Containing This Product:
NeurotoxinsKainate Receptors/Related ProductsExcitatory Amino Acids
 
 

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