ALEXIS Biochemicals: EB-47 . dihydrochloride . dihydrate

ALX-270-383

Revised 22-Dec-04

EB-47 . dihydrochloride . dihydrate
SYNONYMS	1-Piperazineacetamide,4-[1-(6-amino-9H-purin-9-yl)-1-deoxy-β-D-ribofuranuron]-N-(2,3-dihydro-1H-isoindol-4-yl)-1-one . 2HCl . 2H₂O
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	PARP Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-383-M001		1 mg	45.00 USD
ALX-270-383-M005		5 mg	180.00 USD

Product Specification

FORMULA:	C₂₄H₂₇N₉O₆ . 2HCl . 2H₂O
MW:	537.5 . 73.0 . 36.0
PURITY:	≥95% (HPLC)
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in water or DMSO.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Packaged under inert gas. Protect from light.
HAZARD:	MAY BE CARCINOGENIC. HARMFUL.

Product Description

Very potent and water soluble PARP-1 inhibitor (IC₅₀=45nM, 100% inhibition at 200nM). Shows cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.

Product Specific Literature References

The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1): P.G. Jagtap, et al.; Bioorg. Med. Chem. Lett. 14, 81 (2004) Abstract

Further Categories Containing This Product:

DNA Repair Other Products

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.