ALEXIS Biochemicals: ET-Receptor Antagonist [PD 142,893]

ALX-155-008

Revised 04-Dec-06

ET-Receptor Antagonist [PD 142,893]
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Endothelins [ETs] & Endothelin Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-155-008-PC05		0.5 mg*	60.00 USD
ALX-155-008-P001		1 mg*	100.00 USD

Product Specification

SEQUENCE:	Ac-D-Dip-Leu-Asp-Ile-Ile-Trp-OH (D-Dip = D-3,3-Diphenylalanine; Lit. THL 33, 3293 (1992))
FORMULA:	C₅₀H₆₅N₇O₁₀
MW:	924.1
QUANTITY:	*Sold as net peptide weight.
PURITY:	≥97%
APPEARANCE:	White lyophilized powder.
SOLUBILITY:	Soluble in a mixture of 10% acetonitrile and 90% water or in phosphate buffer, pH 7.5.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Non-selective antagonist of endothelin-1 with high affinity for both the ET_Aand ET_Breceptor subtypes.

Product Specific Literature References

Design of a functional hexapeptide antagonist of endothelin: W.L. Cody, et al.; J. Med. Chem. 35, 3301 (1992) Abstract
Structure-activity relationships of C-terminal endothelin hexapeptide antagonists: A.M. Doherty, et al.; J. Med. Chem. 36, 2585 (1993) Abstract
Endothelin: progress in pharmacology and physiology: W.G. Haynes, et al.; TIPS 14, 225 (1993), (Review) Abstract

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