ALEXIS Biochemicals: ETA-Receptor Antagonist [BQ-123] . sodium salt

ALX-155-004

Revised 11-Mar-05

ETA-Receptor Antagonist [BQ-123] . sodium salt
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Endothelins [ETs] & Endothelin Receptors/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-155-004-P001		1 mg*	95.00 USD
ALX-155-004-P005		5 mg*	380.00 USD

Product Specification

SEQUENCE:	cyclo(D-Asp-Pro-D-Val-Leu-D-Trp . Na)
FORMULA:	C₃₁H₄₂N₆O₇ . Na
MW:	633.7
CAS NUMBER:	136553-81-6
QUANTITY:	*Sold as net peptide weight.
PURITY:	≥96%
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 3 years after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C.

Product Description

Highly potent and selective ET_Aantagonist.

Product Specific Literature References

Identification of a domain of ETA receptor required for ligand binding: M. Adachi, et al.; FEBS Lett. 311, 179 (1992) Abstract
Conformational study of cyclo[D-Trp-D-Asp-Pro-D-Val-Leu], an endothelin- A receptor-selective antagonist: R.A. Atkinson & J.T. Pelton; FEBS Lett. 296, 1 (1992) Abstract
A novel ETA antagonist (BQ-123) inhibits endothelin-1-induced phosphoinositide breakdown and DNA synthesis in rat vascular smooth muscle cells: S. Eguchi, et al.; FEBS Lett. 302, 243 (1992) Abstract
Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor: M. Ihara, et al.; Life Sci. 50, 247 (1992) Abstract
Cyclic pentapeptide endothelin antagonists with high ETA selectivity. Potency- and solubility-enhancing modifications: K. Ishikawa, et al.; J. Med. Chem. 35, 2139 (1992) Abstract
Endothelin: progress in pharmacology and physiology: W.G. Haynes, et al.; TIPS 14, 225 (1993), (Review) Abstract

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