ALEXIS Biochemicals: ETB-Receptor Agonist [IRL-1620]

ALX-155-006

Revised 24-Feb-05

ETB-Receptor Agonist [IRL-1620]
SYNONYMS	Suc-[Glu⁹, Ala^11,15]-Endothelin-1 (8-21)
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Endothelins [ETs] & Endothelin Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-155-006-PC05		0.5 mg*	100.00 USD
ALX-155-006-P001		1 mg*	175.00 USD

Product Specification

SEQUENCE:	Suc-Asp-Glu-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH
FORMULA:	C₈₆H₁₁₇N₁₇O₂₇
MW:	1821.0
QUANTITY:	*Sold as net peptide weight.
PURITY:	≥97%
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Most potent and selective ligand for the ET_Breceptor. IRL-1620 together with IRL-1038 (Prod. No. ALX-155-007) is an indispensable pharmacological tool to assess the participation of the ET_B receptor in some pathophysiological phenomena, by selectively stimulating ET_Breceptor-mediated responses in various pathophysiological models established in vitro and in vivo.

Product Specific Literature References

A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptor: M. Takai, et al.; BBRC 184, 953 (1992) Abstract
Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB- selective agonists: A. Sakamoto, et al.; J. Biol. Chem. 268, 8547 (1993) Abstract; Full Text
Endothelin: progress in pharmacology and physiology: W.G. Haynes, et al.; TIPS 14, 225 (1993), (Review) Abstract

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