ALEXIS Biochemicals: ETB-Receptor Antagonist [IRL-1038]

ALX-155-007

Revised 24-Feb-05

ETB-Receptor Antagonist [IRL-1038]
SYNONYMS	[Cys¹¹-Cys¹⁵]-Endothelin-1 (11-21)
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Endothelins [ETs] & Endothelin Receptors/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-155-007-PC05		0.5 mg*	110.00 USD
ALX-155-007-P001		1 mg*	190.00 USD

Product Specification

SEQUENCE:	H-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Disulfide bonds between Cys¹-Cys⁵)
FORMULA:	C₆₈H₉₂N₁₄O₁₅S₂
MW:	1409.7
QUANTITY:	*Sold as net peptide weight.
PURITY:	≥97%
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Antagonist for the ET_Breceptor with a controversial pattern of activity.

Product Specific Literature References

A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptor: M. Takai, et al.; BBRC 184, 953 (1992) Abstract
An endothelin B receptor-selective antagonist: IRL 1038, [Cys11-Cys15]- endothelin-1(11-21) [retracted in: FEBS Lett 1994 Mar 28;342(1):103]: Y. Urade, et al.; FEBS Lett. 311, 12 (1992) Abstract
Endothelin: progress in pharmacology and physiology: W.G. Haynes, et al.; TIPS 14, 225 (1993), (Review) Abstract
An endothelin B receptor-selective antagonist: IRL 1038, [Cys11- Cys15]- endothelin-1(11-21): Y. Urade, et al.; FEBS Lett. 342, 103 (1994) Abstract

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