ALEXIS Biochemicals: ETB-Receptor Antagonist [RES-701-1]

ALX-155-018

Revised 23-Oct-07

ETB-Receptor Antagonist [RES-701-1]
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Endothelins [ETs] & Endothelin Receptors/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-155-018-MC05		0.5 mg	130.00 USD
ALX-155-018-M001		1 mg	200.00 USD

Product Specification

SEQUENCE:	Gly-Asn-Trp-His-Gly-Thr-Ala-Pro-Asp-Trp-Phe-Phe-Asn-Tyr-Tyr-Trp-OH (Beta peptide bond between Gly¹and Asp⁹).
FORMULA:	C₁₀₃H₁₁₅N₂₃O₂₃
MW:	2043.2
PEPTIDE CONTENT:	75-90%
PURITY:	≥97% (HPLC)
FORMULATION:	Lyophilized.
SOLUBILITY:	Soluble in DMSO (5mg/ml); dilute with 0.6ml distilled water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Inhibits selectively the ET-1 binding to the ET_B receptor.

Product Specific Literature References

RES-701-1, a novel and selective endothelin type B receptor antagonist produced by Streptomyces sp. RE-701. I. Characterization of producing strain, fermentation, isolation, physico-chemical and biological properties: Y. Morishita, et al.; J. Antibiot. 47, 269 (1994) Abstract
Subtypes of endothelin ETA and ETB receptors mediating venous smooth muscle contraction: S.A. Sudjarwo, et al.; BBRC 200, 627 (1994) Abstract
J.X. He, et al.; Bioorg. Med. Chem. Lett. 5, 621 (1995)

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