ALEXIS Biochemicals: ETI

ALX-340-009

Revised 04-Feb-05

ETI
SYNONYMS	5,8,11-Eicosatriynoic acid
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	Lipoxygenases / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-340-009-M001		1 mg	77.00 USD
ALX-340-009-M005		5 mg	346.00 USD

Product Specification

FORMULA:	C₂₀H₂₈O₂
MW:	300.4
CAS NUMBER:	13488-22-7
PURITY:	≥99%
APPEARANCE:	Off-white solid.
SOLUBILITY:	Soluble in ethanol, DMSO or DMF.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from oxygen and light.

Product Description

Inhibitor of 5- and 12-lipoxygenase. No activity versus cyclooxygenase (COX) in whole cells. Also inhibits hepatic glutathione S-transferase and leukotriene C₄ biosynthesis.

Product Specific Literature References

Selective inhibition of platelet n-8 lipoxygenase by 5,8,11- eicosatriynoic acid: S. Hammarström; Biochem. Biophys. Acta 487, 517 (1977) Abstract
Inhibition of leukotriene C and leukotriene D biosynthesis: L. Örning & S. Hammarström; J. Biol. Chem. 255, 8023 (1980) Abstract; Full Text
Inhibition of mammalian hepatic glutathione S-transferases by acetylenic fatty acids: K. Datta & A.P. Kulkarni; Toxicol. Lett. 73, 157 (1994) Abstract

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