ALEXIS Biochemicals: Ebelactone B

ALX-270-014

Revised 17-Jul-06

Ebelactone B
SYNONYMS	2-Ethyl-3,11-dihydroxy-4,6,8,10,12-pentamethyl-9-oxo-6-tetradecenoic 1,3-lactone
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Aminopeptidases/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-014-M001		1 mg	95.00 USD
ALX-270-014-M005		5 mg	380.00 USD

Product Specification

FORMULA:	C₂₁H₃₆O₄
MW:	352.5
CAS NUMBER:	76808-15-6
SOURCE/HOST:	Microbial.
PURITY:	≥99%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).

Product Specific Literature References

Ebelactone, an inhibitor of esterase, produced by actinomycetes: H. Umezawa, et al.; J. Antibiot. (Tokyo) 33, 1594 (1980) Abstract
Identification of an isoprenylated cysteine methyl ester hydrolase activity in bovine rod outer segment membranes: E.W. Tan & R.R. Rando; Biochemistry 31, 5572 (1992) Abstract
Structural studies on ebelactone A and B, esterase inhibitors produced by actinomycetes: K. Uotani, et al.; J. Antibiot. (Tokyo) 35, 1495 (1982) Abstract
Biosynthetic studies of ebelactone A and B by 13C NMR spectrometry: K. Uotani, et al.; J. Antibiot. (Tokyo) 35, 1670 (1982) Abstract
Diuretic and natriuretic effect of ebelactone B in anesthetized rats by inhibition of a urinary carboxypeptidase Y-like kininase: M. Majima, et al.; Jpn. J. Pharmacol. 65, 79 (1994) Abstract
Inhibition of kinin degradation on the luminal side of renal tubules reduces high blood pressure in deoxycorticosterone acetate salt-treated rats: S. Nakajima, et al.; Clin. Exp. Pharmacol. Physiol. 27, 80 (2000) Abstract

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