ALEXIS Biochemicals: Elbfluorene

ALX-270-389

Revised 17-Jul-07

Elbfluorene
SYNONYMS	3-Acetyl-6-hydroxy-4-phenylbenzo[4,5]furo[2,3-b]pyridine 1-Aza-9-oxafluorene 5b
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	DNA Repair Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-389-M001		1 mg	75.00 USD
ALX-270-389-M005		5 mg	300.00 USD

Product Specification

FORMULA:	C₁₉H₁₃NO₃
MW:	303.3
PURITY:	≥95% (HPLC)
APPEARANCE:	Off-white to brownish powder.
SOLUBILITY:	Soluble in DMSO. Insoluble in water or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Selective inhibitor of CDK1/cyclin B (IC₅₀=4.2µM) with some P-glycoprotein-modulating properties (inhibitory activity ratio 1.26 at 7µM). Weakly inhibits CDK5/p25 (6% inhibition at 10µM) with no effect on CDK2/cyclin E and CDK4/cyclin D1 (IC₅₀>100µM).

Product Specific Literature References

Evaluation of the first cytostatically active 1-aza-9-oxafluorenes as novel selective CDK1 inhibitors with P-glycoprotein modulating properties: K. Brachwitz, et al.; J. Med. Chem. 46, 876 (2003) Abstract

Further Categories Containing This Product:

CDK & Cyclin Inhibitors

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