ALEXIS Biochemicals: F16

ALX-430-140

Revised 08-Mar-07

F16
SYNONYMS	4-[(E)-2-(Indol-3-yl)ethenyl]-N-methylpyridinium iodide
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Antitumor Agents (Apoptosis Inducers)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-140-M005		5 mg	40.00 USD
ALX-430-140-M025		25 mg	160.00 USD

Product Specification

FORMULA:	C₁₆H₁₅IN₂
MW:	362.2
CAS NUMBER:	36098-33-6
PURITY:	≥98% (HPLC)
APPEARANCE:	Orange solid.
SOLUBILITY:	Soluble in 100% ethanol, DMSO or dimethyl formamide; also soluble in PBS, pH 7.2.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for 2 years after receipt when stored at -20°C. Organic stock solutions are stable for at least 6 months when stored at -20°C. We do not recommend storing the aqueous solutions for more than one day.
HANDLING:	Protect from light. Hygroscopic.
HAZARD:	MAY BE CARCINOGENIC. HARMFUL.

Product Description

Cell permeable, fluorogenic, delocalized lipophilic mitochondrial toxin. Induces apoptosis as well as necrosis in tumor cells.

Product Specific Literature References

A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth: V.R. Fantin, et al.; Cancer Cell 2, 29 (2002) Abstract
F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell: V.R. Fantin and P. Leder; Cancer Res. 64, 329 (2004) Abstract
A predictive model for the selective accumulation of chemicals in tumor cells: S. Trapp and R.W. Horobin; Eur. Biophys. 34, 959 (2005) Abstract

Further Categories Containing This Product:

Cell Structure and Organelle Markers • Dyes / Stains / Fluorescent Probes / Fluorescent Labels • Non-apoptotic Cell Death / Necrosis

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