ALEXIS Biochemicals: FTO (human) (recombinant) (His)

ALX-201-421

Revised 14-Oct-08

FTO (human) (recombinant) (His)
SYNONYMS	Fat Mass and Obesity-associated Protein (human) (recombinant) (His) FATSO (human) (recombinant) (His)
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Obesity & Diabetes Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-201-421-C010		10 µg	230.00 USD
ALX-201-421-C050		50 µg	510.00 USD

Product Specification

SOURCE/HOST:	Expressed in E. coli. The mature peptide of human FTO (aa 2-505) is fused at the N-terminus to a His-tag.
CONCENTRATION:	0.5mg/ml
PURITY:	≥90% (SDS-PAGE)
FORMULATION:	Liquid. 0.2μm-filtered solution in 55mM TRIS, pH 8.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT:	<1EU/µg protein (LAL-test).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING:	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Product Images

Please click on thumbnails to enlarge.

General Information

The FTO (fat mass and obesity-associated) gene is well conserved and found in a single copy in vertebrate species. It is suggested that the FTO protein plays a role in fat cell lipolysis, which may be important in explaining why the FTO gene (and FTO gene variants) is implicated in body weight regulation.
BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link Q9C0B1: FTO (human)
MANUFACTURER	Manufactured by AdipoGen, Inc.

General Literature References

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity: T.M. Frayling, et al.; Science 316, 889 (2007) Abstract
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase: T. Gerken, et al.; Science 318, 1469 (2007) Abstract
The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis: K. Wahlen, et al.; J. Lipid Res. 49, 607 (2008) Abstract
The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain: R. Fredriksson, et al.; Endocrinology 149, 2062 (2008) Abstract
Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans: N. Klöting, et al.; Diabetologia 51, 641 (2008) Abstract
Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes: J.A. Jacobsson, et al.; BBRC 368, 476 (2008) Abstract
Regulation of Fto/Ftm gene expression in mice and humans: G. Stratigopoulos, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 294, R1185 (2008) Abstract