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Recombinant Proteins / Fusion Proteins
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ALX-201-207 Revised 14-Oct-08
pro-β-Nerve Growth Factor (human) (recombinant)
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SYNONYMS pro-β-NGF (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Nerve Growth Factors [NGF] & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-207-C020   20 µg 490.00 USD Add To Cart
Product Specification
MW: ~49.7kDa.
SOURCE/HOST: Produced in E. coli.
CONCENTRATION:

PURITY: ≥98% (SDS-PAGE)
FORMULATION: Liquid. In 50mM sodium phosphate, pH 7.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT: <0.05EU/µg protein.
BIOLOGICAL ACTIVITY: Stimulates the proliferation of TF1 cells (EC50=130±30pM).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for up to 5 weeks after receipt when stored at +4°C and for at least 1 year when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
General Information
MANUFACTURER Manufactured by Scil Proteins GmbH.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-044 Revised 25-Oct-05
Nerve Growth Factor Receptor (human):Fc (human) (recombinant)
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SYNONYMS NGFR (human):Fc (human) (recombinant)
TNFRSF 16 (human):Fc (human) (recombinant)
p75NTR (human):Fc (human) (recombinant)
p75 Neurotrophin Receptor (human):Fc (human) (recombinant)
CD271 (human):Fc (human) (recombinant)
Low-affinity Nerve Growth Factor Receptor (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Nerve Growth Factors [NGF] & Receptors / Related Products
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ALX-522-044-C050   50 µg 360.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
MW: ~80kDa (under reducing conditions).
SOURCE/HOST: Produced in HEK 293 cells. The cysteine-rich domain of human NGFR (nerve growth factor receptor; p75NTR) (aa 1-264) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute in 50µl sterile water. Further dilutions can be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds human, mouse and rat NGF (nerve growth factor).
BIOLOGICAL ACTIVITY: Inhibits rat NGF-mediated activation of rat PC12 cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C. After reconstitution, it is recommended to make appropriate aliquots and to store them at -20°C.
HANDLING: Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P08138: NGFR (human) (precursor)
AfCS Signalling Gateway link A001650: NGFR (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Neurotrophins in cell survival/death decisions: P. Casaccia-Bonnefil, et al.; Adv. Exp. Med. Biol. 468, 275 (1999) Abstract
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Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-112 Revised 27-Mar-08
Nesfatin-1 (mouse) (recombinant)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Nesfatin / Related Products
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ALX-522-112-C010   10 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
MW: ~8kDa
SOURCE/HOST: Recombinant mouse nesfatin-1 (aa 25-106) produced in E. coli.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 0.2% bovine serum albumin (BSA).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Description
Nesfatin-1, a polypeptide produced by cleavage of the NEFA/nucleobindin-2 (NUCB2), is a secreted protein expressed in the appetite-control hypothalamic nuclei. Nesfatin is involved in the regulation of the feeding behaviour. Intracerebroventricular injection of nesfatin-1 reduces body weight in rat by affecting the animal food intake.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P81117: Nucleobindin-2 (mouse) [Precursor]
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Identification of nesfatin-1 as a satiety molecule in the hypothalamus: I.S. Oh, et al.; Nature 443, 709 (2006) Abstract
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Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-114 Revised 27-Mar-08
Nesfatin-1 (mouse) (recombinant) (tagged)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Nesfatin / Related Products
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ALX-522-114-C050   50 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
MW: ~35kDa
SOURCE/HOST: Produced in E. coli. Recombinant mouse nesfatin-1 (aa 25-106) is fused at the N-terminus to a GST-tag.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 0.2% bovine serum albumin (BSA).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Description
Nesfatin-1, a polypeptide produced by cleavage of the NEFA/nucleobindin-2 (NUCB2), is a secreted protein expressed in the appetite-control hypothalamic nuclei. Nesfatin is involved in the regulation of the feeding behaviour. Intracerebroventricular injection of nesfatin-1 reduces body weight in rat by affecting the animal food intake.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P81117: Nucleobindin-2 (mouse) [Precursor]
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Identification of nesfatin-1 as a satiety molecule in the hypothalamus: I.S. Oh, et al.; Nature 443, 709 (2006) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-116 Revised 27-Mar-08
Nesfatin-1 (rat) (recombinant)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Nesfatin / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-116-C010   10 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
MW: ~8kDa
SOURCE/HOST: Recombinant rat nesfatin-1 (aa 25-106) produced in E. coli.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 0.2% bovine serum albumin (BSA).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Description
Nesfatin-1, a polypeptide produced by cleavage of the NEFA/nucleobindin-2 (NUCB2), is a secreted protein expressed in the appetite-control hypothalamic nuclei. Nesfatin is involved in the regulation of the feeding behaviour. Intracerebroventricular injection of nesfatin-1 reduces body weight in rat by affecting the animal food intake.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9JI85: Nucleobindin-2 (rat) [Precursor]
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Identification of nesfatin-1 as a satiety molecule in the hypothalamus: I.S. Oh, et al.; Nature 443, 709 (2006) Abstract
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Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-118 Revised 27-Mar-08
Nesfatin-1 (rat) (recombinant) (tagged)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Nesfatin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-118-C050   50 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
MW: ~35kDa
SOURCE/HOST: Produced in E. coli. Recombinant rat nesfatin-1 (aa 25-106) is fused at the N-terminus to a GST-tag.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 0.2% bovine serum albumin (BSA).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Description
Nesfatin-1, a polypeptide produced by cleavage of the NEFA/nucleobindin-2 (NUCB2), is a secreted protein expressed in the appetite-control hypothalamic nuclei. Nesfatin is involved in the regulation of the feeding behaviour. Intracerebroventricular injection of nesfatin-1 reduces body weight in rat by affecting the animal food intake.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9JI85: Nucleobindin-2 (rat) [Precursor]
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Identification of nesfatin-1 as a satiety molecule in the hypothalamus: I.S. Oh, et al.; Nature 443, 709 (2006) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-136 Revised 26-May-08
Netrin-4 (mouse) (recombinant)
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SYNONYMS β-Netrin (mouse) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
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ALX-522-136-2010   2x10 µg 390.00 USD Add To Cart
Product Specification
MW: ~65kDa
SOURCE/HOST: Produced in HEK 293 cells. Mouse netrin-4 (aa 21-628) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9JI33: Netrin-4 (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
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Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-106 Revised 19-Jun-08
Netrin-1 (chicken) (recombinant)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
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ALX-522-106-2010   2x10 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~80kDa
SOURCE/HOST: Produced in HEK 293 cells. Chicken netrin-1 (aa 27-606) is fused at the C-terminus to a linker peptide (6 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
RECONSTITUTION: Reconstitute with 100µl sterile distilled water. Resuspended protein should be used immediately upon reconstitution to avoid loss in activity due to non-specific binding to the vial. Further dilutions should be made with medium containing 5% fetal calf serum or 0.5% BSA.
SPECIFICITY: Binds to human receptor UNC5B.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
The Netrins (whose name means “one who guides” in Sanskrit) are a family of laminin-related secreted protein. In mice, human and rat, netrin-1, netrin-3/NTL2, netrin-4 and G-netrins have been cloned. Netrin-1 is predominantly expressed by floor plate cells as commissural axons extend toward the ventral midline. Netrin-1 induces axonal outgrowth, axon orientation and neuronal migration in neuronal development. It is chemoattractive for some neurons and chemorepellent for others.
To carry its functions, netrin-1 interacts with specific receptors: DCC/neogenin and UNC-5. These receptors belong to the family of “dependence receptors” that induce apoptosis in the absence of their respective ligand, and promote survival when bound to their ligand. The Netrin-1 mediated survival signal inhibits p53-induced apoptosis.
Netrin-1 is also expressed in organs such as pancreas, lung, bowel, bone and mammary gland. In these tissues, netrin-1 has different roles such as invasion of epithelial cells, leukocytes migration, cell adhesion or angiogenesis. Netrin-1, as a survival factor, also contributes to the control of tumorigenesis.
Chicken netrin-1 shares 87% aa identity with mouse and human netrin-1.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q90922: Netrin-1 (chicken)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Netrin-1 and its receptors in tumorigenesis: H. Arakawa; Nat. Rev. Cancer 4, 978 (2004), (Review) Abstract
Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis: P. Mehlen & C. Furne; Cell. Mol. Life Sci. 62, 2599 (2005), (Review) Abstract
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Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-100 Revised 14-Apr-08
Netrin-1 (human) (recombinant)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
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ALX-522-100-2010   2x10 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
MW: ~85kDa
SOURCE/HOST: