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Tumor Markers
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ALX-201-234 Revised 07-Nov-07
Proliferating Cell Nuclear Antigen (human) (recombinant)
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SYNONYMS PCNA (human) (recombinant)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Proliferating Cell Nuclear Antigen [PCNA] / Related Products
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ALX-201-234-C025   25 µg 240.00 USD Add To Cart
Product Specification
MW: 87kDa (homotrimer of 29kDa)
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 25mM TRIS-HCl, pH 7.5, containing 50% glycerol, 50mM sodium chloride, 1mM DTT and 1mM EDTA.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 4 weeks when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles.
Product Specific Literature References
The solution structure of functionally active human proliferating cell nuclear antigen determined by small-angle neutron scattering: P. Schurtenberger, et al.; J. Mol. Biol. 275, 123 (1998) Abstract
General Literature References
Proliferating cell nuclear antigen (PCNA): a dancer with many partners: G. Maga and U. Hubscher; J. Cell Sci. 116, 3051 (2003) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Tumor Markers
 
 
ALX-201-241 Revised 18-Mar-08
TPD52L1 (human) (recombinant) (His)
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SYNONYMS D53 (human) (recombinant) (His)
PRODUCT LINE Cancer
PRODUCT CATEGORY Tumor Markers
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ALX-201-241-C100   100 µg 430.00 USD Add To Cart
Product Specification
MW: ~16kDa
SOURCE/HOST: Produced in E. coli. Recombinant human TPD52L1 (D53) (aa 1-128) is fused at the N-terminus to a His-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. In PBS, pH 7.4.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q16890: TPD52L1 (human) (recombinant)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-210-151 Revised 19-Mar-08
Polyclonal Antibody to Androgen Receptor
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Androgens & Androgen Receptors / Related Products
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ALX-210-151-R200   200 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Monkey
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Antiserum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Recombinant human androgen receptor (aa 331-572).
SPECIFICITY: Recognizes human, mouse, rat and monkey androgen receptor. Detects a band of ~110kDa by Western blot.
APPLICATION: Immunocytochemistry
Immunohistochemistry (paraffin sections, frozen sections) (1:100)
Immunoprecipitation
Western Blot (1:500)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies • Tumor Markers
 
 
ALX-210-152/1 Revised 28-Feb-08
Polyclonal Antibody to Androgen Receptor
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Androgens & Androgen Receptors / Related Products
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ALX-210-152/1-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Epitope affinity-purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to N-terminal aa 1-21 (M1EVQLGLGRVYPRPPSKTYRG21C) of human, mouse and rat androgen receptor.
SPECIFICITY: Recognizes human androgen receptor. Detects a band of ~110kDa by Western blot. Does not cross-react with estrogen, progesterone, or glucocorticoid receptors.
APPLICATION: Western Blot (2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-151-033.
Product Specific Literature References
Immunocytochemical analysis of androgen receptor along the ducts of the separate rat prostate lobes after androgen withdrawal and replacement: G.S. Prins, et al.; Endocrinology 132, 169 (1993) Abstract
Androgen receptor localization in different cell types of the adult rat prostate: G.S. Prins, et al.; Endocrinology 129, 3187 (1991) Abstract
Related Products
Further Categories Containing This Product:
Polyclonal Antibodies • Tumor Markers
 
 
ALX-210-356 Revised 20-Jun-07
Polyclonal Antibody to α-Actinin-4
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PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Actin / Related Products
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ALX-210-356-C050   50 µg 490.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Pig
Others
SOURCE/HOST: From rabbit.
CONCENTRATION: 250µg/ml
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.01% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 28-38 (M28GDYMAQEDDW38) of human and rat actinin-4 and to aa 29-39 of mouse actinin-4.
SPECIFICITY: Recognizes human, mouse, rat, pig, and Chinese hamster actinin-4. Does not cross-react with actinin-1, -2 or -3.
APPLICATION: Immunohistochemistry (frozen sections (1µg/ml), paraffin sections [3])
Immunoprecipitation (25µg/ml)
Western Blot (0.1-0.25µg/ml)
The recommended dilutions refer to the analysis of mouse cells and tissues with intermediate levels of actinin-4 expression and must be viewed as approximate.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
POSITIVE CONTROL: Human platelet protein (500µg) (Prod. No. ALX-840-007), supplied at 5mg/ml in SDS sample buffer (100mM NaCl, 73mM TRIS/HCl pH 6.7, 10mM DTT, 8mM EDTA, 5% glycerol, 2% SDS, 10µg/ml Bromophenol Blue sodium salt).
Use 5µl (25µg) per lane for Western blotting of tricine gels (13% acrylamide) or 15% Laemmli gels.
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Product Specific Literature References
[1] Expression of alpha-actinin-4 in acquired human nephrotic syndrome: a quantitative immunoelectron microscopy study: N.P. Goode, et al.; Nephrol. Dial. Transplant. 19, 844 (2004) Abstract; Full Text
[2] CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling: Q. Yan, et al.; Mol. Biol. Cell 16, 2470 (2005) Abstract; Full Text
[3] Podocyte involvement in human immune crescentic glomerulonephritis: J. Bariety, et al.; Kidney Int. 68, 1109 (2005) Abstract
General Information
α-Actinin-4 is an actin-bundling protein of ~100kDa that is associated with cell motility, endocytosis, and cancer invasion [1, 2]. The α-actinin family comprises two non-muscle isoforms (α-actinin-1 and -4) and two skeletal muscle isoforms (α-actinin-2 and -3), with α-actinin-2 being also expressed in cardiac muscle [3]. While α-actinin-4 is almost ubiquitously expressed, particularly high concentrations are found in glomeruli. On the subcellular level it is associated with actin stress fibers, but in certain cells it also localizes to the nucleus [1]. Mutations in the α-actinin-4 gene cause an autosomal-dominant form of familial focal segmental glomerulosclerosis (FSGS) [4], which is thought to result from a defect in glomerular podocyte function. A point mutation in the α-actinin-4 gene was found to generate an antigenic peptide that is recognized by autologous cytolytic T lymphocytes (CTL) on a human lung carcinoma [5]. α-actinin-4 interacts with a variety of proteins, including the ring finger protein BERP [6], the PDZ-LIM protein CLP-36 [7], the hemidesmosomal and cell-cell contact protein BP180 [8], and the tight junction protein MAGI-1 [9]. Moreover, α-actinin-4 forms a ternary complex with Ca2+ / Calmodulin-dependent protein kinase II and Densin-180, a protein of postsynaptic densities in CNS neurons [10]. Ca2+-dependent association of α-actinin-4 with E3KARP is required for Ca2+-dependent inhibition of the Na+ / H+ exchanger 3 (NHE3) [11].
General Literature References
[1] Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion: K. Honda, et al.; J. Cell Biol. 140, 1383 (1998) Abstract
[2] Alpha-Actinins: D.R. Critchley & G. Flood; in: Guidebook to the Cytoskeletal and Motor Proteins, T. Kreis & R. Vale, Editors, Oxford University Press: Oxford p. 24 (1999)
[3] Actinin-4 is preferentially involved in circular ruffling and macropinocytosis in mouse macrophages: analysis by fluorescence ratio imaging: N. Araki, et al.; J. Cell Sci. 113, 3329 (2000) Abstract
[4] Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis: J.M. Kaplan, et al.; Nat. Genet. 24, 251 (2000) Abstract
[5] BERP, a novel ring finger protein, binds to alpha-actinin-4: A.E. El-Husseini, et al.; BBRC 267, 906 (2000) Abstract
[6] CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4: T. Vallenius, et al.; J. Biol. Chem. 275, 11100 (2000) Abstract
[7] A point mutation in the alpha-actinin-4 gene generates an antigenic peptide recognized by autologous cytolytic T lymphocytes on a human lung carcinoma: H. Echchakir, et al.; Cancer Res. 61, 4078 (2001) Abstract
[8] Interactions of a hemidesmosome component and actinin family members: A.M. Gonzalez, et al.; J. Cell Sci. 114, 4197 (2001) Abstract
[9] Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin: R.S. Walikonis, et al.; J. Neurosci. 21, 423 (2001) Abstract
[10] Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1: K.M. Patrie, et al.; J. Biol. Chem. 277, 30183 (2002) Abstract
[11] Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis: J.H. Kim, et al.; J. Biol. Chem. 277, 23714 (2002) Abstract
Further Categories Containing This Product:
Endocytosis • Polyclonal Antibodies • Tumor Markers
 
 
ALX-210-894 Revised 12-Sep-05
Polyclonal Antibody to Tenascin-W
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PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Cytoskeleton & Extracellular Matrix Other Products
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ALX-210-894-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY: ≥90%
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In TRIS/glycine, pH 8.0, containing 0.01% sodium azide.
IMMUNOGEN: Recombinant FNIII repeats 7-9 of mouse tenascin-W.
SPECIFICITY: Recognizes human, mouse and rat tenascin-W.
APPLICATION: ELISA (1:10’000)
Immunocytochemistry (1:1’000)
Immunohistochemistry (frozen sections, paraffin sections (1:500))
Immunoprecipitation
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Murine tenascin-W: a novel mammalian tenascin expressed in kidney and at sites of bone and smooth muscle development: A. Scherberich, et al.; J. Cell Sci. 117, 571 (2004) Abstract; Full Text
Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro: A. Scherberich, et al.; Oncogene 24, 1525 (2005) Abstract
General Literature References
Tenascins: R. Chiquet-Ehrismann; Int. J. Biochem. Cell Biol. 36, 986 (2004) Abstract
Connective tissues: signalling by tenascins: R. Chiquet-Ehrismann and R.P. Tucker; Int. J. Biochem. Cell Biol. 36, 1085 (2004) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies • Tumor Markers
 
 
ALX-210-922 Revised 26-Aug-05
Polyclonal Antibody to Cornulin (human) (SZ1229)
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SYNONYMS anti-Tumor Related Protein (human) PAb (SZ1229)
anti-C1orf10 Gene Product (human) PAb (SZ1229)
anti-Chromosome 1 Open Reading Frame 10 Gene Product (human) PAb (SZ1229)
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Cell Differentiation
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ALX-210-922-C050   50 µg 180.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.5mg/ml
FORMULATION: Liquid. In PBS containing 1% BSA and 0.01% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 259-274 (E259ATNDQNRGTETHGQG274) of human cornulin.
SPECIFICITY: Recognizes human cornulin. Detects a band of ~70kDa by Western blot.
APPLICATION: Immunohistochemistry (frozen sections (1:100))
Western Blot (1:2’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
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Product Specific Literature References
[1] Cornulin, a new member of the "fused gene" family, is expressed during epidermal differentiation: R. Contzler, et al.; J. Invest. Dermatol. 124, 990 (2005) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Tissue Markers • Polyclonal Antibodies • Tumor Markers
 
 
ALX-210-940 Revised 24-Apr-08
Polyclonal Antibody to SLP-2
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SYNONYMS anti-Stomatin-like Protein 2 PAb
anti-EPB72-like 2 PAb
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY HtrA2 / Omi, ARTS, EndoG / Related Products
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ALX-210-940-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 199-213 of mouse SLP-2 (stomatin-like protein 2).
SPECIFICITY: Recognizes human, mouse and rat SLP-2.
APPLICATION: Immunocytochemistry (1:100)
Immunoprecipitation (1:500)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
SLP-2 (stomatin-like protein 2) is an unusual stomatin homolog. SLP-2 was identified as a cancer-related gene overexpressed in human ESCC, lung cancer, laryngeal cancer, and endometrial adenocarcinoma. In tumor cells, SLP-2 promotes cell growth, cell adhesion, and tumorigenesis.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Proteomic analysis of the mouse liver mitochondrial inner membrane: S. Da Cruz, et al.; J. Biol. Chem. 278, 41566 (2003) Abstract; Full Text
Stomatin-like protein 2 is overexpressed in cancer and involved in regulating cell growth and cell adhesion in human esophageal squamous cell carcinoma: L. Zhang, et al.; Clin. Cancer Res. 12, 1639 (2006) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies • Tumor Markers
 
 
ALX-801-001 Revised 22-Feb-05
Monoclonal Antibody to P-glycoprotein (human) (4E3.16)
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SYNONYMS anti-ABCB1 (human) MAb (4E3.16)
anti-CD243 (human) MAb (4E3.16)
PRODUCT LINE Cancer
PRODUCT CATEGORY P-glycoprotein [Pgp] / Related Products
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ALX-801-001-C050   50 µg 790.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 4E3.16
ISOTYPE: Mouse IgG2a
CONCENTRATION: ~0.05mg/ml
FORMULATION: Liquid. In 0.01M PBS containing 1% BSA and 0.1% sodium azide.
IMMUNOGEN: MDR (multidrug resistant) human squamous lung cancer cell line SW-1573/500 (doxorubicin resistant) and MDR human uterine adenocarcinoma cell line ME180/DOX 500 (doxorubicin resistant).
SPECIFICITY: Recognizes an external epitope of human P-glycoprotein. Does not cross-react with human MDR3 P-glycoprotein.
APPLICATION: Flow Cytometry
Immunocytochemistry
Immunohistochemistry (frozen sections; not recommended for paraffin sections)
Immunoprecipitation.
Note: Not recommended for Western blot.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
POSITIVE CONTROL: Cell lines: Appropriate drug-sensitive parental cell lines and their multidrug resistant derivatives prepared by the same methods as the test specimens can be used as control materials.
Tissue: Liver (positive staining detected along luminal surfaces of bile canaliculi) or colon (positive staining localized to luminal surface of secretory epithelium).
Product Specific Literature References
Monoclonal antibody to an external epitope of the human mdr1 P-glycoprotein: R.J. Arceci, et al.; Cancer Res. 53, 310 (1993) Abstract
Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations: W.T. Beck, et al.; Cancer Res. 56, 3010 (1996) Abstract
Reference method for detection of Pgp mediated multidrug resistance in human hematological malignancies: a method validated by the laboratories of the French Drug Resistance Network: S. Huet, et al.; Cytometry 34, 248 (1998) Abstract
Identification of a multidrug resistance-like system in Tetrahymena pyriformis: evidence for a new detoxication mechanism in freshwater ciliates: M. Bamdad, et al.; FEBS Lett. 456, 389 (1999) Abstract
Discordance of P-glycoprotein expression and function in acute leukemia: B. De Moerloose, et al.; Adv. Exp. Med. Biol. 457, 107 (1999) Abstract
Bcl-2, bax and bcl-xL expression in human sensitive and resistant leukemia cell lines: V. Nuessler, et al.; Leukemia 13, 1864 (1999) Abstract
Conformational heterogeneity of P-glycoprotein: K. Goda, et al.; Cancer Detect. Prevent. 24, 415 (2000) Abstract
Functional characterization of glycosylation-deficient human P-glycoprotein using A vaccinia virus expression system: J.J. Gribar, et al.; J. Membr. Biol. 173, 203 (2000) Abstract
Simultaneous measurement of cellular P-glycoprotein content and function by multiparametric flow-cytometry: M.R. Muller, et al.; Int. J. Clin. Pharmacol. Ther. 38, 180 (2000) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies • Tumor Markers • CD Antibodies
 
 
ALX-801-002 Revised 10-Nov-08
Monoclonal Antibody to P-glycoprotein (C219)
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SYNONYMS anti-ABCB1 MAb (C219)
anti-CD243 MAb (C219)
PRODUCT LINE Cancer
PRODUCT CATEGORY P-glycoprotein [Pgp] / Related Products
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ALX-801-002-C100   100 µg 690.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
CLONE: C219
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.1mg/ml
FORMULATION: Liquid. In 0.01M PBS containing 1% BSA and 0.1% sodium azide.
IMMUNOGEN: SDS-solubilized plasma membranes of an MDR (multidrug resistant) Chinese hamster ovary (CHO) cell line and a human cell line.
SPECIFICITY: Recognizes an internal, highly conserved amino acid sequence (VQEALD and VQAALD) found in both protein isoforms, P-glycoprotein and MDR3 P-glycoprotein; not species specific.
CROSSREACTIVITY PROTEINS: Cross-re