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Items 26 of 26
ALX-270-239
Revised 19-Jun-08
AM 251
SYNONYMS
N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1
H
-pyrazole-3-carboxamide
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Cannabinoid Receptor Agonists & Antagonists / Related Products
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Format:
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ALX-270-239-M001
1 mg
29.00 USD
ALX-270-239-M005
5 mg
131.00 USD
Product Specification
FORMULA:
C
22
H
21
Cl
2
IN
4
O
MW:
555.2
CAS NUMBER:
183232-66-8
PURITY:
≥98%
APPEARANCE:
White to light pink solid.
SOLUBILITY:
Soluble in 100% ethanol, DMSO or dimethyl formamide.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Product Description
Structurally related to the cannabinoid receptor (CB) antagonist SR 141716A. Binds with high affinity to cannabinoid receptor CB
1
(K
i
=7.49nM; 306-fold selective over CB
2
receptors).
Product Specific Literature References
Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors:
S.J. Gatley, et al.; Life Sci.
61
, PL 191 (1997)
Abstract
Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists
:
R. Lan, et al.; J. Med. Chem.
42
, 769 (1999)
Abstract
Inhibition of voltage-sensitive sodium channels by the cannabinoid 1 receptor antagonist AM 251 in mammalian brain:
C. Liao, et al.; Basic Clin. Pharmacol. Toxicol.
94
, 73 (2004)
Abstract
Cannabinoid (CB)1 receptor antagonist, AM 251, causes a sustained reduction of daily food intake in the rat:
A.P. Chambers, et al.; Physiol. Behav.
82
, 863 (2004)
Abstract
The cannabinoid CB1 antagonist AM 251 produces food avoidance and behaviors associated with nausea but does not impair feeding efficiency in rats:
P.J. McLaughlin, et al.; Psychopharmacology (Berlin)
180
, 286 (2005)
Abstract
The cannabinoid 1 receptor antagonist, AM251, prolongs the survival of rats with severe acute pancreatitis:
K. Matsuda, et al.; Tohoku J. Exp. Med.
207
, 99 (2005)
Abstract
;
Full Text
Anxiogenic profile of AM-251, a selective cannabinoid CB1 receptor antagonist, in plus-maze-naive and plus-maze-experienced mice:
R.J. Rodgers, et al.; Behav. Pharmacol.
16
, 405 (2005)
Abstract
AM 251 produces sustained reductions in food intake and body weight that are resistant to tolerance and conditioned taste aversion:
A.P. Chambers, et al.; Br. J. Pharmacol.
147
, 109 (2006)
Abstract
;
Full Text
ALX-270-240
Revised 05-May-08
AM 281
SYNONYMS
1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1
H
-pyrazole-3-carboxamide
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Cannabinoid Receptor Agonists & Antagonists / Related Products
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Format:
Size:
Unit Price:
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ALX-270-240-M001
1 mg
25.00 USD
ALX-270-240-M005
5 mg
70.00 USD
ALX-270-240-M025
25 mg
290.00 USD
Product Specification
FORMULA:
C
21
H
19
Cl
2
IN
4
O
2
MW:
557.2
CAS NUMBER:
202463-68-1
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in methanol (1mg/ml) or DMSO (2mg/ml at RT, 50mg/ml in hot DMSO, after cooling this solution is stable over several days.)
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Analog of the cannabinoid receptor (CB) antagonist SR 141716A. Potent CB
1
receptor antagonist/inverse agonist (K
i
=14nM).
Product Specific Literature References
Effect of the cannabinoid receptor SPECT agent, AM 281, on hippocampal acetylcholine release from rat brain slices:
A.N. Gifford, et al.; Neurosci. Lett.
238
, 84 (1997)
Abstract
Imaging the brain marijuana receptor: development of a radioligand that binds to cannabinoid CB1 receptors in vivo:
S.J. Gatley, et al.; J. Neurochem.
70
, 417 (1998)
Abstract
Large receptor reserve for cannabinoid actions in the central nervous system
:
A. N. Gifford, et al.; J. Pharmacol. Exp. Ther.
288
, 478 (1999)
Abstract
Effects of the cannabinoid antagonists AM281 and AM630 on deprivation-induced intake in Lewis rats
:
N.A. Werner, et al.; Brain Res.
967
, 290 (2003)
Abstract
Effects of AM281, a cannabinoid antagonist, on systemic haemodynamics, internal carotid artery blood flow and mortality in septic shock in rats:
Y. Kadoi, et al.; Br. J. Anaesth.
94
, 563 (2005)
Abstract
Cannabinoid antagonist AM 281 reduces mortality rate and neurologic dysfunction after cecal ligation and puncture in rats:
Y. Kadoi, et al.; Crit. Care Med.
33
, 2629 (2005)
Abstract
ALX-270-241
Revised 03-Mar-05
AM 630
SYNONYMS
(6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1
H
-indol-3-yl)(4-methoxyphenyl)methanone
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Cannabinoid Receptor Agonists & Antagonists / Related Products
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ALX-270-241-M001
1 mg
20.00 USD
ALX-270-241-M005
5 mg
60.00 USD
Product Specification
FORMULA:
C
23
H
25
IN
2
O
3
MW:
504.4
CAS NUMBER:
164178-33-0
PURITY:
≥98%
APPEARANCE:
Off-white solid.
SOLUBILITY:
Soluble in DMSO or dimethyl formamide.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light and oxygen.
Product Description
Competitive CB
1
receptor antagonist in guinea-pig brain. Shows also agonist properties. CB
2
antagonist/inverse agonist (K
i
=31.2nM; 165-fold selective over CB
1
receptors).
Product Specific Literature References
AM630, a competitive cannabinoid receptor antagonist:
R. Pertwee, et al.; Life Sci.
56
, 1949 (1995)
Abstract
AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain:
K. Hosohata, et al.; Life Sci.
61
, PL115 (1997)
Abstract
AM630 antagonism of cannabinoid-stimulated [35S]GTP gamma S binding in the mouse brain:
Y. Hosohata, et al.; Eur. J. Pharmacol.
321
, R1 (1997)
Abstract
AM630 is an inverse agonist at the human cannabinoid CB1 receptor:
R.S. Landsman, et al.; Life Sci.
62
, PL109 (1998)
Abstract
Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630
:
R.A. Ross, et al.; Br. J. Pharmacol.
126
, 665 (1999)
Abstract
Effects of the cannabinoid antagonists AM281 and AM630 on deprivation-induced intake in Lewis rats
:
N.A. Werner, et al.; Brain Res.
967
, 290 (2003)
Abstract
ALX-550-383
Revised 11-Apr-07
AM 1241
SYNONYMS
(2-Iodo-5-nitrophenyl)-(1-(1-methylpiperidin-2-ylmethyl)-1H-indol-3-yl)methanone
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Cannabinoid Receptor Agonists & Antagonists / Related Products
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ALX-550-383-M001
1 mg
40.00 USD
ALX-550-383-M005
5 mg
110.00 USD
Product Specification
FORMULA:
C
22
H
22
N
3
O
3
I
MW:
503.3
PURITY:
≥97% (TLC)
APPEARANCE:
Yellow powder.
SOLUBILITY:
Soluble in DMSO, dimethyl formamide, 100% ethanol or methanol; insoluble in water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Unstable in 1M NaOH; slightly unstable in 1M HCl.
HANDLING:
Packaged under inert gas. Protect from light.
Product Description
Potent and selective CB
2
receptor agonist (K
i
=3.4nM (mouse), K
i
=280nM (rat) also
in vivo
.
Product Specific Literature References
CB2 cannabinoid receptor-mediated peripheral antinociception
:
T.P. Malan, Jr., et al.; Pain
93
, 239 (2001)
Abstract
Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS
:
M.M. Ibrahim, et al.; PNAS
100
, 10529 (2003)
Abstract
;
Full Text
Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation
:
A.G. Nackley, et al.; Neuroscience
119
, 747 (2003)
Abstract
Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors
:
A. Quartilho, et al.; Anesthesiology
99
, 955 (2003)
Abstract
Selective activation of cannabinoid CB2 receptors suppresses hyperalgesia evoked by intradermal capsaicin
:
A.G. Hohmann, et al.; J. Pharmacol. Exp. Ther.
308
, 446 (2004)
Abstract
In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?:
B.B. Yao, et al.; Br. J. Pharmacol.
149
, 145 (2006)
Abstract
ALX-340-053
Revised 04-Aug-08
Arachidonoyl 2’-chloroethylamide
SYNONYMS
ACEA
N-(2-Chloroethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Anandamide & Anandamide Analogs
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ALX-340-053-M005
5 mg
46.00 USD
Product Specification
FORMULA:
C
22
H
36
NOCl
MW:
366.0
CAS NUMBER:
220556-69-4
CONCENTRATION:
10mg/ml
PURITY:
≥96%
FORMULATION:
Liquid. Solution in methyl acetate.
SOLUBILITY:
20mg/ml soluble in 100% ethanol, DMSO or dimethyl formamide; 250μg/ml soluble in a 1:3 solution of ethanol:PBS (pH 7.2) (dilute the ethanol solution with PBS).
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -80°C. We do not recommend storing aqueous solutions for more than one day.
Product Description
Non-pungent, potent and highly selective CB
1
receptor agonist (K
i
=1.4nM). Displays >1'400-fold selectivity over CB
2
receptors (K
i
=3.1µM). Active
in vivo
.
Product Specific Literature References
Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1)
:
C.J. Hillard, et al.; J. Pharmacol. Exp. Ther.
289
, 1427 (1999)
Abstract
Arachidonylcyclopropylamide increases microglial cell migration through cannabinoid CB2 and abnormal-cannabidiol-sensitive receptors
:
A. Franklin, et al.; Eur. J. Pharmacol.
474
, 195 (2003)
Abstract
Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide, N-arachidonoyl-dopamine and arachidonyl-2-chloroethylamide
:
T.J. Price, et al.; Br. J. Pharmacol.
141
, 1118 (2004)
Abstract
The cannabinomimetic arachidonyl-2-chloroethylamide (ACEA) acts on capsaicin-sensitive TRPV1 receptors but not cannabinoid receptors in rat joints:
C.L. Baker and J.J. McDougall; Br. J. Pharmacol.
142
, 1361 (2004)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the methyl acetate under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Cannabinoid Receptor Agonists & Antagonists / Related Products
ALX-340-054
Revised 09-Jul-08
Arachidonoyl cyclopropylamide
SYNONYMS
ACPA
N-Cyclopropyl-5Z,8Z,11Z,14Z-eicosatetraenamide
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Anandamide & Anandamide Analogs
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ALX-340-054-M005
5 mg
46.00 USD
Product Specification
FORMULA:
C
23
H
37
NO
MW:
343.6
CAS NUMBER:
229021-64-1
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol.
SOLUBILITY:
10mg/ml soluble in 100% ethanol, DMSO or dimethyl formamide; 1mg/ml soluble in a 1:1 solution of in ethanol:PBS (pH 7.2) (dilute the ethanol solution with PBS).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
Product Description
Potent and selective CB
1
agonist (K
i
=2.2nM). Displays 325-fold selectivity over CB
2
receptors (K
i
=0.7µM). Active
in vivo
.
Product Specific Literature References
Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1)
:
C.J. Hillard, et al.; J. Pharmacol. Exp. Ther.
289
, 1427 (1999)
Abstract
Arachidonylcyclopropylamide increases microglial cell migration through cannabinoid CB2 and abnormal-cannabidiol-sensitive receptors
:
A. Franklin, et al.; Eur. J. Pharmacol.
474
, 195 (2003)
Abstract
The interaction of cannabinoids and opioids on pentylenetetrazole-induced seizure threshold in mice:
H. Shafaroodi, et al.; Neuropharmacology
47
, 390 (2004)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Cannabinoid Receptor Agonists & Antagonists / Related Products
ALX-340-061
Revised 10-Jul-08
Arachidonoyl 2'-fluoroethylamide
SYNONYMS
N-(2-Fluoroethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
2'-Fluoro AEA
2'-Fluoro anandamide
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Anandamide & Anandamide Analogs
Ordering Information
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ALX-340-061-M005
5 mg
63.00 USD
Product Specification
FORMULA:
C
22
H
36
NOF
MW:
349.5
CAS NUMBER:
166100-37-4
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol.
SOLUBILITY:
7mg/ml soluble in DMSO or dimethyl formamide; 8mg/ml soluble in a 1:1 solution of ethanol:PBS (pH 7.2) (dilute the ethanol solution with PBS).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
Product Description
CB
1
receptor agonist (CB
1
: K
i
=26.7nM; CB
2
: K
i
=908nM).
Product Specific Literature References
Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability
:
S. Lin, et al.; J. Med. Chem.
41
, 5353 (1998)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Cannabinoid Receptor Agonists & Antagonists / Related Products
ALX-340-042
Revised 07-Jan-06
Arvanil
SYNONYMS
N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5
Z
,8
Z
,11
Z
,14
Z
-eicosatetraenamide
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Cannabinoid Receptor Agonists & Antagonists / Related Products
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ALX-340-042-M005
5 mg
25.00 USD
Product Specification
FORMULA:
C
28
H
41
NO
3
MW:
439.6
CAS NUMBER:
128007-31-8
PURITY:
≥98%
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Keep cool and dry.
Product Description
"Hybrid" activator of CB
1
receptor (CB
1
: K
i
=0.5µM; CB
2
: K
i
=>15µM) and TRPV1 (K
i
=0.3µM). Also inhibits anandamide uptake (IC
50
=3.6µM) and fatty acid amide hydrolase (FAAH) (IC
50
=3µM). Analgesic, vasodilatory and anti-inflammatory
in vivo
. Apoptosis inducer.
Product Specific Literature References
Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors:
D. Melck, et al.; BBRC
262
, 275 (1999)
Abstract
Neurobehavioral activity in mice of N-vanillyl-arachidonyl-amide
:
V. Di Marzo, et al.; Eur. J. Pharmacol.
406
, 363 (2000)
Abstract
A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid
:
V. Di Marzo, et al.; J. Pharmacol. Exp. Ther.
300
, 984 (2002)
Abstract
The CB1/VR1 agonist arvanil induces apoptosis through an FADD/caspase-8-dependent pathway
:
R. Sancho, et al.; Br. J. Pharmacol.
140
, 1035 (2003)
Abstract
Evidence against the presence of an anandamide transporter
:
S.T. Glaser, et al.; PNAS
100
, 4269 (2003)
Abstract
Arvanil, a hybrid endocannabinoid and vanilloid compound, behaves as an antihyperkinetic agent in a rat model of Huntington's disease:
E. de Lago, et al.; Brain Res.
1050
, 210 (2005)
Abstract
Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis:
A.M. Malfitano, et al.; J. Neuroimmunol.
171
, 110 (2006)
Abstract
Further Categories Containing This Product:
Anandamide Uptake Inhibitors
•
Apoptosis Inducers & Inhibitors Other Products
•
TRPV1 Agonists and Antagonists / Related Products
•
Analgesic / Anti-nociceptive Agents / Related Products
•
Anti-inflammatory Agents Other Products
•
Fatty Acid Amide Hydrolase [FAAH] / Related Products
ALX-550-524
Revised 19-Jul-07
1,3-bis(4-Bromophenyl)-5-phenyl-2,4-imidazolidinedione
SYNONYMS
Compound 25
CB
1
Cannabinoid Receptor Inverse Agonist
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Cannabinoid Receptor Agonists & Antagonists / Related Products
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ALX-550-524-M005
5 mg
25.00 USD
Product Specification
FORMULA:
C
21
H
14
Br
2
N
2
O
2
MW:
486.2
CAS NUMBER:
878533-35-8
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO or dimethyl formamide; sparingly soluble in aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 2 years after receipt when stored at -20°C.
Product Description
Potent and selective inverse agonist of CB
1
receptor (K
i
=243nM and EC
50
=195nM).
Product Specific Literature References
Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: characterization of new CB1 cannabinoid receptor inverse agonists/antagonists:
G.G. Muccioli, et al.; J. Med. Chem.
49
, 872 (2006)
Abstract
ALX-430-152
Revised 03-Apr-08
Cannabidiol
SYNONYMS
CBD
2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Neurological Research
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Format:
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Unit Price:
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ALX-430-152-M001
1 mg
ALX-430-152-M005</
