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ALX-270-261
Revised 14-May-03
(2S,5S)-8-Decylbenzolactam V
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Activators
Ordering Information
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ALX-270-261-C500
500 µg
125.00 USD
Product Specification
FORMULA:
C
25
H
42
N
2
O
2
MW:
402.6
PURITY:
≥95%
APPEARANCE:
Oil.
SOLUBILITY:
Soluble in ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Activator of protein kinase C (PKC) with improved selectivity for the α, β and γ isoforms.
Product Specific Literature References
Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta:
A.P. Kozikowski, et al.; J. Med. Chem.
40
, 1316 (1997)
Abstract
Restoration of TEA-induced calcium responses in fibroblasts from Alzheimer's disease patients by a PKC activator:
S. Bhagavan, et al.; Neurobiol. Dis.
5
, 177 (1998)
Abstract
ALX-300-052
Revised 16-Apr-05
1,2-Dioctanoyl-sn-glycerol
SYNONYMS
DOG
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Mono- & Diacylglycerols
Ordering Information
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Format:
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Quantity:
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ALX-300-052-M010
10 mg
30.00 USD
ALX-300-052-M050
50 mg
90.00 USD
ALX-300-052-M100
100 mg
150.00 USD
Product Specification
FORMULA:
C
19
H
36
O
5
MW:
344.5
CAS NUMBER:
60514-48-9
PURITY:
≥98%
APPEARANCE:
Clear colorless liquid.
SOLUBILITY:
Soluble in DMSO or chloroform.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
At room temperature DOG is an oil. Due to its instability, keep it cool and dry.
Product Description
Potent activator of protein kinase C (PKC).
Product Specific Literature References
Diacylglycerols release LH: structure-activity relations reveal a role for protein kinase C:
P.M. Conn, et al.; BBRC
126
, 532 (1985)
Abstract
sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis:
R.J. Davis, et al.; J. Biol. Chem.
260
, 1562 (1985)
Abstract
;
Full Text
Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation:
J.G. Ebeling, et al.; PNAS
82
, 815 (1985)
Abstract
Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine:
Y.A. Hannun, et al.; J. Biol. Chem.
260
, 10039 (1985)
Abstract
;
Full Text
Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets:
E.G. Lapetina, et al.; J. Biol. Chem.
260
, 1358 (1985)
Abstract
;
Full Text
Further Categories Containing This Product:
PKC Activators
ALX-300-135
Revised 24-Jul-08
1-Stearoyl-2-arachidonoyl-sn-glycerol
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Mono- & Diacylglycerols
Ordering Information
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Format:
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ALX-300-135-M010
10 mg
85.00 USD
Product Specification
FORMULA:
C
41
H
72
O
5
MW:
645.0
CAS NUMBER:
65914-84-3
PURITY:
≥96%
APPEARANCE:
Colorless oil to waxy solid.
SOLUBILITY:
Soluble in 100% ethanol or DMSO.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Avoid contact with acids or bases. Compound may isomerize over time. Solutions are stable for up to 2 months when stored at -20°C. Product is not sterile.
Product Description
Endogenous protein kinase C (PKC) activator, formed during receptor-mediated hydrolysis of inositol phospholipids.
Product Specific Literature References
Further studies on the specificity of diacylglycerol for protein kinase C activation:
M. Go, et al.; BBRC
144
, 598 (1987)
Abstract
Further Categories Containing This Product:
PKC Activators
ALX-300-136
Revised 18-Nov-05
1-Stearoyl-2-linoleoyl-sn-glycerol
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Mono- & Diacylglycerols
Ordering Information
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ALX-300-136-M010
10 mg
95.00 USD
Product Specification
FORMULA:
C
39
H
72
O
5
MW:
621.0
PURITY:
≥98%
APPEARANCE:
Clear oil.
SOLUBILITY:
Soluble in 100% ethanol or DMSO.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Avoid acidic or basic conditions. In solution product may isomerize to the 1,3-isomer over time.
Product Description
Endogenous protein kinase C (PKC) activator, formed during receptor-mediated hydrolysis of inositol phospholipids.
Product Specific Literature References
Further studies on the specificity of diacylglycerol for protein kinase C activation:
M. Go, et al.; BBRC
144
, 598 (1987)
Abstract
Further Categories Containing This Product:
PKC Activators
ALX-300-138
Revised 28-Jan-05
Oleic acid (high purity)
SYNONYMS
cis
-9-Octadecenoic acid 18:1
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Fatty Acids
Ordering Information
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Format:
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ALX-300-138-G001
1 g
25.00 USD
Product Specification
FORMULA:
C
18
H
34
O
2
MW:
282.5
CAS NUMBER:
112-80-1
MERCK INDEX:
14:
6828
PURITY:
≥99%
APPEARANCE:
Colorless liquid.
SOLUBILITY:
Soluble in chloroform or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep under inert gas. Protect from light and oxygen.
HAZARD:
IRRITANT.
Product Description
Unsaturated fatty acid that has been shown to activate protein kinase C (PKC) in hepatocytes. Inhibitor of glucose production and food intake. Upregulates the expression of uncoupling protein-3 (UCP-3) in L6 myotubes.
Product Specific Literature References
Oleic acid promotes changes in the subcellular distribution of protein kinase C in isolated hepatocytes:
M.J. Diaz-Guerra; J. Biol. Chem.
266
, 23568 (1991)
Abstract
;
Full Text
Spinal cord of the rat contains more lipoprotein lipase than other brain regions:
D.H. Bessesen, et al.; J. Lipid Res.
34
, 229 (1993)
Abstract
Free fatty acid-induced alterations in the steroid-binding properties of rat androgen-binding protein:
F. Felden, et al.; BBRC
190
, 602 (1993)
Abstract
Chronic feline leukemia virus infection alters arachidonic acid proportions in vivo and in vitro:
L.L. Williams, et al.; Proc. Soc. Exp. Biol. Med.
202
, 239 (1993)
Abstract
Central administration of oleic acid inhibits glucose production and food intake
:
S. Obici, et al.; Diabetes
51
, 271 (2002)
Abstract
;
Full Text
Effects of rosiglitazone and oleic acid on UCP-3 expression in L6 myotubes
:
A. Costello, et al.; Diabetes Obes. Metab.
5
, 136 (2003)
Abstract
Further Categories Containing This Product:
PKC Activators
•
Obesity & Diabetes Other Products
ALX-300-300
Revised 08-Jul-08
1-Oleoyl-2-acetyl-sn-glycerol
SYNONYMS
OAG
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Mono- & Diacylglycerols
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ALX-300-300-M005
5 mg
62.00 USD
ALX-300-300-M025
25 mg
276.00 USD
Product Specification
FORMULA:
C
23
H
42
O
5
MW:
398.6
CAS NUMBER:
86390-77-4
PURITY:
≥90%
FORMULATION:
Liquid. Solution in acetonitrile.
SOLUBILITY:
20mg/ml soluble in DMSO or dimethyl formamide; miscible with 100% ethanol; 1.7mg/ml soluble in 1:1 solution of ethanol:PBS (pH 7.2) (dilute the ethanol solution with PBS).
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -80°C. Stable for at least 3 months in other organic solvents when stored at -80°C. Use aqueous solutions within 12 hours.
Product Description
In vitro
potent activator of protein kinase C (PKC). Stimulator of secretion and aggregation in blood platelets.
Product Specific Literature References
Phosphatidylinositol turnover in platelet activation; calcium mobilization and protein phosphorylation:
K. Kaibuchi, et al.; Cell Calcium
3
, 323 (1982)
Abstract
Specificity of the fatty acyl moieties of diacylglycerol for the activation of calcium-activated, phospholipid-dependent protein kinase
:
T. Mori, et al.; J. Biochem. (Tokyo)
91
, 427 (1982)
Abstract
Phorbol ester and diacylglycerol induce protein phosphorylation at tyrosine:
T. Gilmore & G.S. Martin; Nature
306
, 487 (1983)
Abstract
Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation:
K. Kaibuchi, et al.; J. Biol. Chem.
258
, 6701 (1983)
Abstract
;
Full Text
A possible role of protein kinase C in signal-induced lysosomal enzyme release:
N. Kajikawa, et al.; BBRC
116
, 743 (1983)
Abstract
B. Michell; TIBS
8
, 263 (1983), (Review)
Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets:
T.J. Rink, et al.; Nature
305
, 317 (1983)
Abstract
Opposite effects of angiotensin II and the protein kinase C activator OAG on cardiac Na+ channels:
I. Benz, et al.; J. Membr. Biol.
130
, 183 (1992)
Abstract
Ca2+ and partly GTP gamma S-dependent particulate phospholipase C hydrolyzing phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate is inhibited by diacyl(acyl-acetyl) glycerols:
E.W. Haeffner & U. Wittmann; J. Lipid Mediat.
5
, 237 (1992)
Abstract
New patterns of diacylglycerol metabolism in intact cells:
J. Florin-Christensen; Biochem. J.
289
, 783 (1993)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the acetonitrile under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
PKC Activators
ALX-340-004
Revised 18-Aug-08
Arachidonic acid
SYNONYMS
5Z,8Z,11Z,14Z-Eicosatetraenoic acid
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Arachidonic Acid / Related Products
Ordering Information
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ALX-340-004-M100
100 mg
147.00 USD
Product Specification
FORMULA:
C
20
H
32
O
2
MW:
304.5
CAS NUMBER:
506-32-1
MERCK INDEX:
14:
765
RTECS:
CE6675000
CONCENTRATION:
100mg/ml
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol containing 0.1% BHT.
SOLUBILITY:
100mg/ml soluble in DMSO or dimethyl formamide; sparingly soluble in basic aqueous buffers (1.7mg/ml). To prevent oxidation, the solvent should be purged with an inert gas.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C. Keep aqueous solutions on ice and use within 12 hours.
HANDLING:
Protect from light and oxygen.
HAZARD:
TOXIC.
Product Description
Precursor to a large family of eicosanoids. Activator for several protein kinase C (PKC) isotypes.
Product Specific Literature References
Arachidonic acid metabolism:
P. Needleman, et al.; Ann. Rev. Biochem.
55
, 69 (1986)
Abstract
Kinetic analysis of the Ca2+-dependent, membrane-bound, macrophage phospholipase A2 and the effects of arachidonic acid:
M.D. Lister, et al.; J. Biol. Chem.
263
, 7506 (1988)
Abstract
;
Full Text
Characterization of the L-arginine:nitric oxide pathway in human platelets:
M.W. Radomski, et al.; Br. J. Pharmacol.
101
, 325 (1990)
Abstract
The LDL receptor pathway delivers arachidonic acid for eicosanoid formation in cells stimulated by platelet-derived growth factor:
A.J.R. Habenicht, et al.; Nature
345
, 634 (1990)
Abstract
The control of free arachidonic acid levels:
R.D. Burgoyne & A. Morgan; TIBS
15
, 365 (1990)
Abstract
A unique pool of free arachidonate serves as substrate for both cyclooxygenase and lipoxygenase in platelets:
F. Chevy, et al.; Lipids
26
, 1080 (1991)
Abstract
Regulation of Ras-GAP and the neurofibromatosis-1 gene product by eicosanoids:
J.W. Han, et al.; Science
252
, 576 (1991)
Abstract
Arachidonic acid as a second messenger. Interactions with a GTP-binding protein of human neutrophils:
S.B. Abramson, et al.; J. Immunol.
147
, 231 (1991)
Abstract
The immediate activator of the NADPH oxidase is arachidonate not phosphorylation:
Henderson, et al.; Eur. J. Biochem.
211
, 157 (1993)
Abstract
Nitric oxide and arachidonic acid modulation of calcium currents in postganglionic neurones of avian cultured ciliary ganglia:
G. Khurana & M.R. Bennett; Br. J. Pharmacol.
109
, 480 (1993)
Abstract
Arachidonic acid-induced Ca2+ release from isolated sarcoplasmic reticulum:
C. Dettbarn & P. Palade; Biochem. Pharmacol.
45
, 1301 (1993)
Abstract
Covalent binding of arachidonate to G protein alpha subunits of human platelets:
H. Hallak, et al.; J. Biol. Chem.
269
, 4713 (1994)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
PKC Activators
•
Nitric Oxide Pathway Other Products
•
Fatty Acids
ALX-340-037
Revised 08-Jul-08
8(S)-HETE
SYNONYMS
8-Hydroxy-[S-(E,Z,Z,Z)]-5,9,11,14-eicosatetraenoic acid
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Hydroxy, Hydroperoxy & Oxo Fatty Acids / Related Products
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ALX-340-037-C025
25 µg
165.00 USD
Product Specification
FORMULA:
C
20
H
32
O
3
MW:
320.5
CAS NUMBER:
98462-03-4
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol.
SOLUBILITY:
Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (0.8mg/ml) or 0.1M Na
2
CO
3
(2mg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months in other organic solvents when stored at -20°C. Keep aqueous solutions on ice and use within 12 hours.
HANDLING:
Protect from light and oxygen.
Product Description
Activator of PPARα. Activates mouse skin protein kinase C (PKC).
Product Specific Literature References
Investigation of the mechanism of biosynthesis of 8-hydroxyeicosatetraenoic acid in mouse skin:
M.A. Hughes & A.R. Brash; Biochim. Biophys. Acta
1081
, 347 (1991)
Abstract
In vitro activation of mouse skin protein kinase C by fatty acids and their hydroxylated metabolites:
H.H. Lo, et al.; Lipids
29
, 547 (1994)
Abstract
Differential activation of peroxisome proliferator-activated receptors by eicosanoids:
K. Yu, et al.; J. Biol. Chem.
270
, 23975 (1995)
Abstract
;
Full Text
Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans:
Y. Guan, et al.; Am. J. Physiol.
273
, F1013 (1997)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
PPAR Agonists
•
PKC Activators
ALX-350-005
Revised 02-Oct-07
Bryostatin 1
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
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ALX-350-005-C010
10 µg
85.00 USD
Product Specification
FORMULA:
C
47
H
68
O
17
MW:
905.0
CAS NUMBER:
83314-01-6
MERCK INDEX:
14:
1457
PURITY:
≥97%
APPEARANCE:
Colorless oil.
SOLUBILITY:
25mg/ml soluble in 100% ethanol or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed. Binds to glass and plastic surfaces in aqueous solutions.
Product Description
Binds to and activates protein kinase C (PKC). Antineoplastic.
Product Specific Literature References
Isolation and structure of Bryostatin 1:
G.R. Pettit, et al.; J. Am. Chem. Soc.
104
, 6846 (1982)
Bryostatin 1: differentiating agent from the depths
:
R.M. Stone; Leuk. Res.
21
, 399 (1997)
Abstract
Chemistry and clinical biology of the bryostatins
:
R. Mutter & M. Wills; Bioorg. Med. Chem.
8
, 1841 (2000), (Review)
Abstract
The clinical development of the bryostatins
:
A. Clamp and G.C. Jayson; Anticancer Drugs
13
, 673 (2002)
Abstract
The chemistry and biology of the bryostatin antitumour macrolides
:
K.J. Hale, et al.; Nat. Prod. Rep.
19
, 413 (2002), Review
Abstract
Bryostatin-1: pharmacology and therapeutic potential as a CNS drug:
M.K. Sun & D.L. Alkon; CNS Drug Rev.
12
, 1 (2006), Review
Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Activators & Inducers)
•
PKC Activators
•
Natural Products - Immunomodulators
•
Natural Products - Antitumor Reagents
•
Marine Natural Products
ALX-350-031
Revised 07-Apr-08
Ingenol (high purity)
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-350-031-M001
1 mg
45.00 USD
ALX-350-031-M005
5 mg
195.00 USD
Product Specification
FORMULA:
C
20
H
28
O
5
MW:
348.4
CAS NUMBER:
30220-46-3
PURITY:
≥98%
APPEARANCE:
Solid.
SOLUBILITY:
Soluble in DMSO and 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
