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Cholesterol & Lipid Transport / Related Products
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Items 14 of 14
ALX-350-151 Revised 21-May-08
Agistatine B
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-151-M001   1 mg 90.00 USD Add To Cart
ALX-350-151-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C11H18O4
MW: 214.3
CAS NUMBER: 144096-46-8
SOURCE/HOST: Isolated from fungus FH-A 6239.
PURITY: ≥98% (1H-NMR)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol, DMSO or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
A tricyclic analog of agistatine A, which has been described as an inhibitor of cholesterol biosynthesis.
Product Specific Literature References
Secondary Metabolites by Chemical Screening, 29: A. Zeeck, et al.; Liebigs Ann. 627 (1996)
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Further Categories Containing This Product:
Cholesterol & Lipid Transport / Related Products
 
 
ALX-350-163 Revised 15-Sep-08 New product
Agistatine D
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-163-M001   1 mg 90.00 USD Add To Cart
ALX-350-163-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C11H14O4
MW: 210.2
CAS NUMBER: 144096-47-9
SOURCE/HOST: Isolated from fungus FH-A 6239.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description
Analog of agistatine A, which has been described as an inhibitor of cholesterol biosynthesis.
Product Specific Literature References
Secondary Metabolites by Chemical Screening, 29: A. Zeeck, et al.; Liebigs Ann. 1996, 627
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Further Categories Containing This Product:
Cholesterol & Lipid Transport / Related Products
 
 
ALX-350-094 Revised 24-Jul-08
Berberine . hemisulfate
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SYNONYMS Natural Yellow 18
5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products with Antibiotic Activity
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ALX-350-094-G001   1 g 15.00 USD Add To Cart
Product Specification
FORMULA: C20H18NO4 . 0.5SO4
MW: 336.4 . 48.0
CAS NUMBER: 633-66-9
MERCK INDEX: 14: 1154
RTECS: DR9867000
PURITY: ≥98% (TLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: 50mg/ml soluble in methanol:water 2:1.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: TOXIC.
IDENTITY: Determined by IR: Identical to standard reference.

Product Description
Alkaloid which exhibits relatively weak antibiotic properties, because of its efflux by multidrug resistance pumps. The antimicrobial action of berberine is potentiated by 5’-methoxyhydnocarpin, a multidrug pump inhibitor. Lowers cholesterol levels through a mechanism different from that of statins. Upregulates the expression of liver low-density lipoprotein receptor (LDLR) resulting in improved clearance of plasma LDL cholesterol through receptor mediated endocytosis. Possesses anti-inflammatory, anti-diabetic and anti-angiogenic effects. Induces apoptosis.
Product Specific Literature References
Berberine sulfate: antimicrobial activity, bioassay, and mode of action: A.H. Amin, et al.; Can. J. Microbiol. 15, 1067 (1969) Abstract
Bacteria lacking a multidrug pump: a sensitive tool for drug discovery: P.C. Hsieh, et al.; PNAS 95, 6602 (1998) Abstract; Full Text
Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5’-methoxyhydnocarpin, a multidrug pump inhibitor: F.R. Stermitz, et al.; PNAS 97, 1433 (2000) Abstract; Full Text
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins: W. Kong, et al.; Nat. Med. 10, 1344 (2004) Abstract
The anti-inflammatory potential of berberine in vitro and in vivo: C.L. Kuo, et al.; Cancer Lett. 203, 127 (2004) Abstract
Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion: S.H. Leng, et al.; Acta Pharmacol. Sin. 25, 496 (2004) Abstract
Berberine inhibits HIF-1alpha expression via enhanced proteolysis: S. Lin, et al.; Mol. Pharmacol. 66, 612 (2004) Abstract
Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3: C.C. Lin, et al.; Anticancer Res. 26, 227 (2006) Abstract
Berberine acutely inhibits insulin secretion from beta cells through cAMP signaling pathway: L. Zhou, et al.; Endocrinology (2008) Abstract
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.: M.K. Pandey, et al.; Cancer Res. 68, 5370 (2008) Abstract
 
 
ALX-370-009 Revised 26-Jun-06
Cholesterol 3-sulfate . sodium salt
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Cholesterol & Lipid Transport / Related Products
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ALX-370-009-M005   5 mg 20.00 USD Add To Cart
ALX-370-009-M025   25 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C27H45O4S . Na
MW: 465.7 . 23.0
CAS NUMBER: 2864-50-8
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Activates multiple protein kinase C (PKC) iso-enzymes, especially the ε, η and ζ isoforms.
Product Specific Literature References
Cholesterol sulfate, a novel activator for the eta isoform of protein kinase C: T. Ikuta, et al.; Cell Growth Differentiation 5, 943 (1994) Abstract
Cholesterol sulfate activates multiple protein kinase C isoenzymes and induces granular cell differentiation in cultured murine keratinocytes: M.F. Denning, et al.; Cell Growth Differentiation 6, 1619 (1995) Abstract
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PKC Activators
 
 
ALX-270-475 Revised 17-Jan-08
Ciprofibrate
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SYNONYMS 2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Cholesterol & Lipid Transport / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-475-M025   25 mg 50.00 USD Add To Cart
ALX-270-475-M100   100 mg 150.00 USD Add To Cart
ALX-270-475-M250   250 mg 300.00 USD Add To Cart
Product Specification
FORMULA: C13H14Cl2O3
MW: 289.2
CAS NUMBER: 52214-84-3
MERCK INDEX: 14: 2313
RTECS: UF0880000
PURITY: ≥98% (HPLC)
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC. MAY BE CARCINOGENIC.

Product Description
Hypolipidemic compound. PPARα (peroxisome proliferator-activated receptor α) agonist.
Product Specific Literature References
Comparison of the effects of various peroxisome proliferators on peroxisomal enzyme activities, DNA synthesis, and apoptosis in rat and human hepatocyte cultures: V. Goll, et al.; Toxicol. Appl. Pharmacol. 160, 21 (1999) Abstract
Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate: P. Passilly, et al.; Biochem. Pharmacol. 58, 1001 (1999) Abstract
Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate: M.C. Clemencet, et al.; Cancer Lett. 222, 217 (2005) Abstract
P450 CYP2C epoxygenase and CYP4A ω-hydroxylase mediate ciprofibrate-induced PPARα-dependent peroxisomal proliferation: A. Gatica, et al.; J. Lipid Res. 48, 924 (2007) Abstract; Full Text
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PPAR AgonistsApoptosis Inducers & Inhibitors Other Products
 
 
ALX-380-133 Revised 20-Nov-08 New product
Decarestrictine D
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SYNONYMS Tuckolide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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ALX-380-133-M001   1 mg 70.00 USD Add To Cart
ALX-380-133-M005   5 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C10H16O5
MW: 216.2
CAS NUMBER: 127393-89-9, 141846-71-1
SOURCE/HOST: Isolated from Penicillium sp.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol, acetone or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description
Shows hypolipidemic activity. Inhibitor of cholesterol biosynthesis.
Product Specific Literature References
Secondary metabolites by chemical screening. 8. Decarestrictines, a new family of inhibitors of cholesterol biosynthesis from Penicillium. I. Strain description, fermentation, isolation and properties: S. Grabley, et al.; J. Antibiot. 45, 56 (1992) Abstract
Secondary metabolites by chemical screening. 9. Decarestrictines, a new family of inhibitors of cholesterol biosynthesis from Penicillium. II. Structure elucidation of the decarestrictines A to D: A. Göhrt, et al.; J. Antibiot. 45, 66 (1992) Abstract
Chemical investigation of the metabolites from the Canadian tuckahoe, Polyporus tuberaster: W.A. Ayer, et al.; J. Nat. Prod. 55, 649 (1992) Abstract
A non-enzymatic reaction in the late biosynthesis of the decarestrictine family: M. Mayer & R. Thiericke; J. Antibiot. 46, 1372 (1993) Abstract
Synthesis of Tuckolide, a New Cholesterol Biosynthesis Inhibitor: M.B. Andrus & T.L. Shih; J. Org. Chem. 61, 8780 (1996) Abstract
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Cholesterol & Lipid Transport / Related Products
 
 
ALX-201-415 Revised 09-Jul-08
Lipocalin-2 (mouse) (recombinant)
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SYNONYMS NGAL (mouse) (recombinant)
Neutrophil Gelatinase-associated Lipocalin (mouse) (recombinant)
Siderocalin (mouse) (recombinant)
Oncogene 24p3 (mouse) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adipokines Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-415-C010   10 µg 150.00 USD Add To Cart
ALX-201-415-C050   50 µg 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The mature peptide of mouse lipocalin-2 (aa 1-200) is fused to a FLAG®-tag at the C-terminus.
CONCENTRATION: 0.3mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P11672: Lipocalin-2 (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
 
 
ALX-201-417 Revised 05-Jun-08
Lipocalin-2 (rat) (recombinant)
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SYNONYMS NGAL (rat) (recombinant)
Neutrophil Gelatinase-associated Lipocalin (rat) (recombinant)
Siderocalin (rat) (recombinant)
Oncogene 24p3 (rat) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adipokines Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-417-C010   10 µg 150.00 USD Add To Cart
ALX-201-417-C050   50 µg 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The mature peptide of rat lipocalin-2 (aa 1-198) is fused to a FLAG®-tag at the C-terminus.
CONCENTRATION: 0.3mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P30152: Lipocalin-2 (rat)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
 
 
ALX-201-411 Revised 03-Apr-08
Lipocalin-2 (human) (recombinant)
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SYNONYMS NGAL (human) (recombinant)
Neutrophil Gelatinase-associated Lipocalin (human) (recombinant)
Siderocalin (human) (recombinant)
Oncogene 24p3 (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adipokines Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-411-C010   10 µg 150.00 USD Add To Cart
ALX-201-411-C050   50 µg 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The mature peptide of human lipocalin-2 is fused to a FLAG®-tag at the C-terminus.
CONCENTRATION: 0.3mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P80188: Lipocalin-2 (human)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron: T.H. Flo, et al.; Nature 432, 917 (2004) Abstract
The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance: Q.W. Yan, et al.; Diabetes 56, 2533 (2007) Abstract
Lipocalin 2-mediated growth suppression is evident in human erythroid and monocyte/macrophage lineage cells: K. Miharada, et al.; J. Cell Physiol. 215, 526 (2008) Abstract
The novel role of neutrophil gelatinase-B associated lipocalin (NGAL)/Lipocalin-2 as a biomarker for lupus nephritis: T. Rubinstein, et al.; Autoimmun. Rev. 7, 229 (2008) Abstract
 
 
ALX-340-039 Revised 05-Feb-05
MEDICA 16