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ALX-804-448
Revised 31-Oct-06
Monoclonal Antibody to Caspase-8 (mouse) (3B10)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-448-C100
100 µg
298.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
3B10
ISOTYPE:
Rat IgG1
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse caspase-8 p18 subunit.
SPECIFICITY:
Recognizes mouse caspase-8. Detects bands of ~55kDa (full-length caspase-8) and ~18kDa (apoptosis-induced cleavage fragment) by Western blot. Does not cross-react with human caspase-8.
APPLICATION:
ELISA (recombinant mouse caspase-8)
Flow Cytometry (overexpressed caspase-8)
Immunocytochemistry (excellent)
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. For long-term storage, aliquot and freeze at -20°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes
:
L.A. O'Reilly; Cell Death Differ.
11
, 724 (2004)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-507
Revised 14-Aug-07
Monoclonal Antibody to Caspase-11 (mouse) (4E11)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-507-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
CLONE:
4E11
ISOTYPE:
Rat IgG1
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Protein G affinity purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:
p20 fragment of mouse caspase-11.
SPECIFICITY:
Recognizes mouse and rat caspase-11 (epitope in the p20 fragment). Detects two bands of ~38kDa and ~43kDa by Western blot.
APPLICATION:
Flow Cytometry
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death:
V.S. Marsden, et al.; Blood
107
, 1872 (2006)
Abstract
;
Full Text
General Information
Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7. Human caspase-4, thought to be the homolog of mouse caspase-11, may be an effective therapeutic target for treatment of septic shock.
General Literature References
Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway
:
J. Hur, et al.; FEBS Lett.
507
, 157 (2001)
Abstract
Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response
:
S.J. Kang, et al.; Cell Death Differ.
9
, 1115 (2002)
Abstract
Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 1
:
R. Schauvliege, et al.; J. Biol. Chem.
277
, 41624 (2002)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-494
Revised 08-Jul-08
Monoclonal Antibody to Caspase-11 (mouse) (8A5)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-494-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
CLONE:
8A5
ISOTYPE:
Rat IgG1
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
p20 fragment of mouse caspase-11.
SPECIFICITY:
Recognizes mouse and rat caspase-11 (epitope in the p20 fragment). Detects two bands of ~38kDa and ~43kDa by Western blot.
APPLICATION:
Flow Cytometry, Western blot.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Product Images
Please click on thumbnails to enlarge.
General Information
Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7. Human caspase-4, thought to be the homolog of mouse caspase-11, may be an effective therapeutic target for treatment of septic shock.
General Literature References
Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway
:
J. Hur, et al.; FEBS Lett.
507
, 157 (2001)
Abstract
Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response
:
S.J. Kang, et al.; Cell Death Differ.
9
, 1115 (2002)
Abstract
Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 1
:
R. Schauvliege, et al.; J. Biol. Chem.
277
, 41624 (2002)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-509
Revised 14-Aug-07
Monoclonal Antibody to Caspase-12 (mouse) (11F10)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-509-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
11F10
ISOTYPE:
Rat IgG1
CONCENTRATION:
1mg/ml.
FORMULATION:
Liquid. Protein G affinity purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:
p20 fragment of mouse caspase-12 and synthetic peptide corresponding to aa 183-205 (N
183
KKFDYLFDRDNADTDILNMQEL
205
) of mouse caspase-12.
SPECIFICITY:
Recognizes an epitope within the p20 fragment of mouse caspase-12. Detects a band of ~51kDa by Western blot. Does not cross-react with mouse caspase-1 or -11.
APPLICATION:
ELISA
Flow Cytometry
Western Blot
Other applications not tested.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death:
V.S. Marsden, et al.; Blood
107
, 1872 (2006)
Abstract
;
Full Text
General Information
Caspase-12 is a member of the ICE/CED-3 family of caspases and is detected as a protein of ~51kDa. Overexpression of caspase-12 in cells induces apoptosis. Capase-12 is localised to the endoplasmatic reticulum (ER) and activated by ER stress and specifically cleaves and activates pro-caspase-9 and is also thought to be involved in the apoptosis induced by viral infection. Caspase-12-deficient mice are resistant to ER stress-induced apoptosis. Caspase-12 is probably expressed in many and perhaps all mouse tissues; and is expressed at high levels in skeletal muscle, heart, lung and kidney, and at moderate levels in brain and liver. In many humans caspase-12 is a pseudo gene and not expressed.
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress
•
Monoclonal Antibodies
ALX-804-511
Revised 10-Mar-06
Monoclonal Antibody to Caspase-12 (mouse) (12G6)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-511-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
12G6
ISOTYPE:
Rat IgG1
CONCENTRATION:
1mg/ml.
FORMULATION:
Liquid. Protein G affinity purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:
p20 fragment of mouse caspase-12 and synthetic peptide corresponding to aa 183-205 (N
183
KKFDYLFDRDNADTDILNMQEL
205
) of mouse caspase-12.
SPECIFICITY:
Recognizes an epitope within the p20 fragment of mouse caspase-12. Detects a band of ~51kDa by Western blot. Does not cross-react with mouse caspase-1 or -11.
APPLICATION:
ELISA
Flow Cytometry
Western Blot
Other applications not tested.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
Caspase-12 is a member of the ICE/CED-3 family of caspases and is detected as a protein of ~51kDa. Overexpression of caspase-12 in cells induces apoptosis. Capase-12 is localised to the endoplasmatic reticulum (ER) and activated by ER stress and specifically cleaves and activates pro-caspase-9 and is also thought to be involved in the apoptosis induced by viral infection. Caspase-12-deficient mice are resistant to ER stress-induced apoptosis. Caspase-12 is probably expressed in many and perhaps all mouse tissues; and is expressed at high levels in skeletal muscle, heart, lung and kidney, and at moderate levels in brain and liver. In many humans caspase-12 is a pseudo gene and not expressed.
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress
•
Monoclonal Antibodies
ALX-804-228
Revised 19-Sep-05
Monoclonal Antibody to Caspase-14 (mouse) (70A1426)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-228-C100
100 µg
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
70A1426
ISOTYPE:
Mouse IgG1
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G affinity-purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 2-18 of mouse caspase-14.
SPECIFICITY:
Recognizes mouse caspase-14. Detects a band of ~30kDa by Western blot.
APPLICATION:
Western Blot (2-4µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 6 months when stored at +4°C.
General Information
Caspase-14 (MICE for mini-ICE) is a recently member of the caspase family, related to human/mouse caspase-2 and human caspase-9. It possesses all the typical amino acid residues of the caspases involved in catalysis, including the QACRG box, and contains no or only a short prodomain. In contrast to the other short prodomain caspases (caspase-3, -6, -7), caspase-14 preferentially associates with large prodomain caspases, including caspase-1, -2, - 4, -8, and -10. Caspase-14 is not processed by multiple death stimuli including activation of members of the tumor necrosis factor receptor family and expression of proapoptotic members of the bcl-2 family.
General Literature References
Caspase-14 is a novel developmentally regulated protease
:
S. Hu, et al.; J. Biol. Chem.
273
, 29648 (1998)
Abstract
;
Full Text
Identification of a new caspase homologue: caspase-14
:
M. Van de Craen, et al.; Cell Death Differ.
5
, 838 (1998)
Abstract
Identification and characterization of murine caspase-14, a new member of the caspase family
:
M. Ahmad, et al.; Cancer Res.
58
, 5201 (1998)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-260/1
Revised 21-Oct-08
Monoclonal Antibody to β-Catenin (8E4)
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
Catenin / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-260/1-C100
100 µg
380.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Dog
CLONE:
8E4
ISOTYPE:
Mouse IgG1
PURITY DETAIL:
Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION:
Lyophilized from 1ml 2x PBS, 0.1% sodium azide, PEG and sucrose.
RECONSTITUTION:
Reconstitute in 1ml distilled water (15 min., RT).
IMMUNOGEN:
Synthetic peptide corresponding to human β-catenin aa 27-37.
SPECIFICITY:
Recognizes human, mouse, rat (weak) and dog β-catenin. Recognizes an epitope between aa 27-37 and an additional epitope in the C-Terminal region (see [5]).
Note:
For specific detection of dephospho-β-catenin use Prod. No.
ALX-804-259
.
APPLICATION:
Flow Cytometry
(see Lit. Ref. [3])
Immunocytochemistry
(see Lit. Ref. [4])
Immunohistochemistry
(paraffin sections) (see Lit. Ref. [3])
Western Blot
: 0.5µg/ml for HRPO/ECL detection. Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4’000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.
BSA may be used alternatively but milk is not recommended for blocking and dilution!
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and freeze in liquid nitrogen.
POSITIVE CONTROL:
Included (Prod. No. ALX-840-022).
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
[2]
Sulindac targets nuclear beta-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines
:
E.M. Boon, et al.; Br. J. Cancer
90
, 224 (2004)
Abstract
[1]
Activation of the canonical beta-catenin pathway by histamine
:
S.H. Diks, et al.; J. Biol. Chem.
278
, 52491 (2003)
Abstract
;
Full Text
[3]
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells
:
P.W. Derksen, et al.; PNAS
101
, 6122 (2004)
Abstract
;
Full Text
[4]
Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids
:
E.M. Schmelz, et al.; Cancer Res.
61
, 6723 (2001)
Abstract
[5]
Wnt signaling and phosphorylation status of beta-catenin: importance of the correct antibody tools:
M. van Noort, et al.; Blood
110
, 2778 (2007)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-101
Revised 04-Jun-08
Monoclonal Antibody to α-Catenin (15D9)
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
Catenin / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-101-C100
100 µg
380.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
CLONE:
15D9
ISOTYPE:
Mouse IgG1
PURITY DETAIL:
Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION:
Lyophilized from 1ml 2x PBS, 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION:
Reconstitute with 1ml distilled water (15 min., RT).
IMMUNOGEN:
Recombinant human α-catenin.
SPECIFICITY:
Recognizes human, mouse, rat and dog α-catenin. Does not cross-react with β-catenins.
APPLICATION:
Immunocytochemistry
(0.1-1µg/ml; formaldehyde fixation is tolerated)
Immunoprecipitation
Western Blot
(0.5µg/ml for HRPO/ECL detection).
Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4’000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING:
After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
POSITIVE CONTROL:
Yes (Prod. No. ALX-840-026).
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-106
Revised 13-Jun-08
Monoclonal Antibody to β-Catenin (CT) (10H8)
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
Catenin / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-106-C100
100 µg
380.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Dog
CLONE:
10H8
ISOTYPE:
Mouse IgG2a
PURITY DETAIL:
Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION:
Lyophilized from 1ml 2x PBS, 0.09% sodium azide, PEG and Sucrose.
RECONSTITUTION:
Reconstitute with 1ml distilled water (15 min., RT).
IMMUNOGEN:
Recombinant human β-catenin.
SPECIFICITY:
Recognizes the C-terminus of human, mouse, rat (weak) and dog β-catenin (aa 769-781).
APPLICATION:
Immunocytochemistry
(0.1-1µg/ml)
Immunoprecipitation
Western blot
(0.1µg/ml for HRPO/ECL detection).
Recommended blocking buffer milk: 2x PBS, 5-8% (w/v) dry milk powder and 0.1% (v/v) Tween 20.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING:
After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
POSITIVE CONTROL:
Included (Prod. No. ALX-840-027).
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-059
Revised 13-Jun-08
Monoclonal Antibody to β-Catenin (CT/Exon 14) (7D8)
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
Catenin / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-059-C100
100 µg
380.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Dog
CLONE:
7D8
ISOTYPE:
Mouse IgG1
PURITY DETAIL:
Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION:
Lyophilized from 1ml 2x PBS, 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION:
Reconstitute with 1ml distilled water (15 min., RT).
IMMUNOGEN:
Recombinant human β-catenin.
SPECIFICITY:
Recognizes the C-terminus (exon 14) of human, mouse, rat (weak) and a dog β-catenin.
APPLICATION:
Immunocytochemistry
(0.1-1µg/ml)
Immunohistochemistry
(paraffin sections)
I
mmunoprecipitation
Western blot
(0.5µg/ml for HRPO/ECL detection).
Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4’000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.
Do not use milk/casein for blocking and dilution! Replace by BSA!
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING:
After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
POSITIVE CONTROL:
Included (Prod. No. ALX-840-027).
Further Categories Containing This Product:
