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ALX-801-024
Revised 25-Oct-06
Monoclonal Antibody to Minor Vault p193 Protein (human) (p193-6)
SYNONYMS
anti-VPARP (human) MAb (p193-6)
anti-PARP-4 (human) MAb (p193-6)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Minor Vault Protein p193 / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-801-024-C125
125 µg
350.00 USD
ALX-801-024-C250
250 µg
630.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
p193-6
ISOTYPE:
Mouse IgG2b
CONCENTRATION:
~250µg/ml.
FORMULATION:
Liquid. In serum free cell culture supernatant containing 1% BSA and 0.1% sodium azide.
IMMUNOGEN:
Minor vault p193 protein (VPARP; PARP-4).
SPECIFICITY:
Recognizes epitope aa 593-599 (FSKVEDY) of human minor vault p193 protein.
APPLICATION:
Immunocytochemistry
(4% paraformaldehyde cytospin preparations (1:10-1:20))
Immunohistochemistry
(frozen sections (1:10-1:20))
Apply the following treatment: 10 minutes in 20 mM glycine in PBS, PH 7.5 and 110 minutes 6N guanidine hydrochloride in 50mM TRIS-HCl, pH 7.5 [1].
Western Blot
(ECL detection)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Specific Literature References
[1]
The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines:
A.B. Schroeijers, et al.; Cancer Res.
60
, 1104 (2000)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-801-025
Revised 25-Oct-06
Monoclonal Antibody to Minor Vault p193 Protein (human) (p193-10)
SYNONYMS
anti-VPARP (human) MAb (p193-10)
anti-PARP-4 (human) MAb (p193-10)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Minor Vault Protein p193 / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-801-025-C125
125 µg
350.00 USD
ALX-801-025-C250
250 µg
630.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
p193-10
ISOTYPE:
Mouse IgG2a
CONCENTRATION:
~250µg/ml
FORMULATION:
Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
IMMUNOGEN:
Minor vault p193 protein (VPARP; PARP-4).
SPECIFICITY:
Recognizes epitope aa 506-510 (VALGK) of human minor vault p193 protein.
APPLICATION:
Immunohistochemistry
: Use 1:10-1:20 dilution for staining of paraformaldehyde (4%) fixed cytospin preparations and frozen tissue sections. Apply the following pretreatment: 10 min in 20mM glycine in PBS (pH 7.5) and 10 min in 6N guanidine hydrochloride in 50mM TRIS-HCl (pH 7.5); Schroeijers et al., 2000.
Western Blot
: Use 1:10-1:20 dilution (ECL)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines:
A.B. Schroeijers, et al.; Cancer Res.
60
, 1104 (2000)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-801-026
Revised 31-Oct-06
Monoclonal Antibody to MVP/LRP (human) (MVP-37)
SYNONYMS
anti-Major Vault Protein/Lung Resistance Protein (human) MAb (MVP-37)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Major Vault Protein [MVP] / Lung Resistance Protein [LRP] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-801-026-C125
125 µg
350.00 USD
ALX-801-026-C250
250 µg
630.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
MVP-37
ISOTYPE:
Mouse IgG2b
CONCENTRATION:
~250µg/ml
FORMULATION:
Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
IMMUNOGEN:
Human MVP/LRP (major vault protein/lung resistance protein).
SPECIFICITY:
Recognizes an internal epitope of human MVP/LRP, which is strongly overexpressed in various non-P-glycoprotein MDR tumor cell lines.
APPLICATION:
Immunohistochemistry (frozen sections, paraffin sections)
: use approx. 1:20-50 dilution for staining of paraformaldehyde (4%) fixed cytospin preparations or frozen tissue sections. Apply the following pretreatment: 10 min in 20mM glycine (pH 7.5) and 10 min in 6N guanidine hydrochloride in 50mM Tris-HCl, pH 7.5 (Schroeijers et al., 2000)
Western Blot
: use 1:50 dilution of MVP-37 (ECL)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Specific Literature References
The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines:
A.B. Schroeijers, et al.; Cancer Res.
60
, 1104 (2000)
Abstract
;
Full Text
Detection of the Mr 110,000 lung resistance-related protein LRP/MVP with monoclonal antibodies
:
A.B. Schroeijers, et al.; J. Histochem. Cytochem.
49
, 1379 (2001)
Abstract
Up-regulation of drug resistance-related vaults during dendritic cell development
:
A.B. Schroeijers, et al.; J. Immunol.
168
, 1572 (2002)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
•
Tumor Markers
ALX-801-027
Revised 15-Oct-07
Monoclonal Antibody to Breast Cancer Resistance Protein (human) (BXP-34)
SYNONYMS
anti-BCRP (human) MAb (BXP-34)
anti-MXR (human) MAb (BXP-34)
anti-ABCG2 (human) MAb (BXP-34)
anti-CD338 (human) MAb (BXP-34)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Breast Cancer Resistance Protein [BCRP / MXR] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-801-027-C125
125 µg
350.00 USD
ALX-801-027-C250
250 µg
630.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
BXP-34
ISOTYPE:
Mouse IgG1
CONCENTRATION:
~250µg/ml
FORMULATION:
Liquid. In serum free cell culture supernatant containing 0.7% BSA and 0.1% sodium azide.
IMMUNOGEN:
Mitoxanthone resistant BCRP (breast cancer resistance protein; MXR) overexpressing cell line MCF7MR.
SPECIFICITY:
Recognizes an internal epitope of human BCRP. Does not cross-react with human P-glycoprotein, MRP1, MRP2 or MRP5.
APPLICATION:
Flow Cytometry
Immunocytochemistry
: Use 1:20-1:50 dilution on acetone fixed cytospin preparations.
Immunohistochemistry (frozen sections)
: Use 1:20 dilution of BXP-34 on acetone fixed frozen sections followed by incubation with rabbit anti-mouse IgG and a monoclonal mouse APAAP complex. BXP-34 cannot be used on formaldehyde-fixed paraffin-embedded human tissues and tumors.
Not recommended for Western blot.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines:
G.L. Scheffer, et al.; Cancer Res.
60
, 2589 (2000)
Abstract
;
Full Text
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues
:
M. Maliepaard, et al.; Cancer Res.
61
, 3458 (2001)
Abstract
;
Full Text
Breast cancer resistance protein expression and resistance to daunorubicin in blast cells from patients with acute myeloid leukaemia
:
J.M. Sargent, et al.; Br. J. Haematol.
115
, 257 (2001)
Abstract
The role of breast cancer resistance protein in acute lymphoblastic leukemia
:
S.L. Plasschaert, et al.; Clin. Cancer Res.
9
, 5171 (2003)
Abstract
General Literature References
A multidrug resistance transporter from human MCF-7 breast cancer cells
:
L.A. Doyle, et al.; PNAS
95
, 15665 (1998)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
•
Tumor Markers
•
CD Antibodies
ALX-801-028
Revised 24-Feb-06
Monoclonal Antibody to MDR3 P-glycoprotein (human) (P3II-26)
SYNONYMS
anti-ABCB4 (human) MAb (P
3
II-26)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
P-glycoprotein [Pgp] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-801-028-C125
125 µg
350.00 USD
ALX-801-028-C250
250 µg
630.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
P
3
II-26
ISOTYPE:
Mouse IgG2b
CONCENTRATION:
~250µg/ml
FORMULATION:
Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
IMMUNOGEN:
MDR3 P-glycoprotein fragment (aa 629-692).
SPECIFICITY:
Recognizes human MDR3 P-glycoprotein. Does not cross-react with human P-glycoprotein.
APPLICATION:
Immunocytochemistry:
Use 1:20-1:50 dilution on acetone fixed cytospin preparations.
Immunohistochemistry (frozen sections):
Use 1:20 dilution on acetone fixed frozen sections followed by incubation with rabbit anti-mouse IgG and a monoclonal mouse APAAP complex. Not recommended for paraffin sections.
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies
:
G.L. Scheffer, et al.; Cancer Res.
60
, 5269 (2000)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-801-029
Revised 15-Oct-07
Monoclonal Antibody to Breast Cancer Resistance Protein (human) (BXP-21)
SYNONYMS
anti-BCRP (human) MAb (BXP-21)
anti-MXR (human) MAb (BXP-21)
anti-ABCG2 (human) MAb (BXP-21)
anti-CD338 (human) MAb (BXP-21)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Breast Cancer Resistance Protein [BCRP / MXR] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-801-029-C125
125 µg
350.00 USD
ALX-801-029-C250
250 µg
630.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
BXP-21
ISOTYPE:
Mouse IgG2a
CONCENTRATION:
~250µg/ml
FORMULATION:
Liquid. In serum free cell culture supernatant containing 0.7% BSA and 0.1% sodium azide.
IMMUNOGEN:
Recombinant human BCRP (breast cancer resistance protein; MXR) (aa 271-396).
SPECIFICITY:
Recognizes an internal epitope of human BCRP. Does not cross-react with human P-glycoprotein, MRP1 or MRP2.
APPLICATION:
Immunocytochemistry:
Use 1:20-1:50 dilution on acetone fixed cytospin preparations.
Immunohistochemistry:
Frozen sections:
Use 1:20 dilution on acetone fixed frozen sections followed by incubation with rabbit anti-mouse IgG and a monoclonal mouse APAAP complex.
Paraffin sections:
Use on formaldehyde-fixed paraffin-embedded human tissues and tumors after pretreatment with 10mM citric acid, pH 6.0, for 20 min.
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues
:
M. Maliepaard, et al.; Cancer Res.
61
, 3458 (2001)
Abstract
;
Full Text
Characterization of Drug Transport, ATP Hydrolysis, and Nucleotide Trapping by the Human ABCG2 Multidrug Transporter
:
C. Özvegy, et al.; J. Biol. Chem.
277
, 47980 (2002)
Abstract
;
Full Text
General Literature References
A multidrug resistance transporter from human MCF-7 breast cancer cells
:
L.A. Doyle, et al.; PNAS
95
, 15665 (1998)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
•
Tumor Markers
ALX-801-030
Revised 15-Nov-07
Monoclonal Antibody to MRP1 (human) (QCRL-2)
SYNONYMS
anti-Multidrug Resistance-associated Protein 1 (human) MAb (QCRL-2)
anti-ABCC1 (human) MAb (QCRL-2)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
MDR-associated Proteins [MRPs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-801-030-L001
1 ml
450.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
QCRL-2
ISOTYPE:
Mouse IgG2b
CONCENTRATION:
40µg/ml
FORMULATION:
Liquid. In 0.22µM-filtered PBS containing 0.7% BSA and 0.1% sodium azide.
IMMUNOGEN:
Non-denatured membranes from the human small cell lung cancer cell line H69AR, which highly overexpresses MRP1 (multidrug resistance-associated protein 1).
SPECIFICITY:
Recognizes human MRP1. Does not cross-react with human P-glycoprotein (Pgp) or MDR3 P-glycoprotein.
APPLICATION:
Flow Cytometry
(cell permeabilization required (see [2]))
Immunocytochemistry
(cytospin preparations fixed in 0.5% paraformaldehyde in PBS (see [2]))
Immunoprecipitation
(see [4])
Functional Application
(inhibits the ATP-dependent transport activity of MRP1 in inside-out membrane vesicles (see [4])).
Note:
Not recommended for Western blot but works well in non-denaturing
dot-blots
(1:1000) (see [2,4])
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Specific Literature References
[1]
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line:
S.P. Cole, et al.; Science
258
, 1650 (1992)
Abstract
[2]
Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies:
D.R. Hipfner, et al.; Cancer Res.
54
, 5788 (1994)
Abstract
[3]
Structural, mechanistic and clinical aspects of MRP1:
D.R. Hipfner, et al.; Biochim. Biophys. Acta
1461
, 359 (1999)
Abstract
[4]
Monoclonal antibodies that inhibit the transport function of the 190- kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein:
D.R. Hipfner, et al.; J. Biol. Chem.
274
, 15420 (1999)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-801-031
Revised 24-Feb-06
Monoclonal Antibody to MRP1 (human) (QCRL-4)
SYNONYMS
anti-Multidrug Resistance-associated Protein 1 (human) MAb (QCRL-4)
anti-ABCC1 (human) MAb (QCRL-4)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
MDR-associated Proteins [MRPs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-801-031-L001
1 ml
450.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
QCRL-4
ISOTYPE:
Mouse IgG1
FORMULATION:
Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
IMMUNOGEN:
Non-denatured membranes from the human small cell lung cancer cell line H69AR, which highly overexpresses MRP1 (multidrug resistance-associated protein 1).
SPECIFICITY:
Recognizes human MRP1. Does not cross-react with human P-glycoprotein (Pgp) or MDR3 P-glycoprotein. Does not cross-react with mouse, rat or guinea pig MRP2 (cMOAT).
APPLICATION:
Flow Cytometry (cell permeabilization required)
Immunocytochemistry
Immunoprecipitation
Functional Application (inhibits the ATP-dependent transport activity of MRP1 in inside-out membrane vesicles).
Not recommended for Western blot.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line:
S.P. Cole, et al.; Science
258
, 1650 (1992)
Abstract
Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies:
D.R. Hipfner, et al.; Cancer Res.
54
, 5788 (1994)
Abstract
Monoclonal antibodies that inhibit the transport function of the 190- kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein:
D.R. Hipfner, et al.; J. Biol. Chem.
274
, 15420 (1999)
Abstract
;
Full Text
Structural, mechanistic and clinical aspects of MRP1:
D.R. Hipfner, et al.; Biochim. Biophys. Acta
1461
, 359 (1999)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-801-032
Revised 24-Feb-06
Monoclonal Antibody to MRP6 (human) (M6II-7)
SYNONYMS
anti-Multidrug Resistance-associated Protein 6 (human) MAb (M
6
II-7)
anti-ABCC6 (human) MAb (M
6
II-7)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
MDR-associated Proteins [MRPs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-801-032-C250
250 µg
630.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
M
6
II-7
ISOTYPE:
Rat IgG2a
CONCENTRATION:
~250µg/ml.
FORMULATION:
Liquid. In serum free cell culture supernatant containing 0.7% BSA and 0.1% sodium azide.
IMMUNOGEN:
Recombinant human MRP6 (multidrug resistance-associated protein 6) (aa 764-964).
SPECIFICITY:
Recognizes human MRP6. Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein or MRP1 to MRP5.
APPLICATION:
ELISA
Immunocytochemistry:
Use 1:20-1:50 dilution on acetone fixed cytospin preparations.
Immunohistochemistry (frozen sections (weak)):
Use 1:20-1:50 dilution on acetone fixed frozen sections followed by incubation with rabbit anti-rat IgG and an APAAP complex.
Not suitable for formaldehyde-fixed paraffin sections.
Western Blot (excellent):
Use 1:20-1:50 dilution and anti-rat-HRP.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Specific Literature References
MRP6 (ABCC6) Detection in Normal Human Tissues and Tumors
:
G.L. Scheffer, et al.; Lab. Invest.
82
, 515 (2002)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-801-033
Revised 24-Feb-06
Monoclonal Antibody to MRP6 (human) (M6II-21)
SYNONYMS
anti-Multidrug Resistance-associated Protein 6 (human) (M
6
II-21)
anti-ABCC6 (human) MAb (M
6
II-21)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
MDR-associated Proteins [MRPs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-801-033-L001
1 ml
630.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
M
6
II-21
ISOTYPE:
Rat IgG1
CONCENTRATION:
~100µg/ml
FORMULATION:
Liquid. In buffer containing 0.1% sodium azide.
IMMUNOGEN:
Recombinant human MRP6 (multidrug resistance-associated protein 6) (aa 764-964).
SPECIFICITY:
Recognizes human MRP6. Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein or MRP1 to MRP5. Does not cross-react with mouse MRP6.
APPLICATION:
ELISA
Immunocytochemistry (cytospin preparations)
Western Blot (weak)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Specific Literature References
MRP6 (ABCC6) Detection in Normal Human Tissues and Tumors
:
G.L. Scheffer, et al.; Lab. Invest.
82
, 515 (2002)
Abstract
