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 Items 350-400 of 725 Page 8 of 15 Select Page: << 1 2 3 4 5 6 7 8 9 10  >>  
ALX-350-157 Revised 18-Feb-08
Isofistularin-3
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Alkaloids
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ALX-350-157-M001   1 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C31H30Br6N4O11
MW: 1114.0
CAS NUMBER: 87099-50-1
SOURCE/HOST: Isolated from Aplysina aerophoba.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white amorphous solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Cytotoxic alkaloid. Shows antibiotic properties. Inhibits cell growth in vitro.
Product Specific Literature References
The bromo-compounds of the true sponge Verongia aerophoba: G. Cimino, et al.; Tetrahedron Lett. 24, 3029 (1983)
Antibiotic and cytotoxic activity of brominated compounds from the marine sponge Verongia aerophoba: R. Teeyapant, et al.; Z. Naturforsch. 48, 939 (1993) Abstract
Two unprecedented dibromotyrosine-derived alkaloids from the Brazilian endemic marine sponge Aplysina caissara: B.M. Saeki, et al.; J. Nat. Prod. 65, 796 (2002) Abstract
Chemical defense of Mediterranean sponges Aplysina cavernicola and Aplysina aerophoba: C. Thoms, et al.; Z. Naturforsch. 59, 113 (2004) Abstract
Stereochemical heterogeneity in Verongid sponge metabolites. Absolute stereochemistry of (+)-fistularin-3 and (+)-11-epi-fistularin-3 by microscale LCMS-Marfey’s analysis: E.W. Rogers, et al.; J. Nat. Prod. 68, 891 (2005) Abstract
Antimycobacterial brominated metabolites from two species of marine sponges: M.F. de Oliveira, et al.; Planta Med. 72, 437 (2006) Abstract
Further Categories Containing This Product:
Natural Products with Antibiotic Activity • Marine Natural Products
 
 
ALX-380-130 Revised 15-Sep-08 New product
Isofusidienol A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-130-M001   1 mg 90.00 USD Add To Cart
ALX-380-130-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C16H12O6
MW: 300.3
SOURCE/HOST: Isolated from Chalara sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or dichloromethane.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description

Chromone-3-oxepine. Displays antifungal and antibacterial activity against Gram-positive and Gram-negative bacteria.
Product Specific Literature References
Isofusidienols: Novel Chromone-3-oxepines Produced by the Endophytic Fungus Chalara sp: S. Lösgen, et al.; Eur. J. Org. Chem. 2008, 698
Further Categories Containing This Product:
Antibiotics - Antifungal
 
 
ALX-350-034 Revised 17-Jul-07
N-6-(Δ2-Isopentenyl)-adenine
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SYNONYMS 6-(γ,γ-Dimethylallylamino)purine
Triacanthine
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-350-034-M100   100 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C10H13N5
MW: 203.3
CAS NUMBER: 2365-40-4
PURITY: ≥98%
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Weakly active olomoucine analog for structure-activity analyses in the olomoucine series. Regulator of plant growth.
Product Specific Literature References
Inhibition of cyclin-dependent kinases by purine analogues: J. Vesely, et al.; Eur. J. Biochem. 224, 771 (1994) Abstract
Further Categories Containing This Product:
Cell Cycle Blockers & Inhibitors / Related Products • Natural Products - Plant Research Reagents • Plant Research Reagents / Related Products
 
 
ALX-385-025 Revised 07-Apr-08
8-Isopentenylnaringenin
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SYNONYMS 8-Prenylnaringenin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavanones
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ALX-385-025-M005   5 mg 155.00 USD Add To Cart
Product Specification
FORMULA: C20H20O5
MW: 340.4
SOURCE/HOST: Isolated from hops (Humulus lupulus L.).
PURITY: ≥97% (HPLC)
APPEARANCE: Light yellow powder
SOLUBILITY: Soluble in methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Prenyl flavonoid. Phytoestrogen. Selective, non-steroidal estrogen receptor α (ERα) ligand. Potent inhibitor of angiogenesis in vitro and in vivo. Chemopreventive agent against cancer induced by heterocyclic amines.
Product Specific Literature References
Prenylflavonoids: a new class of non-steroidal phytoestrogen (Part 1). Isolation of 8-isopentenylnaringenin and an initial study on its structure-activity relationship: M. Kitaoka, et al.; Planta Med. 64, 511 (1998) Abstract
Prenylflavonoids: a new class of non-steroidal phytoestrogen (Part 2). Estrogenic effects of 8-isopentenylnaringenin on bone metabolism: M. Miyamoto, et al.; Planta Med. 64, 516 (1998) Abstract
Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer: S.R. Milligan, et al.; J. Clin. Endocrinol. Metab. 84, 2249 (1999) Abstract
Prenylflavonoids from hops inhibit the metabolic activation of the carcinogenic heterocyclic amine 2-amino-3-methylimidazo[4, 5-f]quinoline, mediated by cDNA-expressed human CYP1A2: C.L. Miranda, et al.; Drug Metab. Dispos. 28, 1297 (2000) Abstract; Full Text
The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids: S.R. Milligan, et al.; J. Clin. Endocrinol. Metab. 85, 4912 (2000) Abstract; Full Text
8-prenylnaringenin, a novel phytoestrogen, inhibits angiogenesis in vitro and in vivo: M.S. Pepper, et al.; J. Cell Physiol. 199, 98 (2004) Abstract
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!: J.F. Stevens & J.E. Page; Phytochemistry 65, 1317 (2004), (Review) Abstract
Rapid yeast estrogen bioassays stably expressing human estrogen receptors alpha and beta, and green fluorescent protein: a comparison of different compounds with both receptor types: T.F. Bovee, et al.; J. Steroid Biochem. Mol. Biol. 91, 99 (2004) Abstract
8-Prenylnaringenin, inhibits estrogen receptor-alpha mediated cell growth and induces apoptosis in MCF-7 breast cancer cells: E. Brunelli, et al.; J. Steroid Biochem. Mol. Biol. 107, 140 (2007) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • Estrogen & Estrogen Receptors / Related Products • Natural Products for Angiogenesis Research • Natural Products - Chemopreventive Agents • Other Natural Products - DNA Regulation / Transcription
 
 
ALX-385-024 Revised 06-Oct-08
Isorhamnetin
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SYNONYMS 3-Methylquercetin
3'-Methoxy-3,4',5,7-tetrahydroxyflavone
3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-benzopyrone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonols
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ALX-385-024-M005   5 mg 90.00 USD Add To Cart
ALX-385-024-M010   10 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C16H12O7
MW: 316.3
CAS NUMBER: 480-19-3
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in acetone, methanol, ethylacetate or DMSO. Only sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: MAY BE CARCINOGENIC. HARMFUL.

Product Description
Antiviral agent. Antioxidant. Antitumor compound. Apoptosis inducer.
Product Specific Literature References
Anti-tumor promoting activity of polyphenols from Cowania mexicana and Coleogyne ramosissima: H. Ito, et al.; Cancer Lett. 143, 5 (1999) Abstract
Inhibition of xanthine oxidase by flavonoids: A. Nagao, et al.; Biosci. Biotechnol. Biochem. 63, 1787 (1999) Abstract
Effects of intrinsic fluorescence and quenching on fluorescence-based screening of natural products: L. Zou, et al.; Phytomedicine 9, 263 (2002) Abstract
Antioxidant effects of isorhamnetin 3,7-di-O-beta-D-glucopyranoside isolated from mustard leaf (Brassica juncea) in rats with streptozotocin-induced diabetes: T. Yokozawa, et al.; J. Agric. Food Chem. 50, 5490 (2002) Abstract
Effect of five flavonoid compounds isolated from leaves of Diospyros kaki on stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils: G. Chen, et al.; Clin. Chim. Acta 326, 169 (2002) Abstract
Isorhamnetin prevent endothelial cell injuries from oxidized LDL via activation of p38MAPK: M. Bao & Y. Lou; Eur. J. Pharmacol. 547, 22 (2006) Abstract
The flavonoid component isorhamnetin in vitro inhibits proliferation and induces apoptosis in Eca-109 cells: G. Ma, et al.; Chem. Biol. Interact. 167, 153 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Antitumor Reagents • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antioxidants • Natural Products - Antiviral / anti-HIV Agents
 
 
ALX-350-035 Revised 14-Nov-07
Isotetrandrine
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SYNONYMS Berbamine methyl ether
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-350-035-M001   1 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C38H42N2O6
MW: 622.8
CAS NUMBER: 477-57-6
RTECS: NX7285000
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Alkaloid inhibitor of G-protein mediated activation of phospholipase A2 (PLA2) but not phospholipase C or D.
Product Specific Literature References
Total syntheses of optically active natural isotetrandrine, phaeanthine and tetrandrine
: Y. Inubushi, et al.; Tetrahedron Lett. 30, 3399 (1968) Abstract
Suppressive effect of biscoclaurine alkaloids on agonist-induced activation of phospholipase A2 in rabbit platelets: T. Hashizume, et al.; Biochem. Pharmacol. 41, 419 (1991) Abstract
Biscoclaurine alkaloids inhibit receptor-mediated phospholipase A2 activation probably through uncoupling of a GTP-binding protein from the enzyme in rat peritoneal mast cells: S. Akiba, et al.; Biochem. Pharmacol. 44, 45 (1992) Abstract
Inhibition of membrane tubule formation and trafficking by isotetrandrine, an antagonist of G-protein-regulated phospholipase A2 enzymes: D. Chan, et al.; Mol. Biol. Cell 15, 1871 (2004) Abstract
Further Categories Containing This Product:
PLA2 Inhibitors • Alkaloids
 
 
ALX-350-279 Revised 02-Jun-08
Isoxanthohumol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-279-M001   1 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C21H22O5
MW: 354.4
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in DMSO (50mg/ml) or methanol (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Prenylated flavonoid. Phytoestrogen. Induces apoptosis in mature adipocytes.
Product Specific Literature References
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!: J.F. Stevens & J.E. Page; Phytochemistry 65, 1317 (2004), (Review) Abstract
Inhibition of endothelial cell functions by novel potential cancer chemopreventive agents: E. Bertl, et al.; BBRC 325, 287 (2004) Abstract
Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes: D. Nikolic, et al.; J. Mass Spectrom. 40, 289 (2005) Abstract
The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine: S. Possemiers, et al.; J. Nutr. 136, 1862 (2006) Abstract
Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.): J. Guo, et al.; Drug Metab. Dispos. 34, 1152 (2006)
Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis: J.Y. Yang, et al.; Apoptosis 12, 1953 (2007) Abstract
Further Categories Containing This Product:
Flavanones • Estrogen & Estrogen Receptors / Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Active Substances from Fruit and Vegetables • Natural Products - Other Signal Transduction Pathway Modulators • Lipid Metabolism Other Products
 
 
ALX-350-275 Revised 04-Aug-08 New product
Jasplakinolide
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SYNONYMS Jaspamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-350-275-C050   50 µg 150.00 USD Add To Cart
ALX-350-275-C100   100 µg 250.00 USD Add To Cart
Product Specification
FORMULA: C36H45BrN4O6
MW: 709.7
CAS NUMBER: 102396-24-7
SOURCE/HOST: Isolated from Jaspis splendens.
PURITY: ≥97% (HPLC)
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in 100% ethanol, 83% methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL.
IDENTITY: Identity determined by MS.

Product Description
Cell permeable F-actin probe. Induces actin polymerization. Completely inhibits the binding of phalloidin to F-actin. Antifungal and anti-proliferative agent.
Product Specific Literature References
New class of antifungal agents: jasplakinolide, a cyclodepsipeptide from the marine sponge, Jaspis species: V.R. Scott, et al.; Antimicrob. Agents Chemother. 32, 1154 (1988) Abstract
In vitro screening of crude extracts and pure metabolites obtained from marine invertebrates for the treatment of breast cancer: J. Stingl, et al.; Cancer Chemother. Pharmacol. 30, 401 (1992) Abstract
Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin: M.R. Bubb, et al.; J. Biol. Chem. 269, 14869 (1994) Abstract; Full Text
Growth modulation and differentiation of acute myeloid leukemia cells by jaspamide: I. Fabian, et al.; Exp. Hematol. 23, 583 (1995) Abstract
Jasplakinolide's inhibition of the growth of prostate carcinoma cells in vitro with disruption of the actin cytoskeleton: A.M. Senderowicz, et al.; J. Natl. Cancer Inst. 87, 46 (1995) Abstract
Jasplakinolide: interaction with radiation and hyperthermia in human prostate carcinoma and Lewis lung carcinoma: H. Takeuchi, et al.; Cancer Chemother. Pharmacol. 42, 491 (1998) Abstract
Role of actin-filament disassembly in lamellipodium protrusion in motile cells revealed using the drug jasplakinolide: L.P. Cramer; Curr. Biol. 9, 1095 (1999) Abstract
Actin stabilization by jasplakinolide enhances apoptosis induced by cytokine deprivation: S.C. Posey & B.E. Bierer; J. Biol. Chem. 274, 4259 (1999) Abstract; Full Text
The anti-proliferative agent jasplakinolide rearranges the actin cytoskeleton of plant cells: H. Sawitzky, et al.; Eur. J. Cell Biol. 78, 424 (1999) Abstract
Effects of jasplakinolide on the kinetics of actin polymerization. An explanation for certain in vivo observations: M.R. Bubb, et al.;; J. Biol. Chem. 275, 5163 (2000) Abstract; Full Text
A role for the actin cytoskeleton in the initiation and maintenance of store-mediated calcium entry in human platelets. Evidence for conformational coupling: J.A. Rosado, et al.; J. Biol. Chem. 275, 7527 (2000) Abstract; Full Text
A simple model for the cooperative stabilisation of actin filaments by phalloidin and jasplakinolide: B. Visegrády, et al.; FEBS Lett. 579, 6 (2005) Abstract
Dynamics of an F-actin aggresome generated by the actin-stabilizing toxin jasplakinolide: F. Lázaro-Diéguez, et al.; J. Cell Sci. 121, 1415 (2008) Abstract
Further Categories Containing This Product:
Actin / Related Products • Marine Natural Products
 
 
ALX-350-378 Revised 19-Aug-08 New product
Jervine
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SYNONYMS (3β,23β)-17,23-Epoxy-3-hydroxyveratraman-11-one
11-Ketocyclopamine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Hedgehog [Hh] Signalling Pathway
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ALX-350-378-M001   1 mg 90.00 USD Add To Cart
ALX-350-378-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C27H39NO3
MW: 425.6
CAS NUMBER: 469-59-0
MERCK INDEX: 14: 5264
RTECS: WG9700000
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (5mg/ml), 100% ethanol (10mg/ml) or dimethyl formamide (6mg/ml). Slight warming may be required.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C.
HAZARD: HARMFUL. MAY BE TERATOGENIC.

Product Description
Cell permeable steroidal alkaloid. Structurally similar to cyclopamine (Prod. No. ALX-430-159). Inhibits the sonic hedgehog pathway (shh) by interacting with smoothened. Tomatidine (Prod. No. ALX-430-377) is a useful negative control.
Product Specific Literature References
Teratogen-mediated inhibition of target tissue response to Shh signaling: M.K. Cooper, et al.; Science 280, 1603 (1998) Abstract
Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport: J.P. Incardona, et al.; Dev. Biol. 224, 440 (2000) Abstract
Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis: D. ten Berge, et al.; Development 128, 2929 (2001) Abstract; Full Text
Cyclopamine and jervine in embryonic rat tongue cultures demonstrate a role for Shh signaling in taste papilla development and patterning: fungiform papillae double in number and form in novel locations in dorsal lingual epithelium: C.M. Mistretta, et al.; Dev. Biol. 254, 1 (2003) Abstract
Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions: J.A. Williams, et al.; PNAS 100, 4616 (2003) Abstract; Full Text
A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis: M.K. Cooper, et al.; Nat. Genet. 33, 508 (2003) Abstract
Related Products
Further Categories Containing This Product:
Alkaloids