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NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-105-001 Revised 06-Jun-06
NG-Nitro-L-arginine
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SYNONYMS L-NOARG
L-Nitroarginine
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-105-001-G005   5 g 22.00 USD Add To Cart
ALX-105-001-G025   25 g 63.00 USD Add To Cart
Product Specification
FORMULA: C6H13N5O4
MW: 219.2
CAS NUMBER: 2149-70-4
PURITY: ≥99%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 0.1N HCl. Moderately soluble in water; insoluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Inhibitor of nitric oxide synthase (NOS).
Product Specific Literature References
L-NG-monomethyl arginine and L-NG-nitro arginine inhibit non-adrenergic, non-cholinergic relaxation of the mouse anococcygeus muscle: A. Gibson, et al.; Br. J. Pharmacol. 99, 602 (1990) Abstract
N omega-nitro-L-arginine: a potent inhibitor of endothelium-derived relaxing factor formation: K. Ishii, et al.; Eur. J. Pharmacol. 176, 219 (1990) Abstract
L-NG-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro: P.K. Moore, et al.; Br. J. Pharmacol. 99, 408 (1990) Abstract
Inhibitory effects of L-NG-nitro-arginine on the synthesis of EDRF and the cerebroarterial response to vasodilator nerve stimulation: N. Toda, et al.; Life. Sci. 47, 345 (1990) Abstract
The influence of L-NG-nitro-arginine on field stimulation induced contractions and acetylcholine release in guinea pig isolated tracheal smooth muscle: S.R. Brave, et al.; BBRC 179, 1017 (1991) Abstract
Nitric oxide synthase: irreversible inhibition by L-NG-nitroarginine in brain in vitro and in vivo: M.A. Dwyer, et al.; BBRC 176, 1136 (1991) Abstract
On the substrate specificity of nitric oxide synthase: M. Hecker, et al.; FEBS Lett. 294, 221 (1991) Abstract
Enhanced photorelaxation in aorta, pulmonary artery and corpus cavernosum produced by BAY K 8644 or N-nitro-L-arginine: X. Chen and C.N. Gillis; BBRC 186, 1522 (1992) Abstract
Possible involvement of nitric oxide in chlordiazepoxide-induced anxiolysis in mice: R.M. Quock and E. Nguyen; Life Sci. 51, PL255 (1992) Abstract
The role of nitric oxide in mediating non-adrenergic non-cholinergic relaxation in longitudinal muscle of human taenia coli: F.S.-F. Tam & K. Hillier; Life Sci 51, 1277 (1992) Abstract
NO- and NO2-carrying molecules potentiate photorelaxation in rat trachea and aorta: K.C. Chang, et al.; BBRC 191, 509 (1993) Abstract
Selective inhibition of constitutive nitric oxide synthase by L-NG- nitroarginine: E.S. Furfine, et al.; Biochemistry 32, 8512 (1993) Abstract
Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor: Y.A. Kolesnikov, et al.; PNAS 90, 5162 (1993) Abstract
Reversible inactivation of endothelial nitric oxide synthase by NG- nitro-L-arginine: B. Mayer, et al.; FEBS Lett. 333, 203 (1993) Abstract
 
 
ALX-105-002 Revised 12-Nov-07
NG-Nitro-D-arginine
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SYNONYMS D-NOARG
D-Nitroarginine
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-105-002-M250   250 mg 22.00 USD Add To Cart
ALX-105-002-G001   1 g 53.00 USD Add To Cart
Product Specification
FORMULA: C6H13N5O4
MW: 219.2
CAS NUMBER: 66036-77-9
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 0.1M HCl. Moderately soluble in water; insoluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

 
 
ALX-105-003 Revised 02-Dec-05
L-NAME . hydrochloride
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SYNONYMS NG-Nitro-L-arginine-methyl ester . HCl
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-105-003-G005   5 g 32.00 USD Add To Cart
ALX-105-003-G025   25 g 133.00 USD Add To Cart
Product Specification
FORMULA: C7H15N5O4 . HCl
MW: 233.2 . 36.5
CAS NUMBER: 51298-62-5
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of nitric oxide synthase (NOS). More soluble than NG-Nitro-L-arginine (Prod. No. ALX-105-001). Suppresses the release of nitric oxide (NO) from endothelial cells. Has a different effect on the superoxide generation by NOS than L-NMMA (Prod. No. ALX-106-001).
Product Specific Literature References
L-NG-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro: P.K. Moore, et al.; Br. J. Pharmacol. 99, 408 (1990) Abstract
Generation of superoxide by purified brain nitric oxide synthase: S. Pou, et al.; J. Biol. Chem. 267, 24173 (1992) Abstract; Full Text
 
 
ALX-105-004 Revised 02-Dec-05
D-NAME . hydrochloride
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SYNONYMS NG-Nitro-D-arginine-methyl ester . HCI
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-105-004-M250   250 mg 32.00 USD Add To Cart
Product Specification
FORMULA: C7H15N5O4 . HCl
MW: 233.2 . 36.5
CAS NUMBER: 50912-92-0
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inactive isomer of L-NAME (Prod. No. ALX-105-003).
 
 
ALX-105-009 Revised 06-Jun-06
N-Methyl-D-aspartic acid
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SYNONYMS NMDA
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-105-009-M010   10 mg 23.00 USD Add To Cart
ALX-105-009-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C5H9NO4
MW: 147.1
CAS NUMBER: 6384-92-5
MERCK INDEX: 14: 6662
RTECS: CI9457000
PURITY: ≥98%
APPEARANCE: White crystalline powder.
SOLUBILITY: Soluble in dilute aqueous base; slightly soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.

Product Description
Selective ionotropic NMDA receptor agonist.
Product Specific Literature References
Excitatory amino acid transmitters: J.C. Watkins & R.H. Evans; Ann. Rev. Pharmacol. Toxicol. 21, 165 (1981), (Review) Abstract
NMDA receptors and ligands in the vertebrate CNS: T.W. Stone & N.R. Burton; Progr. Neurobiol. 30, 333 (1988), (Review) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related ProductsSpecial Amino Acids
 
 
ALX-105-010 Revised 04-Dec-04
N-Methyl-L-aspartic acid
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SYNONYMS NMLA
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
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ALX-105-010-M010   10 mg 20.00 USD Add To Cart
ALX-105-010-M050   50 mg 50.00 USD Add To Cart
Product Specification
FORMULA: C5H9NO4
MW: 147.1
CAS NUMBER: 4226-18-0
PURITY: ≥98%
APPEARANCE: White crystalline powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.

Further Categories Containing This Product:
Special Amino Acids
 
 
ALX-106-001 Revised 30-Nov-06
L-NMMA . monoacetate
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SYNONYMS NG-Monomethyl-L-arginine . monoacetate
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-106-001-M005   5 mg 20.00 USD Add To Cart
ALX-106-001-M025   25 mg 55.00 USD Add To Cart
ALX-106-001-M100   100 mg 180.00 USD Add To Cart
ALX-106-001-G001   1 g 360.00 USD Add To Cart
Product Specification
FORMULA: C7H16N4O2 . CH3COOH
MW: 188.2 . 60.1
CAS NUMBER: 53308-83-1
PURITY: ≥99%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Standard inhibitor of nitric oxide synthase. Suppresses the release of nitric oxide from endothelial cells.
Product Specific Literature References
Identification of arginine as a precursor of endothelium-derived relaxing factor: I. Sakuma, et al.; PNAS 85, 8664 (1988) Abstract
A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation: D.D. Rees, et al.; Br. J. Pharmacol. 96, 418 (1989) Abstract
Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase: M. Palacios-Callender, et al.; PNAS 101, 7630 (2004) Abstract; Full Text
Further Categories Containing This Product:
PRMTs, Mono- & Dimethylarginine / Related Products
 
 
ALX-106-002 Revised 03-Jun-03
D-NMMA . monoacetate
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SYNONYMS NG-Monomethyl-D-arginine . monoacetate
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-106-002-M005   5 mg 27.00 USD Add To Cart
ALX-106-002-M025   25 mg 100.00 USD Add To Cart
ALX-106-002-M100   100 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C7H16N4O2 . CH3COOH
MW: 188.2 . 60.1
CAS NUMBER: 137694-75-8
PURITY: ≥99%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Further Categories Containing This Product:
PRMTs, Mono- & Dimethylarginine / Related Products
 
 
ALX-106-003 Revised 06-Jun-06
L-Citrulline
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PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-106-003-G005   5 g 20.00 USD Add To Cart
Product Specification
FORMULA: C6H13N3O3
MW: 175.2
CAS NUMBER: 372-75-8
MERCK INDEX: 14: 2331
PURITY: ≥99%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Essential intermediate in the biosynthesis of nitric oxide from L-arginine.
Product Specific Literature References
A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells: R.M.J. Palmer and S. Moncada; BBRC 158, 348 (1989) Abstract
The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine: M. Hecker, et al.; PNAS 87, 8612 (1990) Abstract
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine: D.J. Stuehr, et al.; J. Biol. Chem. 266, 6259 (1991) Abstract; Full Text
 
 
ALX-106-004 Revised 11-Jun-08
NG-Hydroxy-L-arginine . monoacetate
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SYNONYMS L-HOArg . AcOH
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-106-004-M005   5 mg 70.00 USD Add To Cart
ALX-106-004-M025   25 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C6H14N4O3 . CH3COOH
MW: 190.2 . 60.1
CAS NUMBER: 53598-01-9
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Intermediate in the biosynthesis of nitric oxide from L-arginine by nitric oxide synthases (NOS). Inhibitor of arginases.
Product Specific Literature References
Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate: M.A. Marletta, et al.; Biochemistry 27, 8706 (1988) Abstract
P.L. Feldman; THL 32, 875 (1991), [Synthesis]
On the substrate specificity of nitric oxide synthase: M. Hecker, et al.; FEBS Lett. 294, 221 (1991) Abstract
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine: D.J. Stuehr, et al.; J. Biol. Chem. 266, 6259 (1991) Abstract; Full Text
Synthesis and bioactivity of N omega-hydroxyarginine: a possible intermediate in the biosynthesis of nitric oxide from arginine: G.C. Wallace & J.M. Fukuto; J. Med. Chem. 34, 1746 (1991), [Synthesis] Abstract
Nitric oxide and another potent vasodilator are formed from NG-hydroxy- L-arginine by cultured endothelial cells: A. Zembowicz, et al.; PNAS 88, 11172 (1991) Abstract
N omega-hydroxy-L-arginine: a novel arginine analog capable of causing vasorelaxation in bovine intrapulmonary artery: G.C. Wallace, et al.; BBRC 176, 528 (1991) Abstract
Mechanistic probes of N-hydroxylation of L-arginine by the inducible nitric oxide synthase from murine macrophages: R.A. Pufahl, et al.; Biochemistry 31, 6822 (1992), [Synthesis] Abstract
Inhibition of rat liver arginase by an intermediate in NO biosynthesis, NG-hydroxy-L-arginine: implications for the regulation of nitric oxide biosynthesis by arginase: F. Daghigh, et al.; BBRC 202, 174 (1994) Abstract
N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase: J.-L. Boucher, et al.; BBRC 203, 1614 (1994) Abstract
Exogenous NG-hydroxyl-L-arginine causes nitrite production in vascular smooth muscle cells in the absence of nitric oxide synthase activity: C.A. Schott, et al.; FEBS Lett. 341, 203 (1994) Abstract
Inhibition of purified nitric oxide synthase from rat cerebellum and macrophage by L-arginine analogs: Y. Komori, et al.; Arch. Biochem. Biophys. 315, 213 (1994) Abstract
Inhibition of arginase by NG-hydroxy-L-arginine in alveolar macrophages: implications for the utilization of L-arginine for nitric oxide synthesis: M. Hecker, et al.; FEBS Lett. 359, 251 (1995) Abstract
Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine during high-output NO production: G.M. Buga, et al.; Am. J. Physiol. 271, H1988 (1996) Abstract
NG-hydroxy-L-arginine and nitric oxide inhibit Caco-2 tumor cell proliferation by distinct mechanisms: G.M. Buga, et al.; Am. J. Physiol. 275, R1256 (1998) Abstract; Full Text
Further Categories Containing This Product:
Arginine & Arginases / Related Products
 
 
ALX-106-005 Revised 24-Feb-05