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Oxidative Stress
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ALX-430-124 Revised 23-Feb-05
Licochalcone A (synthetic)
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SYNONYMS (E)-3-[5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Modulators
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ALX-430-124-M005   5 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C21H22O4
MW: 338.4
CAS NUMBER: 58749-22-7
PURITY: ≥96% (HPLC)
APPEARANCE: Yellow crystalline solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 6 months when stored at –20°C. Dilute stock solution 1:10 with aqueous buffer or medium just prior to use.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Packaged under inert gas. Protect from light.
HAZARD: HARMFUL.

Product Description
Reduces Bcl-2 protein expression.
Further Categories Containing This Product:
Chalcones
 
 
ALX-850-026 Revised 28-Apr-08
Lipid Hydroperoxide (LPO) Assay Kit (100 determinations)
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Lipid Peroxidation
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ALX-850-026-KI01   1 Kit 368.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.25-5nmole
QUANTITY: 100 tests.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
Product Description
Unlike other methods of lipid peroxidation measurement that rely on decomposition products, such as malondialdehyde (Prod. No. ALX-280-018) and 4-hydroxynonenal (Prod. No. ALX-270-245), this new assay features direct measurement of lipid hydroperoxides via a redox reaction. Any sample containing lipid hydroperoxide can be easily and reliably quantified spectrophotometrically using either glass or quartz cuvettes (λmax: 500nm; ε: 16,667M-1cm-1).
Further Categories Containing This Product:
Quantification Kits
 
 
ALX-850-203 Revised 28-Apr-08
Lipid Hydroperoxide (LPO) Assay Kit (96 wells)
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Lipid Peroxidation
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ALX-850-203-KI01   1 Kit 582.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.25-5nmole
QUANTITY: 96 wells (~80 tests).
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
Product Description
Unlike other methods of lipid peroxidation measurement that rely on decomposition products, such as malondialdehyde (Prod. No. ALX-280-018) and 4-hydroxynonenal (Prod. No. ALX-270-245), this new assay features direct measurement of lipid hydroperoxides via a redox reaction. Any sample containing lipid hydroperoxide can be easily and reliably quantified spectrophotometrically using either glass or quartz cuvettes (λmax: 500nm; ε: 16,667M-1cm-1). Contains a reusable glass 96 well plate (for use of organic solvents).
Further Categories Containing This Product:
Quantification Kits
 
 
ALX-270-266 Revised 19-May-03
DL-α-Lipoic acid
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SYNONYMS DL-6,8-Thioctic acid
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Antioxidants, Flavonoids & Free Radical Scavengers Other Products
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ALX-270-266-G001   1 g 20.00 USD Add To Cart
ALX-270-266-G005   5 g 60.00 USD Add To Cart
Product Specification
FORMULA: C8H14O2S2
MW: 206.3
CAS NUMBER: 1077-28-7
MERCK INDEX: 14: 9326
PURITY: ≥97%
APPEARANCE: Solid.
SOLUBILITY: Soluble in 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Antioxidant.
 
 
ALX-620-061 Revised 10-Jul-08
Lucigenin
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SYNONYMS bis-N-Methylacridinium nitrate
N,N'-Dimethyl-9,9'-biacridinium dinitrate
PRODUCT LINE Other Products
PRODUCT CATEGORY Dyes / Stains / Fluorescent Probes / Fluorescent Labels
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ALX-620-061-M010   10 mg 17.00 USD Add To Cart
ALX-620-061-M050   50 mg 28.00 USD Add To Cart
Product Specification
FORMULA: C28H22N4O6
MW: 510.5
CAS NUMBER: 2315-97-1
PURITY: ≥97% (HPLC)
APPEARANCE: Off-white to brown powder.
SOLUBILITY: Soluble in acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Chemiluminescent probe for the detection of superoxide in biological systems.
Product Specific Literature References
Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems: Y. Li, et al.; J. Biol. Chem. 273, 2015 (1998) Abstract; Full Text
Lucigenin as mediator of superoxide production: revisited: S.I. Liochev & I. Fridovich; Free Radic. Biol. Med. 25, 926 (1998) Abstract
What do we measure with luminol-, lucigenin- and penicillin-amplified chemiluminescence? 1. Investigations with hydrogen peroxide and sodium hypochlorite: M. Rost, et al.; J. Biolumin. Chemilumin. 13, 355 (1998) Abstract
Lucigenin is a mediator of cytochrome C reduction but not of superoxide production: I.B. Afanas'ev, et al.; Arch. Biochem. Biophys. 366, 267 (1999) Abstract
Lucigenin as a substrate of microsomal NAD(P)H-oxidoreductases: I.A. Schepetkin; Biochemistry (Mosc.) 64, 25 (1999) Abstract
Validation of lucigenin as a chemiluminescent probe to monitor vascular superoxide as well as basal vascular nitric oxide production: M.P. Skatchkov, et al.; BBRC 254, 319 (1999) Abstract
Chemiluminescent detection of oxidants in vascular tissue. Lucigenin but not coelenterazine enhances superoxide formation: M.M. Tarpey, et al.; Circ. Res. 84, 1203 (1999) Abstract
Further Categories Containing This Product:
Respiratory Chain Other Products • Oxidative Stress Markers & Reagents / Related Products
 
 
ALX-350-355 Revised 26-Mar-08
Lupeol
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SYNONYMS Fagarasterol
20(29)-Lupen-3β-ol
3β-Hydroxy-20(29)-lupene
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
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ALX-350-355-M010   10 mg 35.00 USD Add To Cart
ALX-350-355-M050   50 mg 105.00 USD Add To Cart
ALX-350-355-G001   1 g 990.00 USD Add To Cart
Product Specification
FORMULA: C30H50O
MW: 426.7
CAS NUMBER: 545-47-1
MERCK INDEX: 14: 5608
RTECS: OK5763000
SOURCE/HOST: Isolated from Lupinus polyphyllus.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in ether or warm 100% ethanol; insoluble in water
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Anti-inflammatory, antioxidant and antimutagenic compound. Shows preventive effects on DMBA induced DNA alkylation damage in mouse skin. Modulator of NF-κB and PI(3)K/Akt (protein kinase B; PKB) pathways. Induces Fas-mediated apoptosis via inhibition of Ras signalling. Inhibits tumor growth in mouse in vivo.
Product Specific Literature References
Anti-inflammatory activity of lupeol and lupeol linoleate in rats: T. Geetha & P. Varalakshmi; J. Ethnopharmacol. 76, 77 (2001) Abstract
Lupeol, a triterpene, inhibits early responses of tumor promotion induced by benzoyl peroxide in murine skin: M. Saleem, et al.; Pharmacol. Res. 43, 127 (2001) Abstract
Lupeol modulates NF-kappaB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice: M. Saleem, et al.; Oncogene 23, 5203 (2004) Abstract
Induction of antifertility with lupeol acetate in male albino rats: R.S. Gupta, et al.; Pharmacology 75, 57 (2005) Abstract
A novel dietary triterpene Lupeol induces fas-mediated apoptotic death of androgen-sensitive prostate cancer cells and inhibits tumor growth in a xenograft model: M. Saleem, et al.; Cancer Res. 65, 11203 (2005) Abstract; Full Text
Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway: M. Saleem, et al.; Carcinogenesis 26, 1956 (2005) Abstract; Full Text
Lupeol long-chain fatty acid esters with antimalarial activity from Holarrhena floribunda: J. Fotie, et al.; J. Nat. Prod. 69, 62 (2006) Abstract
Lupeol ameliorates aflatoxin B1-induced peroxidative hepatic damage in rats: S.P. Preetha, et al.; Comp. Biochem. Physiol C. Toxicol. Pharmacol. 143, 333 (2006) Abstract
Role of lupeol and lupeol linoleate on lipemic-oxidative stress in experimental hypercholesterolemia: V. Sudhahar, et al.; Life Sci. 78, 1329 (2006) Abstract
Preventive effects of lupeol on DMBA induced DNA alkylation damage in mouse skin: N. Nigam, et al.; Food Chem. Toxicol. 45, 2331 (2007) Abstract
Lupeol suppresses cisplatin-induced nuclear factor-kappaB activation in head and neck squamous cell carcinoma and inhibits local invasion and nodal metastasis in an orthotopic nude mouse model: T.K. Lee, et al.; Cancer Res. 67, 8800 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Chemopreventive Agents • Natural Products - Antioxidants
 
 
ALX-385-007 Revised 07-Oct-08
Luteolin
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SYNONYMS 3',4',5,7-Tetrahydroxyflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavones
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ALX-385-007-M010   10 mg 15.00 USD Add To Cart
ALX-385-007-M050   50 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C15H10O6
MW: 286.2
CAS NUMBER: 491-70-3
MERCK INDEX: 14: 5614
RTECS: LK9275210
PURITY: ≥90%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in methanol, alkaline solutions; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Antioxidant flavonoid. Inhibits VEGF-induced angiogenesis. Inhibitor of phosphoinositide 3-kinase (PI(3)K). Inhibitor of fatty acid synthase (FAS). Apoptosis inducer.
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity: E. Bagli, et al.; Cancer Res. 64, 7936 (2004)
Dietary flavonoids: bioavailability, metabolic effects, and safety: J.A. Ross & C.M. Kasum; Annu. Rev. Nutr. 221, 19 (2002), (Review) Abstract
Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?: R. Lupu & J. A. Menendez; Curr. Pharm. Biotechnol. 7, 483 (2006), (Review) Abstract
Further Categories Containing This Product:
Natural Products - Other Signal Transduction Pathway Modulators • Fatty Acid Synthase [FAS] / Related Products • Free Radical Scavengers • Phosphoinositide 3-kinase [PI(3)K] / Related Products • Natural Products for Angiogenesis Research • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antioxidants
 
 
ALX-280-018 Revised 14-Sep-07
Malonaldehyde bis(dimethyl acetal)
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SYNONYMS Malondialdehyde Precursor
MDA Precursor
1,1,3,3-Tetramethoxypropane
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Lipid Peroxidation
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ALX-280-018-L005   5 ml 35.00 USD Add To Cart
Product Specification
FORMULA: C7H16O4
MW: 164.2
CAS NUMBER: 102-52-3
MERCK INDEX: 13: 5709 (Malondialdehyde (MDA))
PURITY: ≥98% (GLC)
APPEARANCE: Colorless liquid.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep away from heat, sources of ignition and incompatibles such as oxidizing agents.

Product Description
Precursor of malondialdehyde (MDA), a naturally occuring product of lipid peroxidation and prostaglandin biosynthesis, which is also formed by oxidation of polyunsaturated fatty acids in foods. Reacts with DNA to form adducts to deoxyguanosine and deoxyadenosine.
Product Specific Literature References
[1] Malonaldehyde in aqueous solution and its role as a measure of lipid oxidation in foods: T. W. Kwon, et al.; J. Food Sci. 29, 294 (1964)
[2] Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes: H. Esterbauer, et al.; Free Radic. Biol. Med. 11, 81 (1991) Abstract
[3] Chemistry and biology of DNA damage by malondialdehyde: L.J. Marnett, et al.; IRAC Sci. Publ. 150, 17 (1999) Abstract
[4] Lipid peroxidation-DNA damage by malondialdehyde: L.J. Marnett, et al.; Mutat. Res. 424, 83 (1999) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Malondialdehyde (MDA) is very hygroscopic and can be stored only for a short time [1].
For biological experiments we recommend to use aqueous solutions of MDA freshly prepared by acid hydrolysis (1% H2SO4 at room temperature) of malonaldehyde bis(dimethyl acetal) (Prod. No. ALX-280-018) [2].
 
 
ALX-385-013 Revised 16-Jun-08
Malvidin chloride
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SYNONYMS 3,4',5,7-Tetrahydroxy-3',5'-dimethoxyflavylium chloride
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Anthocyanidins
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ALX-385-013-M010   10 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C17H15O7Cl
MW: 366.8
CAS NUMBER: 643-84-5
MERCK INDEX: 14: 5715
RTECS: LK9900000
PURITY: ≥97%
APPEARANCE: Reddish brown to black powder.
SOLUBILITY: Soluble in 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Hygroscopic.

Product Description
Antioxidant flavonoid. Antitumor compound. Induces cell cycle arrest in the G2/M-phase.
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Biological activities of malvidin, a red wine anthocyanidin: J. Fritz, et al.; Mol. Nutr. Food Res. 50, 390 (2006) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • Cell Cycle Blockers & Inhibitors / Related Products • Natural Products - Antitumor Reagents • Natural Products - Antioxidants • Natural Products for Cell Cycle Research
 
 
ALX-430-083 Revised 19-Sep-06
MCPIO
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SYNONYMS 2-(2-Carboxyethyl)-2-methyl-4-phenyl-2H-imidazole-1-oxide
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Spin Traps, Spin Probes & Spin Labels
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ALX-430-083-M010   10 mg 15.00 USD Add To Cart
ALX-430-083-M050   50 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C13H14N2O3
MW: 246.3
PURITY: ≥98%
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in water, 100% ethanol or DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C

Product Description
Cell permeable, stable spin trap. Alternative to PBN (Prod. No. ALX-430-082).
Product Specific Literature References
2H-imidazole-N-oxides as spin traps: S.I. Dikalov, et al.; Bull. Russ. Acad. Sci. 41, 834 (1992)
Spin trapping of O-, C-, and S-centered radicals and peroxynitrite by 2H-imidazole-1-oxides: S.I. Dikalov, et al.; BBRC 218, 616 (1996) Abstract
 
 
ALX-270-252 Revised 03-Mar-05
MEG . sodium succinate
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SYNONYMS