• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Cell Death / Apoptosis / Autophagy
You are here: Product Lines > Cell Death / Apoptosis / Autophagy
 
Toolbar - View Selection
 
 Items 1-20 of 1119 Page 1 of 56 Select Page: 1 2 3 4 5 6 7 8 9 10  >>  
ALX-106-017 Revised 04-Mar-05
L-Pipecolic acid . hydrochloride
Add to Clipboard
SYNONYMS L-(-)-Pipecolinic acid . HCl
PRODUCT LINE Combinatorial Chemistry
PRODUCT CATEGORY Special Amino Acids
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-106-017-M050   50 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C6H11NO2 . HCl
MW: 129.2 . 36.5
CAS NUMBER: 3105-95-1
PURITY: ≥98%
APPEARANCE: White powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Lysine metabolite. Defect in its catabolism is involved in hyperpipecolic acidemia, cerebro-hepato-renal syndrome, neonatal onset adrenoleukodystrophy, and infantile Refsum disease. Apoptosis inducer in neuronal cells.
Product Specific Literature References
L-pipecolic acid oxidation in the rabbit and cynomolgus monkey. Evidence for differing organellar locations and cofactor requirements in each species: S.J. Mihalik & W.J. Rhead; J. Biol. Chem. 264, 2509 (1989) Abstract; Full Text
Pipecolic acid induces apoptosis in neuronal cells: S. Matsumoto, et al.; Brain Res. 980, 179 (2003) Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-430-156 Revised 21-Apr-08
6BIO
Add to Clipboard
SYNONYMS (2’Z,3’E)-6-Bromoindirubin-3’-oxime
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Non-apoptotic Cell Death / Necrosis
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-156-M001   1 mg 40.00 USD Add To Cart
Product Specification
FORMULA: C16H10BrN3O2
MW: 356.2
CAS NUMBER: 667463-62-9
PURITY: ≥98%
APPEARANCE: Dark red solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Inhibitor of phosphoinositide-dependent kinase 1 (PDK1). Potent, reversible and ATP-competitive inhibitor of glycogen synthase kinase-3α/β (GSK-3α/β).
Product Specific Literature References
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases: P. Polychronopoulos, et al.; J. Med. Chem. 47, 935 (2004) Abstract
7-Bromoindirubin-3’-oxime induces caspase-independent cell death: J. Ribas, et al.; Oncogene 25, 6304 (2006) Abstract
Inverse in silico screening for identification of kinase inhibitor targets: S. Zahler, et al.; Chem. Biol. 14, 1207 (2007) Abstract
An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins: V. Myrianthopoulos, et al.; J. Med. Chem. 50, 4027 (2007) Abstract
Related Products
 
 
ALX-620-065 Revised 07-Mar-07
JC-1 . chloride
Add to Clipboard
SYNONYMS 5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolylcarbocyanine chloride
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Mitochondria-based Apoptosis Detection
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-620-065-M005   5 mg 198.00 USD Add To Cart
Product Specification
FORMULA: C25H27Cl5N4
MW: 561.5
PURITY: ≥97% (HPLC)
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light, especially when in solution.
Product Description
For product description and literature references, see JC-1 . iodide (Prod. No. ALX-620-053).
Further Categories Containing This Product:
Dyes / Stains / Fluorescent Probes / Fluorescent Labels
 
 
ALX-270-244 Revised 03-Apr-08
Caffeic acid phenylethyl ester
Add to Clipboard
SYNONYMS CAPE
Phenethyl caffeiate
Caffeic acid phenethyl ester
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-244-M010   10 mg 20.00 USD Add To Cart
ALX-270-244-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C17H16O4
MW: 284.3
CAS NUMBER: 115610-29-2
SOURCE/HOST: Synthetic.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol, methanol, acetone or acetonitrile; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least one year after receipt when stored at –20°C.
HANDLING: Protect from light and moisture.
HAZARD: IRRITANT.

Product Description
Active component of propolis from honeybee hives, known to have anti-mitogenic, anti-carcinogenic, anti-inflammatory, and immunomodulatory properties. Potent and specific inhibitor of NF-κB activation, induced by TNF-α (Prod. No. ALX-522-008 (human) or Prod. No. ALX-522-009 (mouse)), PMA (Prod. No. ALX-445-004) and other inflammatory agents. Exhibits inhibitory activity against HIV-1 integrase (IC50=7µM). Suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities. Induces apoptosis.
Product Specific Literature References
Hydroxylated aromatic inhibitors of HIV-1 integrase: T.R. Burke Jr., et al.; J. Med. Chem. 38, 4171 (1995) Abstract
Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells: C. Chiao, et al.; Cancer Res. 55, 3576 (1995) Abstract
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B: K. Natarajan, et al.; PNAS 93, 9090 (1996) Abstract
Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation: P. Michaluart, et al.; Cancer Res. 59, 2347 (1999) Abstract
Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation: Z. Orban, et al.; Neuroimmunomodulation 7, 99 (2000) Abstract
Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappaB transcription factors: N. Marquez, et al.; J. Pharmacol. Exp. Ther. 308, 993 (2004) Abstract
Caffeic acid derivatives: in vitro and in vivo anti-inflammatory properties: F.M. da Cunha, et al.; Free Radic. Res. 38, 1241 (2004) Abstract
Drastic effect of several caffeic acid derivatives on the induction of heme oxygenase-1 expression revealed by quantitative real-time RT-PCR: K. Suzuki, et al.; Biofactors 28, 151 (2006) Abstract
Related Products
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • Natural Products - Chemopreventive Agents • Natural Products - Antiviral / anti-HIV Agents • NF-kB Pathway Inhibitors • Natural Products - NF-kB Pathway Inhibitors • Natural Products - Protein Kinase Inhibitors • HIV / AIDS / Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Immunomodulators
 
 
ALX-400-051 Revised 06-Dec-07
Cyclophosphamide . monohydrate
Add to Clipboard
SYNONYMS 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide
Cytoxan
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Apoptosis Inducers & Inhibitors Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-400-051-G001   1 g 35.00 USD Add To Cart
ALX-400-051-G005   5 g 98.00 USD Add To Cart
Product Specification
FORMULA: C7H15CI2N2O2P . H2O
MW: 261.1 . 18.0
CAS NUMBER: 6055-19-2
MERCK INDEX: 14: 2747
RTECS: RP6157750
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water; slightly soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC. MAY BE CARCINOGENIC.

Product Description
Alkylates DNA, forming DNA-DNA cross-links that result in inhibition of DNA synthesis and cell death. Interestingly the repair enzyme O6-alkylguanine-DNA alkyltransferase, long thought to be involved with resistance to methylating and chloroethylating agents, may also contribute to resistance to the cytotoxic and mutagenic effects of cyclophosphamide.
Product Specific Literature References
Induction of apoptosis in murine tumors by cyclophosphamide: R.E. Meyn, et al.; Cancer.Chemother. Pharmacol. 33, 410 (1994) Abstract
An overview of cyclophosphamide and ifosfamide pharmacology: R.A. Fleming; Pharmacotherapy 17, 146S (1997) Abstract
Mechanisms of resistance to the toxicity of cyclophosphamide: M.P. Gamcsik, et al.; Curr. Pharm. Des. 5, 587 (1999) Abstract
Ginsenoside Rh(2) enhances antitumour activity and decreases genotoxic effect of cyclophosphamide: Z. Wang, et al.; Basic Clin. Pharmacol. Toxicol. 98, 411 (2006) Abstract
Protective effect of curcumin and chlorophyllin against DNA mutation induced by cyclophosphamide or benzo[a]pyrene: M.A. Ibrahim, et al.; Z. Naturforsch. 62, 215 (2007) Abstract
Further Categories Containing This Product:
Antitumor Agents (DNA Interaction & Gene Regulation)
 
 
ALX-380-260 Revised 07-Apr-08
Idarubicin . hydrochloride
Add to Clipboard
SYNONYMS Idamycin
DMDR
4-Demethoxydaunorubicin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-260-M001   1 mg 45.00 USD Add To Cart
ALX-380-260-M005   5 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C26H27NO9 . HCl
MW: 497.5 . 36.5
CAS NUMBER: 57852-57-0
MERCK INDEX: 14: 4886
RTECS: HB7877000
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: Orange crystalline solid.
SOLUBILITY: Soluble in water or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: VERY TOXIC. MAY BE TERATOGENIC. MAY BE CARCINOGENIC.

Product Description
More potent, lipophilic and antineoplastic analog of daunorubicin. DNA-damaging effect includes DNA oxidation and methylation, DNA intercalation, inhibition of DNA synthesis, induction of DNA strand breaks and delay of cell cycle progression. Inhibitor of topoisomerase IIα. Produces endonucleolytic cleavage and is a marker of apoptosis.
Product Specific Literature References
Idarubicin (4-demethoxydaunorubicin). A preliminary overview of preclinical and clinical studies: F. Ganzina, et al.; Invest. New Drugs 4, 85 (1986), Review Abstract
Antitumor activity of idarubicin, a derivative of daunorubicin, against drug sensitive and resistant P388 leukemia: T. Tsuruo, et al.; Anticancer Res. 13, 357 (1993) Abstract
Study of apoptosis-related responses of leukemic blast cells to in vitro anthracycline treatment: M.A. Belaud-Rotureau, et al.; Leukemia 14, 1266 (2000) Abstract
A comparison of the in vitro genotoxicity of anticancer drugs idarubicin and mitoxantrone: J. Blasiak, et al.; Acta Biochim. Pol. 49, 145 (2002) Abstract; Full Text
Repair of idarubicin-induced DNA damage: A cause of resistance?: D.C. Dartsch & F. Gieseler; DNA Repair (Amst) 6, 1618 (2007) Abstract
Further Categories Containing This Product:
Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Agents (Apoptosis Inducers) • Antitumor Antibiotics • Antibiotics - Topoisomerase Inhibitors
 
 
ALX-260-005 Revised 03-Mar-05
Chymostatin
Add to Clipboard
SYNONYMS (S)-1-Carboxy-2-phenylethyl)-carbamoyl-α-[2-iminohexahydro-4(S)-pyrimidyl]-(S)-glycyl-X-phenylalaninal
PRODUCT LINE Cancer
PRODUCT CATEGORY Cathepsin Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-005-M001   1 mg 22.00 USD Add To Cart
ALX-260-005-M005   5 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C21H38N4O8
MW: 605.0 (average)
CAS NUMBER: 9076-44-2
SOURCE/HOST: Microbial.
SOLUBILITY: Soluble in DMSO (20 mg/ml) or glacial acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of serine proteinases having a chymotrypsin-like specificity like α-, β-, δ- and γ-chymotrypsin, chymases, cathepsin G, and most cysteine proteinases including papain and cathepsin A, B, H, and L. Mixture of type A (R=L-Leu), type B (R=L-Val), type C (R=L-Ile).
Product Specific Literature References
Chymostatin, a new chymotrypsin inhibitor produced by actinomycetes: H. Umezawa, et al.; J. Antibiot. 23, 425 (1970) Abstract
Further Categories Containing This Product:
Proteases Other Products
 
 
ALX-260-007 Revised 16-Feb-05
E-64
Add to Clipboard
SYNONYMS N-[N-(L-3-trans-Carboxyoxirane-2-carbonyl]-L-leucyl)-agmatine
L-trans-Epoxysuccinyl-leucylamide-(4-guanido)-butane
PRODUCT LINE Cancer
PRODUCT CATEGORY Cathepsin Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-007-M005   5 mg 55.00 USD Add To Cart
ALX-260-007-M025   25 mg 195.00 USD Add To Cart
Product Specification
FORMULA: C15H27N5O5
MW: 357.4
CAS NUMBER: 66701-25-5
SOURCE/HOST: Synthetic.
PURITY: ≥99%
SOLUBILITY: Soluble in DMSO or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Irreversible inhibitor of cysteine proteinases like papain, cathepsin B and L. Acts by forming a thioether bond with the thiol of the active cysteine. Does not inhibit serine proteinases.
Product Specific Literature References
K. Hanada, et al.; Agric. Biol. Chem. 42, 529 (1978)
K. Hanada, et al.; Agric. Biol. Chem. 42, 523 (1978)
Further Categories Containing This Product:
Proteases Other Products
 
 
ALX-260-014 Revised 19-Aug-08
Calpeptin
Add to Clipboard
SYNONYMS Z-Leu-norleucinal
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calpains / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-014-M005   5 mg 85.00 USD Add To Cart
ALX-260-014-M010   10 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C20H30N2O4
MW: 362.5
CAS NUMBER: 117591-20-5
PURITY: ≥94% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: 5mg/ml soluble in DMSO or dimethyl formamide.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 2 months when stored at -20°C.
HANDLING: Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C. Protect from light and moisture.

Product Description
Membrane permeable inhibitor of calpain I and II and cathepsin L. Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin (Prod. No. ALX-450-006) or thrombin.
Product Specific Literature References
Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins: T. Sasaki, et al.; J. Enz. Inhib. 3, 195 (1990) Abstract
Cell-penetrating inhibitors of calpain: S. Mehdi; TIBS 16, 150 (1991) Abstract
Specificity of calcium-activated neutral proteinase (CANP) inhibitors for human mu CANP and mCANP: K. Saito and R.A. Nixon; Neurochem. Res. 18, 231 (1993) Abstract
Calpeptin, a calpain inhibitor, promotes neurite elongation in differentiating PC12 cells: M. Pinter, et al.; Neurosci. Lett. 170, 91 (1994) Abstract
Further Categories Containing This Product:
Cathepsin Inhibitors
 
 
ALX-260-054 Revised 17-Jan-06
Suc-Leu-Tyr-AMC (Fluorogenic)
Add to Clipboard
SYNONYMS Suc-LY-AMC (Fluorogenic)
PRODUCT LINE Ubiquitin & Proteasome
PRODUCT CATEGORY Proteasome / Related Products
Ordering Information
Product Numbers: Format: Size: