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Items 19 of 19
ALX-270-343
Revised 30-May-07
3-O-Methyl-N-acetyl-D-glucosamine
SYNONYMS
3-OMe-GlcNAc
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Carbohydrates
Ordering Information
Product Numbers:
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Size:
Unit Price:
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ALX-270-343-M005
5 mg
190.00 USD
Product Specification
FORMULA:
C
9
H
17
NO
6
MW:
235.2
CAS NUMBER:
94825-74-8
PURITY:
≥98% (
1
H-NMR)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO (10mg/ml) or water (10mg/ml).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
HARMFUL.
Product Description
Inhibitor of N-acetylglucosamine kinase (K
i
=17µM) and N-acetylmannosamine kinase (K
i
=80µM). It has been found that 3-OMe-GlcNAc potently inhibits glucose phosphorylation by N-acetylglucosamine kinase whereas glucokinase is not at all affected by this hexosamine.
Product Specific Literature References
Inhibition of N-acetylglucosamine kinase and N-acetylmannosamine kinase by 3-O-methyl-N-acetyl-D-glucosamine in vitro
:
R. Zeitler, et al.; Eur. J. Biochem.
204
, 1165 (1992)
Abstract
Utility of 3-O-methyl-N-acetyl-D-glucosamine, an N-acetylglucosamine kinase inhibitor, for accurate assay of glucokinase in pancreatic islets and liver
:
I. Miwa, et al.; Enzyme Protein
48
, 135 (1994)
Abstract
Further Categories Containing This Product:
N-Acetylneuraminic Acid / Derivatives
•
Obesity & Diabetes Other Products
ALX-270-404
Revised 24-Jan-06
Cilostamide
SYNONYMS
N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide
OCP 3689
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphodiesterases / Related Products
Ordering Information
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Format:
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Quantity:
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ALX-270-404-M005
5 mg
50.00 USD
ALX-270-404-M025
25 mg
200.00 USD
Product Specification
FORMULA:
C
20
H
26
N
2
O
3
MW:
342.4
CAS NUMBER:
68550-75-4
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light and oxygen. Packaged under inert gas.
Product Description
Selective inhibitor (IC
50
=70nM) of phosphodiesterase 3 (PDE3). Reverses the established effects of leptin on food intake and body weight. Blocks the leptin-induced tyrosine phosphorylation of STAT3 at the hypothalamic level.
General Literature References
A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding.
:
A.Z. Zhao, et al.; Nat. Neurosci.
5
, 727 (2002)
Abstract
Further Categories Containing This Product:
Obesity & Diabetes Other Products
ALX-270-466
Revised 14-Sep-07
Fluvastatin . sodium salt
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Statins / Related Products
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Format:
Size:
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ALX-270-466-M010
10 mg
48.00 USD
ALX-270-466-M050
50 mg
190.00 USD
Product Specification
FORMULA:
C
24
H
25
FNO
4
. Na
MW:
410.5 . 23.0
CAS NUMBER:
93957-54-1
MERCK INDEX:
14:
4218
RTECS:
MJ9675050
SOURCE/HOST:
Synthetic.
PURITY:
≥98%
APPEARANCE:
Off-white to light yellow solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 6 months when stored at -20°C.
HANDLING:
Protect from light.
HAZARD:
TOXIC. MAY BE TERATOGENIC.
Product Description
Anticholesterol agent. HMG-CoA reductase inhibitor and antioxidant.
Product Specific Literature References
Folate and carcinogenesis: an integrated scheme
:
S.W. Choi and J.B. Mason; J. Nutr.
130
, 129 (2000)
Abstract
;
Full Text
Effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on nitric oxide-induced hydroxyl radical generation in the rat heart
:
T. Obata, et al.; Biochim. Biophys. Acta
1536
, 55 (2001)
Abstract
Antioxidative effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes
:
A. Yamamoto, et al.; J. Pharm. Pharmacol.
53
, 227 (2001)
Abstract
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
•
Obesity & Diabetes Other Products
ALX-300-138
Revised 28-Jan-05
Oleic acid (high purity)
SYNONYMS
cis
-9-Octadecenoic acid 18:1
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Fatty Acids
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ALX-300-138-G001
1 g
25.00 USD
Product Specification
FORMULA:
C
18
H
34
O
2
MW:
282.5
CAS NUMBER:
112-80-1
MERCK INDEX:
14:
6828
PURITY:
≥99%
APPEARANCE:
Colorless liquid.
SOLUBILITY:
Soluble in chloroform or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep under inert gas. Protect from light and oxygen.
HAZARD:
IRRITANT.
Product Description
Unsaturated fatty acid that has been shown to activate protein kinase C (PKC) in hepatocytes. Inhibitor of glucose production and food intake. Upregulates the expression of uncoupling protein-3 (UCP-3) in L6 myotubes.
Product Specific Literature References
Oleic acid promotes changes in the subcellular distribution of protein kinase C in isolated hepatocytes:
M.J. Diaz-Guerra; J. Biol. Chem.
266
, 23568 (1991)
Abstract
;
Full Text
Spinal cord of the rat contains more lipoprotein lipase than other brain regions:
D.H. Bessesen, et al.; J. Lipid Res.
34
, 229 (1993)
Abstract
Free fatty acid-induced alterations in the steroid-binding properties of rat androgen-binding protein:
F. Felden, et al.; BBRC
190
, 602 (1993)
Abstract
Chronic feline leukemia virus infection alters arachidonic acid proportions in vivo and in vitro:
L.L. Williams, et al.; Proc. Soc. Exp. Biol. Med.
202
, 239 (1993)
Abstract
Central administration of oleic acid inhibits glucose production and food intake
:
S. Obici, et al.; Diabetes
51
, 271 (2002)
Abstract
;
Full Text
Effects of rosiglitazone and oleic acid on UCP-3 expression in L6 myotubes
:
A. Costello, et al.; Diabetes Obes. Metab.
5
, 136 (2003)
Abstract
Further Categories Containing This Product:
PKC Activators
•
Obesity & Diabetes Other Products
ALX-350-111
Revised 04-Mar-05
Sibutramine . hydrochloride . monohydrate
SYNONYMS
1-(4-Chlorophenyl-
N,N
-dimethyl-α-(2-methylpropyl)cyclobutanemethanamine . HCl . H
2
O
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
Ordering Information
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Size:
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ALX-350-111-M250
250 mg
25.00 USD
ALX-350-111-G001
1 g
60.00 USD
Product Specification
FORMULA:
C
17
H
26
ClN . HCl . H
2
O
MW:
279.9 . 36.5 . 18.0
CAS NUMBER:
125494-59-9
MERCK INDEX:
14:
8485
PURITY:
≥98%
APPEARANCE:
White to off-white crystalline powder.
SOLUBILITY:
Soluble in methanol or water (2.9mg/ml at pH 5.2).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
MELTINGPOINT:
193-198°C
Product Description
Anti-obesity agent. Prevents resorption of the messenger substances serotonin and noradrenalin in the brain, allowing them to act at higher concentration on nerve cells and increasing the feeling of satiety.
Further Categories Containing This Product:
Serotonergics & Serotonin Receptors / Related Products
•
Obesity & Diabetes Other Products
ALX-350-152
Revised 20-Jun-08
Orlistat
SYNONYMS
Tetrahydrolipstatin
N-Formyl-L-leucine-(1S)-1-(((2S,3S)-3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl ester
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Fatty Acid Synthase [FAS] / Related Products
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ALX-350-152-M050
50 mg
40.00 USD
ALX-350-152-M250
250 mg
120.00 USD
Product Specification
FORMULA:
C
29
H
53
NO
5
MW:
495.7
CAS NUMBER:
96829-58-2
MERCK INDEX:
14:
6869
SOURCE/HOST:
Synthetic. Originally isolated from
Streptomyces
sp.
PURITY:
≥97%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 6 weeks when stored at -20°C.
HANDLING:
After reconstitution, prepare aliquots and store at -20°C. Protect from light and moisture.
Product Description
Cell permeable, irreversible inhibitor of gastric and pancreatic lipases. Shows only minimal activity against amylase, trypsin, chymotrypsin, or phospholipase A
2
(PLA
2
). Partially inhibits the hydrolysis of triglycerides and lowers the absorption of dietary fat and promotes weight loss. Anti-obesity drug. Exhibits antitumor activity by inhibition of the thioesterase domain of fatty acid synthase (FAS) both
in vitro
and
in vivo
.
Product Specific Literature References
Interactions of lipoprotein lipase with the active-site inhibitor tetrahydrolipstatin (Orlistat):
A. Lookene, et al.; Eur. J. Biochem.
222
, 395 (1994)
Abstract
Degree of in vivo inhibition of human gastric and pancreatic lipases by Orlistat (Tetrahydrolipstatin, THL) in the stomach and small intestine:
B. Sternby, et al.; Clin. Nutr.
21
, 395 (2002)
Abstract
A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2:
L.M. Knowles, et al.; J. Biol. Chem.
279
, 30540 (2004)
Abstract
;
Full Text
Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity:
S.J. Kridel, et al.; Cancer Res.
64
, 2070 (2004)
Abstract
Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene:
J.A. Menendez, et al.; Ann. Oncol.
16
, 1253 (2005)
Abstract
Differential uptake of subfractions of triglyceride-rich lipoproteins by THP-1 macrophages:
A.M. Palmer, et al.; Atherosclerosis
180
, 233 (2005)
Abstract
Orlistat and sibutramine beyond weight loss:
E. Mannucci, et al.; Nutr. Metab. Cardiovasc. Dis.
70
, 1228 (2008)
Abstract
Further Categories Containing This Product:
Natural Products - Antitumor Reagents
•
Obesity & Diabetes Other Products
ALX-350-280
Revised 07-Oct-08
Xanthohumol
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products - DNA Regulation / Transcription
Ordering Information
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Format:
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ALX-350-280-M005
5 mg
135.00 USD
Product Specification
FORMULA:
C
21
H
22
O
5
MW:
354.4
CAS NUMBER:
569-83-5, 6754-58-1
SOURCE/HOST:
Isolated from hops (
Humulus lupulus
).
PURITY:
≥98% (HPLC)
APPEARANCE:
Yellow to orange powder.
SOLUBILITY:
Soluble in DMSO (25mg/ml), methanol (10mg/ml) or 100% ethanol; soluble in aqueous buffers up to 20μM.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stable as powder for at least 6 months when stored at +4°C in the dark. Stock solution made in DMSO should not be stored for longer than one month. Working solution is stable for 24 hours at 37°C and up to one week when stored at +4°C. Unstable in acidic (pH < 4.5) and alkaline (pH > 7.5) systems.
IDENTITY:
Identity determined by NMR.
Product Description
Prenylated chalcone found in beer. Potent inhibitor of diacylglycerol acetyltransferase (DGAT). Inhibits DNA polymerase and induces cell differentiation. Has antiproliferative and cytotoxic effects in human cancer cell lines. Inhibits human P450 enzymes. Induces quinone reductase. Inhibits the expression of HIF-1α and VEGF under hypoxic conditions. Induces apoptosis in mature adipocytes.
Product Specific Literature References
Xanthohumols, diacylglycerol acyltransferase inhibitors, from
Humulus lupulus
:
N. Tabata, et al.; Phytochemistry
46
, 683 (1997)
Abstract
Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (
Humulus lupulus
) in human cancer cell lines:
C.L. Miranda, et al.; Food Chem. Toxicol.
37
, 271 (1999)
Abstract
In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops,
Humulus lupulus
:
M.C. Henderson, et al.; Xenobiotica
30
, 235 (2000)
Abstract
Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells:
C.L. Miranda, et al.; Cancer Lett.
149
, 21 (2000)
Abstract
Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop
:
C. Gerhauser, et al.; Mol. Cancer Ther.
1
, 959 (2002)
Abstract
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
:
J.F. Stevens & J.E. Page; Phytochemistry
65
, 1317 (2004), (Review)
Abstract
Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis:
J.Y. Yang, et al.; Apoptosis
12
, 1953 (2007)
Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables
•
Estrogen & Estrogen Receptors / Related Products
•
Lipid Metabolism Other Products
•
Hypoxia-inducible Factor [HIF] / Related Products
•
Chalcones
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Antitumor Agents (Anti-proliferative)
•
Respiratory Chain Other Products
•
Natural Products - Antitumor Reagents
•
Obesity & Diabetes Other Products
•
VEGFs
•
Cell Differentiation
ALX-380-010
Revised 08-Oct-08
Streptozotocin
SYNONYMS
Streptozocin
2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
STZ
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Nitric Oxide Pathway Modulators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-380-010-M100
100 mg
25.00 USD
ALX-380-010-5100
5x100 mg
65.00 USD
ALX-380-010-G001
1 g
74.00 USD
Product Specification
FORMULA:
C
8
H
15
N
3
O
7
MW:
265.2
CAS NUMBER:
18883-66-4
MERCK INDEX:
14:
8832
RTECS:
LZ5775000
PURITY:
≥97%
APPEARANCE:
White to pale yellow solid.
SOLUBILITY:
Soluble in water or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
TOXIC. MAY BE CARCINOGENIC.
Product Description
Widely used diabetes inducer in rodents. Inhibition of β-cell O-GlcNAcase by streptozotocin is the mechanism that accounts for its diabetogenic toxicity. N-nitroso-containing antibiotic, acting as a nitric oxide (NO) donor. Potent methylating agent for DNA.
Product Specific Literature References
Studies on the diabetogenic action of streptozotocin
:
N. Rakieten, et al.; Cancer Chemother. Rep.
29
, 91 (1963)
The structure of streptozotocin
:
R.R. Herr, et al.; JACS
89
, 4808 (1967)
Abstract
Alkylation of DNA in rat tissues following administration of streptozotocin:
R.A. Bennett & A.E. Pegg; Cancer Res.
41
, 2786 (1981)
Abstract
Streptozotocin: a nitric oxide carrying molecule and its effect on vasodilation:
G. Thomas & P. Ramwell; Eur. J. Pharmacol.
161
, 279 (1989)
Abstract
NO- and NO2-carrying molecules potentiate photorelaxation in rat trachea and aorta:
K.C. Chang, et al.; BBRC
191
, 509 (1993)
Abstract
Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets:
J. Turk, et al.; BBRC
197
, 1458 (1993)
Abstract
Nitric oxide generation from streptozotocin:
N.S. Kwon, et al.; FASEB J.
8
, 529 (1994)
Abstract
Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotozin contributes to islet cell DNA damage:
K.-D. Kroncke, et al.; Biol. Chem. Hoppe Seyler
376
, 179 (1995)
Abstract
The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas
:
T. Szkudelski; Physiol. Res.
50
, 537 (2001), (Review)
Abstract
Genotoxicity of streptozotocin
:
A.D. Bolzan & M.S. Bianchi; Mutat. Res.
512
, 121 (2002), (Review)
Abstract
Streptozotocin induces G2 arrest in skeletal muscle myoblasts and impairs muscle growth in vivo:
A.P. Johnston, et al.; Am. J. Physiol. Cell Physiol.
292
, C1033 (2007)
Abstract
Further Categories Containing This Product:
Obesity & Diabetes Other Products
•
Nitric Oxide Donors
•
Antitumor Antibiotics
ALX-430-023
Revised 11-Mar-05
KN-93
SYNONYMS
2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
CAM Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-430-023-M001
1 mg
84.00 USD
ALX-430-023-M005
5 mg
336.00 USD
Product Specification
FORMULA:
C
26
H
29
ClN
2
O
4
S
MW:
501.0
CAS NUMBER:
139298-40-1
PURITY:
≥98% (
1
H-NMR)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stable for at least 5 years after receipt when stored at +4°C. DMSO stock solutions are stable for 3-4 months when stored at -20°C.
HANDLING:
Protect from light.
Product Description
Selective inhibitor of rat brain Ca
2+
/calmodulin-dependent protein kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets. Induces G
1
cell cycle arrest and apoptosis.
Product Specific Literature References
The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells:
M. Sumi, et al.; BBRC
181
, 968 (1991)
Abstract
Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93:
N. Mamiya, et al.; BBRC
195
, 608 (1993)
Abstract
Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell:
I. Niki, et al.; BBRC
191
, 255 (1993)
Abstract
G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN- 93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase):
R.M. Tombes, et al.; Cell Growth Differentiation
6
, 1063 (1995)
Abstract
Further Categories Containing This Product:
Obesity & Diabetes Other Products
•
Apoptosis Inducers & Inhibitors Other Products
