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ALX-270-171 Revised 30-Jun-08
Chlorpromazine . hydrochloride
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SYNONYMS 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-171-G001   1 g 22.00 USD Add To Cart
ALX-270-171-G005   5 g 66.00 USD Add To Cart
Product Specification
FORMULA: C17H19ClN2S . HCl
MW: 318.9 . 36.5
CAS NUMBER: 69-09-0
MERCK INDEX: 14: 2185
RTECS: SO1750000
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol or water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Not stable in aqueous solution. We strongly recommend always to use freshly prepared solutions.
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Inhibits calmodulin stimulation of cyclic nucleotide phosphodiesterase. Dopamine antagonist. D2 antagonist. H1 antagonist. Inhibits TNF-α production. Potent PLA2 inhibitor. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in mouse lung. Antipsychotic.
Product Specific Literature References
Chlorpromazine as a substitute for ortho-dianisidine and ortho-tolidine in the determination of chlorine, hemoglobin, and peroxidase activity: H.B. Collier; Clin. Biochem. 7, 331 (1974) Abstract
Drug-protein interactions: binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins: D.R. Marshak, et al.; Biochemistry 24, 144 (1985) Abstract
Selective inhibition of group II phospholipase A2 by quercetin: M. Lindahl & C. Tagesson; Inflammation 17, 573 (1993) Abstract
Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge: M. Palacios, et al.; BBRC 196, 280 (1993) Abstract
Protective effect of calmodulin inhibitors against acute cyanide- induced lethality and convulsions in mice: H. Yamamoto; Toxicol. Lett. 66, 73 (1993) Abstract
Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice: M.G. Netea, et al.; J. Infect. Dis. 171, 393 (1995) Abstract
Pharmacological regulation of mitochondrial nitric oxide synthase: A. Boveris, et al.; Methods Enzymol. 359, 328 (2002) Abstract
Brain mitochondrial nitric oxide synthase: in vitro and in vivo inhibition by chlorpromazine: S. Lores-Arnaiz, et al.; Arch. Biochem. Biophys. 430, 170 (2004) Abstract
Further Categories Containing This Product:
Dopaminergics & Dopamine Receptors / Related Products • Phosphodiesterases / Related Products • TNF-alpha & TNF Receptors Other Products • PLA2 Inhibitors • Chemopreventive Agents Other Products • NOS Inhibitors (NOS Induction & Enzyme Activity)
 
 
ALX-307-002 Revised 24-Feb-05
1-D-3-Deoxy-phosphatidylinositol
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SYNONYMS DPI
3-Deoxy-D-myo-inositol 1-[(R)-2,3-bis(hexa-
decanoyloxy)propyl hydrogenphosphate]
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Inositols & Inositolphosphates / Related Products
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ALX-307-002-C100   100 µg 30.00 USD Add To Cart
ALX-307-002-M001   1 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C41H79O12P
MW: 795.0
PURITY: ≥98%
APPEARANCE: Off-white amorphous solid.
SOLUBILITY: Solube in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Antimetabolite of phosphatidylinositol-3-phosphate. Inhibitor of cancer cell colony formation.
Product Specific Literature References
Synthesis and biology of 1D-3-deoxyphosphatidylinositol: a putative antimetabolite of phosphatidylinositol-3-phosphate and an inhibitor of cancer cell colony formation: A.P. Kozikowski, et al.; J. Med. Chem. 38, 1053 (1995) Abstract
Further Categories Containing This Product:
Chemopreventive Agents Other Products
 
 
ALX-370-002 Revised 19-Sep-06
Dexamethasone
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SYNONYMS 9α-Fluoro-16α-methylprednisolone
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Glucocorticoids & Glucocorticoid Receptors / Related Products
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ALX-370-002-M250   250 mg 22.00 USD Add To Cart
ALX-370-002-G001   1 g 45.00 USD Add To Cart
Product Specification
FORMULA: C22H29FO5
MW: 392.5
CAS NUMBER: 50-02-2
MERCK INDEX: 14: 2943
RTECS: TU3980000
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol. Slightly soluble in acetone or chloroform. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: HARMFUL. MAY BE TERATOGENIC.

Product Description
Inhibits constitutive OPG mRNA steady-state levels in a dose- and time-dependent fashion, promoting osteoclast formation. Glucocorticoid with anti-inflammatory activity. Inhibits the induction of nitric oxide synthases (NOS).
Product Specific Literature References
Inhibition of the induction of nitric oxide synthase by glucocorticoids: yet another explanation for their anti-inflammatory effects?: S. Moncada & R.M.J. Palmer; TIPS 12, 130 (1991), (Review) Abstract
Glucocorticoids inhibit the induction of nitric oxide synthase and the related cell damage in adenocarcinoma cells: K.J. O'Connor & S. Moncada; Biochim. Biophys. Acta 1097, 227 (1991) Abstract
Nitric oxide mediates tumor necrosis factor-alpha cytotoxicity in endothelial cells: C. Estrada, et al.; BBRC 186, 475 (1992) Abstract
Dexamethasone inhibits the expression of an inducible nitric oxide synthase in infarcted rabbit myocardium: R.R. Dudek, et al.; BBRC 202, 1120 (1994) Abstract
Induction of the alkyltransferase (MGMT) gene by DNA damaging agents and the glucocorticoid dexamethasone and comparison with the response of base excision repair genes: T. Grombacher, et al.; Carcinogenesis 17, 2329 (1996) Abstract
Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone: T. Biswas, et al.; Oncogene 18, 525 (1999) Abstract
Dexamethasone-induced thymocyte apoptosis: apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases: M.G. Cifone, et al.; Blood 93, 2282 (1999) Abstract; Full Text
Dexamethasone induces apoptosis in human T cell clones expressing low levels of Bcl-2: M.S. Montani, et al.; Cell Death Differ 6, 79 (1999) Abstract
Dexamethasone inhibits the phosphorylation of retinoblastoma protein in the suppression of human vascular smooth muscle cell proliferation: T.D. Reil, et al.; J. Surg. Res. 92, 108 (2000) Abstract
Dexamethasone suppresses iNOS gene expression by inhibiting NF-kappaB in vascular smooth muscle cells: M. Matsumura, et al.; Life Sci. 69, 1067 (2001) Abstract
Dexamethasone inhibits inducible nitric-oxide synthase expression and nitric oxide production by destabilizing mRNA in lipopolysaccharide-treated macrophages: R. Korhonen, et al.; Mol. Pharmacol. 62, 698 (2002) Abstract; Full Text
Molecular mechanisms underlying dexamethasone inhibition of iNOS expression and activity in C6 glioma cells: J. Shinoda, et al.; Glia 42, 68 (2003) Abstract
Dexamethasone prevents granulocyte-macrophage colony-stimulating factor-induced nuclear factor-kappaB activation, inducible nitric oxide synthase expression and nitric oxide production in a skin dendritic cell line: A.L. Vital, et al.; Mediators Inflamm. 12, 71 (2003) Abstract
Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles: S.C. Schafer, et al.; Am. J. Physiol. Heart Circ. Physiol. 288, H436 (2005) Abstract; Full Text
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Further Categories Containing This Product:
GITR & GITRL Other Products • RANK & RANKL / OPG Other Products • Antitumor Agents (Hormone-related) • NOS Inhibitors (NOS Induction & Enzyme Activity) • Chemopreventive Agents Other Products • DNA & RNA Methyl & Alkyl Transferases / Related Products • Cell Cycle Other Products
 
 
ALX-270-283 Revised 06-May-08
DL-α-Difluoromethylornithine . hydrochloride . monohydrate
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SYNONYMS DFMO . HCl . H2O
Eflornithine . HCl . H2O
RMI-71782
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (Apoptosis Inducers)
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ALX-270-283-M010   10 mg 25.00 USD Add To Cart
ALX-270-283-M050   50 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C6H12F2N2O2 . HCl . H2O
MW: 182.2 . 36.5 . 18.0
CAS NUMBER: 96020-91-6
MERCK INDEX: 14: 3522
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.
HAZARD: HARMFUL.

Product Description
Specific, irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Potent chemopreventive agent. Induces apoptosis. Arginase activity inhibitor.
Product Specific Literature References
Effect of alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on L1210 leukemia in mice: N.J. Prakash, et al.; Cancer Res. 38, 3059 (1978) Abstract
Inhibition of cell proliferation by DL-alpha-difluoromethylornithine, a catalytic irreversible inhibitor of ornithine decarboxylase: S. Oredsson, et al.; Acta Chem. Scand. B 34, 457 (1980) Abstract
Kinetics of alpha-difluoromethylornithine: an irreversible inhibitor of ornithine decarboxylase: K.D. Haegele, et al.; Clin. Pharmacol. Ther. 30, 210 (1981) Abstract
The competitive inhibition of tissue transglutaminase by alpha-difluoromethylornithine: J.G. Delcros, et al.; FEBS Lett. 171, 221 (1984) Abstract
The effect of alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis, on mitogen-induced interleukin 2 production: T.L. Bowlin, et al.; Immunopharmacology 13, 143 (1987) Abstract
The enzyme-activated irreversible inhibitor of ornithine decarboxylase, DL-alpha-difluoromethylornithine: a chemopreventive agent: A.K. Verma; Prev. Med. 18, 646 (1989) Abstract
Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase: A.K. Verma; Basic Life Sci. 52, 195 (1990), (Review) Abstract
The polyamine synthesis inhibitor alpha-difluoromethylornithine blocks NMDA-induced neurotoxicity: M.A. Markwell, et al.; Eur. J. Pharmacol. 182, 607 (1990) Abstract
Difluoromethylornithine (DFMO), an inhibitor of nitrite production by macrophages?: D.M. Morgan; Biochem. Soc. Trans. 22, 389S (1994) Abstract
Alpha-difluoromethylornithine (DFMO) as a potent arginase activity inhibitor in human colon carcinoma cells: M. Selamnia, et al.; Biochem. Pharmacol. 55, 1241 (1998) Abstract
Development of difluoromethylornithine (DFMO) as a chemoprevention agent: F.L. Meyskens, Jr. & E.W. Gerner; Clin. Cancer Res. 5, 945 (1999), (Review) Abstract; Full Text
alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model: Y. Takahashi, et al.; Int. J. Cancer 85, 243 (2000) Abstract
Further Categories Containing This Product:
Arginine & Arginases / Related Products • Chemopreventive Agents Other Products • Antitumor Agents (Enzyme Inhibitors) • Angiogenesis Modulators Other Products
 
 
ALX-350-370 Revised 22-Apr-08
3,3’-Diindolylmethane
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SYNONYMS DIM
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-370-M100   100 mg 20.00 USD Add To Cart
ALX-350-370-M500   500 mg 50.00 USD Add To Cart
Product Specification
FORMULA: C17H14N2
MW: 246.3
CAS NUMBER: 1968-05-4
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (200mg/ml); insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Dimer of indole-3-carbinol (Prod. No. ALX-350-347). Anticancer and antineoplastic agent. Induces apoptosis in human cancer cells. Activator of cytochrome P450. Partial agonist of aryl hydrocarbon receptor (AhR).
Product Specific Literature References
Oligomerization of indole-3-carbinol in aqueous acid: K.R. Grose & L.F. Bjeldanes; Chem. Res. Toxicol. 5, 188 (1992) Abstract
The anticarcinogen 3,3'-diindolylmethane is an inhibitor of cytochrome P-450: D.M. Stresser, et al.; J. Biochem. Toxicol. 10, 191 (1995) Abstract
3,3’-Diindolylmethane induces apoptosis in human cancer cells: X. Ge, et al.; BBRC 228, 153 (1996) Abstract
Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells: I. Chen, et al.; Biochem. Pharmacol. 51, 1069 (1996) Abstract
3,3’-Diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices: B.G. Lake, et al.; Xenobiotica 28, 803 (1998) Abstract
Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor: E.V. Hestermann & M. Brown; Mol. Cell. Biol. 23, 7920 (2003) Abstract; Full Text
Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines: L. Mulvey, et al.; Mol. Med. 13, 69 (2007) Abstract; Full Text
3,3’-Diindolylmethane stimulates murine immune function in vitro and in vivo: L. Xue, et al.; J. Nutr. Biochem. 19, 336 (2008) Abstract
3,3’-diindolylmethane reduces levels of HIF-1alpha and HIF-1 activity in hypoxic cultured human cancer cells: J.E. Riby, et al.; Biochem. Pharmacol. 75, 1858 (2008) Abstract
Indole-3-carbinol as a chemopreventive and anti-cancer agent: J.R. Weng, et al.; Cancer Lett. 262, 153 (2008) Abstract
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Further Categories Containing This Product:
Antitumor Agents (Apoptosis Inducers) • Cytochrome P450 [CYP450] / Related Products • Chemopreventive Agents Other Products
 
 
ALX-550-071 Revised 07-Mar-08
Melatonin
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SYNONYMS N-Acetyl-5-methoxytryptamine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
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ALX-550-071-G001   1 g 35.00 USD Add To Cart
ALX-550-071-G005   5 g 105.00 USD Add To Cart
Product Specification
FORMULA: C13H16N2O2
MW: 232.3
CAS NUMBER: 73-31-4
MERCK INDEX: 14: 5816
RTECS: AC5955000
PURITY: ≥99%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in dilute aqueous acid or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Specific Literature References
Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum: D. Pozo, et al.; Life Sci. 55, PL455 (1994) Abstract
Melatonin receptors: are there multiple subtypes?: M.L. Dubocovich; TIPS 16, 50 (1995), (Review) Abstract
Melatonin comes of age?: R.M. Hagan & N.R. Oakley; TIPS 16, 81 (1995), (Review) Abstract
Melatonin receptors step into the light: cloning and classification of subtypes: S.M. Reppert, et al.; TIPS 17, 100 (1996), (Review) Abstract
Melatonin madness: S.M. Reppert & D.R. Weaver; Cell 83, 1059 (1995), (Minireview) Abstract
Melatonin is a scavenger of peroxynitrite: E. Gilad, et al.; Life Sci. 60, PL169 (1997) Abstract
Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin: D. Pozo, et al.; J. Cell Biochem. 65, 430 (1997) Abstract
Melatonin inhibits expression of the inducible isoform of nitric oxide synthase in murine macrophages: role of inhibition of NFkappaB activation: E. Gilad, et al.; FASEB J. 12, 685 (1998) Abstract; Full Text
Oxidative damage in the central nervous system: protection by melatonin: R.J. Reiter; Prog. Neurobiol. 56, 359 (1998) Abstract
The oxidant/antioxidant network: role of melatonin: R.J. Reiter, et al.; Biol. Signals Recept. 8, 56 (1999), (Review) Abstract
Interactions between melatonin, reactive oxygen species, and nitric oxide: D.K. Lahiri & C. Ghosh; Ann. N. Y. Acad. Sci. 893, 325 (1999) Abstract
Nitrosation of melatonin by nitric oxide and peroxynitrite: B. Blanchard, et al.; J. Pineal. Res. 29, 184 (2000) Abstract
Melatonin suppresses NO-induced apoptosis via induction of Bcl-2 expression in PGT-beta immortalized pineal cells: Y.M. Yoo, et al.; J. Pineal. Res. 33, 146 (2002) Abstract
Mitochondrial regulation by melatonin and its metabolites: D. Acuna-Castroviejo, et al.; Adv. Exp. Med. Biol. 527, 549 (2003), (Review) Abstract
Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding: W.G. Deng, et al.; Blood 108, 518 (2006) Abstract
Melatonin and nitric oxide: S. Aydogan, et al.; J. Endocrinol. Invest. 29, 281 (2006), (Review) Abstract
Melatonin inhibits endothelial nitric oxide production in vitro: E.K. Tamura, et al.; J. Pineal. Res. 41, 267 (2006) Abstract
Further Categories Containing This Product:
Chemopreventive Agents Other Products • Apoptosis Inducers & Inhibitors Other Products • Nitric Oxide Pathway Other Products
 
 
ALX-400-046 Revised 01-Dec-06
Taurine
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SYNONYMS 2-Aminoethanesulfonic acid
PRODUCT LINE Cancer
PRODUCT CATEGORY Chemopreventive Agents Other Products
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ALX-400-046-G010   10 g 25.00 USD Add To Cart
Product Specification
FORMULA: C2H7NO3S
MW: 125.2
CAS NUMBER: 107-35-7
MERCK INDEX: 14: 9074
RTECS: WX0175000
PURITY: ≥99%
SOLUBILITY: 50mg/ml soluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HAZARD: IRRITANT.

Product Description
Inhibitor of lipid peroxidation. Inhibits diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis.
Further Categories Containing This Product:
Lipid Peroxidation
 
 
ALX-420-044 Revised 29-Apr-08
Temozolomide
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SYNONYMS 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (DNA Interaction & Gene Regulation)
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-420-044-M025   25 mg 80.00 USD Add To Cart
ALX-420-044-M100   100 mg 240.00 USD Add To Cart
ALX-420-044-M500   500 mg 840.00 USD Add To Cart
Product Specification
FORMULA: C6H6N6O2
MW: 194.2
CAS NUMBER: 85622-93-1
MERCK INDEX: 14: 9139
RTECS: NJ5927050
PURITY: ≥98% (Assay)
APPEARANCE: White to off-white crystalline powder.
SOLUBILITY: Soluble in DMSO; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE MUTAGENIC. TOXIC.

Product Description
Antitumor and antiangiogenic compound. DNA alkylating agent. Induces G2/M arrest and apoptosis through adduction of a methyl group to O6 position of guanine in genomic DNA. Inactivates DNA repair protein O(6)-alkylguanine DNA alkyltransferase (AGT) in base excision repair (BER) pathway. Chemotherapeutic agent. Modifies drug resistance.
Product Specific Literature References
Antitumor imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one , a novel broad-spectrum antitumor agent: M.F. Stevens, et al.; J. Med. Chem. 27, 196 (1984) Abstract
Antitumor imidazotetrazines--XV. Role of guanine O6 alkylation in the mechanism of cytotoxicity of imidazotetrazinones: M.J. Tisdale; Biochem. Pharmacol. 36, 457 (1987) Abstract
Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials: E.S. Newlands, et al.; Cancer Treat. Rev. 23, 35 (1997) Abstract
Antitumor Imidazotetrazines. 35. New Synthetic Routes to the Antitumor Drug Temozolomide: Y. Wang, et al.; J. Org. Chem. 62, 7288 (1997) Abstract
Temozolomide: a novel oral alkylating agent: S.J. Danson & M.R. Middleton; Expert Rev. Anticancer Ther. 10, 13 (2001) Abstract
p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells: Y. Hirose, et al.; Cancer Res. 61, 1957 (2001) Abstract; Full Text
Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site: L. Tentori, et al.; Blood 99, 2241 (2002) Abstract; Full Text
Temozolomide induces apoptosis and senescence in glioma cells cultured as multicellular spheroids: W. Gunther, et al.; Br. J. Cancer 88, 463 (2003) Abstract
Inhibition of angiogenesis by non-toxic doses of temozolomide: H. Kurzen, et al.; Anticancer Drugs 14, 515 (2003) Abstract
Mutagenic potential of temozolomide in bone marrow cells in vivo: H. Geiger, et al.; Blood 107, 3010 (2006) Abstract; Full Text
Concomitant treatment of brain metastasis with whole brain radiotherapy [WBRT] and temozolomide [TMZ] is acti