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Obesity & Adipokines
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ALX-305-010 Revised 10-Dec-04
N-Acetylneuraminic acid
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SYNONYMS NANA
Sialic acid
Neu5Ac
5-Acetylamino-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Carbohydrates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-305-010-M050   50 mg 30.00 USD Add To Cart
ALX-305-010-M250   250 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C11H19NO9
MW: 309.3
CAS NUMBER: 131-48-6
MERCK INDEX: 14: 8484
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: White to light pink powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable between pH 4.0 and 7.0 when frozen.
HANDLING: Protect from light.
Further Categories Containing This Product:
N-Acetylneuraminic Acid / Derivatives
 
 
ALX-203-002 Revised 23-Mar-06
ACRP30headless (human) (recombinant)
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SYNONYMS Tail Adiponectin (human) (recombinant)
Tail-Adp (human) (recombinant)
Adipocyte Complement Related Protein of 30kDa headless (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-203-002-C010   10 µg 260.00 USD Add To Cart
Product Specification
MW: ~27kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The non-homologous (aa 16-45) and collagen domain of human ACRP30 (aa 45-108) are fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water.
APPLICATION: Negative control. When used at 1µg/g body weight in mouse demonstrated no significant bioactivity in terms of reduction of serum glucose compared to wildtype in an in vivo assay. Control compound for rhsMegaAPRIL™ (Prod. No. ALX-522-035) and rhsMegaTNF-α (Prod. No. ALX-522-046).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Images
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Product Specific Literature References
Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin: Implications for metabolic regulation and bioactivity: U.B. Pajvani, et al.; J. Biol. Chem. 278, 9073 (2003) Abstract; Full Text
Adiponectin acts in the brain to decrease body weight: Y. Qi, et al.; Nat. Med. 10, 524 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q15848: ACRP30 (human) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-203-003 Revised 23-Mar-06
ACRP30headless (mouse) (recombinant)
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SYNONYMS Tail Adiponectin (mouse) (recombinant)
Tail-Adp (mouse) (recombinant)
Adipocyte Complement Related Protein of 30kDa headless (mouse) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-203-003-C010   10 µg 260.00 USD Add To Cart
Product Specification
MW: ~25kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The collagen domain of mouse ACRP30 (aa 18-111) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
APPLICATION: Negative control. Control compound for rmsMegaOX40L [CD134L]™ (Prod. No. ALX-522-062) and rmsMegaTNF-α™ (Prod. No. ALX-522-047).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored as recommended.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q60994: ACRP30 (mouse) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-350-344 Revised 03-Apr-08
Actinotetraose Hexatiglate
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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ALX-350-344-M001   1 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C54H78O27
MW: 1159.2
CAS NUMBER: 216590-44-2
SOURCE/HOST: Isolated from Amycolatopsis sp. MST-AS5902.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Unique tetrasaccharide with six tiglate esters. Shows no significant antimicrobial activity.
Product Specific Literature References
Structure of actinotetraose hexatiglate, a unique glucotetraose from an actinomycete bacterium: R.W. Rickards, et al.; J. Antibiot. (Tokyo) 51, 1093 (1998) Abstract; Full Text
Further Categories Containing This Product:
Carbohydrates
 
 
ALX-522-063 Revised 28-Aug-07
Adiponectin (human) (recombinant)
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SYNONYMS ACRP30 (human) (recombinant)
Adipocyte Complement Related Protein of 30kDa (human) (recombinant)
AdipoQ (human) (recombinant)
apM1 (human) (recombinant)
GBP28 (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-063-C050   50 µg 335.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~33kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. Human adiponectin (aa 16-244) is fused at the N-terminus to a linker peptide (14 aa) and a FLAG®-tag.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum or other carrier protein.
BIOLOGICAL ACTIVITY: Activates AMPK.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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Product Description
Mimics serum adiponectin by forming high molecular weight (HMW) and hexameric species.
Product Specific Literature References
Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase: A. Suzuki, et al.; Mol. Cell. Biol. 27, 4317 (2007) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q15848: Adiponectin (human) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism: A.H. Berg, et al.; Trends Endocrinol. Metab. 13, 84 (2002), (Review) Abstract
Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30): T.S. Tsao, et al.; J. Biol. Chem. 277, 29359 (2002) Abstract; Full Text
Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity: U.B. Pajvani, et al.; J. Biol. Chem. 279, 12152 (2004) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-305 Revised 08-Dec-06
Adiponectin (Globular Domain) (human) (recombinant)
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SYNONYMS ACRP30 (Globular Domain) (human) (recombinant)
Adipocyte Complement Related Protein of 30kDa (Globular Domain) (human) (recombinant)
AdipoQ (Globular Domain) (human) (recombinant)
apM1 (Globular Domain) (human) (recombinant)
GBP28 (Globular Domain) (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-305-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The globular domain of human adiponectin (aa 104-244) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION:   
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 30mM TRIS, pH 8.5.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test; Bio Whittaker).
BIOLOGICAL ACTIVITY: Induces the phosphorylation of acetyl-CoA carboxylase (ACC) in C2C12 cells. Activates AMPK in HUVEC cells in a PI(3)K-independent way.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q15848: Adiponectin (human) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism: A.H. Berg, et al.; Trends Endocrinol. Metab. 13, 84 (2002), (Review) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-088 Revised 08-Dec-06
Adiponectin (Globular Domain) (mouse) (recombinant)
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SYNONYMS ACRP30 (Globular Domain) (mouse) (recombinant)
Adipocyte Complement Related Protein of 30kDa (Globular Domain) (mouse) (recombinant)
AdipoQ (Globular Domain) (mouse) (recombinant)
apM1 (Globular Domain) (mouse) (recombinant)
GBP28 (Globular Domain) (mouse) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-088-C050   50 µg 370.00 USD Add To Cart
Product Specification
MW: ~26kDa
SOURCE/HOST: Produced in HEK 293 cells. The globular domain of mouse adiponectin (aa 111-247) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: >95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test; BioWhittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
Adiponectin, also known as ACRP30 (30kDa adipocyte complement-related protein) is a hormone synthesized and secreted by adipocytes. Expression and plasma levels of adiponectin are decreased in insulin resistance and obesity and synthesis of this adipokine increases when insulin sensitivity is improved and weight is lost.
Adiponectin consists of a carboxyl-terminal globular domain and an amino-terminal collagen-like domain containing 22 Gly-X-Y repeats. The presence of a small amount of a carboxyl-terminal fragment containing the globular domain of adiponectin (gAdiponectin) has been demonstrated in human serum by immunoprecipitation. Adiponectin and gAdiponectin act in the brain to increase energy expenditure and to decrease body weight.
BACKGROUND/TECHNICAL INFORMATION FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice: J. Fruebis, et al.; PNAS 98, 2005 (2001) Abstract; Full Text
Adiponectin, obesity, and cardiovascular disease: M. Fasshauer, et al.; Biochimie 86, 779 (2004) Abstract
Adiponectin acts in the brain to decrease body weight: Y. Qi, et al.; Nat. Med. 10, 524 (2004) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-059 Revised 02-Mar-07
Adiponectin (mouse) (recombinant)
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SYNONYMS ACRP30 (mouse) (recombinant)
Adipocyte Complement Related Protein of 30kDa (mouse) (recombinant)
AdipoQ (mouse) (recombinant)
apM1 (mouse) (recombinant)
GBP28 (mouse) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-059-C050   50 µg 335.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Mouse
MW: ~35kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. Mouse adiponectin (aa 18-247) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.
CONCENTRATION: 0.5mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water.
BIOLOGICAL ACTIVITY: Inhibits serum glucose production in mice. Protects mouse hepatocytes from TNF-α-induced cell death in vitro.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Description
Mimics serum adiponectin by forming high molecular weight (HMW) and hexameric species.
Product Specific Literature References
Regulation of T-cell mediated hepatic inflammation by adiponectin and leptin: J.A. Sennello, et al.; Endocrinology 146, 2157 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q60994: Adiponectin (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30): T.S. Tsao, et al.; J. Biol. Chem. 277, 29359 (2002) Abstract; Full Text
Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity: U.B. Pajvani, et al.; J. Biol. Chem. 279, 12152 (2004) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-306 Revised 28-Nov-07
Adiponectin (Globular Domain) (mouse) (recombinant) (His)
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SYNONYMS ACRP30 (Globular Domain) (mouse) (recombinant) (His)
Adipocyte Complement Related Protein of 30kDa (Globular Domain) (mouse) (recombinant) (His)
AdipoQ (Globular Domain) (mouse) (recombinant) (His)
apM1 (Globular Domain) (mouse) (recombinant) (His)
GBP28 (Globular Domain) (mouse) (recombinant) (His)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-306-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The globular domain of mouse adiponectin (aa 104-247) is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 30mM TRIS-Cl, pH 8.5.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL test; Bio Whittaker).
BIOLOGICAL ACTIVITY: Induces the phosphorylation of acetyl-CoA carboxylase (ACC) in C2C12 cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q60994: Adiponectin (mouse) (precursor)
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism: A.H. Berg, et al.; Trends Endocrinol. Metab. 13, 84 (2002), (Review) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-303 Revised 10-Jul-08
Adiponectin (rat) (recombinant)
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SYNONYMS ACRP30 (rat) (recombinant)
Adipocyte Complement Related Protein of 30kDa (rat) (recombinant)
AdipoQ (rat) (recombinant)
apM1 (rat) (recombinant)
GBP28 (rat) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products