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Items 9 of 9
ALX-350-160
Revised 03-Sep-08
Aloeresin A
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products
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ALX-350-160-M001
1 mg
185.00 USD
Product Specification
FORMULA:
C
28
H
28
O
11
MW:
540.5
CAS NUMBER:
74545-79-2
SOURCE/HOST:
Isolated from
Aloe
sp.
PURITY:
≥97% (HPLC)
APPEARANCE:
Brown solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H-NMR and MS.
Product Description
Metabolite of aloesin (Prod. No. ALX-350-158). Inhibits α-glucosidases.
Product Specific Literature References
Metabolism of aloesin and related compounds by human intestinal bacteria: a bacterial cleavage of the C-glucosyl bond and the subsequent reduction of the acetonyl side chain:
Q.M. Che, et al.; Chem. Pharm. Bull. (Tokyo)
39
, 704 (1991)
Abstract
Geographical variation in the major compounds of Aloe ferox leaf exudate:
B.E. van Wyk, et al.; Planta Med.
61
, 250 (1995)
Abstract
High-performance liquid chromatographic profiles of aloe constituents and determination of aloin in beverages, with reference to the EEC regulation for flavouring substances:
F. Zonta, et al.; J. Chromatogr. A.
718
, 99 (1995)
Abstract
Determination of aloesin and aloeresin A for the detection of aloe in beverages:
M. Dell’Agli, et al.; J. Agric. Food Chem.
55
, 3363 (2007)
Abstract
A reversed-phase high-performance liquid chromatographic method for the determination of aloesin, aloeresin A and anthraquinone in Aloe ferox:
M. Zahn, et al.; Phytochem. Anal.
19
, 122 (2008)
Abstract
alpha-Glucosidase inhibitor from Chinese aloes:
N. Jong-Anurakkun, et al.; Fitoterapia
79
, 456 (2008)
Abstract
Related Products
ALX-350-158
Aloesin
Further Categories Containing This Product:
Glycosidases / Related Products
ALX-270-157
Revised 03-Apr-08
Australine . hydrochloride
SYNONYMS
(1R,2R,3R,7S,7aR)-3-Hydroxymethyl-1,2,7-trihydroxypyrrolizidine . HCI
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
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ALX-270-157-M001
1 mg
180.00 USD
Product Specification
FORMULA:
C
8
H
15
NO
4
. HCl
MW:
189.2 . 36.5
CAS NUMBER:
186766-07-4
SOURCE/HOST:
Isolated from
Castanospermum australe
seeds.
PURITY:
≥95%
APPEARANCE:
Crystalline solid.
SOLUBILITY:
Soluble in water, methanol and 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
After reconstitution, prepare aliquots and store at -20°C.
HAZARD:
HARMFUL.
Product Description
Alkaloid. Inhibitor of α-glucosidase, amyloglucosidase and glucosidase I. Does not inhibit glucosidase II, and is reported to be the first glucosidase inhibitor which differentiates glucosidase I from glucosidase II. Does not inhibit α-galactosidase, β-galactosidase, β-glucosidase, α-mannosidase and β-mannosidase.
Product Specific Literature References
Australine, a pyrrolizidine alkaloid that inhibits amyloglucosidase and glycoprotein processing:
J.E. Tropea, et al.; Biochemistry
28
, 2027 (1989)
Abstract
Calystegins, a novel class of alkaloid glycosidase inhibitors:
R.J. Molyneux, et al.; Arch. Biochem. Biophys.
304
, 81 (1993)
Abstract
Stereoselective synthesis of the glycosidase inhibitor australine through a one-pot, double-cyclization strategy:
C. Ribes, et al.; Org. Lett.
9
, 77 (2007)
Abstract
Further Categories Containing This Product:
Alkaloids
•
Glycosidases / Related Products
ALX-350-314
Revised 20-Dec-07
(+)-Calystegine B2
SYNONYMS
(1R,2S,3R,4S,5R)-8-Azabicyclo[3.2.1]octane-1,2,3,4-tetrol
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
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ALX-350-314-M001
1 mg
90.00 USD
ALX-350-314-M005
5 mg
360.00 USD
Product Specification
FORMULA:
C
7
H
13
NO
4
MW:
175.2
CAS NUMBER:
127414-85-1
SOURCE/HOST:
Isolated from
Lycopersicon sp.
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Selective glycosidase inhibitor sharing such activity with other hydroxylated nitrogen containing bicyclic compounds like swainsonine (Prod. No.
ALX-350-077
), castanospermine (Prod. No.
ALX-270-160
), monocyclic deoxynojirimycin (Prod. No.
ALX-580-003
) or fagomine. Most abundant form is calystegine B2 occurring in almost all plants displaying calystegines. Inhibitory potency of calystegine B2 is comparable to other alkaloidal glycosidase inhibitors showing K
i
values below 1µM.
Product Specific Literature References
Identification of the glycosidase inhibitors swainsonine and calystegine B2 in Weir vine (Ipomoea sp. Q6 [aff. calobra]) and correlation with toxicity:
R.J. Molyneux, et al.; J. Nat. Prod.
58
, 878 (1995)
Abstract
The effects of calystegines isolated from edible fruits and vegetables on mammalian liver glycosidases:
N. Asano, et al.; Glycobiology
70
, 1085 (1997)
Abstract
Synthesis and evaluation of calystegine B2 analogues as glycosidase inhibitors:
M.I. Garcia-Moreno, et al.; J. Org. Chem.
66
, 7604 (2001)
Abstract
Biosynthesis of calystegines: 15N NMR and kinetics of formation in root cultures of Calystegia sepium:
Y. Scholl, et al.; Phytochemistry
62
, 325 (2003)
Abstract
Chemistry and biology of calystegines:
B. Drager; Nat. Prod. Rep.
21
, 211 (2004)
Abstract
Calystegines in potatoes with genetically engineered carbohydrate metabolism:
U. Richter, et al.; J. Exp. Bot.
58
, 1603 (2007)
Abstract
Related Products
ALX-270-160
Castanospermine
ALX-350-077
Swainsonine
ALX-580-003
1-Deoxynojirimycin
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables
•
Glycosidases / Related Products
•
Alkaloids
ALX-270-160
Revised 27-Sep-07
Castanospermine
SYNONYMS
(1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyoctahydroindolizine
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
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ALX-270-160-M010
10 mg
60.00 USD
ALX-270-160-M050
50 mg
180.00 USD
Product Specification
FORMULA:
C
8
H
15
NO
4
MW:
189.2
CAS NUMBER:
79831-76-8
MERCK INDEX:
14:
1896
SOURCE/HOST:
Isolated from
Castanospermum australe
seeds.
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from moisture.
Product Description
Plant alkaloid. Potent inhibitor of α- and β-glucosidase activity in fibroblast extracts; inhibits the glycoprotein processing cycle. Exhibits antiviral properties. Prevents angiogenesis.
Product Specific Literature References
Castanospermine inhibits the processing of the oligosaccharide portion of the influenza viral hemagglutinin:
Y.T. Pan, et al.; Biochemistry
22
, 3975 (1983)
Abstract
Glycoproteins: their structure, biosynthesis and possible clinical implications:
H. Schachter; Clin. Biochem.
17
, 3 (1984)
Abstract
The effects of processing inhibitors of N-linked oligosaccharides on the intracellular migration of glycoprotein E2 of mouse hepatitis virus and the maturation of coronavirus particles:
R. Repp, et al.; J. Biol. Chem.
260
, 15873 (1985)
Abstract
;
Full Text
Effects of the anti-inflammatory compounds castanospermine, mannose-6- phosphate and fucoidan on allograft rejection and elicited peritoneal exudates:
M.R. Bartlett, et al.; Immunol. Cell Biol.
72
, 367 (1994)
Abstract
Antiviral activity and metabolism of the castanospermine derivative MDL 28,574, in cells infected with herpes simplex virus type 2:
S.P. Ahmed, et al.; BBRC
208
, 267 (1995)
Abstract
The alpha-glucosidase I inhibitor castanospermine alters endothelial cell glycosylation, prevents angiogenesis, and inhibits tumor growth:
R. Pili, et al.; Cancer Res.
55
, 2920 (1995)
Abstract
Perturbation of free oligosaccharide trafficking in endoplasmic reticulum glucosidase I-deficient and castanospermine-treated cells:
C. Durrant & S.E. Moore; Biochem. J.
365
, 239 (2002)
Abstract
Further Categories Containing This Product:
Alkaloids
•
Glycosidases / Related Products
•
Natural Products - Antiviral / anti-HIV Agents
•
Natural Products for Angiogenesis Research
ALX-270-082
Revised 28-Jan-05
Conduritol B epoxide
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Glycosidases / Related Products
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ALX-270-082-M005
5 mg
35.00 USD
ALX-270-082-M025
25 mg
140.00 USD
Product Specification
FORMULA:
C
6
H
10
O
5
MW:
162.1
CAS NUMBER:
6090-95-5
PURITY:
≥97%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from moisture.
Product Description
Irreversible, high-potency inhibitor of various plant β-glucosidases and mammalian glucocerebrosidase. Used
in vitro
and animal models for study of Gaucher's disease.
Product Specific Literature References
[Mechanism of action of glycoside-splitting enzymes. V. Labelling of the active center of beta-glucosidases A and B from sweet almond emulsin with (3H)6-bromo-6-deoxyconduritol B epoxide]:
G. Legler; Hoppe-Seyler's Z. Physiol. Chem.
351
, 25 (1970)
Abstract
The Gaucher mouse: differential action of conduritol B epoxide and reversibility of its effects:
M.C. Stephens, et al.; J. Neurochem.
30
, 1023 (1978)
Abstract
Destruction and resynthesis of mouse beta-glucosidases:
A. Hara & N.S. Radin; Biochim. Biophys. Acta
582
, 412 (1979)
Abstract
beta-Glucosidase inhibition in murine peritoneal macrophages by conduritol-B-epoxide: an in vitro model of the Gaucher cell:
D.S. Newburg, et al.; Biochim. Biophys. Acta
877
, 121 (1986)
Abstract
Normalization of liver glucosylceramide levels in the "Gaucher" mouse by phosphatidylserine injection:
S.C. Datta and N.S. Radin; BBRC
152
, 155 (1988)
Abstract
Further Categories Containing This Product:
Plant Research Reagents / Related Products
ALX-580-001
Revised 21-May-08
Deoxygalactonojirimycin . hydrochloride
SYNONYMS
Galactostatin . HCl
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
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ALX-580-001-M001
1 mg
40.00 USD
ALX-580-001-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
6
H
13
NO
4
. HCl
MW:
163.2 . 36.5
CAS NUMBER:
108147-54-2
SOURCE/HOST:
Synthetic.
PURITY:
≥98%
APPEARANCE:
Lyophilized.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Potent and selective α-D-galactosidase inhibitor. Small molecule chemical chaperone.
Product Specific Literature References
Monosaccharides Containing Nitrogen in the Ring, XXXVII. Synthesis of 1,5-Dideoxy-1,5-imino-D-galactitol:
H. Paulsen, et al.; Chem. Ber.
113
, 2601 (1980)
Synthesis of 5-amino-5-deoxy-D-galactopyranose and 1,5-dideoxy-1,5-imino-D-galactitol, and their inhibition of alpha- and beta-D-galactosidases:
G. Legler & S. Pohl; Carbohydr. Res.
155
, 119 (1986)
Abstract
In vitro inhibition and intracellular enhancement of lysosomal alpha-galactosidase A activity in Fabry lymphoblasts by 1-deoxygalactonojirimycin and its derivatives:
N. Asano, et al.; Eur. J. Biochem.
267
, 4179 (2000)
Abstract
A synthetic chaperone corrects the trafficking defect and disease phenotype in a protein misfolding disorder:
G.H. Yam, et al.; FASEB J.
19
, 12 (2005)
Abstract
Active-site-specific chaperone therapy for Fabry disease. Yin and Yang of enzyme inhibitors:
J. Q. Fan & S. Ishii; FEBS J.
274
, 4962 (2007)
Abstract
Further Categories Containing This Product:
Glycosidases / Related Products
•
Alkaloids
ALX-580-002
Revised 03-Apr-08
1-Deoxymannojirimycin . hydrochloride
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
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ALX-580-002-M001
1 mg
26.00 USD
ALX-580-002-M005
5 mg
78.00 USD
Product Specification
FORMULA:
C
6
H
13
NO
4
. HCl
MW:
163.2 . 36.5
CAS NUMBER:
84444-90-6
SOURCE/HOST:
Synthetic.
PURITY:
≥98%
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in water, methanol (warm) or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
HARMFUL.
Product Description
Potent inhibitor of α-mannosidase I. Blocks the biosynthesis of complex-type oligosaccharides. Does not inhibit the biosynthesis of lipid-linked oligosaccharides. Induces ER stress in human cells.
Product Specific Literature References
Inhibitors of oligosaccharide processing:
U. Fuhrmann, et al.; Biochim. Biophys. Acta
825
, 95 (1985)
Abstract
Secretion of high-mannose-type alpha 1-proteinase inhibitor and alpha 1- acid glycoprotein by primary cultures of rat hepatocytes in the presence of the mannosidase I inhibitor 1-deoxymannojirimycin:
V. Gross, et al.; Eur. J. Biochem.
150
, 41 (1985)
Abstract
The use of 1-deoxymannojirimycin to evaluate the role of various alpha- mannosidases in oligosaccharide processing in intact cells:
J. Bischoff, et al.; J. Biol. Chem.
261
, 4766 (1986)
Abstract
;
Full Text
Effect of retinyl acetate on the assembly of the fibronectin extracellular matrix and the processing of the fibronectin receptor beta subunit of confluent C3H/10T1/2 mouse embryo fibroblasts:
S.S. Suzuki & L.H. Piette; J. Cell. Biochem.
51
, 181 (1993)
Abstract
1-Deoxymannojirimycin, the alpha1,2-mannosidase inhibitor, induced cellular endoplasmic reticulum stress in human hepatocarcinoma cell 7721:
Y. Lu, et al.; Biochem. Biophys. Res. Commun.
344
, 221 (2006)
Abstract
Further Categories Containing This Product:
Glycosidases / Related Products
•
Alkaloids
ALX-580-003
Revised 19-Feb-08
1-Deoxynojirimycin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
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ALX-580-003-M001
1 mg
28.00 USD
ALX-580-003-M005
5 mg
98.00 USD
Product Specification
FORMULA:
C
6
H
13
NO
4
MW:
163.2
CAS NUMBER:
19130-96-2
SOURCE/HOST:
Isolated from
Bacillus subtilis
strain.
PURITY:
≥98%
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of mammalian glucosidases I and II.
Product Specific Literature References
Effects of the glucosidase inhibitors nojirimycin and deoxynojirimycin on the biosynthesis of membrane and secretory glycoproteins:
N. Peyrieras, et al.; EMBO J.
2
, 823 (1983)
Abstract
Characterization of Bacillus subtilis DSM704 and its production of 1-deoxynojirimycin:
D.C. Stein, et al.; Appl. Environ. Microbiol.
48
, 280 (1984)
Abstract
Inhibition of N-linked oligosaccharide trimming does not interfere with surface expression of certain integral membrane proteins:
B. Burke, et al.; EMBO J.
3
, 551 (1984)
Abstract
Purification by affinity chromatography of glucosidase I, an endoplasmic reticulum hydrolase involved in the processing of asparagine-linked oligosaccharides:
H. Hettkamp, et al.; Eur. J. Biochem.
142
, 85 (1984)
Abstract
Inhibitors of oligosaccharide processing:
U. Fuhrmann, et al.; Biochim. Biophys. Acta
825
, 95 (1985)
Abstract
Identification of a novel mechanism for the removal of glucose residues from high mannose-type oligosaccharides:
K. Suh, et al.; J. Biol. Chem.
267
, 21671 (1992)
Abstract
;
Full Text
Deoxynojirimycin: synthesis and biological activity
:
A. B. Hughes & A. J. Rudge; Nat. Prod. Rep.
11
, 135 (1994), (Review)
Abstract
The alpha-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step:
M.J. Papandreou, et al.; Mol. Pharmacol.
61
, 186 (2002)
Abstract
Glycosidase inhibitors as potential HIV entry inhibitors?:
I. Robina, et al.; Curr. Drug Metab.
5
, 329 (2004), (Review)
Abstract
Further Categories Containing This Product:
Glycosidases / Related Products
•
Alkaloids
ALX-350-077
Revised 30-Jun-08
Swainsonine
SYNONYMS
8α,β-Octahydroindolizidine-1α,2α,8β-triol
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antitumor Reagents
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ALX-350-077-MC05
0.5 mg
85.00 USD
ALX-350-077-M001
1 mg
148.00 USD
Product Specification
FORMULA:
C
8
H
15
NO
3
MW:
173.2
CAS NUMBER:
72741-87-8
SOURCE/HOST:
Synthetic.
PURITY:
≥98% (TLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO, methanol or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Reversibly inhibits the active site of lysosomal α-mannosidase. Also inhibits the growth of tumors and prevents metastasis in murine models. Could inhibit cell proliferation
in vitro
and the growth of human gastric carcinoma
in vivo
. Blocks the processing of high mannose oligosaccharides to form complex type oligosaccharides.
Product Specific Literature References
Inhibitors of glycoprotein synthesis:
A.D. Elbein; Meth. Enzymol.
98
, 135 (1983)
Abstract
Purification and characterization of Ca2+/calmodulin-dependent protein kinase V from rat cerebrum:
H. Mochizuki, et al.; J. Biol. Chem.
268
, 9143 (1993)
Abstract
;
Full Text
Swainsonine protects both murine and human haematopoietic systems from chemotherapeutic toxicity:
J.L. Klein, et al.; Br. J. Cancer
80
, 87 (1999)
Abstract
Swainsonine stimulates bone marrow cell proliferation and differentiation in different strains of inbred mice:
O.A. Oredipe, et al.; Pharmacol. Res.
47
, 69 (2003)
Abstract
Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine:
J.Y. Sun, et al.; Phytomedicine
14
, 353 (2007)
Abstract
Further Categories Containing This Product:
Alkaloids
•
Natural Products with Antibiotic Activity
•
Glycosidases / Related Products
