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Antibiotics for Molecular Biology Application
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ALX-380-013 Revised 12-Jun-08
G418 . sulfate
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SYNONYMS Geneticin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Molecular Biology Application
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-013-M100   100 mg 20.00 USD Add To Cart
ALX-380-013-M500   500 mg 39.00 USD Add To Cart
ALX-380-013-G001   1 g 48.00 USD Add To Cart
ALX-380-013-G005   5 g 160.00 USD Add To Cart
Product Specification
FORMULA: C20H40N4O10 . 2H2SO4
MW: 496.6 . 196.1
CAS NUMBER: 108321-42-2
RTECS: CB9378500
PURITY: ~98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
ACTIVITY: Potency: ≥650µg/mg.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Solutions are stable for 3 to 6 months when stored at -20 °C.
HANDLING: Avoid freeze/thaw cycles.

Product Description
Gentamycin-class aminoglycoside antibiotic. Cytotoxic to prokaryotic and eukaryotic cells. Induces apoptosis. Widely employed in the selection of eukaryotic expression vectors, in combination with either aminoglycoside phosphotransferase 3’ or APH II.
Product Specific Literature References
Antibiotic G-418, a new Micromonospora-produced aminoglycoside with activity against protozoa and helminths: fermentation, isolation, and preliminary characterization: G.H. Wagman, et al.; Antimicrob. Agents Chemother. 6, 144 (1974) Abstract
Phosphatidylinositol phospholipase C is activated allosterically by the aminoglycoside G418. 2-deoxy-2-fluoro-scyllo-inositol-1-O-dodecylphosphonate and its analogs inhibit glycosylphosphatidylinositol phospholipase C: J.C. Morris, et al.; J. Biol. Chem. 271, 15468 (1996) Abstract
Addition of G418 and other aminoglycoside antibiotics to mammalian cells results in the release of GPI-anchored proteins: M. Kung, et al.; FEBS Lett. 409, 333 (1997) Abstract
Cytochrome c release and endoplasmic reticulum stress are involved in caspase-dependent apoptosis induced by G418: Q.H. Jin, et al.; Cell. Mol. Life Sci. 61, 1816 (2004) Abstract
Expression and distribution of HSP27 in response to G418 in different human breast cancer cell lines: L. Qian, et al.; Histochem. Cell Biol. 126, 593 (2006) Abstract
Further Categories Containing This Product:
Carbohydrates • Antibiotics - Apoptosis Inducers & Inhibitors
 
 
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