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Ubiquitination Other Products
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ALX-380-116 Revised 07-Apr-08
Hypothemycin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-116-C250   250 µg 140.00 USD Add To Cart
ALX-380-116-M001   1 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C19H22O8
MW: 378.4
CAS NUMBER: 76958-67-3
SOURCE/HOST: Isolated from Phoma sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO or acetone; insoluble in methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Exhibits antifungal and cytotoxic activity against some tumor cell lines partly attributed to inhibition of Ras-inducible genes. Inhibits proliferation of mouse and human T cells and modulates production of cytokines during T cell activation. Facilitates the ubiquitinylation process of cyclin D1. Has been identified as a potent and selective inhibitor of threonine/tyrosine-specific kinase, MEK, and other protein kinases that contain a conserved cysteine residue in the ATP-binding site in both in vitro and in vivo studies.
Product Specific Literature References
Metabolites of pyrenomycetes XIII: Structure of (+) hypothemycin, an antibiotic macrolide from hypomyces trichothecoides: M.S.R. Nair & S.T. Carey; Tetrahedron Lett. 21, 2011 (1980)
Metabolites of pyrenomycetes. XIV: Structure and partial stereochemistry of the antibiotic macrolides hypothemycin and dihydrohypothemycin: M.S.R. Nair, et al.; Tetrahedron 37, 2445 (1981)
Revised structure and stereochemistry of hypothemycin: T. Agatsuma et al.; Chem. Pharm. Bull. 41, 373 (1993)
Antitumor efficacy of hypothemycin, a new Ras-signaling inhibitor: H. Tanaka, et al.; Jpn. J. Cancer Res. 90, 1139 (1999) Abstract
Hypothemycin inhibits the proliferative response and modulates the production of cytokines during T cell activation: R. Camacho, et al.; Immunopharmacology 44, 255 (1999) Abstract
Suppression of oncogenic transformation by hypothemycin associated with accelerated cyclin D1 degradation through ubiquitin-proteasome pathway: H. Sonoda, et al.; Life Sci. 65, 381 (1999) Abstract
Resorcylic acid lactones: naturally occurring potent and selective inhibitors of MEK: A. Zhao, et al.; J. Antibiot. 52, 1086 (1999) Abstract
Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides: A. Schirmer, et al.; PNAS 103, 4234 (2006) Abstract; Full Text
Chemistry and biology of resorcylic acid lactones: N. Winssinger, et al.; Chem. Commun. (Camb). 1, 22 (2007), (Review) Abstract
Further Categories Containing This Product:
MAPK Pathway Inhibitors • Antibiotics - Protein Kinase Inhibitors • Tyrosine Kinase Inhibitors • Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Antibiotics • Antibiotics - Proteasome / Ubiquitin Modulators • Ubiquitination Other Products • CDKs & Cyclins Other Products • Ras Signalling Pathway Other Products
 
 
ALX-430-103 Revised 14-Mar-05
Lovastatin
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SYNONYMS Mevinolin
6-α-Methylcompactin
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Statins / Related Products
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ALX-430-103-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C24H36O5
MW: 404.5
CAS NUMBER: 75330-75-5
MERCK INDEX: 14: 5586
PURITY: ≥98%
SOLUBILITY: Soluble in DMSO, chloroform or acetone; sparingly soluble in acetonitrile, methanol or 100 % ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
Product Description
Inhibitor of HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis. Induces apoptosis in cancer cells.
Product Specific Literature References
Statins as a newly recognized type of immunomodulator: B. Kwak, et al.; Nat. Med. 6, 1399 (2000) Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products • Ubiquitination Other Products
 
 
ALX-210-938 Revised 31-Aug-07
Polyclonal Antibody to SGT1 (AL257)
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SYNONYMS anti-Suppressor of G2 Allele of SKP1 Homolog PAb (AL257)
anti-Putative 40-6-3 Protein PAb (AL257)
PRODUCT LINE Ubiquitin & Proteasome
PRODUCT CATEGORY Ubiquitination Other Products
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ALX-210-938-C100   100 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human SGT1 (aa 1-364).
SPECIFICITY: Recognizes human and mouse SGT1.
APPLICATION: Western Blot (1:1’000)
Note: Does not work for Immunoprecipitation.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses: A. Mayor, et al.; Nat. Immunol. 8, 497 (2007) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-430-104 Revised 18-Apr-07
Simvastatin
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SYNONYMS Zocor
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Statins / Related Products
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ALX-430-104-M050   50 mg 85.00 USD Add To Cart
Product Specification
FORMULA: C25H38O5
MW: 418.6
CAS NUMBER: 79902-63-9
MERCK INDEX: 14: 8539
RTECS: EK7798000
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Store solutions at -20°C.

Product Description
HMG-CoA reductase inhibitor. Synthetic analog of lovastatin (Prod. No. ALX-430-103). Antihyperlipidemic.
Product Specific Literature References
Lovastatin and simvastatin are modulators of the proteasome: C. Wojcik, et al.; Int. J. Biochem. Cell Biol. 32, 957 (2000) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Inhibitors) • Antitumor Agents (Anti-proliferative) • Ubiquitination Other Products
 
 
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