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ALX-350-134 Revised 28-May-08
Pyripyropene A
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SYNONYMS (+)-Pyripyropene A
PPPA
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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ALX-350-134-C500   500 µg 190.00 USD Add To Cart
Product Specification
FORMULA: C31H37NO10
MW: 583.6
CAS NUMBER: 147444-03-9
SOURCE/HOST: Isolated from Aspergillus fumigatus.
PURITY: ≥90% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol or ethyl acetate; insoluble in water or hexane.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Highly specific inhibitor of acyl-coenzyme A:cholesterol acetyltransferase 2 (ACAT2).
Product Specific Literature References
Pyripyropenes, highly potent inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus: S. Omura, et al.; J. Antibiot. 46, 1168 (1993) Abstract
Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. I. Production, isolation, and biological properties: H. Tomoda, et al.; J. Antibiot. 47, 148 (1994) Abstract
Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D: Y.K. Kim, et al.; J. Antibiot. 47, 154 (1994) Abstract
Aflavinines and other antiinsectan metabolites from the ascostromata of Eupenicillium crustaceum and related species: H.J. Wang, et al.; Appl. Environ. Microbiol. 61, 4429 (1995) Abstract; Full Text
Total Synthesis of (+)-Pyripyropene A, a Potent, Orally Bioavailable Inhibitor of
Acyl-CoA:Cholesterol Acyltransferase: T. Nagamitsu, et al.; J. Org. Chem. 60, 8126 (1995)
Biosynthesis of Pyripyropene A: H. Tomoda, et al.; J. Org. Chem. 61, 882 (1996)
Meroterpenoids with various biological activities produced by fungi: K. Shiomi, et al.; Pure Appl. Chem. 71, 1059 (1999) Full Text
A formal synthesis of (+)-pyripyropene A using a biomimetic epoxy-olefin cyclisation: effect of epoxy alcohol/ether on cyclisation efficiency: V.K. Aggarwal, et al.; J. Chem. Soc. 3315 (1999) Full Text
Mass-production of human ACAT-1 and ACAT-2 to screen isoform-specific inhibitor: a different substrate specificity and inhibitory regulation: K.H. Cho, et al.; BBRC 309, 864 (2003) Abstract
Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay: individual ACAT uniqueness: A.T. Lada, et al.; J. Lipid Res. 45, 378 (2004) Abstract; Full Text
ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver: P. Parini, et al.; Circulation 110, 2017 (2004) Abstract; Full Text
Exploiting PdII and TiIII chemistry to obtain gamma-dioxygenated terpenoids: synthesis of rostratone and novel approaches to aphidicolin and pyripyropene A: J. Justicia, et al.; J. Org. Chem. 70, 8265 (2005) Abstract
Total synthesis of alpha-pyrone meroterpenoids, novel bioactive microbial metabolites: T. Sunazuka and S. Omura; Chem. Rev. 105, 4559 (2005) Abstract
Potential therapeutics for obesity and atherosclerosis: inhibitors of neutral lipid metabolism from microorganisms: H. Tomoda & S. Omura; Pharmacol. Ther. 115, 375 (2007) Abstract
General Information
MANUFACTURER Fungal strain courtesy of The Kitasato Institute, Tokyo.
Further Categories Containing This Product:
Cholesterol & Lipid Transport/Related Products
 
 
ALX-350-151 Revised 21-May-08
Agistatine B
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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ALX-350-151-M001   1 mg 90.00 USD Add To Cart
ALX-350-151-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C11H18O4
MW: 214.3
CAS NUMBER: 144096-46-8
SOURCE/HOST: Isolated from fungus FH-A 6239.
PURITY: ≥98% (1H-NMR)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol, DMSO or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
A tricyclic analog of agistatine A, which has been described as an inhibitor of cholesterol biosynthesis.
Product Specific Literature References
Secondary Metabolites by Chemical Screening, 29: A. Zeeck, et al.; Liebigs Ann. 627 (1996)
Further Categories Containing This Product:
Cholesterol & Lipid Transport/Related Products
 
 
ALX-350-160 Revised 18-Aug-08 New product
Aloeresin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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ALX-350-160-M001   1 mg 185.00 USD Add To Cart
Product Specification
FORMULA: C28H28O11
MW: 540.5
CAS NUMBER: 74545-79-2
SOURCE/HOST: Isolated from Aloe sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR and MS.

Product Description
Metabolite of aloesin (Prod. No. ALX-350-158).  Inhibits α-glucosidases.
Product Specific Literature References
Metabolism of aloesin and related compounds by human intestinal bacteria: a bacterial cleavage of the C-glucosyl bond and the subsequent reduction of the acetonyl side chain: Q.M. Che, et al.; Chem. Pharm. Bull. (Tokyo) 39, 704 (1991) Abstract
Geographical variation in the major compounds of Aloe ferox leaf exudate: B.E. van Wyk, et al.; Planta Med. 61, 250 (1995) Abstract
High-performance liquid chromatographic profiles of aloe constituents and determination of aloin in beverages, with reference to the EEC regulation for flavouring substances: F. Zonta, et al.; J. Chromatogr. A. 718, 99 (1995) Abstract
Determination of aloesin and aloeresin A for the detection of aloe in beverages: M. Dell’Agli, et al.; J. Agric. Food Chem. 55, 3363 (2007) Abstract
A reversed-phase high-performance liquid chromatographic method for the determination of aloesin, aloeresin A and anthraquinone in Aloe ferox: M. Zahn, et al.; Phytochem. Anal. 19, 122 (2008) Abstract
alpha-Glucosidase inhibitor from Chinese aloes: N. Jong-Anirallim, et al.; Fitoterapia Epub ahead of print, (2008) Abstract
Related Products
Further Categories Containing This Product:
Glycosidases/Related Products
 
 
ALX-350-161 Revised 11-Aug-08 New product
Macrosporin
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SYNONYMS 1,7-Dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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ALX-350-161-M001   1 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C16H12O5
MW: 284.3
CAS NUMBER: 22225-67-8
SOURCE/HOST: Isolated from Alternaria sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR and MS.

Product Description

Anthraquinone.
Product Specific Literature References
Metabolites of Dactylaria lutea. The structures of dactylariol and the antiprotozoal antibiotic dactylarin: A.M. Becker, et al.; J. Antibiot. (Tokyo) 31, 324 (1978) Abstract
High-performance liquid chromatographic determination of macrosporin, altersolanol A, alterporriol A, B and C in fermentation of Alternaria porri (Ellis) Ciferri: R. Suemitsu, et al.; J. Chromatogr. 454, 406 (1988) Abstract
Biologically active polyketide metabolites from an undetermined fungicolous hyphomycete resembling Cladosporium: U. Höller, et al.; J. Nat. Prod. 65, 876 (2002) Abstract
Natural occurrence of fungi and fungal metabolites in moldy tomatoes: B. Andersen & J.C. Frisvad; J. Agric. Food Chem. 52, 7507 (2004) Abstract
New and cytotoxic anthraquinones from Pleospora sp. IFB-E006, an endophytic fungus in Imperata cylindrical: H.M. Ge, et al.; Planta Med. 71, 1063 (2005) Abstract
Secondary metabolite profiling of Alternaria dauci, A. porri, A. solani, and A. tomatophila: B. Andersen, et al.; Mycol. Res. 112, 241 (2007) Abstract
Metabolite production by different Ulocladium species: B. Andersen & M. Hollensted; Int. J. Food Microbiol. 126, 172 (2008) Abstract
Further Categories Containing This Product:
Other Toxins
 
 
ALX-350-344 Revised 03-Apr-08
Actinotetraose Hexatiglate
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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ALX-350-344-M001   1 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C54H78O27
MW: 1159.2
CAS NUMBER: 216590-44-2
SOURCE/HOST: Isolated from Amycolatopsis sp. MST-AS5902.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Unique tetrasaccharide with six tiglate esters. Shows no significant antimicrobial activity.
Product Specific Literature References
Structure of actinotetraose hexatiglate, a unique glucotetraose from an actinomycete bacterium: R.W. Rickards, et al.; J. Antibiot. (Tokyo) 51, 1093 (1998) Abstract; Full Text
Further Categories Containing This Product:
Carbohydrates
 
 
ALX-380-262 Revised 09-Apr-08
Amidepsine A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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ALX-380-262-M001   1 mg 230.00 USD Add To Cart
ALX-380-262-MM25   2.5 mg 470.00 USD Add To Cart
Product Specification
FORMULA: C29H29NO11
MW: 567.6
SOURCE/HOST: Isolated from fungal strain FO-2943.
PURITY: ≥95% (HPLC)
APPEARANCE: Pale white to pale yellow powder.
SOLUBILITY: Soluble in methanol or ethyl acetate; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC50=10.2µM) and Raji cells (IC50=15.5µM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.
Product Specific Literature References
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties: H. Tomoda, et al.; J. Antibiot. 48, 937 (1995) Abstract
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C: H. Tomoda, et al.; J. Antibiot. 48, 942 (1995) Abstract
General Information
MANUFACTURER Fungal strain courtesy of the Kitasato Institute, Tokyo.
Related Products
Further Categories Containing This Product:
Lipid Metabolism Other Products
 
 
ALX-380-263 Revised 09-Apr-08
Amidepsine D
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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ALX-380-263-M001   1 mg 230.00 USD Add To Cart
ALX-380-263-MM25   2.5 mg 470.00 USD Add To Cart
Product Specification
FORMULA: C26H24O10
MW: 496.5
SOURCE/HOST: Isolated from fungal strain FO-2943.
PURITY: ≥95% (HPLC)
APPEARANCE: White to light pink powder.
SOLUBILITY: Soluble in methanol (1mg/ml); insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC50=17.5µM) and Raji cells (IC50=2.8µM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.
Product Specific Literature References
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties: H. Tomoda, et al.; J. Antibiot. 48, 937 (1995) Abstract
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C: H. Tomoda, et al.; J. Antibiot. 48, 942 (1995) Abstract
General Information
MANUFACTURER Fungal strain courtesy of the Kitasato Institute, Tokyo.
Related Products
Further Categories Containing This Product:
Lipid Metabolism Other Products
 
 
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