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Adiponectin [ACRP30]/Related Products
You are here: Product Lines > Obesity & Adipokines > Adipokines/Related Products > Adiponectin [ACRP30]/Related Products
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ALX-270-113 Revised 08-Apr-08
Phloretin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-113-M100   100 mg 37.00 USD Add To Cart
Product Specification
FORMULA: C15H14O5
MW: 274.3
CAS NUMBER: 60-82-2
MERCK INDEX: 14: 7326
PURITY: ≥98%
APPEARANCE: Off-white to beige solid.
SOLUBILITY: Soluble in acetone, DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Flavonoid. Protein kinase C (PKC) inhibitor. PGF2a receptor antagonist. In astrocytes, these receptors are linked to phospholipase C, thus affecting phosphoinositide hydrolysis and intracellular Ca2+ levels. Inhibits myo-inositol uptake and 5’-iodothyronine deiodinase. Prevents TNF-α stimulated upregulation of VCAM-1, ICAM-1 and E-selectin. Enhances adiponectin expression.
Product Specific Literature References
Effects on water diffusion of inhibitors affecting various transport processes in human red blood cells: G. Benga, et al.; Eur. J. Cell Biol. 59, 219 (1992) Abstract
Phloretin as an antagonist of prostaglandin F2 alpha receptor in cultured rat astrocytes: J. Kitanaka, et al.; J. Neurochem. 60, 704 (1993) Abstract
Characterization of the inhibition by stilbene disulphonates and phloretin of lactate and pyruvate transport into rat and guinea-pig cardiac myocytes suggests the presence of two kinetically distinct carriers in heart cells: X. Wang, et al.; Biochem. J. 290, 249 (1993) Abstract
The effect of glucose and galactose toxicity on myo-inositol transport and metabolism in human skin fibroblasts in culture: G.T. Berry, et al.; Pediat. Res. 35, 141 (1994) Abstract
Activating effect of the flavonoid phloretin on Ca(2+)-activated K+ channels in myelinated nerve fibers of Xenopus laevis: D.S. Koh, et al.; Neurosci. Lett. 165, 167 (1994) Abstract
Thyroid hormones in tissues from fetal and adult rats: G. Morreale de Escobar; Endocrinology 134, 2410 (1994) Abstract
Gonadotropin-releasing hormone induced Ca2+ influx in nonsecreting pituitary adenoma cells: role of voltage-dependent Ca2+ channels and protein kinase C: N. Prevarskaya, et al.; Mol. Cell. Neurosci. 5, 699 (1994) Abstract
The flavonoid phloretin suppresses stimulated expression of endothelial adhesion molecules and reduces activation of human platelets: V. Stangl, et al.; J. Nutr. 135, 172 (2005) Abstract
Phloretin enhances adipocyte differentiation and adiponectin expression in 3T3-L1 cells: M. Hassan, et al.; BBRC 361, 208 (2007) Abstract
Further Categories Containing This Product:
Adiponectin [ACRP30]/Related Products • PKC Inhibitors • Adhesion Molecules & Receptors Other Products • Active Substances from Fruit and Vegetables
 
 
ALX-201-303 Revised 10-Jul-08
Adiponectin (rat) (recombinant)
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SYNONYMS ACRP30 (rat) (recombinant)
Adipocyte Complement Related Protein of 30kDa (rat) (recombinant)
AdipoQ (rat) (recombinant)
apM1 (rat) (recombinant)
GBP28 (rat) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30]/Related Products
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ALX-201-303-C050   50 µg 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Rat adiponectin (aa 16-244) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION:

PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 30mM TRIS-HCl, pH 8.5.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test; Bio Whittaker).
BIOLOGICAL ACTIVITY: Induces the phosphorylation of acetyl-CoA carboxylase (ACC) in C2C12 cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
BACKGROUND/TECHNICAL INFORMATION FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism: A.H. Berg, et al.; Trends Endocrinol. Metab. 13, 84 (2002), (Review) Abstract
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-201-304 Revised 30-Jul-08
Adiponectin (Globular Domain) (human) (recombinant) (His)
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SYNONYMS ACRP30 (Globular Domain) (human) (recombinant) (His)
Adipocyte Complement Related Protein of 30kDa (Globular Domain) (human) (recombinant) (His)
AdipoQ (Globular Domain) (human) (recombinant) (His)
apM1 (Globular Domain) (human) (recombinant) (His)
GBP28 (Globular Domain) (human) (recombinant) (His)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-304-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The globular domain of human adiponectin (aa 104-244) is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 30mM TRIS-Cl, pH 8.5.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL test; Bio Whittaker).
BIOLOGICAL ACTIVITY: Activates AMPK in HUVEC in a PI(3)K-independent way.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q15848: Adiponectin (human) (precursor)
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism: A.H. Berg, et al.; Trends Endocrinol. Metab. 13, 84 (2002), (Review) Abstract
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-201-305 Revised 08-Dec-06
Adiponectin (Globular Domain) (human) (recombinant)
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SYNONYMS ACRP30 (Globular Domain) (human) (recombinant)
Adipocyte Complement Related Protein of 30kDa (Globular Domain) (human) (recombinant)
AdipoQ (Globular Domain) (human) (recombinant)
apM1 (Globular Domain) (human) (recombinant)
GBP28 (Globular Domain) (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-305-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The globular domain of human adiponectin (aa 104-244) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION:   
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 30mM TRIS, pH 8.5.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test; Bio Whittaker).
BIOLOGICAL ACTIVITY: Induces the phosphorylation of acetyl-CoA carboxylase (ACC) in C2C12 cells. Activates AMPK in HUVEC cells in a PI(3)K-independent way.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q15848: Adiponectin (human) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism: A.H. Berg, et al.; Trends Endocrinol. Metab. 13, 84 (2002), (Review) Abstract
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-201-306 Revised 28-Nov-07
Adiponectin (Globular Domain) (mouse) (recombinant) (His)
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SYNONYMS ACRP30 (Globular Domain) (mouse) (recombinant) (His)
Adipocyte Complement Related Protein of 30kDa (Globular Domain) (mouse) (recombinant) (His)
AdipoQ (Globular Domain) (mouse) (recombinant) (His)
apM1 (Globular Domain) (mouse) (recombinant) (His)
GBP28 (Globular Domain) (mouse) (recombinant) (His)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-306-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The globular domain of mouse adiponectin (aa 104-247) is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 30mM TRIS-Cl, pH 8.5.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL test; Bio Whittaker).
BIOLOGICAL ACTIVITY: Induces the phosphorylation of acetyl-CoA carboxylase (ACC) in C2C12 cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q60994: Adiponectin (mouse) (precursor)
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism: A.H. Berg, et al.; Trends Endocrinol. Metab. 13, 84 (2002), (Review) Abstract
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-201-323 Revised 08-Dec-06
Adiponectin (rat) (recombinant) (His)
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SYNONYMS ACRP30 (rat) (recombinant) (His)
Adipocyte Complement Related Protein of 30kDa (rat) (recombinant) (His)
AdipoQ (rat) (recombinant) (His)
apM1 (rat) (recombinant) (His)
GBP28 (rat) (recombinant) (His)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-323-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Mature rat adiponectin (aa 16-244) is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
MANUFACTURER Manufactured by Adipogen, Inc.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-201-324 Revised 20-Dec-07
Adiponectin (Globular Domain) (rat) (recombinant) (His)
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SYNONYMS ACRP30 (Globular Domain) (rat) (recombinant) (His)
Adipocyte Complement Related Protein of 30kDa (Globular Domain) (rat) (recombinant) (His)
AdipoQ (Globular Domain) (rat) (recombinant) (His)
apM1 (Globular Domain) (rat) (recombinant) (His)
GBP28 (Globular Domain) (rat) (recombinant) (His)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-324-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The globular domain of rat adiponectin is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2-µm filtered solution in 30mM TRIS-HCl, pH 8.5.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Statin reverses reduction of adiponectin receptor expression in infarcted heart and in TNF-{alpha}-treated cardiomyocytes in association with improved glucose uptake: Y. Saito, et al.; Am. J. Physiol. Heart Circ. Physiol. 293, H3490 (2007) Abstract
Role of adiponectin receptors in endothelin-induced cellular hypertrophy in cultured cardiomyocytes and their expression in infarcted heart: D. Fujioka, et al.; Am. J. Physiol. Heart Circ. Physiol. 290, H2409 (2006) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Adipogen, Inc.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-203-002 Revised 23-Mar-06
ACRP30headless (human) (recombinant)
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SYNONYMS Tail Adiponectin (human) (recombinant)
Tail-Adp (human) (recombinant)
Adipocyte Complement Related Protein of 30kDa headless (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30]/Related Products
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ALX-203-002-C010   10 µg 260.00 USD Add To Cart
Product Specification
MW: ~27kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The non-homologous (aa 16-45) and collagen domain of human ACRP30 (aa 45-108) are fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water.
APPLICATION: Negative control. When used at 1µg/g body weight in mouse demonstrated no significant bioactivity in terms of reduction of serum glucose compared to wildtype in an in vivo assay. Control compound for rhsMegaAPRIL™ (Prod. No. ALX-522-035) and rhsMegaTNF-α (Prod. No. ALX-522-046).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
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Product Specific Literature References
Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin: Implications for metabolic regulation and bioactivity: U.B. Pajvani, et al.; J. Biol. Chem. 278, 9073 (2003) Abstract; Full Text
Adiponectin acts in the brain to decrease body weight: Y. Qi, et al.; Nat. Med. 10, 524 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q15848: ACRP30 (human) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-203-003 Revised 23-Mar-06
ACRP30headless (mouse) (recombinant)
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SYNONYMS Tail Adiponectin (mouse) (recombinant)
Tail-Adp (mouse) (recombinant)
Adipocyte Complement Related Protein of 30kDa headless (mouse) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-203-003-C010   10 µg 260.00 USD Add To Cart
Product Specification
MW: ~25kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The collagen domain of mouse ACRP30 (aa 18-111) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
APPLICATION: Negative control. Control compound for rmsMegaOX40L [CD134L]™ (Prod. No. ALX-522-062) and rmsMegaTNF-α™ (Prod. No. ALX-522-047).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored as recommended.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q60994: ACRP30 (mouse) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-522-059 Revised 02-Mar-07
Adiponectin (mouse) (recombinant)
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SYNONYMS ACRP30 (mouse) (recombinant)
Adipocyte Complement Related Protein of 30kDa (mouse) (recombinant)
AdipoQ (mouse) (recombinant)
apM1 (mouse) (recombinant)
GBP28 (mouse) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-059-C050   50 µg 335.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Mouse
MW: ~35kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. Mouse adiponectin (aa 18-247) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.
CONCENTRATION: 0.5mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water.
BIOLOGICAL ACTIVITY: Inhibits serum glucose production in mice. Protects mouse hepatocytes from TNF-α-induced cell death in vitro.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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Product Description