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Natural Products - Antimalarial Agents
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ALX-350-219 Revised 28-May-08
Artemisinin
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SYNONYMS Qinghaosu
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antimalarial Agents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-219-M100   100 mg 35.00 USD Add To Cart
ALX-350-219-G001   1 g 220.00 USD Add To Cart
Product Specification
FORMULA: C15H22O5
MW: 282.4
CAS NUMBER: 63968-64-9
MERCK INDEX: 14: 817
SOURCE/HOST: Isolated from the traditional Chinese anti-malarial herb Artemisia annua L.
PURITY: ≥98%
APPEARANCE: White crystalline solid.
SOLUBILITY: Soluble in methanol, 100% ethanol, dimethyl formamide, DMSO, chloroform or acetone; almost insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture.
HAZARD: TOXIC.

Product Description
Powerful antimalarial agent. Inhibits angiogenesis by down-regulating HIF-1α and VEGF expression in mouse embryonic stem cells. Crosses the blood-brain barrier. Inhibitor of human iNOS (NOS II).
Product Specific Literature References
Qinghaosu (artemisinin): an antimalarial drug from China: D.L. Klayman; Science 228, 1049 (1985) Abstract
The chemistry, pharmacology, and clinical applications of qinghaosu (artemisinin) and its derivatives: X.D. Luo & C.C. Shen; Med. Res. Rev. 7, 29 (1987) Abstract
Inhibition of angiogenesis in embryoid bodies by artemisinin: M. Wartenberg, et al.; Pflugers Arch. Eur. J. Physiol. 445, S85 (1994)
Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication: M.A. van Agtmael, et al.; Trends Pharmacol. Sci. 20, 199 (1999), Review Abstract
Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation: E. Aldieri, et al.; FEBS Lett. 552, 141 (2003) Abstract
The antimalaria agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies: M. Wartenberg, et al.; Lab. Invest. 83, 1647 (2003) Abstract
An over four millennium story behind qinghaosu (artemisinin)--a fantastic antimalarial drug from a traditional chinese herb: Y. Li & Y.L. Wu; Curr. Med. Chem. 10, 2197 (2003), Review Abstract
From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements: R.K. Haynes; Curr. Top. Med. Chem. 6, 509 (2006), Review Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • Hypoxia-inducible Factor [HIF]/Related Products • Malaria/Related Products • Natural Products - Nitric Oxide Pathway Modulators • Natural Products for Angiogenesis Research
 
 
ALX-350-294 Revised 16-Jun-08
Manzamine A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-294-M001   1 mg 195.00 USD Add To Cart
Product Specification
FORMULA: C36H44N4O
MW: 548.8
CAS NUMBER: 104196-68-1
SOURCE/HOST: Isolated from Xestospongia sp.
PURITY: >98% (HPLC)
FORMULATION: Yellow oil
SOLUBILITY: Soluble in DMSO, methanol or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
β-Carboline alkaloid with anti-inflammatory, antimalarial, antifungal, anti-HIV-1and insecticidal activity. Also active against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. Inhibits GSK-3. Has native fluorescence, highest when solubilized in methanol (Ex: 340nm, Em: 387nm).
Product Specific Literature References
Four new bioactive manzamine-type alkaloids from the Philippine marine sponge Xestospongia ashmorica: R.A. Edrada, et al.; J. Nat. Prod. 59, 1056 (1996) Abstract
In vivo antimalarial activity of the beta-carboline alkaloid manzamine A: K.K. Ang, et al.; Antimicrob. Agents Chemother. 44, 1645 (2000) Abstract; Full Text
Immune-mediated parasite clearance in mice infected with Plasmodium berghei following treatment with manzamine A: K.K. Ang, et al.; Parasitol. Res. 87, 715 (2001) Abstract
New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge: K.V. Rao, et al.; J. Nat. Prod. 66, 823 (2003) Abstract
Spectrofluorimetric determination of manzamine A in spiked human urine and plasma: A. Khalil, et al.; Pharmazie 58, 385 (2003) Abstract
New manzamine alkaloids from an Indo-Pacific sponge. Pharmacokinetics, oral availability, and the significant activity of several manzamines against HIV-I, AIDS opportunistic infections, and inflammatory diseases: M. Yousaf, et al.; J. Med. Chem. 47, 3512 (2004) Abstract
Antimalarial activity of a new family of analogues of manzamine A: J.D. Winkler, et al.; Org. Lett. 8, 2591 (2006) Abstract
Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer’s disease: M. Hamann, et al.; J. Nat. Prod. 70, 1397 (2007) Abstract
Further Categories Containing This Product:
Malaria/Related Products • Natural Products - Antiviral/anti-HIV Agents • Natural Products with Antibiotic Activity • Natural Products - Antifungal Agents • Alkaloids • Natural Products - Antimalarial Agents • GSK-3 Inhibitors • Pesticides/Related Products
 
 
ALX-550-292 Revised 22-Jan-08
Quinine . hemisulfate
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
Ordering Information
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ALX-550-292-G010   10 g 30.00 USD Add To Cart
Product Specification
FORMULA: C20H24N2O2 . 0.5H2SO4
MW: 324.2 . 49.0
CAS NUMBER: 6119-70-6
MERCK INDEX: 14: 8061
PURITY: ≥91%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Stereoisomer of quinidine (Prod. No. ALX-550-291). Plant alkaloid with a broad spectrum of biological effects including anti-cholinergic, hypoglycemic and antimalarial properties. K+ channel blocker. Flavor component of tonic waters, bitter lemon and vermouth.
Product Specific Literature References
Class I antiarrhythmic agents: quinidine, procainamide and N- acetylprocainamide, disopyramide: D.M. Roden & R.L. Woosley; Pharmacol. Ther. 23, 179 (1983) Abstract
Quinine toxicity: D.N. Bateman & E.H. Dyson; Adverse Drug React. Acute Poisoning Rev. 5, 215 (1986), (Review) Abstract
Quinine-induced hypoglycemia
: P.J. Limburg, et al.; Ann. Intern. Med. 119, 218 (1993) Abstract
Quinine inhibits mitochondrial ATP-regulated potassium channel from bovine heart: P. Bednarczyk, et al.; J. Membr. Biol. 199, 63 (2004) Abstract
The quest for quinine: those who won the battles and those who won the war: T.S. Kaufman & E.A. Ruveda; Angew. Chem. Int. Ed. Engl. 44, 854 (2005) Abstract
Effects of quinine, quinidine, and chloroquine on alpha9alpha10 nicotinic cholinergic receptors: J.A. Ballestero, et al.; Mol. Pharmacol. 68, 822 (2005) Abstract
Artesunate, artemether or quinine in severe Plasmodium falciparum malaria?: A. M. Checkley & C. J. Whitty; Expert. Rev. Anti. Infect. Ther. 5, 199 (2007), (Review) Abstract
Further Categories Containing This Product:
Malaria/Related Products • Cholinergics/Related Products • K+ Channel Blockers & Inhibitors • Natural Products - Antimalarial Agents • Alkaloids
 
 
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