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ALX-385-021

Revised 23-Oct-07

4'-Amino-6-hydroxyflavone
SYNONYMS	Aminogenistein
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavonoids / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-021-M001		1 mg	140.00 USD

Product Specification

FORMULA:	C₁₅H₁₁NO₃
MW:	253.3
PURITY:	≥95%
APPEARANCE:	Yellow powder.
SOLUBILITY:	Soluble in DMSO or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Inhibitor of the p56^lck protein-tyrosine kinase.

Product Specific Literature References

Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogues: M. Cushman, et al.; J. Med. Chem. 34, 798 (1991) Abstract
Expression of p56lck in B-cell neoplasias: A. Von Knethen, et al.; Leuk. Lymphoma 26, 551 (1997) Abstract

Further Categories Containing This Product:

Tyrosine Kinase Inhibitors • Src Family Kinases / Related Products • Kinases in T Cell Signal Transduction / Related Products

ALX-385-008

Revised 13-Mar-08

Apigenin
SYNONYMS	4',5,7-Trihydroxyflavone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavonoids / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-008-M010		10 mg	35.00 USD
ALX-385-008-M050		50 mg	105.00 USD

Product Specification

FORMULA:	C₁₅H₁₀O₅
MW:	270.2
CAS NUMBER:	520-36-5
MERCK INDEX:	14: 730
SOURCE/HOST:	Synthetic.
PURITY:	≥90% (HPLC)
APPEARANCE:	Light yellow to slightly brown powder.
SOLUBILITY:	Soluble in diluted potassium hydroxide or DMSO; slightly soluble in 100% ethanol (hot). Insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	IRRITANT.

Product Description

Antioxidant flavonoid. Has chemopreventive and antitumor properties. Induces apoptosis. Inhibits the proliferation of malignant tumor cells by G2/M arrest. MAP kinase (MAPK/ERK) inhibitor. Inhibits hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression.

Product Specific Literature References

Apigenin and tangeretin enhance gap junctional intercellular communication in rat liver epithelial cells: C. Chaumontet, et al.; Carcinogenesis 15, 2325 (1994) Abstract
Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells: F. Sato, et al.; BBRC 204, 578 (1994) Abstract
Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes: M.L. Kuo and N.C. Yang; BBRC 212, 767 (1995) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Apigenin inhibits endothelial-cell proliferation in G(2)/M phase whereas it stimulates smooth-muscle cells by inhibiting P21 and P27 expression: V. Trochon, et al.; Int. J. Cancer 85, 691 (2000) Abstract
Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma: R. Torkin, et al.; Mol. Cancer Ther. 4, 1 (2005) Abstract
Apigenin and cancer chemoprevention: progress, potential and promise: D. Patel, et al.; Int. J. Oncol. 30, 233 (2007), (Review) Abstract
Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression: J. Fang, et al.; Carcinogenesis 28, 858 (2007) Abstract
Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells: S. Shukla & S. Gupta; Cell Cycle 6, 1102 (2007) Abstract
Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation: C. Nicholas, et al.; J. Immunol. 179, 7121 (2007) Abstract

Further Categories Containing This Product:

MAPK Pathway Inhibitors • Antitumor Agents (Enzyme Inhibitors) • Natural Products for Angiogenesis Research • Hypoxia-inducible Factor [HIF] / Related Products • Natural Products - Protein Kinase Inhibitors • Natural Products - Apoptosis Inducers & Inhibitors • Antitumor Agents (Anti-proliferative) • Natural Products - Antitumor Reagents • Natural Products - Antioxidants

ALX-385-022

Revised 19-Nov-07

Baicalein
SYNONYMS	5,6,7-Trihydroxyflavone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavonoids / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-022-M005		5 mg	25.00 USD
ALX-385-022-M025		25 mg	100.00 USD

Product Specification

FORMULA:	C₁₅H₁₀O₅
MW:	270.2
CAS NUMBER:	491-67-8
MERCK INDEX:	14: 942
PURITY:	≥97%
APPEARANCE:	Yellow to yellow-green crystalline powder.
SOLUBILITY:	Soluble in DMSO, 100% ethanol or methanol; almost insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	IRRITANT.

Product Description

Inhibitor of 12-lipoxygenase, leukotriene biosynthesis and the release of lysosomal enzymes. Inhibits cellular Ca2+ uptake and calcium mobilization. Inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis. Anti-inflammatory compound. Has anti-thrombotic, anti-proliferative and anti-mitogenic effects.

Product Specific Literature References

Specific action of the lipoxygenase pathway in mediating angiotensin II- induced aldosterone synthesis in isolated adrenal glomerulosa cells: J.L. Nadler, et al.; J. Clin. Invest. 80, 1763 (1987) Abstract
Inhibition of reverse transcriptase activity by a flavonoid compound, 5,6,7-trihydroxyflavone: K. Ono, et al.; BBRC 160, 982 (1989) Abstract
Biliary excretion of metabolites of baicalin and baicalein in rats: K. Abe, et al.; Chem. Pharm. Bull. 38, 209 (1990) Abstract
Effects of baicalein and esculetin on transduction signals and growth factors expression in T-lymphoid leukemia cells: H.C. Huang, et al.; Eur. J. Pharmacol. 268, 73 (1994) Abstract
Protective effects of baicalein against cell damage by reactive oxygen species: D. Gao, et al.; Chem. Pharm. Bull. (Tokyo) 46, 1383 (1998) Abstract
Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules
: S.L. Hsu, et al.; Eur. J. Pharmacol. 425, 165 (2001) Abstract
Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes: Y.C. Shen, et al.; Eur. J. Pharmacol. 465, 171 (2003) Abstract
Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells: H.Z. Lee, et al.; Anticancer Res. 25, 959 (2005) Abstract
Biological properties of baicalein in cardiovascular system: Y. Huang, et al.; Curr. Drug Targets Cardiovasc. Haematol. Disord. 5, 177 (2005), (Review) Abstract
Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression: H.Y. Lin, et al.; Biochim. Biophys. Acta 1773, 1073 (2007) Abstract

Further Categories Containing This Product:

Leukotrienes Other Products • Natural Products for Angiogenesis Research • Tyrosine Kinase Inhibitors • Natural Products - Protein Kinase Inhibitors • Natural Products - Antiviral / anti-HIV Agents • Lipoxygenases / Related Products • Cell Cycle Blockers & Inhibitors / Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Anti-inflammatory Agents • Natural Products for Cell Cycle Research • Natural Products - Antioxidants

ALX-350-147

Revised 03-Oct-07

Bavachin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-147-MC05		0.5 mg	120.00 USD

Product Specification

FORMULA:	C₂₀H₂₀O₄
MW:	324.4
CAS NUMBER:	19879-32-4
SOURCE/HOST:	Isolated from plant Psoralea corylifolia.
PURITY:	≥97% (HPLC)
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
IDENTITY:	Determined by ¹H-NMR, ¹³C-NMR and MS.

Product Description

Weak antioxidant. Antimutagenic. Stimulates bone formation and has potential activity against osteoporosis. Shows inhibitory activities against the antigen-induced degranulation and weak estrogen-like activity.

Product Specific Literature References

Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod. 59, 671 (1996) Abstract
Osteoblastic proliferation stimulating activity of Psoralea corylifolia extracts and two of its flavonoids: D. Wang, et al.; Planta Med. 67, 748 (2001) Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002) Abstract
Bioactive constituents from Chinese natural medicines. XX. Inhibitors of antigen-induced degranulation in RBL-2H3 cells from the seeds of Psoralea corylifolia: H. Matsuda, et al.; Chem. Pharm. Bull. (Tokyo) 55, 106 (2007) Abstract
Synthesis of four natural prenylflavonoids and their estrogen-like activities: X. Dong, et al.; Arch. Pharm. (Weinheim) 340, 372 (2007) Abstract

Further Categories Containing This Product:

Estrogen & Estrogen Receptors / Related Products • Bone Metabolism Other Products • Flavonoids / Related Products • Natural Products - Immunomodulators

ALX-385-029

Revised 08-Apr-08

4’-Bromoflavone
SYNONYMS	4’-Bromo-2-phenylbenzopyran 4’-Bromo-2-phenyl-4H-1-benzopyran-4-one
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavonoids / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-029-G001		1 g	90.00 USD

Product Specification

FORMULA:	C₁₅H₉BrO₂
MW:	301.1
SOURCE/HOST:	Synthetic.
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	IRRITANT.

Product Description

Chemopreventive compound. Potent inducer of phase II detoxifying enzymes. Quininone reductase and glutathione S-transferase in cell culture and different tissues of rats. Aryl hydrocarbon hydroxylase inducer.

Product Specific Literature References

Simple vs. complex inheritance of inducible aryl hydrocarbon hydroxylase in mouse tissues: K. Burki, et al.; Biochem. Genet. 13, 417 (1975) Abstract
Cancer chemopreventive activity mediated by 4’-bromoflavone, a potent inducer of phase II detoxification enzymes: L.L. Song, et al.; Cancer Res. 59, 578 (1999) Abstract

Further Categories Containing This Product:

Respiratory Chain Other Products • Natural Products - Chemopreventive Agents

ALX-350-246

Revised 07-Mar-08

Butein
SYNONYMS	2',3,4,4'-Tetrahydroxychalcone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Protein Kinase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-246-M010		10 mg	190.00 USD

Product Specification

FORMULA:	C₁₅H₁₂O₅
MW:	272.3
CAS NUMBER:	487-52-5
PURITY:	≥98% (HPLC)
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in DMSO (>50mg/ml) or methanol; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light. Keep cool and dry under inert gas.
IDENTITY:	Identity determined by ¹H-NMR, ¹³C-NMR and MS.

Product Description

Plant polyphenol that acts as a specific tyrosine kinase inhibitor. Potently inhibits the tyrosine kinase activity of the EGF receptor and p60^c-^src. Potent antioxidant and anti-inflammatory agent. Inhibits glutathione reductase and rat liver glutathione S-transferase. Activator of human deacetylase SIRT1. Inhibits aromatase, showing chemopreventive properties. Directly inhibits IKK.

Product Specific Literature References

Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects: E. Aizu, et al.; Carcinogenesis 7, 1809 (1986) Abstract
Protective effects of hydroxychalcones on free radical-induced cell damage: S. Sogawa, et al.; Biol. Pharm. Bull. 17, 251 (1994) Abstract
Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation: C.C. Yit & N.P. Das; Cancer Lett. 82, 65 (1994) Abstract
Inhibitory effects of plant polyphenols on rat liver glutathione S-transferase: K. Zhang & N.P. Das; Biochem. Pharmacol. 47, 2063 (1994) Abstract
Endothelium-dependent relaxation of rat aorta by butein, a novel cyclic AMP-specific phosphodiesterase inhibitor: S.M. Yu, et al.; Eur. J. Pharmacol. 280, 69 (1995) Abstract
Butein (3,4,2',4'-tetrahydroxychalcone) ameliorates experimantal anti-glomerular basement membrane antibody-associated glomerulonephritis (3): K. Hayashi, et al.; Eur. J. Pharmacol. 316, 297 (1996) Abstract
Inhibition of glutathione reductase by plant polyphenols: K. Zhang, et al.; Biochem. Pharmacol 54, 1047 (1997) Abstract
Butein, a specific protein tyrosine kinase inhibitor: E.-B. Yang, et al.; BBRC 245, 435 (1998) Abstract
Antioxidant properties of butein isolated from Dalbergia odorifera: Z.J. Cheng, et al.; Biochim. Biophys. Acta 1392, 291 (1998) Abstract
Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells: K. Iwashita, et al.; Biosci. Biotechnol. Biochem. 64, 1813 (2000) Abstract
Butein, a plant polyphenol, induces apoptosis concomitant with increased caspase-3 activity, decreased Bcl-2 expression and increased Bax expression in HL-60 cells: N.Y. Kim, et al.; Pharmacol. Toxicol. 88, 261 (2001) Abstract
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature 425, 191 (2003) Abstract
The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase: Y. Wang, et al.; Life Sci. 77, 39 (2005) Abstract
Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue: M.K. Pandey, et al.; J. Biol. Chem. 282, 17340 (2007) Abstract

Further Categories Containing This Product:

Tyrosine Kinase Inhibitors • Natural Products - Anti-inflammatory Agents • Phosphodiesterases / Related Products • EGFR Kinase Inhibitors • Glutathione / Related Products • Glutathione S-Transferase • Natural Products - Chemopreventive Agents • IkB Kinases [IKKs] / Related Products • Natural Products - Antioxidants • Flavonoids / Related Products

ALX-385-017

Revised 01-Apr-08

(+)-Catechin . monohydrate
SYNONYMS	(+)-3,3',4',5,7-Flavanpentol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-017-G001		1 g	20.00 USD

Product Specification

FORMULA:	C₁₅H₁₄O₆ . H₂O
MW:	290.3 . 18.0
CAS NUMBER:	88191-48-4, 225937-10-0
MERCK INDEX:	14: 1902
PURITY:	≥98% (TLC)
APPEARANCE:	Off-white to yellow powder.
SOLUBILITY:	Soluble in 100% ethanol (50mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	IRRITANT.

Product Description

Antioxidant flavonoid. Free radical scavenger. Has chemopreventive and antitumor properties.

Product Specific Literature References

Adjuvant chemoprevention of experimental cancer: catechin and dietary turmeric in forestomach and oral cancer models: M.A. Azuine & S.V. Bhide; J. Ethnopharmacol. 44, 211 (1994) Abstract
Chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products: S.V. Bhide, et al.; Breast Cancer Res. Treat. 30, 233 (1994) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Flavonoids as anticancer agents: structure-activity relationship study: M. Lopez-Lazaro; Curr. Med. Chem. Anticancer Agents 2, 691 (2002), (Review) Abstract
In vitro biological properties of flavonoid conjugates found in vivo: G. Williamson, et al.; Free Radic. Res. 39, 457 (2005), (Review) Abstract
(+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation: W.B. Wu, et al.; Life Sci. 79, 801 (2006) Abstract
Antispasmodic, bronchodilator and vasodilator activities of (+)-catechin, a naturally occurring flavonoid: M.N. Ghayur, et al.; Arch. Pharm. Res. 30, 970 (2007) Abstract

Further Categories Containing This Product:

Free Radical Scavengers • Active Substances from Fruit and Vegetables • Flavonoids / Related Products • Natural Products - Antitumor Reagents • Natural Products - Chemopreventive Agents

ALX-385-002

Revised 19-Nov-07

(±)-Catechin
SYNONYMS	(±)-3,3',4',5,7-Flavanpentol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-002-G001		1 g	80.00 USD

Product Specification

FORMULA:	C₁₅H₁₄O₆
MW:	290.3 (anhydrous basis)
CAS NUMBER:	7295-85-4
MERCK INDEX:	14: 1902
PURITY:	≥98% (HPLC)
APPEARANCE:	White to yellow powder.
SOLUBILITY:	Soluble in methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HAZARD:	IRRITANT.

Product Description

Antioxidant flavonoid. Free radical scavenger. Has chemopreventive and antitumor properties.

Product Specific Literature References

Further Categories Containing This Product:

Active Substances from Fruit and Vegetables • Free Radical Scavengers • Natural Products - Antitumor Reagents • Natural Products - Chemopreventive Agents • Flavonoids / Related Products

ALX-385-009

Revised 03-Apr-08

Chrysin
SYNONYMS	5,7-Dihydroxyflavone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavonoids / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-009-G001		1 g	15.00 USD

Product Specification

FORMULA:	C₁₅H₁₀O₄
MW:	254.2
CAS NUMBER:	480-40-0
MERCK INDEX:	14: 2256
RTECS:	LK8329050
PURITY:	≥96%
APPEARANCE:	Yellow to tan solid.
SOLUBILITY:	Soluble in pyridine or alkaline solutions; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C

Product Description

Antioxidant flavonoid. Shows anti-inflammatory and antitumor properties. Inhibits hypoxia-inducible factor-1α (HIF-1α). Induces apoptosis.

Product Specific Literature References

Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells: K.J. Woo, et al.; Biochem. Biophys. Res. Commun. 325, 1215 (2004) Abstract
Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: involvement of p38 mitogen-activated protein kinase: M.S. Weng, et al.; Biochem. Pharmacol. 69, 1815 (2005) Abstract
Dietary flavonoids: effects on xenobiotic and carcinogen metabolism:: Y.J. Moon, et