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Stress & Heat Shock Proteins
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AG-CC06H2 Revised 11-Jan-08
Clusterin (human) Competitive ELISA Kit
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SYNONYMS TRPM-2 (human) Competitive ELISA Kit
Apolipoprotein J (human) Competitive ELISA Kit
APO-J (human) Competitive ELISA Kit
CLI (human) Competitive ELISA Kit
CLU (human) Competitive ELISA Kit
SGP-2 (human) Competitive ELISA Kit
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Clusterin / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
AG-CC06H2EK-KI01   96 wells 550.00 USD Add To Cart
AG-CC06H2TP-KI01 Twin Plex 2x96 wells 890.00 USD Add To Cart
AG-CC06H2PP-KI01 Penta Plex 5x96 wells 1'870.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 1ng/ml
APPLICATION: For the quantitative determination of clusterin in human serum, plasma or cell culture supernatant.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-151-026 Revised 20-Jun-08
N-Acetyl-Asp-Tyr(2-malonyl)-Val-Pro-Met-Leu-NH2
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrosine Kinase Inhibitors
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ALX-151-026-M001   1 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C39H57N7O14S
MW: 880.0
PURITY: ≥96% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (1mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Peptide is very unstable.
Product Description
Peptide containing a phosphotyrosyl mimetic. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.
Product Specific Literature References
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides: B. Ye, et al.; J. Med. Chem. 38, 4270 (1995) Abstract
Further Categories Containing This Product:
Peptides • Phosphoinositide 3-kinase [PI(3)K] / Related Products
 
 
ALX-151-027 Revised 17-Jan-05
N-Acetyl-Asp-Tyr(PO3H2)-Val-Pro-Met-Leu-NH2
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrosine Kinase Inhibitors
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ALX-151-027-M001   1 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C36H57N7O13SP
MW: 858.9
PURITY: ≥96%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Phosphotyrosine containing peptide. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.
Product Specific Literature References
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides: B. Ye, et al.; J. Med. Chem. 38, 4270 (1995) Abstract
Further Categories Containing This Product:
Peptides • Phosphoinositide 3-kinase [PI(3)K] / Related Products
 
 
ALX-159-600 Revised 14-Jul-08
JNK Inhibitor 1 (L-stereoisomer)
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SYNONYMS L-JNKI1
c-Jun N-terminal Kinase Peptide Inhibitor 1, L-stereoisomer
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY JNK [SAPK1] / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-159-600-R100   100 µl 125.00 USD Add To Cart
ALX-159-600-R200   200 µl 225.00 USD Add To Cart
Product Specification
SEQUENCE: GRKKRRQRRR-PP-RPKRPTTLNLFPQVPRSQD-amide
FORMULA: C164H286N66O40
MW: 3822.5
CONCENTRATION: 1mM
PURITY: ≥97% (HPLC)
FORMULATION: Liquid. Sterile, ready-to-use solution in PBS.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Keep on ice at all times.
POSITIVE CONTROL: Prod. No. ALX-168-009/1
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Product Description

Cell permeable JNK (c-Jun N-terminal kinase) inhibitor. For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter. Neuroprotective agent for stroke.
Product Specific Literature References
[1] Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death: C. Bonny, et al.; Diabetes 50, 77 (2001) Abstract; Full Text
Hyperosmolarity and CD95L trigger CD95/EGF receptor association and tyrosine phosphorylation of CD95 as prerequisites for CD95 membrane trafficking and DISC formation: R. Reinehr, et al.; FASEB J. 17, 731 (2003) Abstract
Translation inhibitors sensitize prostate cancer cells to TRAIL-induced apoptosis by activating c-Jun N-terminal kinase: N.K. Sah, et al.; J. Biol. Chem. 278, 20593 (2003) Abstract; Full Text
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia: T. Borsello, et al.; Nat. Med. 9, 1180 (2003) Abstract
Activation of JNK in sensory neurons protects against sensory neuron cell death in diabetes and on exposure to glucose/oxidative stress in vitro: S.A. Price, et al.; Ann. NY Acad. Sci. 1010, 95 (2003)
Insulin-secreting beta-cell dysfunction induced by human lipoproteins: M.E. Roehrich, et al.; J. Biol. Chem. 278, 18368 (2003) Abstract; Full Text
Inhibition of c-Jun NH2-terminal kinase activity improves ischemia/reperfusion injury in rat lungs: M. Ishii, et al.; J. Immunol. 172, 2569 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION A protein inhibitor named IB1 has been described that competitively blocks the interaction between JNK and c-Jun, thereby inhibiting the signalling events downstream of JNK [2,3] like c-Jun, ATF2 and ELK1 phosphorylation. To convert IB1 into cell-permeable inhibitors of JNK (JNKI peptides) the minimal 20 aa inhibitory sequence of IB1 was covalently linked to the 10 amino acids recognized by TAT transporter [4].
The L-JNKI1 and the protease resistant D-JNKI1 peptides represent the only potent inhibitors that are specific for JNK (JNK1, JNK2 and JNK3). Different from chemical inhibitors that directly affect kinase activity e.g. by competing with the ATP-binding site of the protein kinase, JNKI1 rather inhibits the interaction between JNK and its substrate, resulting in a JNK K.O. phenotype. In contrast to pure diffusion the TAT-peptides are actively transported into cells, where they remain until their proteolytic degradation. They can be used for in vitro as well as for in vivo applications (IC50~1µM).
D-JNKI1 is the only form found to be active on neuronal cells, probably due to a high level of proteolytic degradation of the L-stereoisomer (T. Borsello and C. Bonny; unpublished data). As these peptides tend to be toxic in neurons above concentrations of 5µM, it is recommended to use concentrations of ~1µM or less. When interpreting results of c-Jun inhibition, one should also note that a number of other c-Jun kinases are thought to contribute to c-Jun phosphorylation (C. Bonny, personal communication).

*For in vivo applications in mice it is suggested to start with 30-50µl of a 1mM stock solution administered intraperitoneally. Cellular uptake of L-JNKI1 peptides can now be confirmed using the FITC-conjugated L-TAT control peptide (Prod. No. ALX-168-009F).
Note: L-TAT control peptides should only be used with L-JNKI1.
General Literature References
[2] IB1, a JIP-1-related nuclear protein present in insulin-secreting cells: C. Bonny, et al.; J. Biol. Chem. 273, 1843 (1998) Abstract; Full Text
[3] A cytoplasmic inhibitor of the JNK signal transduction pathway: M. Dickens, et al.; Science 277, 693 (1997) Abstract
[4] In vivo protein transduction: delivery of a biologically active protein into the mouse: S.R. Schwarze, et al.; Science 285, 1569 (1999) Abstract
Related Products
Further Categories Containing This Product:
MAPK Pathway Inhibitors • Peptides
 
 
ALX-168-009/1 Revised 07-Nov-08 New product
L-TAT Control Peptide (for Prod. No. ALX-159-600)
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SYNONYMS JNK Inhibitor 1 (L-stereoisomer) Control Peptide (for Prod. No. ALX-159-600)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY JNK [SAPK1] / Related Products
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ALX-168-009/1-R050   50 µl 40.00 USD Add To Cart
Product Specification
SEQUENCE: GRKKRRQRRR-amide
FORMULA: C55H109N31O12
MW: 1396.6
CONCENTRATION: 1mM
PURITY: ≥95% (HPLC)
FORMULATION: Liquid. Sterile solution in PBS.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C. Keep on ice at all times.
Product Description
Control peptide for L-JNKI. For more details see L-JNKI1 (Prod.No. ALX-159-600).
Product Specific Literature References
Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death: C. Bonny, et al.; Diabetes 50, 77 (2001) Abstract; Full Text
Hyperosmolarity and CD95L trigger CD95/EGF receptor association and tyrosine phosphorylation of CD95 as prerequisites for CD95 membrane trafficking and DISC formation: R. Reinehr, et al.; FASEB J. 17, 731 (2003) Abstract; Full Text
Related Products
Further Categories Containing This Product:
Peptides
 
 
ALX-168-009F Revised 28-Jul-08 New product
L-TAT Control Peptide (for Prod. No. ALX-159-600) (FITC)
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SYNONYMS JNK Inhibitor 1 (L-stereoisomer) Control Peptide (for Prod. No. ALX-159-600) (FITC)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY JNK [SAPK1] / Related Products
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ALX-168-009F-R050 FITC 50 µl 110.00 USD Add To Cart
Product Specification
SEQUENCE: FITC-β-A-RKKRRQRRRA-amide
FORMULA: C80H128N34O17S
MW: 1870.2
CONCENTRATION: 1mM
PURITY: ≥90% (HPLC)
FORMULATION: Liquid. In sterile PBS.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. Keep on ice at all times.
Product Description
Control peptide for L-JNKI. For more details see L-JNKI1 (Prod.No. ALX-159-600).
Product Specific Literature References
Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death: C. Bonny, et al.; Diabetes 50, 77 (2001) Abstract; Full Text
Hyperosmolarity and CD95L trigger CD95/EGF receptor association and tyrosine phosphorylation of CD95 as prerequisites for CD95 membrane trafficking and DISC formation: R. Reinehr, et al.; FASEB J. 17, 731 (2003) Abstract; Full Text
Related Products
Further Categories Containing This Product:
Peptides
 
 
ALX-168-010 Revised 14-Aug-06
D-TAT Control Peptide (for Prod. No. ALX-159-601)
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SYNONYMS JNK Inhibitor 1 (D-stereoisomer) Control Peptide (for Prod. No. ALX-159-601)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY JNK [SAPK1] / Related Products
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ALX-168-010-R025   25 µl 95.00 USD Add To Cart
ALX-168-010F-R025 FITC 25 µl 145.00 USD Add To Cart
Product Specification
SEQUENCE: Unconjugated peptide: rrrqrrkkr-amide
FITC-conjugated peptide: FITC-β-a-rkkrrqrrra-amide
FORMULA: Unconjugated peptide: C53H107N31O10
FITC-conjugated peptide: C80H128N34O17S
MW: Unconjugated peptide: 1338.6
FITC-conjugated peptide: 1870.2
CONCENTRATION: 1mM
PURITY: ≥95% (HPLC)
FORMULATION: Liquid. In sterile PBS.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Protect from moisture. Avoid freeze/thaw cycles. Keep on ice at all times.
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Product Description
Control peptide for D-JNKI. For more details see JNK Inhibitor 1 (D-stereoisomer) (Prod. No. ALX-159-601).
Product Specific Literature References
Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death: C. Bonny, et al.; Diabetes 50, 77 (2001) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Note: D-TAT consists of D-amino acids. The sequence of unconjugated D-TAT is retro-inverse compared to L-TAT.
Further Categories Containing This Product:
Peptides
 
 
ALX-201-023 Revised 06-Aug-07
Cyclophilin A (human) (recombinant)
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SYNONYMS CyPA (human) (recombinant)
Peptidyl-prolyl cis-trans Isomerase A (human) (recombinant)
PRODUCT LINE Immunology
PRODUCT CATEGORY Immunophilins / Related Products
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ALX-201-023-C100   100 µg 586.00 USD Add To Cart
Product Specification
MW: ~18kDa.
EC: 5.2.1.8
SOURCE/HOST: Produced in E. coli.
CONCENTRATION:  
PURITY: ≥90%
FORMULATION: Liquid. In 20mM TRIS-HCl, pH 7.8.
BIOLOGICAL ACTIVITY: Catalyzes cis-trans-isomerization of X-Pro-peptide bonds. Accelerates protein folding reactions that are limited by the isomerization of X-Pro-peptide bonds.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P05092: Cyclophilin A (human)
AfCS Signalling Gateway link A000735: Cyclophilin A (mouse)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-024 Revised 24-Feb-05
HSF1 (human) (recombinant)
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SYNONYMS Heat Shock Factor 1 (human) (recombinant)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY Stress & Heat Shock Proteins Other Products
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ALX-201-024-C150   150 µg 343.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli.
FORMULATION: Liquid. Sonicated E. coli extract at a total protein concentration of 6mg/ml in 25mM HEPES, pH 7.9, 12.5mM MgCl, 0.1mM EDTA, 10% glycerol, 1mM DTT, 0.1% NP-40 and 300mM KCl and protease inhibitors.
APPLICATION: Positive control in gel shift assays (25 tests) or Western blot (50 tests) with PAb to HSF1 (Prod. No. ALX-210-129). DNase I footprinting and in vitro transcription assays.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -20°C
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q00613: HSF 1 (human)
Further Categories Containing This Product:
Transcription Factors Other Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-201-055 Revised 17-Apr-07
Phosphoinositide 3-kinase p110γ (human) (recombinant)
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SYNONYMS PI(3)K p110γ (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphoinositide 3-kinase [PI(3)K] / Related Products
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ALX-201-055-C010   10 µg 330.00 USD Add To Cart
Product Specification
EC: 2.7.1.137
SOURCE/HOST: Produced in Sf9 cells. Full length PI(3)K p110γ (human phosphoinositide-3-kinase p110γ) is fused at the N-terminus to a His-tag.
CONCENTRATION: 1mg/ml  
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 10mM HEPES, pH 7.5, containing 100mM sodium chloride, 0.5mM magnesium chloride and 50% glycerol.
SPECIFIC ACTIVITY: ~4.5nmol/mg/min using phosphatidylinositol as the substrate (lipid kinase activity test).
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -20°C
Product Specific Literature References
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase: B. Stoyanov, et al.; Science 269, 690 (1995) Abstract
Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma: M. Lopez-Ilasaca, et al.; Science 275, 394 (1997) Abstract
Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase gamma: structure-activity analysis and interactions with wortmannin: S. Stoyanova, et al.; Biochem. J. 324, 489 (1997) Abstract; Full Text
Gbetagamma stimulates phosphoinositide 3-kinase-gamma by direct interaction with two domains of the catalytic p110 subuni: D. Leopoldt, et al.; J. Biol. Chem. 273, 7024 (1998) Abstract; Full Text
General Information