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ALX-163-011
Revised 14-Jul-08
NBD Peptide / NF-κB Blocker (cell permeable)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Pathway Inhibitors
Ordering Information
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ALX-163-011-1
1 Vial
240.00 USD
Product Specification
SEQUENCE:
GRKKRRQRRR-GG-TALDWSWLQTE-amide
FORMULA:
C
121
H
202
N
48
O
32
MW:
2841.2
QUANTITY:
50µl
CONCENTRATION:
10mM
PURITY:
≥95% (HPLC)
FORMULATION:
Liquid. In sterile PBS.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
-20°C
LONG TERM STORAGE:
-80°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Protect from moisture. Keep on ice at all times.
POSITIVE CONTROL:
Prod. No.
ALX-168-009/1
Product Description
For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.
Product Specific Literature References
Selective inhibition of NF-kappaB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo:
E. Jimi, et al.; Nature Med.
10
, 617 (2004)
Abstract
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex:
M.J. May, et al.; Science
289
, 1550 (2000)
Abstract
Characterization of the Ikappa B-kinase NEMO binding domain:
M.J. May, et al.; J. Biol. Chem.
277
, 45992 (2002)
Abstract
Related Products
ALX-168-009/1
L-TAT Control Peptide (for Prod. No.
ALX-159-600
)
Further Categories Containing This Product:
Peptides
ALX-167-024
Revised 17-May-06
SN50
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Pathway Inhibitors
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ALX-167-024-C500
500 µg
125.00 USD
Product Specification
SEQUENCE:
H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
FORMULA:
C
129
H
230
N
36
O
29
S
MW:
2781.5
PEPTIDE CONTENT:
50-75%
PURITY:
≥96% (HPLC)
APPEARANCE:
White to off-white solid.
FORMULATION:
Counter Ion:
Trifluoroacetate salt.
SOLUBILITY:
Soluble in distilled water, 100% ethanol or ethanol:water 1:1.
RECONSTITUTION:
Reconstitute in sterile distilled water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Peptides in solution have limited stability.
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Description
Inhibits translocation of the NF-κB active complex into the nucleus. In mouse endothelial LE-II cells induced with LPS, inhibition of NF-κB nuclear translocation was 88% at 50µg/ml (18µM). In human monocytic THP-1 cells induced by LPS or TNF-α there was 85% inhibition at 100µg/ml.
For control peptide, see SN50M (Prod. No.
ALX-167-025
).
Product Specific Literature References
Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence:
Y.Z. Lin, et al.; J. Biol. Chem.
270
, 14255 (1995)
Abstract
;
Full Text
p38 MAP kinase and MKK-1 co-operate in the generation of GM-CSF from LPS-stimulated human monocytes by an NF-kappa B-independent mechanism:
K.K. Meja, et al.; Br. J. Pharmacol.
131
, 1143 (2000)
Abstract
Nuclear factor-kappaB activates dual inhibition sites in the regulation of tumor necrosis factor-alpha-induced neutrophil apoptosis:
M. Niwa, et al.; Eur. J. Pharmacol
407
, 211 (2000)
Abstract
Activation of nuclear factor kappaB and induction of apoptosis by tumor necrosis factor-alpha in the mouse uterine epithelial WEG-1 cell line:
S. Pampfer, et al.; Biol. Reprod.
63
, 879 (2000)
Abstract
Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells
:
Y. Dai, et al.; Blood
103
, 2761 (2004)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Nuclear localization sequence (NLS) aa 360-369 (AAVALLPAVLLALLAPVQRKRQKLMP) of the transcription factor NF-κB p50 linked to a peptide cell-permeablization sequence, the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF).
Further Categories Containing This Product:
Nuclear Envelope & Nuclear Transport
•
Peptides
ALX-167-025
Revised 17-May-06
SN50M Control Peptide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Pathway Inhibitors
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ALX-167-025-C500
500 µg
125.00 USD
Product Specification
SEQUENCE:
H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Pro-Val-Gln-Arg-Asn-Gly-Gln-Lys-Leu-Met-Pro-OH
FORMULA:
C
123
H
215
N
33
O
30
S
MW:
2668.4
PEPTIDE CONTENT:
70-90%
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white solid.
FORMULATION:
Counter Ion:
Trifluoroacetate salt.
SOLUBILITY:
Soluble in water.
RECONSTITUTION:
Reconstitute in sterile distilled water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Peptides in solution have limited stability.
HANDLING:
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Description
Inactive control peptide for SN50 (Prod. No.
ALX-167-024
). In mouse endothelial LE-II cells, induced with LPS, 50µg/ml SN50M had no measurable effect on NF-κB translocation. In human monocytic THP-1 cells induced by LPS or TNF-α there was slight inhibition at 100µg/ml.
Product Specific Literature References
Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
:
Y.Z. Lin, et al.; J. Biol. Chem.
270
, 14255 (1995)
Abstract
;
Full Text
Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells
:
Y. Dai, et al.; Blood
103
, 2761 (2004)
Abstract
Further Categories Containing This Product:
Nuclear Envelope & Nuclear Transport
•
Peptides
ALX-210-939
Revised 11-May-07
Polyclonal Antibody to ZUD (AT116)
SYNONYMS
anti-ZU5 and Death Domain-containing Inhibitor of NF-κB PAb (AT116)
anti-Unc-5 Homolog C
(C. elegans)
-like PAb (AT116)
anti-UNC5CL PAb (AT116)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Netrins & Receptors/Related Products
Ordering Information
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ALX-210-939-C100
100 µg
380.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein A-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human ZUD domain (aa 402-518).
SPECIFICITY:
Recognizes human and mouse ZUD.
APPLICATION:
Immunocytochemistry (1:100)
Immunoprecipitation (1:200)
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
ZUD is cytoplasmic protein with a ZU5 and death domain. It interacts with the NF-κB subunit p105 and transactivator p65 and inhibits NF-κB -dependent transcription when its overexpressed. ZUD seems to be a inhibitor of NF-κB signalling, and enhance cell death to apoptotic stimuli like TNF and TRAIL.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB:
J. Zhang, et al.; J. Biol. Chem.
279
, 17819 (2004)
Abstract
;
Full Text
Further Categories Containing This Product:
TNF & TNF Receptor Superfamily Other Products
•
TRAIL & TRAIL Receptors Other Products
•
Polyclonal Antibodies
•
NF-kB Pathway Inhibitors
ALX-260-092
Revised 05-Jun-08
MG-132
SYNONYMS
Z-LLL-CHO
Z-Leu-Leu-Leu-CHO
PRODUCT LINE
Ubiquitin & Proteasome
PRODUCT CATEGORY
Proteasome/Related Products
Ordering Information
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ALX-260-092-M001
1 mg
25.00 USD
ALX-260-092-M005
5 mg
60.00 USD
Product Specification
SEQUENCE:
Z-Leu-Leu-Leu-CHO
FORMULA:
C
26
H
41
N
3
O
5
MW:
475.6
CAS NUMBER:
133407-82-6
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
IDENTITY:
Identity determined by MS.
Product Description
Potent, reversible and cell permeable proteasome inhibitor. Inhibits NF-κB activation.
Product Specific Literature References
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules:
K.L. Rock, et al.; Cell
78
, 761 (1994)
Abstract
Multiple proteolytic systems, including the proteasome, contribute to CFTR processing:
T.J. Jensen, et al.; Cell
83
, 129 (1995)
Abstract
The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression:
M.A. Read, et al.; Immunity
2
, 493 (1995)
Abstract
Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in
Saccharomyces cerevisiae
:
D.H. Lee and A.L. Goldberg; J. Biol. Chem.
271
, 27280 (1996)
Abstract
;
Full Text
The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol:
E.J. Wiertz, et al.; Cell
84
, 769 (1996)
Abstract
Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis:
A.B. Meriin, et al.; J. Biol. Chem.
273
, 6373 (1998)
Abstract
;
Full Text
Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIalpha expression:
L. Salmena, et al.; Biochem. Pharmacol.
61
, 795 (2001)
Abstract
Further Categories Containing This Product:
NF-kB Pathway Inhibitors
ALX-260-166
Revised 07-Apr-08
Z-VRPR-FMK
SYNONYMS
Z-Val-Arg-Pro-DL-Arg-FMK . TFA
MALT1 Inhibitor
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
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ALX-260-166-MC05
0.5 mg
280.00 USD
ALX-260-166-M001
1 mg
520.00 USD
Product Specification
SEQUENCE:
Z-Val-Arg-Pro-DL-Arg-fluoromethylketone
FORMULA:
C
31
H
49
FN
10
O
6
. C
2
HF
3
O
2
MW:
676.8 . 114.0
PURITY:
≥90% (HPLC)
APPEARANCE:
White to slightly yellow powder.
SOLUBILITY:
Soluble in water (1mg/ml).
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Description
Inhibits the proteolytic activity of the paracaspase MALT1. MALT1 impairs TCR-induced activation of NF-κB and production of IL-2. It does not affect viability or morphology of cells. The proteolytic activity of MALT1 is key to T cell activation.
Product Specific Literature References
The proteolytic activity of the paracaspase MALT1 is key in T cell activation:
F. Rebeaud, et al.; Nat. Immunol.
9
, 272 (2008)
Abstract
Further Categories Containing This Product:
T Cell Signalling Other Products
•
NF-kB Pathway Inhibitors
ALX-270-219
Revised 15-May-07
BAY 11-7082
SYNONYMS
(E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Pathway Inhibitors
Ordering Information
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ALX-270-219-M010
10 mg
55.00 USD
Product Specification
FORMULA:
C
10
H
9
NO
2
S
MW:
207.3
CAS NUMBER:
195462-67-7
PURITY:
≥99%
SOLUBILITY:
Soluble in DMSO, 100% ethanol, methanol or methylene dichloride; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Keep under inert gas.
Product Description
Inhibitor of cytokine induced IκBα phosphorylation resulting thereby in a decreased expression of NF-κB and adhesion molecules. Potential anti-inflammatory agent.
Product Specific Literature References
Novel inhibitor of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo:
J.W. Pierce, et al.; J. Biol. Chem.
272
, 21096 (1997)
Abstract
;
Full Text
Inhibition of NF-kappaB induces apoptosis of KSHV-infected primary effusion lymphoma cells:
S.A. Keller, et al.; Blood
96
, 2537 (2000)
Abstract
Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha- induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways:
M.M. Remacle-Bonnet, et al.; Cancer Res.
60
, 2007 (2000)
Abstract
Up-regulation of multidrug resistance P-glycoprotein via nuclear factor- kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis:
F. Thevenod, et al.; J. Biol. Chem.
275
, 1887 (2000)
Abstract
;
Full Text
Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E:
V. Petegnief, et al.; Neuroscience
104
, 223 (2001)
Abstract
Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death:
T.M. Kauppinen & R.A. Swanson; J. Immunol.
174
, 2288 (2005)
Abstract
;
Full Text
Further Categories Containing This Product:
Anti-inflammatory Agents Other Products
ALX-270-220
Revised 04-Nov-05
BAY 11-7085
SYNONYMS
(E)-3-(
t
-Butylphenylsulfonyl)-2-propenenitrile
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Pathway Inhibitors
Ordering Information
Product Numbers:
Format:
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ALX-270-220-M010
10 mg
60.00 USD
Product Specification
FORMULA:
C
13
H
15
NO
2
S
MW:
249.3
CAS NUMBER:
196309-76-9
PURITY:
≥98%
APPEARANCE:
White to off-white crystalline powder.
SOLUBILITY:
Soluble in DMSO or ethanol; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Keep under inert gas.
Product Description
Has biological properties very similar to those of BAY 11-7082 (Prod. No.
ALX-270-219
). In addition, the product exhibits potent anti-inflammatory properties
in vivo
.
Product Specific Literature References
Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo
:
J.W. Pierce, et al.; J. Biol. Chem.
272
, 21096 (1997)
Abstract
;
Full Text
Pharmacologic interference with NF-kappaB activation attenuates central nervous system complications in experimental Pneumococcal meningitis:
U. Koedel, et al.; J. Infect Dis.
182
, 1437 (2000)
Abstract
Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E:
V. Petegnief, et al.; Neuroscience
104
, 223 (2001)
Abstract
Further Categories Containing This Product:
Anti-inflammatory Agents Other Products
ALX-270-244
Revised 03-Apr-08
Caffeic acid phenylethyl ester
SYNONYMS
CAPE
Phenethyl caffeiate
Caffeic acid phenethyl ester
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Anti-inflammatory Agents
Ordering Information
Product Numbers:
Format:
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Unit Price:
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ALX-270-244-M010
10 mg
20.00 USD
ALX-270-244-M050
50 mg
60.00 USD
Product Specification
FORMULA:
C
17
H
16
O
4
MW:
284.3
CAS NUMBER:
115610-29-2
SOURCE/HOST:
Synthetic.
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in DMSO, 100% ethanol, methanol, acetone or acetonitrile; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least one year after receipt when stored at –20°C.
HANDLING:
Protect from light and moisture.
HAZARD:
IRRITANT.
Product Description
Active component of propolis from honeybee hives, known to have anti-mitogenic, anti-carcinogenic, anti-inflammatory, and immunomodulatory properties. Potent and specific inhibitor of NF-κB activation, induced by TNF-α
(Prod. No.
ALX-522-008
(human) or Prod. No.
ALX-522-009
(mouse)), PMA (Prod. No.
ALX-445-004
) and other inflammatory agents. Exhibits inhibitory activity against HIV-1 integrase (IC
50
=7µM). Suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities. Induces apoptosis.
Product Specific Literature References
Hydroxylated aromatic inhibitors of HIV-1 integrase:
T.R. Burke Jr., et al.; J. Med. Chem.
38
, 4171 (1995)
Abstract
Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells:
C. Chiao, et al.; Cancer Res.
55
, 3576 (1995)
Abstract
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B:
K. Natarajan, et al.; PNAS
93
, 9090 (1996)
Abstract
Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation:
P. Michaluart, et al.; Cancer Res.
59
, 2347 (1999)
Abstract
Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation:
Z. Orban, et al.; Neuroimmunomodulation
7
, 99 (2000)
Abstract
Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappaB transcription factors:
N. Marquez, et al.; J. Pharmacol. Exp. Ther.
308
, 993 (2004)
Abstract
Caffeic acid derivatives: in vitro and in vivo anti-inflammatory properties:
F.M. da Cunha, et al.; Free Radic. Res.
38
, 1241 (2004)
Abstract
Drastic effect of several caffeic acid derivatives on the induction of heme oxygenase-1 expression revealed by quantitative real-time RT-PCR:
K. Suzuki, et al.; Biofactors
28
, 151 (2006)
Abstract
Related Products
ALX-270-231
Caffeic acid
ALX-270-480
Caffeic acid ethyl ester
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
Natural Products - Chemopreventive Agents
•
Natural Products - Antiviral/anti-HIV Agents
•
NF-kB Pathway Inhibitors
•
Natural Products - NF-kB Pathway Inhibitors
•
Natural Products - Protein Kinase Inhibitors
•
HIV/AIDS/Related Products
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Natural Products - Immunomodulators
ALX-270-480
Revised 10-Mar-08
Caffeic acid ethyl ester
SYNONYMS
CAEE
Ethyl caffeate
PRODUCT LINE
