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Items 12 of 12
ALX-260-128
Revised 03-Apr-08
Actinonin
SYNONYMS
3[[1-[[2-(Hydroxymethyl)-1-pyrrolidinyl]-carbonyl]-2-methylpropyl]-carbamoyl]-octanohydroxamic acid
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antitumor Antibiotics
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-260-128-M005
5 mg
90.00 USD
Product Specification
FORMULA:
C
19
H
35
N
3
O
5
MW:
385.5
CAS NUMBER:
13434-13-4
SOURCE/HOST:
Synthetic.
PURITY:
≥98%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of aminopeptidase M, leucine aminopeptidase and deformylase. Shows antitumor activity. Apoptosis inducer.
Product Specific Literature References
Production of actinonin, an inhibitor of aminopeptidase M, by actinomycetes:
H. Umezawa, et al.; J. Antibiot. (Tokyo)
38
, 1629 (1985)
Abstract
Analgesic effect of actinonin, a new potent inhibitor of multiple enkephalin degrading enzymes:
M. Hachisu, et al.; Life Sci.
41
, 235 (1987)
Abstract
Effects of an antibiotic protease inhibitor, actinonin on the growth within collagen gels of non-metastatic and metastatic mouse mammary tumors of the same origin:
K. Sayama, et al.; Cancer Lett
94
, 171 (1995)
Abstract
Inhibition of alanyl aminopeptidase induces MAP-kinase p42/ERK2 in the human T cell line KARPAS-299:
U. Lendeckel, et al.; BBRC
252
, 5 (1998)
Abstract
Antitumor activity of actinonin in vitro and in vivo:
Y. Xu, et al.; Clin. Cancer Res.
4
, 171 (1998)
Abstract
Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor:
D.Z. Chen, et al.; Biochemistry
39
, 1256 (2000)
Abstract
Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics:
M.D. Lee, et al.; J. Clin. Invest.
114
, 1107 (2004)
Abstract
Actinonin induces apoptosis in U937 leukemia cells:
M. Grujic, et al.; Cancer Lett.
223
, 211 (2005)
Abstract
Further Categories Containing This Product:
Aminopeptidases/Related Products
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Antitumor Agents (Enzyme Inhibitors)
ALX-260-003
Revised 09-May-07
Amastatin . hydrochloride
SYNONYMS
[(2S,3R)-3-Amino-2-hydroxy-5-methyl-hexanoyl]-Val-Val-Asp-OH . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Aminopeptidases/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-003-M001
1 mg
73.00 USD
ALX-260-003-M005
5 mg
235.00 USD
Product Specification
FORMULA:
C
21
H
38
N
4
O
8
. HCl
MW:
474.6 . 36.5
CAS NUMBER:
100938-10-1
SOURCE/HOST:
Synthetic.
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in acetic acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Competitive inhibitor of human serum aminopeptidase A, pig kidney leucine aminopeptidase, leucine aminopeptidase, tyrosine aminopeptidase, but not of aminopeptidase B. Has been used to potentiate the action of some bioactive peptides by inhibiting their degradation by aminopeptidases.
Product Specific Literature References
Amastatin, an inhibitor of aminopeptidase A, produced by actinomycetes:
T. Aoyagi, et al.; J. Antibiot. (Tokyo)
31
, 636 (1978)
Abstract
H. Tobe, et al.; Agric. Biol. Chem.
43
, 591 (1979)
Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes:
D.H. Rich, et al.; J. Med. Chem.
27
, 417 (1984)
Abstract
ALX-270-011
Revised 07-Dec-04
Arphamenine A
SYNONYMS
(2R,5S)-5-Amino-8-guanidino-4-oxo-2-phenylmethyloctanoic acid (sulfate form)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Aminopeptidases/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-011-M005
5 mg
60.00 USD
Product Specification
FORMULA:
C
16
H
24
N
4
O
3
. 0.5 H
2
SO
4
MW:
320.4 . 49.0
CAS NUMBER:
144110-37-2
SOURCE/HOST:
Microbial.
PURITY:
≥99%
APPEARANCE:
Pale yellow powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of aminopeptidase B.
Product Specific Literature References
Arphamenines A and B, new inhibitors of aminopeptidase B, produced by bacteria:
H. Umezawa, et al.; J. Antibiot. (Tokyo)
36
, 1572 (1983)
Abstract
The structure of arphamenines A and B:
S. Ohuchi, et al.; J. Antibiot. (Tokyo)
36
, 1576 (1983)
Abstract
ALX-270-012
Revised 07-Dec-04
Arphamenine B
SYNONYMS
(2R,5S)-5-Amino-8-guanidino-4-oxo-2-p-hydroxyphenylmethyloctanoic acid (sulfate form)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Aminopeptidases/Related Products
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ALX-270-012-M001
1 mg
25.00 USD
ALX-270-012-M005
5 mg
105.00 USD
Product Specification
FORMULA:
C
16
H
24
N
4
O
4
. 0.5 H
2
SO
4
MW:
336.4 . 49.0
CAS NUMBER:
144110-38-3
SOURCE/HOST:
Microbial.
PURITY:
≥99%
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of aminopeptidase B.
Product Specific Literature References
Arphamenines A and B, new inhibitors of aminopeptidase B, produced by bacteria:
H. Umezawa, et al.; J. Antibiot. (Tokyo)
36
, 1572 (1983)
Abstract
The structure of arphamenines A and B:
S. Ohuchi, et al.; J. Antibiot. (Tokyo)
36
, 1576 (1983)
Abstract
ALX-260-012
Revised 14-Aug-08
Bestatin . hydrochloride
SYNONYMS
[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucine . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Aminopeptidases/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-260-012-M005
5 mg
55.00 USD
ALX-260-012-M025
25 mg
200.00 USD
Product Specification
FORMULA:
C
16
H
24
N
2
O
4
. HCl
MW:
308.4 . 36.5
CAS NUMBER:
65391-42-6
SOURCE/HOST:
Synthetic.
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in methanol, acetic acid, DMSO, dimethyl formamide or 100% ethanol; slightly soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions in organic solvents are stable for 1 month at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING:
Protect from light.
Product Description
Inhibits aminopeptidases like aminopeptidase B, leucine aminopeptidase, tripeptide aminopeptidase, aminopeptidases on the surface of mammalian cells. Does not inhibit carboxypeptidases. May be used in
in vitro
translation system to inhibit the aminopeptidases found in reticulocate or wheat germ lysates. Activates macrophages and T lymphocytes. Has antitumor properties and enhances not only blastogenesis and lymphocytes
in vitro
, but also establishes a delayed-type hypersensitivity
in vivo
.
Product Specific Literature References
Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes:
H. Umezawa, et al.; J. Antibiot.
29
, 97 (1976)
Abstract
Low-molecular-weight enzyme inhibitors of microbial origin:
H. Umezawa; Ann. Rev. Microbiol.
36
, 75 (1982)
Abstract
Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes:
D.H. Rich, et al.; J. Med. Chem.
27
, 417 (1984)
Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Inhibitors)
ALX-260-036
Revised 12-Aug-08
Diprotin A
SYNONYMS
H-Ile-Pro-Ile-OH
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Aminopeptidases/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-260-036-M005
5 mg
22.00 USD
ALX-260-036-M025
25 mg
58.00 USD
Product Specification
FORMULA:
C
17
H
31
N
3
O
4
MW:
341.5
CAS NUMBER:
90614-48-5
SOURCE/HOST:
Synthetic.
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water (1mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of dipeptidyl aminopeptidase IV.
Product Specific Literature References
Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria:
H. Umezawa, et al.; J. Antibiot.
37
, 422 (1984)
Abstract
Purification and some properties of a membrane-bound dipeptidyl peptidase IV of guinea pig casein-induced intraperitoneal leukocytes:
M. Kudo, et al.; J. Biochem.
97
, 1211 (1985)
Abstract
Murine thymocytes possess specific cell surface-associated exoaminopeptidase activities: preferential expression by immature CD4- CD8- subpopulation:
B. Bauvois; Eur. J. Immunol.
20
, 459 (1990)
Abstract
ALX-260-013
Revised 06-Dec-04
Diprotin B
SYNONYMS
H-Val-Pro-Leu-OH
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Aminopeptidases/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-260-013-M005
5 mg
30.00 USD
ALX-260-013-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
16
H
29
N
3
O
4
MW:
327.4
CAS NUMBER:
90614-49-6
SOURCE/HOST:
Synthetic product.
PURITY:
≥96%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of dipeptidyl aminopeptidase IV.
Product Specific Literature References
Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria:
H. Umezawa, et al.; J. Antibiot.
37
, 422 (1984)
Abstract
ALX-270-013
Revised 25-Feb-05
Ebelactone A
SYNONYMS
3,11-Dihydroxy-2,4,6,8,10,12-hexamethyl-9-oxo-6-tetradecenoic 1,3-lactone
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Aminopeptidases/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-013-M001
1 mg
120.00 USD
ALX-270-013-M005
5 mg
420.00 USD
Product Specification
FORMULA:
C
20
H
34
O
4
MW:
338.5
CAS NUMBER:
76808-16-7
SOURCE/HOST:
Microbial.
PURITY:
≥99%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of esterases, lipases and N-formylmethionine aminopeptidase.
Product Specific Literature References
Ebelactone, an inhibitor of esterase, produced by actinomycetes:
H. Umezawa, et al.; J. Antibiot. (Tokyo)
33
, 1594 (1980)
Abstract
Acylpeptide hydrolase: inhibitors and some active site residues of the human enzyme:
A. Scaloni, et al.; J. Biol. Chem.
267
, 3811 (1992)
Abstract
;
Full Text
Structural studies on ebelactone A and B, esterase inhibitors produced by actinomycetes:
K. Uotani, et al.; J. Antibiot. (Tokyo)
35
, 1495 (1982)
Abstract
Biosynthetic studies of ebelactone A and B by 13C NMR spectrometry:
K. Uotani, et al.; J. Antibiot. (Tokyo)
35
, 1670 (1982)
Abstract
ALX-270-014
Revised 17-Jul-06
Ebelactone B
SYNONYMS
2-Ethyl-3,11-dihydroxy-4,6,8,10,12-pentamethyl-9-oxo-6-tetradecenoic 1,3-lactone
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Aminopeptidases/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-270-014-M001
1 mg
95.00 USD
ALX-270-014-M005
5 mg
380.00 USD
Product Specification
FORMULA:
C
21
H
36
O
4
MW:
352.5
CAS NUMBER:
76808-15-6
SOURCE/HOST:
Microbial.
PURITY:
≥99%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
Product Specific Literature References
Ebelactone, an inhibitor of esterase, produced by actinomycetes:
H. Umezawa, et al.; J. Antibiot. (Tokyo)
33
, 1594 (1980)
Abstract
Identification of an isoprenylated cysteine methyl ester hydrolase activity in bovine rod outer segment membranes:
E.W. Tan & R.R. Rando; Biochemistry
31
, 5572 (1992)
Abstract
Structural studies on ebelactone A and B, esterase inhibitors produced by actinomycetes:
K. Uotani, et al.; J. Antibiot. (Tokyo)
35
, 1495 (1982)
Abstract
Biosynthetic studies of ebelactone A and B by 13C NMR spectrometry:
K. Uotani, et al.; J. Antibiot. (Tokyo)
35
, 1670 (1982)
Abstract
Diuretic and natriuretic effect of ebelactone B in anesthetized rats by inhibition of a urinary carboxypeptidase Y-like kininase:
M. Majima, et al.; Jpn. J. Pharmacol.
65
, 79 (1994)
Abstract
Inhibition of kinin degradation on the luminal side of renal tubules reduces high blood pressure in deoxycorticosterone acetate salt-treated rats:
S. Nakajima, et al.; Clin. Exp. Pharmacol. Physiol.
27
, 80 (2000)
Abstract
Further Categories Containing This Product:
Proteases Other Products
ALX-350-119
Revised 20-Feb-08
Fumagillin
SYNONYMS
Fumidil B
Fumadil B
TNP-470
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics for Angiogenesis Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-119-MC05
0.5 mg
65.00 USD
ALX-350-119-M001
1 mg
105.00 USD
Product Specification
FORMULA:
C
26
H
34
O
7
MW:
458.6
CAS NUMBER:
23110-15-8
MERCK INDEX:
14:
4286
SOURCE/HOST:
Isolated from
Aspergillus fumigatus.
PURITY:
≥95%
APPEARANCE:
Light yellow solid
SOLUBILITY:
Soluble in chloroform or diluted aqueous bases. Slightly soluble in methanol and other alcoholic solvents. Insoluble in water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Unstable in aqueous solutions with pH >9.0 or pH <5.0.
HANDLING:
Packaged under inert gas. Protect from light.
HAZARD:
HARMFUL.
Product Description
Inhibitor of angiogenesis and endothelial cell proliferation. Specific inhibitor of methionine aminopeptidase type II (MetAP-II). Antineoplastic. Anti-infective.
Product Specific Literature References
Fumagillin (H-3), a new antibiotic with amebicidal properties
:
C.M. Mc, et al.; Science
113
, 202 (1951)
Abstract
Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth
:
D. Ingber, et al.; Nature
348
, 555 (1990)
Abstract
The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase
:
W.T. Lowther, et al.; PNAS
95
, 12153 (1998)
Abstract
;
Full Text
Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2:
E.C. Griffith, et al.; PNAS
95
, 15183 (1998)
Abstract
Fumagillin treatment of intestinal microsporidiosis:
J.M. Molina, et al.; N. Engl. J. Med.
346
, 1963 (2002)
Abstract
Whirling disease of salmonid fish: life cycle, biology, and disease:
M.A. Gilbert & W.O. Granath, Jr.; J. Parasitol.
89
, 658 (2003)
Abstract
Fumagillin treatment of hepatocellular carcinoma in rats: an in vivo study of antiangiogenesis:
I.S. Sheen, et al.; World J. Gastroenterol.
11
, 771 (2005)
Abstract
Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors:
B. Lefkove, et al.; Expert Rev. Anti Infect. Ther.
5
, 573 (2007), Review
Abstract
FGFR1/PI3K/AKT signaling pathway is a novel target for antiangiogenic effects of the cancer drug fumagillin (TNP-470):
G.J. Chen, et al.; J. Cell Biochem.
101
, 1492 (2007)
Abstract
Further Categories Containing This Product:
Aminopeptidases/Related Products
•
Fibroblast Growth Factors [FGFs] & Receptors/Related Products
•
Natural Products - Other Anti-infective Agents
•
Antitumor Antibiotics
•
Antitumor Agents (Anti-proliferative)
ALX-270-015
Revised 11-Jan-07
Leuhistin
