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Estrogen & Estrogen Receptors/Related Products
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Items 19 of 19
ALX-210-132 Revised 07-Jan-08
Polyclonal Antibody to Estrogen Receptor β
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SYNONYMS anti-ERβ PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Estrogen & Estrogen Receptors/Related Products
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ALX-210-132-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 512-530 (C512SSTEDSKN KESSQNLQSQ530) of C-terminal rat ERβ (estrogen receptor β).
SPECIFICITY: Recognizes human, mouse and rat ERβ. Detects a band of ~55kDa by Western blot. Does not cross-react with ERα.
APPLICATION: Immunocytochemistry (1µg/ml)
Immunohistochemistry ((paraffin sections, frozen sections (1:50))
Western Blot (1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-155-025.
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Product Specific Literature References
Transcription and translation of estrogen receptor-beta in the male reproductive tract of estrogen receptor-alpha knock-out and wild-type mice: C.S. Rosenfeld, et al.; Endocrinology 139, 2982 (1998) Abstract
Generation and reproductive phenotypes of mice lacking estrogen receptor beta: J.H. Krege, et al.; PNAS 95, 15677 (1998) Abstract; Full Text
Distribution of estrogen-beta-like immunoreactivity in rat forebrain: X. Li, et al.; Neuroendocrinology 66, 63 (1997) Abstract
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Polyclonal Antibodies
 
 
ALX-210-135 Revised 21-May-08
Polyclonal Antibody to Estrogen Receptor β
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SYNONYMS anti-ERβ PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Estrogen & Estrogen Receptors/Related Products
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ALX-210-135-C050   50 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Others
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 100-115 (A100EPQKSPWCEARSLEH115) of human, mouse and rat ERβ (estrogen receptor β).
SPECIFICITY: Recognizes human, mouse, rat, sheep and monkey ERβ. Detects a band of ~55kDa by Western blot. Does not cross-react with ERα.
APPLICATION: Gel Shift Assay (1-5µg/ml)
Immunocytochemistry (2-4µg/ml))
Immunohistochemistry ((frozen sections, paraffin sections (1-2µg/ml))
Western Blot (1-2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-155-027.
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Product Specific Literature References
Cloning of a novel receptor expressed in rat prostate and ovary: G.G.J.H. Kuiper, et al.; PNAS 93, 5925 (1996) Abstract
ER beta: identification and characterization of a novel human estrogen receptor: S. Mosselman, et al.; FEBS Lett. 392, 49 (1996) Abstract
Transcription and translation of estrogen receptor b in the male reproductive tract of estrogen receptor a-knock-out and wild-type mice: C.S. Rosenfeld, et al.; Endocrinology 139, 2982 (1998) Abstract
Differing roles found for estrogen's two receptors: E. Pennisi; Science 277, 1439 (1997), (Research News) Abstract
Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta: G.B. Tremblay, et al.; Mol. Endocrinol. 11, 353 (1997) Abstract
Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta: G.G.J.H. Kuiper, et al.; Endocrinology 138, 863 (1997) Abstract
Distribution of estrogen receptor-beta-like immunoreactivity in rat forebrain: X. Li, et al.; Neuroendocrinology 66, 63 (1997) Abstract
A new actor in the estrogen receptor drama--enter ER-beta: B.S. Katzenellenbogen & K.S. Korach; Endocrinology 138, 861 (1997), (Editorial) Abstract
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Polyclonal Antibodies
 
 
ALX-210-178 Revised 11-Nov-05
Polyclonal Antibody to Estrogen Receptor β
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SYNONYMS anti-ERβ PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Estrogen & Estrogen Receptors/Related Products
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ALX-210-178-C050   50 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Epitope affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 512-530(C512CSTEDSKSKEGSQNLQSQ530) of C-terminal mouse ERβ (estrogen receptor β).
SPECIFICITY: Recognizes human and rat  ERβ. Detects a band of ~55kDa by Western blot. Does not cross-react with ERα.
APPLICATION: Immunohistochemistry (frozen sections (1-2µg/ml), paraffin sections (1-2µg/ml))
Western Blot (2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-155-030.
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Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-180 Revised 21-Dec-06
Polyclonal Antibody to Estrogen Receptor β
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SYNONYMS anti-ERβ PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Estrogen & Estrogen Receptors/Related Products
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ALX-210-180-C050   50 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 512-530(C512SPAEDSKSK
EGSQNPQSQ530) of C-terminal human ERβ (estrogen receptor β).
SPECIFICITY: Recognizes human and rat ERβ. Detects a band of ~55kDa by Western blot. Does not cross-react with ERα.
APPLICATION: Immunohistochemistry (frozen sections (2-5µg/ml), paraffin sections (2-5µg/ml))
Western Blot (1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-155-029.
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Product Specific Literature References
Differential Regulation of Estrogen Receptor Subtypes alpha and beta in Human Aortic Smooth Muscle Cells by Oligonucleotides and Estradiol: F. Barchiesi, et al.; J. Clin. Endocrinol. Metab. 89, 2373 (2004) Abstract; Full Text
Cytochromes 1A1/1B1- and catechol-O-methyltransferase-derived metabolites mediate estradiol-induced antimitogenesis in human cardiac fibroblast: R.K. Dubey, et al.; J. Clin. Endocrinol. Metab. 90, 247 (2005) Abstract; Full Text
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Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-201 Revised 22-May-06
Polyclonal Antibody to Estrogen Receptor α
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SYNONYMS anti-ERα PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Estrogen & Estrogen Receptors/Related Products
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ALX-210-201-C050   50 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 1-21 (M1TMTLHTKASGMALLHQIQGN21) of N-terminal human ERα (estrogen receptor α). This sequence is completely conserved in rat and mouse ERα and is highly conserved in sheep, pig, dog, bovine and chicken ERα.
SPECIFICITY: Recognizes human and rat endogenous ERα . Detects a band of ~64kDa by Western blot. Does not cross-react with ERβ.
APPLICATION: Immunocytochemistry
Immunohistochemistry (frozen sections, paraffin sections (1-5µg/ml))
Western Blot (1µg/ml).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-155-031.
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Product Specific Literature References
Differential Regulation of Estrogen Receptor Subtypes alpha and beta in Human Aortic Smooth Muscle Cells by Oligonucleotides and Estradiol: F. Barchiesi, et al.; J. Clin. Endocrinol. Metab. 89, 2373 (2004) Abstract
Cytochromes 1A1/1B1- and catechol-O-methyltransferase-derived metabolites mediate estradiol-induced antimitogenesis in human cardiac fibroblast: R.K. Dubey, et al.; J. Clin. Endocrinol. Metab. 90, 247 (2005) Abstract; Full Text
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Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-202 Revised 20-Dec-07
Polyclonal Antibody to Estrogen Receptor α
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SYNONYMS anti-ERα PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Estrogen & Estrogen Receptors/Related Products
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ALX-210-202-C050   50 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Pig
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 21-32 (N21ELEPLNRPQLK32) of N-terminal human ERα (estrogen receptor α). This sequence is completely conserved in mouse, rat, rabbit, sheep, pig and bovine ERα.
SPECIFICITY: Recognizes human, rat and pig endogenous ERα. Detects a band of ~64kDa by Western blot. Does not cross-react with ERβ.
APPLICATION: Immunocytochemistry (0.5µg/ml)
Immunohistochemistry (frozen sections, paraffin sections (1-5µg/ml))
Western Blot (1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-155-032.
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Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-954 Revised 22-Jul-08
Polyclonal Antibody to WIPI-1 (human) (AT129)
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SYNONYMS anti-WD Repeat Domain Phosphoinositide-interacting Protein 1 (human) PAb (AT129)
anti-WD40 Repeat Protein Interacting with Phosphoinositides of 49kDa (human) PAb (AT129)
anti-WIPI 49kDa (human) PAb (AT129)
anti-Atg18 Protein Homolog (human) PAb (AT129)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Autophagy-related Proteins [APG; ATG]/Related Products
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ALX-210-954-C050   50 µg 310.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.5mg/ml
PURITY: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa of C-terminal human WIPI-1.
SPECIFICITY: Recognizes human WIPI-1.
APPLICATION: Western blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
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General Information

WIPI-1 (WD-repeat protein interacting with phosphoinosides) is highly expressed in a variety of tumors. It interacts with phosphatidylinositol-3-P and this interaction is required for recruitment to membranes. WIPI-1 contains the signature motif LXXLL for nuclear receptor association and it binds to estrogen and androgen receptors in vitro. The WIPI-1 homolog in S. cerevisiae (Atg18) plays a role in autophagy. WIPI-1 accumulates in multi-membrane structures under autophagic conditions and it co-localizes with LC3.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy: T. Proikas-Cezanne, et al.; FEBS Lett. 581, 3396 (2007) Abstract
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Further Categories Containing This Product:
Androgens & Androgen Receptors/Related Products • Polyclonal Antibodies • Estrogen & Estrogen Receptors/Related Products • Inositols & Inositolphosphates/Related Products
 
 
ALX-210-955 Revised 11-Mar-08
Polyclonal Antibody to WIPI-1 (AT130)
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SYNONYMS anti-WD Repeat Domain Phosphoinositide-interacting Protein 1 PAb (AT130)
anti-WD40 Repeat Protein Interacting with Phosphoinositides of 49kDa PAb (AT130)
anti-WIPI 49kDa PAb (AT130)
anti-Atg18 Protein Homolog PAb (AT130)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Autophagy-related Proteins [APG; ATG]/Related Products
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ALX-210-955-C100   100 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Others
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.5mg/ml
PURITY: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa in the middle of human WIPI-1.
SPECIFICITY: Recognizes human and mouse WIPI-1.
APPLICATION: Western blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
WIPI-1 (WD-repeat protein interacting with phosphoinosides) is highly expressed in a variety of tumors. It interacts with phosphatidylinositol-3-P and this interaction is required for recruitment to membranes. WIPI-1 contains the signature motif LXXLL for nuclear receptor association and it binds to estrogen and androgen receptors in vitro. The WIPI-1 homolog in S. cerevisiae (Atg18) plays a role in autophagy. WIPI-1 accumulates in multi-membrane structures under autophagic conditions and it co-localizes with LC3.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy: T. Proikas-Cezanne, et al.; FEBS Lett. 581, 3396 (2007) Abstract
Related Products
Further Categories Containing This Product:
Androgens & Androgen Receptors/Related Products • Polyclonal Antibodies • Estrogen & Estrogen Receptors/Related Products • Inositols & Inositolphosphates/Related Products
 
 
ALX-270-312 Revised 03-Jan-08
Formononetin (high purity)
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SYNONYMS 7-Hydroxy-4’-methoxyisoflavone (high purity)
7-Hydroxy-3-(4’-methoxyphenyl)-4H-benzopyran-4-one (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonoids/Related Products
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ALX-270-312-M005   5 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C16H12O4
MW: 268.3
CAS NUMBER: 485-72-3
MERCK INDEX: 14: 4244
PURITY: ≥97%
APPEARANCE: White to greyish powder.
SOLUBILITY: Soluble in DMSO (200mg/ml) or methanol (2mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Place in a desiccator under vacuum for 48 hours before use.
HANDLING: Protect from light.

Product Description
Interacts with human estrogen receptors with low potency. Enhances IL-4 production in a dose-dependent manner. Inhibits lecithin peroxidation induced by hydroxyl radicals. Selective inhibitor of the γ-isoform of alcohol dehydrogenase. Antioxidant.
Product Specific Literature References
Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor: R.J. Miksicek; J. Steroid Biochem. Mol. Biol. 49, 153 (1994) Abstract
Dietary estrogenic isoflavones are potent inhibitors of beta-hydroxysteroid dehydrogenase of P. testosteronii: W.M. Keung; BBRC 215, 1137 (1995) Abstract
Proliferative response of mammary glandular tissue to formononetin: W. Wang, et al.; Nutr. Cancer 23, 131 (1995) Abstract
Antioxidant activity of phytoestrogenic isoflavones: M.B. Ruiz-Larrea, et al.; Free Radic. Res. 26, 63 (1997) Abstract
Inhibitory effects of isoflavones on lipid peroxidation by reactive oxygen species: S. Toda and Y. Shirataki; Phytother. Res. 13, 163 (1999) Abstract
Isoflavonoids and lignans have different potentials to modulate oxidative genetic damage in human colon cells: B.L. Pool-Zobel, et al.; Carcinogenesis 21, 1247 (2000) Abstract
Disposition of flavonoids via enteric recycling: enzyme-transporter coupling affects metabolism of biochanin A and formononetin and excretion of their phase II conjugates: X. Jia, et al.; J. Pharmacol. Exp. Ther. 310, 1103 (2004) Abstract
Formononetin, a phyto-oestrogen, and its metabolites up-regulate interleukin-4 production in activated T cells via increased AP-1 DNA binding activity: J. Park, et al.; Immunology 116, 71 (2005) Abstract
Further Categories Containing This Product:
Other Natural Products for Inflammation Research • Interleukins Other Products • Active Substances from Fruit and Vegetables • Estrogen & Estrogen Receptors/Related Products • Natural Products - Antioxidants
 
 
ALX-350-098 Revised 05-Apr-08
Ferutinin (high purity)
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SYNONYMS Tefestrol (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation/Transcription
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