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ALX-260-114
Revised 24-Feb-05
Ac-AEVD-AFC
SYNONYMS
Caspase-6 Substrate (Fluorogenic)
Caspase-8 Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-114-M005
5 mg
157.00 USD
ALX-260-114-M010
10 mg
295.00 USD
Product Specification
SEQUENCE:
Ac-Ala-Glu-Val-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
FORMULA:
C
29
H
34
F
3
N
5
O
11
MW:
685.6
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-6 and -8.
General Information
BACKGROUND/TECHNICAL INFORMATION
AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
ALX-260-032
Revised 27-Apr-05
Ac-DEVD-AFC
SYNONYMS
Caspase-3 Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-032-M001
1 mg
47.00 USD
ALX-260-032-M005
5 mg
138.00 USD
Product Specification
SEQUENCE:
Ac-Asp-Glu-Val-Asp-AFC (AFC = 7-Amino-4-trifluoromethylcoumarin)
FORMULA:
C
30
H
34
F
3
N
5
O
13
MW:
729.6
PEPTIDE CONTENT:
65-95%
PURITY:
≥96% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in dimethyl formamide, DMSO or methanol; slightly soluble in water (0.4mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-3. Also a substrate for caspase-1, -4 and -7. This product is similar to Ac-DEVD-AMC (Prod. No.
ALX-260-031
) but the AFC fluorophore has a greater Stokes’ shift upon cleavage. The peptide sequence is based on the PARP cleavage site Asp
216
for caspase-3.
Product Specific Literature References
BAX-induced cell death may not require interleukin 1 β-converting enzyme-like proteases:
J. Xiang, et al.; Proc. Natl. Acad. Sci. USA
93
, 14559 (1996)
Abstract
Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver:
J.M. Chandler, et al.; J. Biol. Chem.
273
, 10815 (1998)
Abstract
;
Full Text
Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP:
M. Marcelli, et al.; Cancer Res.
58
, 76 (1998)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
ALX-260-031
Revised 02-Mar-06
Ac-DEVD-AMC
SYNONYMS
Caspase-3 Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-031-M001
1 mg
40.00 USD
ALX-260-031-M005
5 mg
115.00 USD
Product Specification
SEQUENCE:
Ac-Asp-Glu-Val-Asp-AMC (AMC = 7-Amino-4-methylcoumarin)
FORMULA:
C
30
H
37
N
5
O
13
MW:
675.7
PEPTIDE CONTENT:
70-95%
PURITY:
≥97% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO. Dilute with buffer, pH 7.5.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Fluorogenic substrate for caspase-3. Also a substrate for caspase-1, -4, -7 and -8. The peptide sequence is based on the PARP cleavage site Asp
216
for caspase-3.
Product Specific Literature References
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis:
D.W. Nicholson, et al.; Nature
376
, 37 (1995)
Abstract
Purification and catalytic properties of human caspase family members:
M. Garcia-Calvo, et al.; Cell Death Differ.
6
, 362 (1999)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
AMC has an excitation maximum of 380nm and an emission maximum of 460nm.
ALX-260-033
Revised 10-Sep-08
Ac-DEVD-pNA
SYNONYMS
Caspase-3 Substrate (Chromogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-033-M001
1 mg
27.00 USD
ALX-260-033-M005
5 mg
73.00 USD
Product Specification
SEQUENCE:
Ac-Asp-Glu-Val-Asp-pNA (pNA = p-Nitroaniline)
FORMULA:
C
26
H
34
N
6
O
13
MW:
638.6
PEPTIDE CONTENT:
70-95%
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO or buffer, pH 7.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Always use fresh solutions.
HANDLING:
Keep cool and dry.
Product Description
Chromogenic substrate for caspase-3. Also a substrate for caspase-1, -4 and -7.
Product Specific Literature References
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis:
D.W. Nicholson, et al.; Nature
376
, 37 (1995)
Abstract
Activation of the CPP32 protease in apoptosis induced by 1-beta-D- arabinofuranosylcytosine and other DNA-damaging agents:
R. Datta, et al.; Blood
88
, 1936 (1996)
Abstract
Substrate specificities of caspase family proteases:
R.V. Talanian, et al.; J. Biol. Chem.
272
, 9677 (1997)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
λmax of pNA is 400nm.
ALX-260-078
Revised 17-Jan-06
Ac-DMQD-AMC
SYNONYMS
Caspase-3 Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-078-M001
1 mg
42.00 USD
ALX-260-078-M005
5 mg
163.00 USD
Product Specification
SEQUENCE:
Ac-Asp-Met-Gln-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
FORMULA:
C
30
H
38
N
6
O
12
S
MW:
706.7
PEPTIDE CONTENT:
75-95%.
PURITY:
≥98% (HPLC)
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in DMSO. Dilute with distilled water or buffer. Also soluble in phosphate buffer, pH 7.5
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-3.
Product Specific Literature References
Bid truncation, bid/bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colony-stimulating factor
:
N.A. Maianski, et al.; J. Immunol.
172
, 7024 (2004)
Abstract
The effects of TNF-alpha and inhibitors of arachidonic acid metabolism on human colon HT-29 cells depend on differentiation status
:
M. Kovarikova, et al.; Differentiation
72
, 23 (2004)
Abstract
Interaction of polyunsaturated fatty acids and sodium butyrate during apoptosis in HT-29 human colon adenocarcinoma cells
:
J. Hofmanova; Eur. J. Nutrition
44
, 40 (2005)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
AMC has an excitation maximum of 380nm and an emission maximum of 460nm.
ALX-260-113
Revised 16-Nov-05
Ac-DQMD-AFC
SYNONYMS
Caspase-3 Substrate (Fluorogenic)
Caspase-6 Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-113-M005
5 mg
157.00 USD
ALX-260-113-M010
10 mg
295.00 USD
Product Specification
SEQUENCE:
Ac-Asp-Gln-Met-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
FORMULA:
C
30
H
35
F
3
N
6
O
12
S
MW:
760.7
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Irreversible, cell permeable fluorogenic substrate for caspase-3 and -6.
General Information
BACKGROUND/TECHNICAL INFORMATION
AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
ALX-260-115
Revised 05-Apr-05
Ac-IEPD-AFC
SYNONYMS
Caspase-8 Substrate (Fluorogenic)
Granzyme B Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-115-M005
5 mg
157.00 USD
ALX-260-115-M010
10 mg
295.00 USD
Product Specification
SEQUENCE:
Ac-Ile-Glu-Pro-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
FORMULA:
C
32
H
38
F
3
N
5
O
11
MW:
725.7
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-8 and granzyme B.
General Information
BACKGROUND/TECHNICAL INFORMATION
AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
Further Categories Containing This Product:
Granzyme Substrates
ALX-260-151
Revised 17-Jan-06
Ac-IEPD-AMC
SYNONYMS
Caspase-8 Substrate (Fluorogenic)
Granzyme B Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-151-M001
1 mg
70.00 USD
ALX-260-151-M005
5 mg
210.00 USD
Product Specification
SEQUENCE:
Ac-Ile-Glu-Pro-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
FORMULA:
C
32
H
41
N
5
O
11
MW:
671.7
PEPTIDE CONTENT:
70-95%
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-8 and granzyme B.
Product Specific Literature References
Definition and redesign of the extended substrate specificity of granzyme B:
J.L. Harris, et al.; J. Biol. Chem.
273
, 27364 (1998)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
AMC has an excitation maximum of 380nm and an emission maximum of 460nm.
Further Categories Containing This Product:
Granzyme Substrates
ALX-260-152
Revised 05-Apr-05
Ac-IEPD-pNA
SYNONYMS
Caspase-8 Substrate (Chromogenic)
Granzyme B Substrate (Chromogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-152-M001
1 mg
60.00 USD
ALX-260-152-M005
5 mg
180.00 USD
Product Specification
SEQUENCE:
Ac-Ile-Glu-Pro-Asp-pNA (pNA=p-Nitroaniline)
FORMULA:
C
28
H
38
N
6
O
11
MW:
634.6
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Chromogenic substrate for caspase-8 and granzyme B.
Product Specific Literature References
Definition and redesign of the extended substrate specificity of granzyme B:
J.L. Harris, et al.; J. Biol. Chem.
273
, 27364 (1998)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
λmax of pNA is 400nm.
Further Categories Containing This Product:
Granzyme Substrates
ALX-260-110
Revised 05-Apr-05
Ac-IETD-AFC
SYNONYMS
Caspase-8 Substrate (Fluorogenic)
Granzyme B Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-110-M005
5 mg
157.00 USD
ALX-260-110-M010
10 mg
295.00 USD
Product Specification
SEQUENCE:
Ac-Ile-Glu-Thr-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
FORMULA:
C
31
H
38
F
3
N
5
O
12
MW:
729.7
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-8/caspase-3 processing enzyme and granzyme B. Also a substrate for caspase-10.
Product Specific Literature References
Rapid cytochrome c release, activation of caspases 3, 6, 7 and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy:
D.J. Granville, et al.; FEBS Lett.
437
, 5 (1998)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
Further Categories Containing This Product:
Granzyme Substrates
ALX-260-042
Revised 02-Oct-07
Ac-IETD-AMC
SYNONYMS
Caspase-8 Substrate (Fluorogenic)
Granzyme B Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-042-M001
1 mg
42.00 USD
ALX-260-042-M005
5 mg
163.00 USD
Product Specification
SEQUENCE:
Ac-Ile-Glu-Thr-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
FORMULA:
C
31
H
41
N
5
O
12
MW:
675.7
PEPTIDE CONTENT:
70-90%
PURITY:
≥98% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO. Dilute with buffer, pH 7.5.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product D
