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Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-270-086 Revised 07-May-08
Indomethacin
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-270-086-G005   5 g 30.00 USD Add To Cart
ALX-270-086-G025   25 g 80.00 USD Add To Cart
Product Specification
FORMULA: C19H16ClNO4
MW: 357.8
CAS NUMBER: 53-86-1
MERCK INDEX: 14: 4968
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in acetone or methanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: VERY TOXIC.

Product Description
Non-steroidal anti-inflammatory and analgesic agent. Inhibits prostaglandin synthesis. Far more potent for inhibition of cyclooxygenases (COX) than for inhibition of lipoxygenases.
Product Specific Literature References
Chemical and biological studies on indomethacin, sulindac and their analogs: T.Y. Shen, et al.; Adv. Drug Res. 12, 90 (1977) Abstract
Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets: H. Salari, et al.; Prostagl. Leukotr. Med. 13, 53 (1984) Abstract
Effects of indomethacin on fetal renal function, renal and umbilicoplacental blood flow and lung liquid production: K.M. Stevenson & E.R. Lumbers; J. Dev. Physiol. 17, 257 (1992) Abstract
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro: N. Futaki, et al.; Prostaglandins 47, 55 (1994) Abstract
Further Categories Containing This Product:
Analgesic / Anti-nociceptive Agents / Related Products • COX Inhibitors
 
 
ALX-270-102 Revised 10-Aug-07
Naproxen
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SYNONYMS (S)-6-Methoxy-α-methyl-2-naphthalene acetic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-270-102-G005   5 g 35.00 USD Add To Cart
Product Specification
FORMULA: C14H14O3
MW: 230.3
CAS NUMBER: 22204-53-1
MERCK INDEX: 14: 6417
PURITY: ≥98% (Assay)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, dimethyl formamide and 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: MAY BE MUTAGENIC. HARMFUL. MAY BE TERATOGENIC.

Product Description
Cyclooxygenase (COX) inhibitor. Widely used non-steroidal anti-inflammatory drug.
Product Specific Literature References
Perspectives in nonsteroidal anti-inflammatory agents: T.Y. Shen; Angew. Chem. Int. Ed. 11, 460 (1972) Abstract
Further Categories Containing This Product:
PPAR Agonists • COX Inhibitors
 
 
ALX-270-193 Revised 04-Mar-05
Nimesulide
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SYNONYMS N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-270-193-G005   5 g 80.00 USD Add To Cart
Product Specification
FORMULA: C13H12N2O5S
MW: 308.3
CAS NUMBER: 51803-78-2
MERCK INDEX: 14: 6548
PURITY: ≥99%
APPEARANCE: Light tan crystals.
SOLUBILITY: Soluble in 100% ethanol, methanol, DMSO or acetonitrile. Ethanol is most commonly used for stock solutions, but solubility is only about 4mg/ml.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Selective inhibitor of cyclooxygenase 2 (COX-2). Platelet aggregation inhibitor.
Product Specific Literature References
Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system: J. Barnett, et al.; Biochim. Biophys. Acta 1209, 130 (1994) Abstract
A structural feature of N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulfonamide (NS-398) that governs its selectivity and affinity for cyclooxygenase 2 (COX2): R. Huff, et al.; Inflamm. Res. 44, S145 (1995) Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons: J.L. Johnson, et al.; Arch. Biochem. Biophys. 324, 26 (1995) Abstract
Further Categories Containing This Product:
Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • COX Inhibitors • Antitumor Agents (Enzyme Inhibitors) • Antitumor Agents (Apoptosis Inducers)
 
 
ALX-270-194 Revised 19-Sep-05
Valeryl salicylate
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SYNONYMS 2-Valeryloxybenzoic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-270-194-M100   100 mg 51.00 USD Add To Cart
Product Specification
FORMULA: C12H14O4
MW: 222.2
CAS NUMBER: 64206-54-8
PURITY: ≥99%
APPEARANCE: White crystalline solid.
SOLUBILITY: Soluble in 100% ethanol (95mg/ml), methanol, DMSO (43mg/ml) or dimethyl formamide (70mg/ml); also soluble in PBS, pH 7.2 (6mg/ml)). Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Selective inhibitor of cyclooxygenase-1 (COX-1).
Product Specific Literature References
Selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid: D.K. Bhattacharyya, et al.; Arch. Biochem. Biophys. 317, 19 (1995) Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons: J.L. Johnson, et al.; Arch. Biochem. Biophys. 324, 26 (1995) Abstract
Further Categories Containing This Product:
COX Inhibitors
 
 
ALX-270-196 Revised 12-Sep-05
Niflumic acid
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SYNONYMS Nifluril
2-[[3-(Trifluoromethyl)phenyl]-amino]-3-pyridinecarboxylic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-270-196-G005   5 g 26.00 USD Add To Cart
Product Specification
FORMULA: C13H9F3N2O2
MW: 282.2
CAS NUMBER: 4394-00-7
MERCK INDEX: 14: 6531
PURITY: ≥99%
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, DMSO or acetonitrile.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Stable for at least 1 year when stored at room temperature. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. We do not recommend storing the aqueous solution for more than one day.

Product Description
Selective inhibitor of cyclooxygenase 2 (COX-2).
Product Specific Literature References
Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system: J. Barnett, et al.; Biochim. Biophys. Acta 1209, 130 (1994) Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons: J.L. Johnson, et al.; Arch. Biochem. Biophys. 324, 26 (1995) Abstract
Further Categories Containing This Product:
COX Inhibitors
 
 
ALX-270-197 Revised 15-Jan-08
NS-398
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SYNONYMS N-[2-(Cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-270-197-M005   5 mg 55.00 USD Add To Cart
ALX-270-197-M010   10 mg 98.00 USD Add To Cart
ALX-270-197-M050   50 mg 395.00 USD Add To Cart
Product Specification
FORMULA: C13H18N2O5S
MW: 314.4
CAS NUMBER: 123653-11-2
PURITY: ≥98% (1H-NMR)
APPEARANCE: White to off-white crystalline solid
SOLUBILITY: Soluble in 100% ethanol (warm; sonification), DMSO or dimethyl formamide; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Potent and selective cyclooxygenase-2 (COX-2) inhibitor.
Product Specific Literature References
Effect of NS-398, a new nonsteroidal anti-inflammatory agent, on gastric ulceration and acid secretion in rats: I. Arai, et al.; Res. Comm. Chem. Pathol. Pharmacol. 81, 259 (1993) Abstract
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions: N. Futaki, et al.; Gen. Pharmacol. 24, 105 (1993) Abstract
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro: N. Futaki, et al.; Prostaglandins 47, 55 (1994) Abstract
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic: J.L. Masferrer, et al.; PNAS 91, 3228 (1994) Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons: J.L. Johnson, et al.; Arch. Biochem. Biophys. 324, 26 (1995) Abstract
Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms: M. Ouellet & M.D. Percival; Biochem. J. 306, 247 (1995) Abstract
Cyclooxygenase-2 inhibitors reverse chemoresistance phenotype in medullary thyroid carcinoma by a permeability glycoprotein-mediated mechanism: M.C. Zatelli, et al.; J. Clin. Endocrinol. Metab. 90, 5754 (2005) Abstract; Full Text
Further Categories Containing This Product:
COX Inhibitors
 
 
ALX-380-126 Revised 17-Jul-08
Asperloxine A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-126-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C21H19N3O5
MW: 393.4
SOURCE/HOST: Isolated from Aspergillus ochraceus.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR.

Product Description

Natural benzodiazepine. Anti-inflammatory.
Product Specific Literature References
Big effects from small changes: possible ways to explore nature’s chemical diversity: H.B. Bode, et al.; Chembiochem. 3, 619 (2002) Abstract
Further Categories Containing This Product:
Non-Steroidal Anti-Inflammatory Drugs [NSAIDS] • Benzodiazepines / Related Products
 
 
ALX-430-040 Revised 18-Feb-03
Piroxicam
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-430-040-G001   1 g 40.00 USD Add To Cart
ALX-430-040-G005   5 g 180.00 USD Add To Cart
Product Specification
FORMULA: C15H13N3O4S
MW: 331.4
CAS NUMBER: 36322-90-4
MERCK INDEX: 14: 7506
PURITY: ≥99%
APPEARANCE: Yellowish solid.
SOLUBILITY: Soluble in DMSO or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Cyclooxygenase (COX) inhibitor. Clinically useful non-steroidal anti-inflammatory drug.
Product Specific Literature References
Piroxicam, a potent inhibitor of prostaglandin production in cell culture. Structure-activity study: T.J. Carty, et al.; Prostaglandins 19, 51 (1980) Abstract
Further Categories Containing This Product:
COX Inhibitors
 
 
ALX-430-105 Revised 10-Dec-04
Sulindac
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SYNONYMS MK-231
(1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
cis-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]-indene-3-acetic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-430-105-G001   1 g 10.00 USD Add To Cart
Product Specification
FORMULA: C20H17FO3S
MW: 356.4
CAS NUMBER: 38194-50-2
MERCK INDEX: 14: 8982
RTECS: NK8226000
PURITY: ≥98%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or aqueous bases.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Inhibits the NF-κB pathway. Non-steroidal anti-inflammatory drug. Reduces the level and activity of several cyclin-dependent kinases (CDKs) and induces apoptosis. For the active metabolite sulindac sulfide see Prod. No. ALX-430-106.
Further Categories Containing This Product:
NF-kB Pathway Inhibitors • Apoptosis Inducers & Inhibitors Other Products • COX Inhibitors
 
 
ALX-430-106 Revised 31-Aug-04
Sulindac sulfide
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-430-106-M005   5 mg 32.00 USD Add To Cart
ALX-430-106-M025   25 mg 85.00 USD Add To Cart
Product Specification
FORMULA: C20H17FO2S
MW: 340.4
CAS NUMBER: 32004-67-4
PURITY: ≥98%
APPEARANCE: Yellow-orange solid.
SOLUBILITY: Soluble in 100% ethanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Active metabolite of sulindac (Prod. Nr. ALX-430-105). NF-κB inhibitor. Induces apoptosis. Inhibits Ras signaling. Also inhibits cyclooxygenase (COX).
Product Specific Literature References
Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis: G.A. Piazza, et al.; Cancer Res. 55, 3110 (1995) Abstract
Sulindac sulfide inhibits Ras signaling: C. Herrmann, et al.; Oncogene 17, 1769 (1998) Abstract
Sulindac inhibits activation of the NF-kappaB pathway: Y. Yamamoto, et al.; J. Biol. Chem. 274, 27307 (1999) Abstract; Full Text
Further Categories Containing This Product:
NF-kB Pathway Inhibitors • COX Inhibitors • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-430-107 Revised 20-Aug-08
Sulindac sulfone
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-430-107-M005   5 mg 30.00 USD Add To Cart
ALX-430-107-M050   50 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C20H17FO4S
MW: