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Other Antibiotics - DNA Regulation / Transcription
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ALX-380-240 Revised 03-Apr-08
Aureothricin
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SYNONYMS Propionylpyrrothione
Farcinicin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-380-240-MC05   0.5 mg 220.00 USD Add To Cart
Product Specification
FORMULA: C9H10N2O2S2
MW: 242.3
CAS NUMBER: 574-95-8
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS4782.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow to orange solid.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; partially soluble in methanol or 100% ethanol; poorly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description

Antibiotic. More hydrophobic analog of the antibiotic thiolutin (Prod. No. ALX-380-200) with selective antitumor activity. Potent inhibitor of bacterial and yeast RNA polymerases and of fungal mannan and glucan formation.
Product Specific Literature References
Studies on a common hydrolysis product of thiolutin and aureothricin: W.D. Celmer & I.A. Solomons; Antibiot. Annu. 622, (1953)
Anticancer properties of dithiolopyrrolones: J.M. Webster, et al.; US Patent 6,020,360, (2000)
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Further Categories Containing This Product:
Other Antibiotics - DNA Regulation / Transcription • Antitumor Antibiotics • RNA Polymerases / Related Products
 
 
ALX-380-055 Revised 13-Jun-08
Chromomycin A3
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SYNONYMS Toyomycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Antibiotics - DNA Regulation / Transcription
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ALX-380-055-M005   5 mg 65.00 USD Add To Cart
ALX-380-055-M025   25 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C57H82O26
MW: 1183.3
CAS NUMBER: 7059-24-7
MERCK INDEX: 14: 2238
RTECS: GB7875000
SOURCE/HOST: Isolated from Streptomyces griseus.
PURITY: ≥97% (HPLC)
APPEARANCE: Off white to yellow powder.
SOLUBILITY: Soluble in ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Antibiotic. Inhibits RNA synthesis. Cell permeable fluorescent dye that can be used with Bisbenzimide H33258 (Prod. No. ALX-620-051) to distinguish chromosomes by their total DNA concentration and their DNA base composition. Binds to G:C pairs of helical DNA but does not intercalate. Ex(max): 445nm; Em(max): 575nm.
General Literature References
K. Mizuno; J. Antibiot. 16, 22 (1963)
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Further Categories Containing This Product:
Transcription Inhibitors / Related Products
 
 
ALX-380-228 Revised 09-Jun-08
Gilvocarcin M
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SYNONYMS Anandimycin B
Toromycin B
Antibiotic 1072A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Antibiotics - DNA Regulation / Transcription
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ALX-380-228-MC05   0.5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C26H26O9
MW: 482.5
CAS NUMBER: 77879-89-1
RTECS: DI2250000
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5353.
PURITY: ≥95% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in dimethyl formamide or DMSO; slightly soluble in methanol or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description
Antibiotic. Has antibacterial, antifungal, antiviral and antitumor activities. Interacts with DNA. Less active than gilvocarcin V (Prod. No. ALX-380-113).
Product Specific Literature References
Gilvocarcins, new antitumor antibiotics. 1. Taxonomy, fermentation, isolation and biological activities: H. Nakano, et al.; J. Antibiot. (Tokyo) 34, 266 (1981) Abstract
Activation of antitumor agent gilvocarcins by visible light: R.K. Elespuru and S.K. Gonda; Science 223, 69 (1984) Abstract
Photophysical properties of gilvocarcins V and M and their binding constant to calf thymus DNA: R. Oyola, et al.; Photochem. Photobiol. 65, 802 (1997) Abstract
Further Categories Containing This Product:
Antibiotics - Antifungal • Antitumor Antibiotics • Antitumor Agents (DNA Interaction & Gene Regulation)
 
 
ALX-380-113 Revised 16-Jun-08
Gilvocarcin V
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SYNONYMS Anandimycin A
Toromycin
B 21085
Antibiotic 1072B
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Antibiotics - DNA Regulation / Transcription
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ALX-380-113-C250   250 µg 180.00 USD Add To Cart
ALX-380-113-M001   1 mg 540.00 USD Add To Cart
Product Specification
FORMULA: C27H26O9
MW: 494.5
CAS NUMBER: 77879-90-4; 84236-01-1
RTECS: DI2240000
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for at least 3 months when stored at -20°C.
HANDLING: Protect from light also when in solution.
HAZARD: HARMFUL.

Product Description

Antibiotic. Cytotoxic against Gram-positive bacteria. Mediates a unique cross-linking reaction between DNA and histidine H3. Weakly active against Gram-negative bacteria, fungi and tumors. Antineoplastic and photosensitizing compound.
Product Specific Literature References
Gilvocarcins, new antitumor antibiotics. 1. Taxonomy, fermentation, isolation and biological activities: H. Nakano, et al.; J. Antibiot. (Tokyo) 34, 266 (1981) Abstract
Activation of antitumor agent gilvocarcins by visible light: R.K. Elespuru and S.K. Gonda; Science 223, 69 (1984) Abstract
Photosensitized DNA breaks and DNA-to-protein crosslinks induced in human cells by antitumor agent gilvocarcin V: M.J. Peak, et al.; Chem. Biol. Interact. 67, 267 (1988) Abstract
Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II: A. Lorico & B. H. Long; Eur. J. Cancer 29A, 1985 (1993) Abstract
Photophysical properties of gilvocarcins V and M and their binding constant to calf thymus DNA: R. Oyola, et al.; Photochem. Photobiol. 65, 802 (1997) Abstract
Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated gilvocarcin V in human fibroblasts: A. Matsumoto and P.C. Hanawalt; Cancer Res. 60, 3921 (2000) Abstract; Full Text
Further Categories Containing This Product:
Antibiotics - Antifungal • Antitumor Antibiotics • Antitumor Agents (DNA Interaction & Gene Regulation)
 
 
ALX-380-088 Revised 30-Jul-08
Netropsin . dihydrochloride
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SYNONYMS 4-([((Aminoiminomethyl)amino)acetyl)amino)-N-(5-(((3-amino-3-iminopropyl)amino)carbonyl]-1-methyl-1H-pyrrol-3-yl)-1-methyl-1H-pyrrole-3-carboxamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-088-M005   5 mg 40.00 USD Add To Cart
Product Specification
FORMULA: C18H26N10O3 . 2HCl
MW: 430.5 . 73.0
CAS NUMBER: 63770-20-7 (hydrochloride)
RTECS: DW2973000
SOURCE/HOST: Isolated from Streptomyces netropsis.
PURITY: ≥93% (HPLC)
APPEARANCE: Faint yellow powder.
SOLUBILITY: Soluble in alcohols or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description
Nucleic acid binding ligand. Binds to A-T-rich regions of the minor groove of DNA.
Product Specific Literature References
Netropsin, a New Antibiotic Produced by a Streptomyces: A.C. Finlay et al.; J. Am. Chem. Soc. 73, 341 (1951)
Efficient Total Syntheses of the Oligopeptide Antibiotics Netropsin and Distamycin: J.W. Lown et al.; J. Org. Chem. 50, 3774 (1985)
Sequence and structural selectivity of nucleic acid binding ligands: J. Ren & J.B. Chaires; Biochemistry 38, 16067 (1999) Abstract
Molecular modelling of the interaction of carbocyclic analogues of netropsin and distamycin with d(CGCGAATTCGCG)2: K. Bielawski, et al.; Acta Biochim. Pol. 47, 855 (2000) Abstract
Recent developments in sequence selective minor groove DNA effectors: B.S. Reddy, et al.; Curr. Med. Chem. 8, 475 (2001), (Review) Abstract
Further Categories Containing This Product:
Other Antibiotics - DNA Regulation / Transcription • Antibiotics - Antiviral / Anti-HIV
 
 
ALX-380-236 Revised 08-Apr-08
Quinaldopeptin
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SYNONYMS Antibiotic BMY 28662
Antibiotic BU 3845T
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Antibiotics - DNA Regulation / Transcription
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ALX-380-236-MC05   0.5 mg 390.00 USD Add To Cart
Product Specification
FORMULA: C62H78N14O14
MW: 1243.4
CAS NUMBER: 130743-07-6
SOURCE/HOST: Isolated from Amycolatopsis sp. MST-AS5902.
PURITY: ≥95% (HPLC).
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Antibiotic. DNA bisintercalating agent. Displays antimicrobial, antifungal and cytotoxic properties. Shows antitumor activity in vitro and in vivo.
Product Specific Literature References
Quinaldopeptin, a novel antibiotic of the quinomycin family: S. Toda, et al.; J. Antibiot. (Tokyo) 43, 796 (1990) Abstract
Structure of actinotetraose hexatiglate, a unique glucotetraose from an actinomycete bacterium: R.W. Rickards, et al.; J. Antibiot. (Tokyo) 51, 1093 (1998) Abstract; Full Text
Bisintercalator natural products with potential therapeutic applications: isolation, structure determination, synthetic and biological studies: S. Dawson, et al.; Nat. Prod. Rep. 24, 109 (2007) Abstract
Further Categories Containing This Product:
Antibiotics - Antifungal • Antitumor Antibiotics • DNA Intercalators & Crosslinkers
 
 
ALX-380-111 Revised 16-Jun-08
Resistomycin
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SYNONYMS Geliomycin
Heliomycin
Itamycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Antibiotics - DNA Regulation / Transcription
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ALX-380-111-M001   1 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C22H16O6
MW: 376.4
CAS NUMBER: 20004-62-0
RTECS: DJ6350000
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow to orange solid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for at least 3 months when stored at -20°C.
HAZARD: MAY BE CARCINOGENIC. HARMFUL.

Product Description
Antibacterial against Gram-positive and mycobacteria. Inhibits RNA polymerase. Induces apoptosis.
Product Specific Literature References
Effects of the antibiotic resistomycin on the synthesis of macromolecules: I. Haupt, et al.; Z. Allg. Mikrobiol. 156, 411 (1975) Abstract
3-Alkanoyl-5-hydroxymethyl tetronic acid homologues and resistomycin: new inhibitors of HIV-1 protease. I. Fermentation, isolation and biological activity: B.E. Roggo, et al.; J. Antibiot. (Tokyo) 47, 136 (1994) Abstract
Effects of Polyphenolic Anthrone Derivatives,Resistomycin and Hypericin, on Apoptosis in Human Megakaryoblastic Leukemia CMK-7 Cell Line: Y. Shiono et al.; Z. Naturforsch. 57c, 923 (2002) Full Text
Further Categories Containing This Product:
Antibiotics - Apoptosis Inducers & Inhibitors • RNA Polymerases / Related Products
 
 
ALX-380-071 Revised 18-Nov-08
Rifampicin
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SYNONYMS Rifampin
3-(4-Methylpiperazinyl-iminomethyl)rifamycin SV
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cell Cycle Research
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ALX-380-071-M100   100 mg 18.00 USD Add To Cart
Product Specification
FORMULA: C43H58N4O12
MW: 823.0
CAS NUMBER: 13292-46-1
MERCK INDEX: 14: 8216
RTECS: VJ7000000
SOURCE/HOST: Semisynthetic.
PURITY: ≥95%
APPEARANCE: Orange to brown powder.
SOLUBILITY: Soluble in DMSO (25mg/ml) or methanol (25mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Antibacterial (tuberculostatic). Inhibits DNA-dependent RNA polymerase. Potent inducer of hepatic cytochrome P450 enzymes.
Product Specific Literature References
Rifampicin: a new orally active rifamycin: N. Maggi, et al.; Chemotherapy 11, 285 (1966) Abstract
Rifampicin sensitivity of the components of DNA-dependent RNA polymerase: E. di Mauro, et al.; Nature 222, 533 (1969) Abstract
Chemical and biological properties of rifampicin: S. Furesz; Antibiot. Chemother. 16, 316 (1970) Abstract
On the mechanism of rifampicin inhibition of RNA synthesis: W.R. McClure and C.L. Cech; J. Biol. Chem. 253, 8949 (1978) Abstract
Pharmacokinetic drug interactions with rifampicin: K. Venkatesan; Clin. Pharmacokinet. 22, 47 (1992), Review Abstract
Pharmacokinetic interactions with rifampicin : clinical relevance: M. Niemi, et al.; Clin. Pharmacokinet. 42, 819 (2003), Review Abstract
Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor: J. Chen and K. Raymond; Ann. Clin. Microbiol. Antimicrob. 50, 3 (2006), Review Abstract
Further Categories Containing This Product:
Other Antibiotics - DNA Regulation / Transcription • Cytochrome P450 [CYP450] / Related Products • RNA Polymerases / Related Products
 
 
ALX-380-070 Revised 25-Jun-08
Sinefungin
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SYNONYMS 6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-D-glycero-α-L-talo-decafuranuronic acid
A-9145
Adenosylornithine
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-380-070-M001   1 mg 70.00 USD Add To Cart
ALX-380-070-M005   5 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C15H23N7O5
MW: 381.4
CAS NUMBER: 58944-73-3
MERCK INDEX: 14: 8544
PURITY: ≥95% (HPLC)
APPEARANCE: White to yellow powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Strong competitive inhibitor of methyltransferases which uses S-adenosyl-1-methionine as the methyl group donor to yield methylated products such as 5-methylcytosine or N6-methyl adenosine on DNA and RNA. In addition, sinefungin is involved in a number of physiological processes.
Product Specific Literature References
A9145, a new adenine-containing antifungal antibiotic. I. Discovery and isolation: R.L. Hamil & M.M. Hoehn (Tokyo); J. Antibiot. 26, 463 (1973) Abstract
Sinefungin, a potent inhibitor or S-adenosylmethionine: protein O- methyltransferase: R.T. Borchardt, et al.; BBRC 89, 919 (1979) Abstract
Effects of S-adenosylhomocysteine and analogs on Epstein-Barr virus- induced transformation, expression of the Epstein-Barr virus capsid antigen, and methylation of Epstein-Barr virus DNA: W.K. Long, et al.; J. Virol. 61, 221 (1987) Abstract
Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to the adenine-specific DNA methyltransferase M.TaqI: G. Schluckebier, et al.; J. Mol. Biol. 265, 56 (1997) Abstract
Two intertwined methylation activities of the MmeI restriction- modification class-IIS system from Methylophilus methylotrophus: J. Tucholski, et al.; Gene 223, 293 (1998) Abstract
Enzyme-mediated cytosine deamination by the bacterial methyltransferase M.MspI: J.M. Zingg, et al.; Biochem. J. 332, 223 (1998) Abstract
The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism: G. Schluckebier, et al.; J. Mol. Biol. 289, 277 (1999) Abstract
Substrate binding in vitro and kinetics of RsrI [N6-adenine] DNA methyltransferase: S.S. Szegedi, et al.; Nucl. Acids Res. 28, 3962 (2000) Abstract
Identification of prenylcysteine carboxymethyltransferase in bovine adrenal chromaffin cells: H.M. De Busser, et al.; Int. J. Biochem. Cell Biol. 32, 1007 (2000) Abstract
Further Categories Containing This Product:
DNA & RNA Methyl & Alkyl Transferases / Related Products • Other Antibiotics - DNA Regulation / Transcription
 
 
ALX-380-220 Revised 13-Nov-07
Steffimycin B
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SYNONYMS Antibiotic U 40615
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Antibiotics - DNA Regulation / Transcription
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ALX-380-220-M001   1 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C29H32O13
MW: 588.6
CAS NUMBER: 54526-94-2