ALEXIS Biochemicals: 4’-Bromoflavone

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ALX-210-238

Revised 22-Sep-04

Polyclonal Antibody to UCP-3
SYNONYMS	anti-Uncoupling Protein-3 PAb
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Obesity & Diabetes Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-238-C100		100 µg	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Rat
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml
FORMULATION:	Liquid. Epitope affinity purified antibody in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 295-308 (R²⁹⁵ALMKVQVLRESPF³⁰⁸) of mouse and rat UCP-3 (mitochondrial uncoupling protein-3). This sequence differs from human and pig UCP-3 by a single amino acid substitution.
SPECIFICITY:	Recognizes human, mouse and rat UCP-3. Detects a band of ~30kDa by Western blot. Does not recognize UCP-3 from mouse liver or kidney.
APPLICATION:	Western Blot (1µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:	For Blocking Peptide see Prod. No. ALX-162-025.

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General Information

The uncoupling proteins are found in the inner mitochondrial membranes and belong to a family of mitochondrial anion transport proteins that include the PO4 and oxologutarate carriers, and the ADP/ATP translocator. Three UCP subtypes have been identified and cloned. UCP-1 is abundantly expressed in brown adipose tissue of mammals. UCP-1 allows H⁺ re-entry into the mitochondrial matrix without involving the F0-F1 ATPase which produces heat instead of ATP. It is thought that UCP-2 and 3 also dissipate the mitochondrial proton gradient produced by the respiratory chain in cells and tissues within which they are expressed. Studies have shown UCP-2 to be expressed by a variety of tissues. UCP-3 is expressed predominantly in brown adipose tissue, skeletal muscle, at lower levels in heart and smooth muscle, and is absent in liver and kidney.

General Literature References

The uncoupling proteins, a review : O. Boss, et al.; Eur. J. Endocrinol. 139, 1 (1998), (Review) Abstract
The mechanism of proton transport mediated by mitochondrial uncoupling proteins: K.D. Garlid, et al.; FEBS Lett. 438, 10 (1998), (Minireview) Abstract; Full Text

Further Categories Containing This Product:

Respiratory Chain Other Products • Polyclonal Antibodies

ALX-270-003

Revised 08-Aug-08

Diphenyleneiodonium chloride
SYNONYMS	Dibenziodolium chloride
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-003-M025		25 mg	85.00 USD
ALX-270-003-M100		100 mg	255.00 USD

Product Specification

FORMULA:	C₁₂H₈ICl
MW:	314.5
CAS NUMBER:	4673-26-1
PURITY:	≥98% (TLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	10mg/ml soluble in DMSO (warm).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	HARMFUL.

Product Description

Binds strongly to flavoproteins and is thus a powerful and specific inhibitor of several important enzymes, including nitric oxide synthase (NOS), NADPH-ubiquinone oxidoreductase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Nitric oxide synthase, which shows significant homology with cytochrome P450 reductase, has shown to be irreversibly inhibited by this compound.

Product Specific Literature References

Specific labelling of a constituent polypeptide of bovine heart mitochondrial reduced nicotinamide-adenine dinucleotide-ubiquinone reductase by the inhibitor diphenyleneiodonium: C.I. Ragan & D.P. Bloxham; Biochem. J. 163, 605 (1977) Abstract
The inhibition by diphenyleneiodonium and its analogues of superoxide generation by macrophages: J.T. Hancock & O.T.G. Jones; Biochem. J. 242, 103 (1987) Abstract
Indications to an NADPH oxidase as a possible pO2 sensor in the rat carotid body: H. Acker, et al.; FEBS Lett. 256, 75 (1989) Abstract
Purification and some properties of the 45 kDa diphenylene iodonium- binding flavoprotein of neutrophil NADPH oxidase: C.M. Yea, et al.; Biochem. J. 265, 95 (1990) Abstract
Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs: D.J. Stuehr, et al.; FASEB J. 5, 98 (1991) Abstract
Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications: D.G. Tew; Biochemistry 32, 10209 (1993) Abstract
Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat: H. Kono, et al.; Am. J. Physiol. Gastrointest. Liver Physiol. 280, G1005 (2001) Abstract
Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species: A.F. Mendes, et al.; Mediators Inflamm. 10, 209 (2001) Abstract
Preferential inhibition of the plasma membrane NADH oxidase (NOX) activity by diphenyleneiodonium chloride with NADPH as donor: D.J. Morre; Antioxid. Redox Signal 4, 207 (2002) Abstract
G2 cell cycle arrest, down-regulation of cyclin B, and induction of mitotic catastrophe by the flavoprotein inhibitor diphenyleneiodonium: R.M. Scaife; Mol. Cancer Ther. 3, 1229 (2004) Abstract
Induction of apoptosis and modulation of production of reactive oxygen species in human endothelial cells by diphenyleneiodonium: A. Balcerczyk, et al.; Biochem. Pharmacol. 69, 1263 (2005) Abstract
Selective and irreversible cell cycle inhibition by diphenyleneiodonium: R.M. Scaife; Mol. Cancer Ther. 4, 876 (2005) Abstract

Further Categories Containing This Product:

Respiratory Chain Other Products • Oxygenases Other Products • Cytochrome P450 [CYP450] / Related Products

ALX-350-028

Revised 12-Sep-08

Curcumin (high purity)
SYNONYMS	1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione Diferuloylmethane
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Anti-inflammatory Agents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-028-M010		10 mg	15.00 USD
ALX-350-028-M050		50 mg	60.00 USD
ALX-350-028-M250		250 mg	240.00 USD

Product Specification

FORMULA:	C₂₁H₂₀O₆
MW:	368.4
CAS NUMBER:	458-37-7
MERCK INDEX:	14: 2673
SOURCE/HOST:	Isolated from turmeric (Curcuma longa).
PURITY:	≥98.5% (Note: This highly purified product is free of demethoxy- and bis-demethoxycurcumin and does not contain 30-40% bioactive impurities)
APPEARANCE:	Orange-yellow crystalline powder.
SOLUBILITY:	Soluble in acetic acid or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HANDLING:	Protect from light.

Product Description

Dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase. Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Antioxidant. Inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1), disrupting the binding of NQO1 to wild type p53 inducing ubiquitin-independent degradation of p53 and inhibits p53-mediated apoptosis in normal thymocytes and myeloid leukemic cells.

Product Specific Literature References

Modification of certain inflammation-induced biochemical changes by curcumin: R. Srivastava & R.C. Srimal; Indian J. Med. Res. 81, 215 (1985) Abstract
Inhibition of 5-hydroxy-eicosatetraenoic acid (5-HETE) formation in intact human neutrophils by naturally-occurring diarylheptanoids: inhibitory activities of curcuminoids and yakuchinones: D.L. Flynn, et al.; Prostagl. Leukotr. Med. 22, 357 (1986) Abstract
Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells: L. Korutla & R. Kumar; Biochim. Biophys. Acta 1224, 597 (1994) Abstract
Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages: I. Brouet & H. Okshima; BBRC 206, 533 (1995) Abstract
Cytotoxicity and cytoprotective activities of natural compounds. The case of curcumin: J.N. Commandeur & N.P. Vermeulen; Xenobiotica 26, 667 (1996) Abstract
Nitric oxide scavenging by curcuminoids: Sreejayan & M.N. Rao; J. Pharm. Pharmacol. 49, 105 (1997) Abstract
Inhibitory effects of curcumin on tumorigenesis in mice: M.T. Huang, et al.; J. Cell. Biochem. (Suppl.) 27, 26 (1997) Abstract
In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties: M.M. Chan, et al.; Biochem. Pharmacol. 55, 1955 (1998) Abstract
Effect of curcumin on the production of nitric oxide by cultured rat mammary gland: M. Onoda & H. Inano; Nitric Oxide 4, 505 (2000) Abstract
Suppression of nitric oxide oxidation to nitrite by curcumin is due to the sequestration of the reaction intermediate nitrogen dioxide, not nitric oxide: B.D. Johnston & E.G. DeMaster; Nitric Oxide 8, 231 (2003) Abstract
Biological properties of curcumin-cellular and molecular mechanisms of action: B. Joe, et al.; Crit. Rev. Food Sci. Nutr. 44, 97 (2004), (Review) Abstract
Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects: M.E. Egan, et al.; Science 304, 600 (2004) Abstract
Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin: P. Tsvetkov, et al.; PNAS 102, 5535 (2005) Abstract
Immunomodulatory effects of curcumin: V.S. Yadav, et al.; Immunopharmacol. Immunotoxicol. 27, 485 (2005) Abstract
Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases: S. Bengmark; JPEN J. Parenter. Enteral. Nutr. 30, 45 (2006), (Review) Abstract
Curcumin is an inhibitor of p300 histone acetylatransferase: M.G. Marcu, et al.; Med. Chem. 2, 169 (2006) Abstract
Multiple biological activities of curcumin: a short review: R.K. Maheshwari, et al.; Life Sci. 78, 2081 (2006), (Review) Abstract
Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1: M.K. Bae, et al.; Oncol. Rep. 15, 1557 (2006) Abstract
Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells: Z. Wang, et al.; Cancer 106, 2503 (2006) Abstract
Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species: M. Panchatcharam, et al.; Mol. Cell Biochem. 290, 87 (2006) Abstract
Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia: K.K. Jung, et al.; Life Sci. 79, 2022 (2006) Abstract
The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats: T. Morimoto, et al.; J. Clin. Invest. 118, 868 (2008) Abstract; Full Text

Further Categories Containing This Product:

Other Natural Products for Cancer Research • EGFR Kinase Inhibitors • Respiratory Chain Other Products • Glutathione S-Transferase • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Antioxidants • Natural Products - Protein Kinase Inhibitors • Active Substances from Fruit and Vegetables • Cell Cycle Blockers & Inhibitors / Related Products • Polyphenols Other Products • Natural Products for Angiogenesis Research • Natural Products - NF-kB Pathway Inhibitors • Lipoxygenases / Related Products • COX Inhibitors • Natural Products - Apoptosis Inducers & Inhibitors • NF-kB Pathway Inhibitors • Natural Products - Immunomodulators

ALX-350-230

Revised 03-Nov-08

L-Sulforaphane
SYNONYMS	R-Sulforaphane (-)-1-Isothiocyanato-(4R)-(methylsulfinyl)butane
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Chemopreventive Agents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-230-M010		10 mg	180.00 USD

Product Specification

FORMULA:	C₆H₁₁NOS₂
MW:	177.3
CAS NUMBER:	142825-10-3; 4478-93-7
MERCK INDEX:	14: 8962
SOURCE/HOST:	Chiral natural product isolated from broccoli.
PURITY:	≥98% (UPLC)
APPEARANCE:	Slightly yellowish liquid.
SOLUBILITY:	Soluble in methanol, 100% ethanol, DMSO or ethyl acetate.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Potent, selective inducer of phase II detoxification enzymes. Inhibits chemically induced mammary tumor formation in rats.

Product Specific Literature References

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure: Y. Zhang, et al.; PNAS 89, 2399 (1992) Abstract; Full Text
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates: Y. Zhang, et al.; PNAS 91, 3147 (1994) Abstract; Full Text
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors: J.W. Fahey, et al.; PNAS 99, 7610 (2002) Abstract; Full Text
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase: M.C. Myzak ,et al.; Cancer Res. 64, 5767 (2004) Abstract; Full Text
Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex: M.L. Kerns, et al.; PNAS 104, 14460 (2007) Abstract
Sulforaphane targets pancreatic tumor-initiating cells by NF-{kappa}B-induced anti-apoptotic signaling: G. Kallifatidis, et al.; Gut Epub ahead of print, (2008) Abstract

Further Categories Containing This Product:

Glutathione S-Transferase • Antitumor Agents (Enzyme Activators & Inducers) • Respiratory Chain Other Products • Cytochrome P450 [CYP450] / Related Products • Active Substances from Fruit and Vegetables • Natural Products - Apoptosis Inducers & Inhibitors

ALX-350-232

Revised 06-Oct-08

DL-Sulforaphane
SYNONYMS	R,S-Sulforaphane 1-Isothiocyanato-4-methylsulfinyl-butane
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Chemopreventive Agents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-232-M025		25 mg	140.00 USD

Product Specification

FORMULA:	C₆H₁₁NOS₂
MW:	177.3
CAS NUMBER:	142825-10-3; 4478-93-7 (unspecified stereo)
MERCK INDEX:	14: 8962
SOURCE/HOST:	Synthetic.
PURITY:	≥98% (UPLC)
APPEARANCE:	Slightly yellowish liquid.
SOLUBILITY:	Soluble in methanol or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
IDENTITY:	Identity determined by ¹H-NMR and MS.

Product Description

Potent, selective inducer of phase II detoxification enzymes. Inhibits chemically induced mammary tumor formation in rats. Inhibits LPS-induced HMGB1 (high mobility group box 1) secretion.

Product Specific Literature References

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure: Y. Zhang, et al.; PNAS 89, 2399 (1992) Abstract; Full Text
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates: Y. Zhang, et al.; PNAS 91, 3147 (1994) Abstract; Full Text
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase: M.C. Myzak, et al.; Cancer Res. 64, 5767 (2004) Abstract; Full Text
The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells: M.E. Killeen, et al.; J. Pharmacol. Exp. Ther. 316, 1070 (2006) Abstract
Sulforaphane targets pancreatic tumor-initiating cells by NF-{kappa}B-induced anti-apoptotic signaling: G. Kallifatidis, et al.; Gut Epub ahead of print, (2008) Abstract

Further Categories Containing This Product:

ALX-350-280

Revised 07-Oct-08

Xanthohumol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Natural Products - DNA Regulation / Transcription

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-280-M005		5 mg	135.00 USD

Product Specification

FORMULA:	C₂₁H₂₂O₅
MW:	354.4
CAS NUMBER:	569-83-5, 6754-58-1
SOURCE/HOST:	Isolated from hops (Humulus lupulus).
PURITY:	≥98% (HPLC)
APPEARANCE:	Yellow to orange powder.
SOLUBILITY:	Soluble in DMSO (25mg/ml), methanol (10mg/ml) or 100% ethanol; soluble in aqueous buffers up to 20μM.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Stable as powder for at least 6 months when stored at +4°C in the dark. Stock solution made in DMSO should not be stored for longer than one month. Working solution is stable for 24 hours at 37°C and up to one week when stored at +4°C. Unstable in acidic (pH < 4.5) and alkaline (pH > 7.5) systems.
IDENTITY:	Identity determined by NMR.

Product Description

Prenylated chalcone found in beer. Potent inhibitor of diacylglycerol acetyltransferase (DGAT). Inhibits DNA polymerase and induces cell differentiation. Has antiproliferative and cytotoxic effects in human cancer cell lines. Inhibits human P450 enzymes. Induces quinone reductase. Inhibits the expression of HIF-1α and VEGF under hypoxic conditions. Induces apoptosis in mature adipocytes.

Product Specific Literature References

Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus: N. Tabata, et al.; Phytochemistry 46, 683 (1997) Abstract
Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines: C.L. Miranda, et al.; Food Chem. Toxicol. 37, 271 (1999) Abstract
In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus: M.C. Henderson, et al.; Xenobiotica 30, 235 (2000) Abstract
Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells: C.L. Miranda, et al.; Cancer Lett. 149, 21 (2000) Abstract
Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop: C. Gerhauser, et al.; Mol. Cancer Ther. 1, 959 (2002) Abstract
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!: J.F. Stevens & J.E. Page; Phytochemistry 65, 1317 (2004), (Review) Abstract
Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis: J.Y. Yang, et al.; Apoptosis 12, 1953 (2007) Abstract

Further Categories Containing This Product:

Active Substances from Fruit and Vegetables • Antitumor Agents (Anti-proliferative) • Cell Differentiation • Estrogen & Estrogen Receptors / Related Products • Respiratory Chain Other Products • Chalcones • Hypoxia-inducible Factor [HIF] / Related Products • Obesity & Diabetes Other Products • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antitumor Reagents • Lipid Metabolism Other Products • VEGFs

ALX-350-360

Revised 28-May-08

Rotenone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Toxins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-360-G001		1 g	45.00 USD
ALX-350-360-G005		5 g	125.00 USD

Product Specification

FORMULA:	C₂₃H₂₂O₆
MW:	394.4
CAS NUMBER:	83-79-4
MERCK INDEX:	14: 8271
RTECS:	DJ2800000
SOURCE/HOST:	Synthetic. Originally isolated from Lonchocarpus sp. or Derris sp.
PURITY:	≥98% (Assay)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol; slightly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	TOXIC.

Product Description

Insecticide. Inhibitor of mitochondrial electron transport. Specifically inhibits NAD-linked substrate oxidation at the oxygen side of NADH dehydrogenase (EC₅₀=10pmol/mg). Inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding.

Product Specific Literature References

Metabolism of rotenone in vitro by tissue homogenates from mammals and insects: J.I. Fukami, et al.; Science 155, 713 (1967) Abstract
[3H]dihydrorotenone binding to NADH: ubiquinone reductase (complex I) of the electron transport chain: an autoradiographic study: D.S. Higgins, Jr. & J.T. Greenamyre; J. Neurosci. 16, 3807 (1996) Abstract; Full Text
Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures: C.M. Testa, et al.; Brain Res. Mol. Brain Res. 134, 109 (2005) Abstract; Full Text
Fatality after deliberate ingestion of the pesticide rotenone: a case report: D.M. Wood, et al.; Crit Care 9, R280 (2005) Abstract; Full Text
Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons: Q. Jiang, et al.; J. Biol. Chem. 281, 29391 (2006) Abstract
Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells: J. Jin, et al.; BMC Neurosci. 8, 67 (2007) Abstract; Full Text
Rotenone inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding: P. Srivastava & D. Panda; FEBS J. 274, 4788 (2007) Abstract
Protection by the NDI1 Gene against Neurodegeneration in a Rotenone Rat Model of Parkinson’s Disease: M. Marella, et al.; PLoS ONE 3, e1433 (2008) Abstract; Full Text

Further Categories Containing This Product:

MPTP [Mitochondrial Transition Pore] / Related Products • Respiratory Chain Other Products • Natural Products for Cytoskeletal Research • Apoptosome Other Products • Pesticides / Related Products

ALX-380-036

Revised 10-Dec-07

Oligomycin A
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Apoptosis Inducers & Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-036-M005		5 mg	140.00 USD

Product Specification

FORMULA:	C₄₅H₇₄O₁₁
MW:	791.1
CAS NUMBER:	579-13-5
MERCK INDEX:	14: 6833
RTECS:	RK3328000
SOURCE/HOST:	Isolated from Streptomyces sp. MST-AS5339.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	MAY BE MUTAGENIC. HARMFUL.

Product Description

Major component of the oligomycin complex. Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F₁F₀), preventing phosphoryl group transfer. Induces apoptosis. Induces autophagy in the IPLB-LdFB insect cell line.

Product Specific Literature References

Production and isolation of the antibiotic, oligomycin: J. Visser, et al.; J. Biochem. Microbiol. Technol. Egr. 2, 31 (1960) Abstract
The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin: M.E. Fitch, et al.; Cell Death Differ. 7, 338 (2000)