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ALX-151-020

Revised 10-Feb-05

N-Acetyl-Asp-Glu-OH
SYNONYMS	α-NAAG Spaglumic acid
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Glutamate Receptors (Metabotropic) / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-151-020-M010		10 mg	35.00 USD
ALX-151-020-M050		50 mg	140.00 USD

Product Specification

FORMULA:	C₁₁H₁₆N₂O₈
MW:	304.3
CAS NUMBER:	3106-85-2
PURITY:	≥98%
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Endogenous neurotransmitter with high affinity for the brain glutamate receptor. N-acetylated α-linked acidic dipeptidase (NAALADase), a membrane-bound peptidase, hydrolyzes α-NAAG, a major brain peptide, to N-acetylaspartate and glutamate. Discriminates between mGluR2 and mGluR3. mGluR3 activator. NMDA receptor antagonist. Neuroprotective.

Product Specific Literature References

N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain glutamate receptor: R. Zaczek, et al.; PNAS 80, 1116 (1983) Abstract
Characterization of the interactions of N-acetyl-aspartyl-glutamate with [3H]L-glutamate receptors: K.J. Koller & J.T. Coyle; Eur. J. Pharmacol. 98, 193 (1984) Abstract
The neurobiology of N-acetylaspartylglutamate: R.D. Blakely & J.T. Coyle; Int. Rev. Neurobiol. 30, 39 (1988) Abstract
Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase: P.F. Jackson, et al.; J. Med. Chem. 39, 619 (1996) Abstract
The nagging question of the function of N-acetylaspartylglutamate: J.T. Coyle; Neurobiol. Dis. 4, 231 (1997) Abstract
N-acetylaspartylglutamate stimulates metabotropic glutamate receptor 3 to regulate expression of the GABA(A) alpha6 subunit in cerebellar granule cells: S. Ghose, et al.; J. Neurochem. 69, 2326 (1997) Abstract
N-acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo: L.R. Orlando, et al.; Neurosci. Lett. 236, 91 (1997) Abstract
N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases: L.A. Passani, et al.; Mol. Chem. Neuropathol. 31, 97 (1997) Abstract
Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease: L.A. Passani, et al.; Brain Res. 772, 9 (1997) Abstract
N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells: B. Wroblewska, et al.; J. Neurochem. 69, 174 (1997) Abstract
Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells: V. Bruno, et al.; Neuroscience 85, 751 (1998) Abstract
N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes: B. Wroblewska, et al.; Glia 24, 172 (1998) Abstract
A.P. Burlina, et al.; Eur. J. Pediatr. 158, 406 (1999) Abstract

Further Categories Containing This Product:

NMDA Receptors / Related Products • NAALADase / Related Products • Peptides

ALX-151-026

Revised 20-Jun-08

N-Acetyl-Asp-Tyr(2-malonyl)-Val-Pro-Met-Leu-NH2
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Tyrosine Kinase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-151-026-M001		1 mg	90.00 USD

Product Specification

FORMULA:	C₃₉H₅₇N₇O₁₄S
MW:	880.0
PURITY:	≥96% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in water (1mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Peptide is very unstable.

Product Description

Peptide containing a phosphotyrosyl mimetic. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.

Product Specific Literature References

L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides: B. Ye, et al.; J. Med. Chem. 38, 4270 (1995) Abstract

Further Categories Containing This Product:

Peptides • Phosphoinositide 3-kinase [PI(3)K] / Related Products

ALX-151-027

Revised 17-Jan-05

N-Acetyl-Asp-Tyr(PO3H2)-Val-Pro-Met-Leu-NH2
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Tyrosine Kinase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-151-027-M001		1 mg	90.00 USD

Product Specification

FORMULA:	C₃₆H₅₇N₇O₁₃SP
MW:	858.9
PURITY:	≥96%
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Phosphotyrosine containing peptide. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.

Product Specific Literature References

L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides: B. Ye, et al.; J. Med. Chem. 38, 4270 (1995) Abstract

Further Categories Containing This Product:

Peptides • Phosphoinositide 3-kinase [PI(3)K] / Related Products

ALX-151-035

Revised 22-Jul-08

Ac-muramyl-Ala-D-Glu-amide
SYNONYMS	MDP-LD N-Acetylmuramyl-L-alanyl-D-isoglutamine Adjuvant Peptide
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	Nod-complex / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-151-035-M001		1 mg	35.00 USD
ALX-151-035-M005		5 mg	120.00 USD

Product Specification

FORMULA:	C₁₉H₃₂N₄O₁₁
MW:	492.5
CAS NUMBER:	53678-77-6
SOURCE/HOST:	Synthetic.
PURITY:	≥95% (TLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in water (50mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	After reconstitution, prepare aliquots and store at -20°C.

Product Description

Specific ligand for NALP3. For inactive control compound see MDP-DD (Prod. No. ALX-151-036).

Product Specific Literature References

Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives: F. Ellouz, et al.; Biochem. Biophys. Res. Commun. 59, 1317 (1974) Abstract

Further Categories Containing This Product:

Peptides

ALX-151-024

Revised 03-Mar-05

H-Ala-Pro-Arg-Thr-Pro-Gly-Gly-Arg-Arg-OH
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Myelin Basic Protein / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-151-024-M001		1 mg	95.00 USD
ALX-151-024-M005		5 mg	380.00 USD

Product Specification

FORMULA:	C₃₉H₇₀N₁₈O₁₁
MW:	967.1
PURITY:	≥98%
APPEARANCE:	White powder.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Substrate for myelin basic protein kinase (p44^mpk) and for MAP kinase (MAPK/ERK).

Product Specific Literature References

Identification of the sites in myelin basic protein that are phosphorylated by meiosis-activated protein kinase p44mpk: J.S. Sanghera, et al.; FEBS Lett. 273, 223 (1990) Abstract
Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase: I. Clark-Lewis, et al.; J. Biol. Chem. 266, 15180 (1991) Abstract; Full Text
M. Daeipour, et al.; J. Immunol. 150, 4743 (1993) Abstract

Further Categories Containing This Product:

Peptides

ALX-151-016

Revised 17-Jan-05

cAMP-dependent Protein Kinase Inhibitor (5-22) amide
SYNONYMS	PKA Inhibitor (5-22) amide
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	PKA Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-151-016-MC05		0.5 mg	110.00 USD
ALX-151-016-M001		1 mg	180.00 USD

Product Specification

SEQUENCE:	H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH₂
FORMULA:	C₈₄H₁₃₇N₂₉O₂₆
MW:	1969.2
PURITY:	≥97%
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Potent inhibitor of cAMP-dependent protein kinase (PKA).

Product Specific Literature References

A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase: H.-C. Cheng, et al.; J. Biol. Chem. 261, 989 (1986) Abstract; Full Text
Primary structural determinants essential for potent inhibition of cAMP- dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein: D.B. Glass, et al.; J. Biol. Chem. 264, 8802 (1989) Abstract; Full Text

Further Categories Containing This Product:

Peptides

ALX-151-014

Revised 15-Dec-04

cAMP-dependent Protein Kinase Inhibitor (5-24)
SYNONYMS	PKA Inhibitor (5-24)
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	PKA Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-151-014-MC05		0.5 mg	90.00 USD
ALX-151-014-M001		1 mg	160.00 USD

Product Specification

SEQUENCE:	H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH
FORMULA:	C₉₄H₁₄₈N₃₂O₃₁
MW:	2222.4
PURITY:	≥97%
APPEARANCE:	White to off-white powder.
FORMULATION:	Lyophilized.
SOLUBILITY:	Soluble in water or 5 % acetic acid.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Keep cool and dry.

Product Description

Potent inhibitor of cAMP-dependent protein kinase (PKA). The peptide corresponds to the active site of the skeletal muscle inhibitor protein.

Product Specific Literature References

A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase: H.-C. Cheng, et al.; J. Biol. Chem. 261, 989 (1986) Abstract; Full Text
Phosphorylation of Avena phytochrome in vitro as a probe of light- induced conformational changes: Y.S. Wong, et al.; J. Biol. Chem. 261, 12089 (1986) Abstract; Full Text

Further Categories Containing This Product:

Peptides

ALX-151-018

Revised 13-Feb-06

cAMP-dependent Protein Kinase Inhibitor (5-24) amide
SYNONYMS	PKA Inhibitor (5-24) amide
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	PKA Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-151-018-MC05		0.5 mg	90.00 USD
ALX-151-018-M001		1 mg	160.00 USD

Product Specification

SEQUENCE:	H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-NH₂
FORMULA:	C₉₄H₁₄₉N₃₃O₃₀
MW:	2221.4
PURITY:	≥97%
APPEARANCE:	White to off-white lyophilized powder.
SOLUBILITY:	Soluble in water or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Specific Literature References

A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase: H.-C. Cheng, et al.; J. Biol. Chem. 261, 989 (1986) Abstract; Full Text

Further Categories Containing This Product:

Peptides

ALX-151-017

Revised 15-Dec-04

cAMP-dependent Protein Kinase Inhibitor (14-24) amide
SYNONYMS	PKA Inhibitor (14-24) amide
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	PKA Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-151-017-M001		1 mg	90.00 USD
ALX-151-017-M005		5 mg	360.00 USD

Product Specification

SEQUENCE:	H-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-NH₂
FORMULA:	C₄₉H₈₆N₂₄O₁₅
MW:	1251.4
PURITY:	≥97%
APPEARANCE:	White powder.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Further Categories Containing This Product:

Peptides

ALX-151-019

Revised 15-Dec-04

cAMP-dependent Protein Kinase Substrate
SYNONYMS	PKA Substrate
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	PKA Substrates

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-151-019-MC05		0.5 mg	95.00 USD
ALX-151-019-M001		1 mg	165.00 USD

Product Specification

SEQUENCE:	H-Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-Ser-Val-Ala-Ala-Glu-OH
FORMULA:	C₉₂H₁₅₀N₂₈O₂₉
MW:	2112.4
PURITY:	≥95%
APPEARANCE:	White powder.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Derived from the RII subunit of cAMP-dependent protein kinase (PKA). Substrate for PKA. Has been used in a non-radioactive assay of calcineurin (protein phosphatase 2B) for screening purposes.

Product Specific Literature References

Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity: D.K. Blumenthal, et al.; J. Biol. Chem. 261, 8140 (1986) Abstract; Full Text
Nonradioactive assay for protein phosphatase 2B (calcineurin) activity using a partial sequence of the subunit of cAMP-dependent protein kinase as substrate: A. Enz, et al.; Anal. Biochem. 216, 147 (1994) Abstract

Further Categories Containing This Product:

PP2B [Calcineurin] / Related Products • Peptides

ALX-350-106

Revised 29-Nov-07

Ampullosporin A
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-106-M001		1 mg	50.00 USD

Product Specification

SEQUENCE:	Ac-Trp-Ala-Aib-Aib-Leu-Aib-Gln-Aib-Aib-Aib-Gln-Leu-Aib-Gln-Leucinol
FORMULA:	C₇₇H₁₂₇N₁₉O₁₉
MW:	1623.0
SOURCE/HOST:	Antibiotic isolated from Sepedonium ampullosporum.
PURITY:	≥98% (HPLC)
SOLUBILITY:	Soluble in alcohols, chloroform or dichloromethane. Insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	TOXIC.

Product Description

Peptaibol-type polypeptide. Induces pigment formation by the fungus Phoma destructiva, causes hypothermia in mice, displays neuroleptic activity in rats and forms instable pores in artificial bilayer membranes.

Product Specific Literature References

Ampullosporin, a new peptaibol-type antibiotic from Sepedonium ampullosporum HKI-0053 with neuroleptic activity in mice: M. Ritzau, et al.; J. Antibiot. 50, 722 (1997) Abstract
Differences in ion permeability of an artificial bilayer membrane caused by ampullosporin and bergofungin, new 15-membered peptaibol-type antibiotics: P. Grigoriev, et al.; Bioelectrochemistry 44, 155 (1997)
Differences in ion-channel formation by ampullosporins B, C, D and semisynthetic desacetyltryptophanyl ampullosporin A: P. Grigoriev, et al.; Bioelectrochemistry 57, 119 (2002) Abstract
Synthesis and biological evaluation of analogues of the peptaibol ampullosporin A: H.H. Nguyen, et al.; J. Med. Chem. 45, 2781 (2002) Abstract
Crystal structure and conformational analysis of ampullosporin A: M. Kronen, et al.; J. Pept. Sci. 9, 729 (2003) Abstract
Membrane association and activity of 15/16-membered peptide antibiotics: zervamicin IIB, ampullosporin A and antiamoebin I: T.N. Kropacheva, et al.; Biochim. Biophys. Acta 1715, 6 (2005) Abstract
Transcriptional response to the neuroleptic-like compound Ampullosporin A in the rat ketamine model: H. Krugel, et al.; J. Neurochem. 97, Suppl. 1, 74 (2006) Abstract

Further Categories Containing This Product:

Alzheimer Research Other Products • Ion Channels & Transporters Other Products • Peptides