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ALX-380-009 Revised 26-Jun-08
Actinomycin D
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SYNONYMS Actinomycin IV
Actinomycin C1
Dactinomycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-009-M005   5 mg 50.00 USD Add To Cart
ALX-380-009-M025   25 mg 200.00 USD Add To Cart
ALX-380-009-M100   100 mg 540.00 USD Add To Cart
Product Specification
FORMULA: C62H86N12O16
MW: 1255.5
CAS NUMBER: 50-76-0
MERCK INDEX: 14: 2800
RTECS: AU1575000
SOURCE/HOST: Isolated from Streptomyces parvulus.
PURITY: ≥98%
APPEARANCE: Red shiny crystals.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Sensitive to strong acids and bases.
HANDLING: Protect from light. Hygroscopic.
HAZARD: VERY TOXIC.

Product Description
Antitumor antibiotic. DNA intercalating agent. Cytotoxic inducer of apoptosis against tumor cells. Inhibitor of RNA synthesis.

For nomenclature see S.A. Waksman, E. Katz & L.C. Vining; PNAS 44, 602 (1958)
Product Specific Literature References
Apoptosis induced by Actinomycin D, Camptothecin or Aphidicolin can occur in all phases of the cell cycle: J.M. Glynn, et al.; Biochem. Soc. Trans. 20, 84S (1992) Abstract
Influence of DNA base sequence on the binding energetics of actinomycin D: S.A. Bailey, et al.; Biochemistry 32, 5881 (1993) Abstract
Nitric oxide ameliorates actinomycin D/endotoxin-induced apoptotic liver failure in mice: M. Akahori, et al.; J. Surg. Res. 85, 286 (1999) Abstract
Tumor necrosis factor-alpha plus actinomycin D-induced apoptosis of L929 cells is prevented by nitric oxide: S. Hakoda, et al.; Surg. Today 29, 1059 (1999) Abstract
Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells: J. Kleeff, et al.; Int. J. Cancer 86, 399 (2000) Abstract
Actinomycin D inhibiting K562 cell apoptosis elicited by salvicine but not decreasing its cytotoxicity: C. Qing, et al.; Acta Pharmacol. Sin. 24, 415 (2003) Abstract; Full Text
Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II: H.E. Mischo, et al.; J. Biol. Chem. 280, 9586 (2005) Abstract
Actinomycin D upregulates proapoptotic protein Puma and downregulates Bcl-2 mRNA in normal peripheral blood lymphocytes: I. Kalousek, et al.; Anticancer Drugs 18, 763 (2007) Abstract
Actinomycin D enhances TRAIL-induced caspase-dependent and -independent apoptosis in SH-SY5Y neuroblastoma cells: M.J. Wang, et al.; Neurosci. Res. 59, 40 (2007) Abstract
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Further Categories Containing This Product:
Antitumor Agents (Apoptosis Inducers) • Transcription Inhibitors/Related Products • Antibiotics - Apoptosis Inducers & Inhibitors
 
 
ALX-380-024 Revised 30-Oct-07
Actinomycin C
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SYNONYMS Cactinomycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-024-M005   5 mg 40.00 USD Add To Cart
ALX-380-024-M025   25 mg 140.00 USD Add To Cart
Product Specification
CAS NUMBER: 8052-16-2
MERCK INDEX: 14: 1606
SOURCE/HOST: Isolated from Streptomyces chrysomallus.
PURITY: ≥98%
APPEARANCE: Orange solid.
FORMULATION: Mixture of actinomycin C1(= actinomycin D) (R = R’ = D-Val)  ~3%, C2(R = D-Val, R’ = D-allo-Ile) ~45%, C3(R = R’ = D-allo-Ile) ~53%.
SOLUBILITY: Soluble in methanol. Sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Antibiotic complex with antitumor activity.
Product Specific Literature References
Nomenclature of the Actinomycins: S.A. Waksman, et al.; PNAS 44, 602 (1958) Abstract
General Information
For nomenclature see S.A. Waksman, E. Katz and L.C. Vining; PNAS 44, 602 (1958).
Further Categories Containing This Product:
Antitumor Agents (Apoptosis Inducers) • Transcription Inhibitors/Related Products • Antibiotics - Apoptosis Inducers & Inhibitors
 
 
ALX-380-055 Revised 13-Jun-08
Chromomycin A3
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SYNONYMS Toyomycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Antibiotics - DNA Regulation/Transcription
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-055-M005   5 mg 65.00 USD Add To Cart
ALX-380-055-M025   25 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C57H82O26
MW: 1183.3
CAS NUMBER: 7059-24-7
MERCK INDEX: 14: 2238
RTECS: GB7875000
SOURCE/HOST: Isolated from Streptomyces griseus.
PURITY: ≥97% (HPLC)
APPEARANCE: Off white to yellow powder.
SOLUBILITY: Soluble in ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Antibiotic. Inhibits RNA synthesis. Cell permeable fluorescent dye that can be used with Bisbenzimide H33258 (Prod. No. ALX-620-051) to distinguish chromosomes by their total DNA concentration and their DNA base composition. Binds to G:C pairs of helical DNA but does not intercalate. Ex(max): 445nm; Em(max): 575nm.
General Literature References
K. Mizuno; J. Antibiot. 16, 22 (1963)
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Transcription Inhibitors/Related Products
 
 
ALX-380-077 Revised 30-Oct-07
Actinomycin C3
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-077-M001   1 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C64H90N12O16
MW: 1283.5
MERCK INDEX: 14: 1606
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (solvent free)
APPEARANCE: Orange crystals.
SOLUBILITY: Soluble in methanol, acetone or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep cool and dry.
HAZARD: TOXIC.
IDENTITY: Determined by 1H-NMR: Identical to standard reference.

Product Description
Antitumor antibiotic.
Product Specific Literature References
Nomenclature of the Actinomycins: S.A. Waksman, et al.; PNAS 44, 602 (1958) Abstract
Further Categories Containing This Product:
Transcription Inhibitors/Related Products
 
 
ALX-380-080 Revised 03-Apr-08
Actinomycin X2
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-080-M001   1 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C62H84N12O17
MW: 1269.4
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥95% (solvent free)
APPEARANCE: Orange crystals.
SOLUBILITY: Soluble in methanol, acetone or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep cool and dry.
HAZARD: TOXIC.
IDENTITY: Determined by 1H-NMR: Identical to standard reference.

Product Description
Antitumor antibiotic. Has higher cytotoxicity toward cultured human leukemia (HL-60) cells than actinomycin D (Prod. No. ALX-380-009). Induces cell death via apoptosis.
Product Specific Literature References
Nomenclature of the Actinomycins: S.A. Waksman, et al.; PNAS 44, 602 (1958) Abstract
Correlation of actinomycin X2 to the lipid profile in static and shaken cultures of Streptomyces nasri strain YG62: M.Y. el-Naggar, et al.; Microbios. 100, 117 (1999) Abstract
Characterization of Streptomyces MITKK-103, a newly isolated actinomycin X2-producer: K. Kurosawa, et al.; Appl. Microbiol. Biotechnol. 72, 145 (2006) Abstract
Further Categories Containing This Product:
Antibiotics - Apoptosis Inducers & Inhibitors • Transcription Inhibitors/Related Products
 
 
ALX-380-082 Revised 30-Oct-07
Actinomycin C2
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-082-C500   500 µg 80.00 USD Add To Cart
Product Specification
FORMULA: C63H88N12O16
MW: 1269.5
MERCK INDEX: 14: 1606
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (contains traces of ethylacetate or cyclohexane)
APPEARANCE: Orange crystals.
SOLUBILITY: Soluble in methanol, acetone or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep cool and dry.
HAZARD: TOXIC.
IDENTITY: Determined by 1H-NMR: Identical to standard reference.

Product Description
Antitumor antibiotic.
Product Specific Literature References
Nomenclature of the Actinomycins: S.A. Waksman, et al.; PNAS 44, 602 (1958) Abstract
Actinomycin D, C2 and VII, inhibitors of Grb2-SHC interaction produced by Streptomyces: J. Y. Nam, et al.; Bioorg. Med. Chem. Lett. 8, 2001 (1998) Abstract
Further Categories Containing This Product:
Transcription Inhibitors/Related Products
 
 
ALX-380-083 Revised 30-Oct-07
Actinomycin X0β
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-083-C200   200 µg 70.00 USD Add To Cart
Product Specification
FORMULA: C62H86N12O17
MW: 1271.5
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (contains traces of ethyl acetate or cyclohexane)
APPEARANCE: Orange crystals.
SOLUBILITY: Soluble in methanol, acetone or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep cool and dry.
HAZARD: TOXIC.
IDENTITY: Detemined by 1H-NMR: Identical to standard reference.

Product Description
Antitumor antibiotic.
Product Specific Literature References
Nomenclature of the Actinomycins: S.A. Waksman, et al.; PNAS 44, 602 (1958) Abstract
Identification of actinomycins by high performance liquid chromatography and fast atom bombardment mass spectrometry: S. Cho, et al.; Arch. Pharm. Res. 17, 424 (1994) Abstract
Further Categories Containing This Product:
Antibiotics - Apoptosis Inducers & Inhibitors • Transcription Inhibitors/Related Products
 
 
ALX-380-084 Revised 30-Oct-07
Actinomycin X0δ
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-084-C200   200 µg 70.00 USD Add To Cart
Product Specification
FORMULA: C62H86N12O17
MW: 1271.5
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (contains traces of ethyl acetate or cyclohexane)
APPEARANCE: Red crystals.
SOLUBILITY: Soluble in methanol, acetone or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep cool and dry.
HAZARD: TOXIC.
IDENTITY: Determined by 1H-NMR: Identical to standard reference.

Product Description
Antitumor antibiotic.
Product Specific Literature References
Identification of actinomycins by high performance liquid chromatography and fast atom bombardment mass spectrometry: S. Cho, et al.; Arch. Pharm. Res. 17, 424 (1994) Abstract
Further Categories Containing This Product:
Antibiotics - Apoptosis Inducers & Inhibitors • Transcription Inhibitors/Related Products
 
 
ALX-380-085 Revised 30-Oct-07
Actinomycin Z1
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-085-C200   200 µg 70.00 USD Add To Cart
Product Specification
FORMULA: C62H84N12O19
MW: 1301.5
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥95% (contains traces of ethyl acetate or cyclohexane)
SOLUBILITY: Soluble in methanol, acetone or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep cool and dry.
HAZARD: TOXIC.
IDENTITY: Determined by 1H-NMR: Identical to standard reference.

Product Description
Antitumor antibiotic.
Product Specific Literature References
Identification of actinomycins by high performance liquid chromatography and fast atom bombardment mass spectrometry: S. Cho, et al.; Arch. Pharm. Res. 17, 424 (1994) Abstract
Further Categories Containing This Product:
Transcription Inhibitors/Related Products
 
 
ALX-380-283 Revised 21-May-08
7-Amino-actinomycin D
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SYNONYMS 7-AAD
7-Aminoactinomycin C1
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-283-M001   1 mg 90.00 USD Add To Cart
ALX-380-283-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C62H87N13O16
MW: 1270.4
CAS NUMBER: 7240-37-1
RTECS: AU1579000
SOURCE/HOST: Semisynthetic from actinomycin D (Prod. No. ALX-380-009).
PURITY: ≥96% (HPLC)
APPEARANCE: Red to dark purple powder.
SOLUBILITY: Soluble in DMSO (20mg/ml), methanol or 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Hygroscopic.
HAZARD: VERY TOXIC.

Product Description
Membrane impermeable fluorescent DNA intercalator. Used as a fluorescent DNA stain. Inhibitor of DNA-primed RNA polymerase and DNA polymerase. Induces apoptosis and is used as a tool to identify apoptotic cells. Cytochemical probe. Exhibits growth-inhibitory activity against certain leukemias and sarcomas. Has antibacterial properties.
Product Specific Literature References
7-Amino-actinomycin D as a cytochemical probe. I. Spectral properties: J.E. Gill, et al.; J. Histochem. Cytochem. 23, 793 (1975) Abstract; Full Text
7-substituted actinomycin D analogs. Chemical and growth-inhibitory studies: S.K. Sengupta, et al.; J. Med. Chem. 18, 1175 (1975) Abstract
Simultaneous cell cycle analysis and two-color surface immunofluorescence using 7-amino-actinomycin D and single laser excitation: applications to study of cell activation and the cell cycle of murine Ly-1 B cells: P.S. Rabinovitch, et al.; J. Immunol. 136, 2769 (1986) Abstract
Binding specificities of actinomycin D to non-self-complementary -XGCY-tetranucleotide sequences: F.M. Chen; Biochemistry 31, 6223 (1992) Abstract
Dead